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Protein

Secreted Ly-6/uPAR-related protein 1

Gene

Slurp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner (By similarity). In T cells may be involved in regulation of intracellular Ca2+ signaling (PubMed:17286989). Seems to have a immunomodulatory function in the cornea. The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation (PubMed:23139280, PubMed:25168896).By similarity3 Publications

GO - Molecular functioni

GO - Biological processi

  • cell activation Source: GO_Central
  • locomotory behavior Source: MGI
  • negative regulation of cell migration Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of keratinocyte proliferation Source: MGI
  • neuromuscular process controlling posture Source: MGI
  • urokinase plasminogen activator signaling pathway Source: Ensembl

Keywordsi

Molecular functionCytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted Ly-6/uPAR-related protein 1
Short name:
SLURP-1
Alternative name(s):
ARS component B
Gene namesi
Name:Slurp1
Synonyms:Ars
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1930923. Slurp1.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Severe palmoplantar keratoderma, reduced adiposity, protection from obesity on a high-fat diet, low plasma lipid levels, and neuromuscular abnormality (hind-limb clasping).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000003616823 – 110Secreted Ly-6/uPAR-related protein 1By similarityAdd BLAST88

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 50Sequence analysisBy similarity
Disulfide bondi28 ↔ 37Sequence analysisBy similarity
Disulfide bondi43 ↔ 73Sequence analysisBy similarity
Disulfide bondi77 ↔ 93Sequence analysisBy similarity
Disulfide bondi94 ↔ 99Sequence analysisBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9Z0K7.
PRIDEiQ9Z0K7.

PTM databases

PhosphoSitePlusiQ9Z0K7.

Expressioni

Tissue specificityi

Expressed in skin, eye, whole lung, trachea, esophagus and stomach (PubMed:14721776). Widely expressed in various tissues including spleen and thymus but not pancreas. Expressed in macrophages, dendritic cells, T and B cells (PubMed:17286989). Expressed in lung specifically in ciliated bronchial epithelial cells (at protein level). Expression is decreased in lungs of asthmatic model mice(PubMed:19396877, PubMed:20621062). Expressed in the cornea (PubMed:23139280).5 Publications

Inductioni

Down-regulated in the cornea under proinflammatory conditions.1 Publication

Gene expression databases

BgeeiENSMUSG00000022596.
CleanExiMM_SLURP1.
ExpressionAtlasiQ9Z0K7. baseline and differential.
GenevisibleiQ9Z0K7. MM.

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with PLAU (PubMed:25168896). Interacts with CHRNA7.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PlauP068694EBI-14060702,EBI-8365661

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9Z0K7. 1 interactor.
STRINGi10090.ENSMUSP00000023261.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0K7.
SMRiQ9Z0K7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 73UPAR/Ly6Add BLAST50

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J33S. Eukaryota.
ENOG411196K. LUCA.
GeneTreeiENSGT00510000047304.
HOGENOMiHOG000035114.
HOVERGENiHBG094857.
InParanoidiQ9Z0K7.
OMAiPMVTRSC.
OrthoDBiEOG091G0UOB.
PhylomeDBiQ9Z0K7.
TreeFamiTF336080.

Family and domain databases

InterProiView protein in InterPro
IPR018363. CD59_antigen_CS.
IPR016054. LY6_UPA_recep-like.
PfamiView protein in Pfam
PF00021. UPAR_LY6. 1 hit.
PROSITEiView protein in PROSITE
PS00983. LY6_UPAR. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0K7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLRWAMWLL LLAAWSMGYG EAFRCYTCEQ PTAINSCKNI AQCKMEDTAC
60 70 80 90 100
KTVLETVEAA FPFNHSPMVT RSCSSSCLAT DPDGIGVAHP VFCCFRDLCN
110
SGFPGFVAGL
Length:110
Mass (Da):12,016
Last modified:May 1, 1999 - v1
Checksum:iAAB69CF6C5FE5BFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132356 Genomic DNA. Translation: CAA10646.1.
AK003904 mRNA. Translation: BAB23068.1.
AK029079 mRNA. Translation: BAC26282.1.
BC111105 mRNA. Translation: AAI11106.1.
BC125244 mRNA. Translation: AAI25245.1.
CCDSiCCDS27528.1.
RefSeqiNP_065265.1. NM_020519.1.
UniGeneiMm.27630.

Genome annotation databases

EnsembliENSMUST00000190433; ENSMUSP00000141013; ENSMUSG00000022596.
GeneIDi57277.
KEGGimmu:57277.
UCSCiuc007wft.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiSLUR1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0K7
Secondary accession number(s): Q2TA55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: May 1, 1999
Last modified: August 30, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot