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Protein

Secreted Ly-6/uPAR-related protein 1

Gene

Slurp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Was found to be a marker of late differentiation of the skin.By similarity

GO - Biological processi

  • cell activation Source: GO_Central
  • locomotory behavior Source: MGI
  • negative regulation of cell migration Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of keratinocyte proliferation Source: MGI
  • neuromuscular process controlling posture Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted Ly-6/uPAR-related protein 1
Short name:
SLURP-1
Alternative name(s):
ARS component B
Gene namesi
Name:Slurp1
Synonyms:Ars
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1930923. Slurp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000003616823 – 110Secreted Ly-6/uPAR-related protein 1By similarityAdd BLAST88

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 50Sequence analysis
Disulfide bondi28 ↔ 37Sequence analysis
Disulfide bondi43 ↔ 73Sequence analysis
Disulfide bondi77 ↔ 93Sequence analysis
Disulfide bondi94 ↔ 99Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9Z0K7.
PRIDEiQ9Z0K7.

PTM databases

PhosphoSitePlusiQ9Z0K7.

Expressioni

Tissue specificityi

Expressed in skin, eye, whole lung, trachea, esophagus and stomach.1 Publication

Gene expression databases

BgeeiENSMUSG00000022596.
CleanExiMM_SLURP1.
ExpressionAtlasiQ9Z0K7. baseline and differential.
GenevisibleiQ9Z0K7. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023261.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0K7.
SMRiQ9Z0K7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 73UPAR/Ly6Add BLAST50

Sequence similaritiesi

Contains 1 UPAR/Ly6 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J33S. Eukaryota.
ENOG411196K. LUCA.
GeneTreeiENSGT00510000047304.
HOGENOMiHOG000035114.
HOVERGENiHBG094857.
InParanoidiQ9Z0K7.
OMAiPMVTRSC.
OrthoDBiEOG091G0UOB.
PhylomeDBiQ9Z0K7.
TreeFamiTF336080.

Family and domain databases

InterProiIPR018363. CD59_antigen_CS.
IPR016054. LY6_UPA_recep-like.
IPR027103. SLURP1.
[Graphical view]
PANTHERiPTHR10036:SF10. PTHR10036:SF10. 1 hit.
PfamiPF00021. UPAR_LY6. 1 hit.
[Graphical view]
PROSITEiPS00983. LY6_UPAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0K7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLRWAMWLL LLAAWSMGYG EAFRCYTCEQ PTAINSCKNI AQCKMEDTAC
60 70 80 90 100
KTVLETVEAA FPFNHSPMVT RSCSSSCLAT DPDGIGVAHP VFCCFRDLCN
110
SGFPGFVAGL
Length:110
Mass (Da):12,016
Last modified:May 1, 1999 - v1
Checksum:iAAB69CF6C5FE5BFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132356 Genomic DNA. Translation: CAA10646.1.
AK003904 mRNA. Translation: BAB23068.1.
AK029079 mRNA. Translation: BAC26282.1.
BC111105 mRNA. Translation: AAI11106.1.
BC125244 mRNA. Translation: AAI25245.1.
CCDSiCCDS27528.1.
RefSeqiNP_065265.1. NM_020519.1.
UniGeneiMm.27630.

Genome annotation databases

EnsembliENSMUST00000190433; ENSMUSP00000141013; ENSMUSG00000022596.
GeneIDi57277.
KEGGimmu:57277.
UCSCiuc007wft.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132356 Genomic DNA. Translation: CAA10646.1.
AK003904 mRNA. Translation: BAB23068.1.
AK029079 mRNA. Translation: BAC26282.1.
BC111105 mRNA. Translation: AAI11106.1.
BC125244 mRNA. Translation: AAI25245.1.
CCDSiCCDS27528.1.
RefSeqiNP_065265.1. NM_020519.1.
UniGeneiMm.27630.

3D structure databases

ProteinModelPortaliQ9Z0K7.
SMRiQ9Z0K7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023261.

PTM databases

PhosphoSitePlusiQ9Z0K7.

Proteomic databases

PaxDbiQ9Z0K7.
PRIDEiQ9Z0K7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000190433; ENSMUSP00000141013; ENSMUSG00000022596.
GeneIDi57277.
KEGGimmu:57277.
UCSCiuc007wft.1. mouse.

Organism-specific databases

CTDi57152.
MGIiMGI:1930923. Slurp1.

Phylogenomic databases

eggNOGiENOG410J33S. Eukaryota.
ENOG411196K. LUCA.
GeneTreeiENSGT00510000047304.
HOGENOMiHOG000035114.
HOVERGENiHBG094857.
InParanoidiQ9Z0K7.
OMAiPMVTRSC.
OrthoDBiEOG091G0UOB.
PhylomeDBiQ9Z0K7.
TreeFamiTF336080.

Miscellaneous databases

PROiQ9Z0K7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022596.
CleanExiMM_SLURP1.
ExpressionAtlasiQ9Z0K7. baseline and differential.
GenevisibleiQ9Z0K7. MM.

Family and domain databases

InterProiIPR018363. CD59_antigen_CS.
IPR016054. LY6_UPA_recep-like.
IPR027103. SLURP1.
[Graphical view]
PANTHERiPTHR10036:SF10. PTHR10036:SF10. 1 hit.
PfamiPF00021. UPAR_LY6. 1 hit.
[Graphical view]
PROSITEiPS00983. LY6_UPAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSLUR1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0K7
Secondary accession number(s): Q2TA55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.