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Protein

Secreted Ly-6/uPAR-related protein 1

Gene

Slurp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Was found to be a marker of late differentiation of the skin.By similarity

GO - Biological processi

  • cell activation Source: GO_Central
  • locomotory behavior Source: MGI
  • negative regulation of cell migration Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of keratinocyte proliferation Source: MGI
  • neuromuscular process controlling posture Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted Ly-6/uPAR-related protein 1
Short name:
SLURP-1
Alternative name(s):
ARS component B
Gene namesi
Name:Slurp1
Synonyms:Ars
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1930923. Slurp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 11088Secreted Ly-6/uPAR-related protein 1By similarityPRO_0000036168Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 50Sequence analysis
Disulfide bondi28 ↔ 37Sequence analysis
Disulfide bondi43 ↔ 73Sequence analysis
Disulfide bondi77 ↔ 93Sequence analysis
Disulfide bondi94 ↔ 99Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9Z0K7.
PRIDEiQ9Z0K7.

PTM databases

PhosphoSiteiQ9Z0K7.

Expressioni

Tissue specificityi

Expressed in skin, eye, whole lung, trachea, esophagus and stomach.1 Publication

Gene expression databases

BgeeiQ9Z0K7.
CleanExiMM_SLURP1.
ExpressionAtlasiQ9Z0K7. baseline and differential.
GenevisibleiQ9Z0K7. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023261.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0K7.
SMRiQ9Z0K7. Positions 39-100.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 7350UPAR/Ly6Add
BLAST

Sequence similaritiesi

Contains 1 UPAR/Ly6 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J33S. Eukaryota.
ENOG411196K. LUCA.
GeneTreeiENSGT00510000047304.
HOGENOMiHOG000035114.
HOVERGENiHBG094857.
InParanoidiQ9Z0K7.
OMAiMVTRSCS.
OrthoDBiEOG7P8P9W.
PhylomeDBiQ9Z0K7.
TreeFamiTF336080.

Family and domain databases

InterProiIPR018363. CD59_antigen_CS.
IPR016054. LY6_UPA_recep-like.
IPR027103. SLURP1.
[Graphical view]
PANTHERiPTHR10036:SF10. PTHR10036:SF10. 1 hit.
PfamiPF00021. UPAR_LY6. 1 hit.
[Graphical view]
PROSITEiPS00983. LY6_UPAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0K7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLRWAMWLL LLAAWSMGYG EAFRCYTCEQ PTAINSCKNI AQCKMEDTAC
60 70 80 90 100
KTVLETVEAA FPFNHSPMVT RSCSSSCLAT DPDGIGVAHP VFCCFRDLCN
110
SGFPGFVAGL
Length:110
Mass (Da):12,016
Last modified:May 1, 1999 - v1
Checksum:iAAB69CF6C5FE5BFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132356 Genomic DNA. Translation: CAA10646.1.
AK003904 mRNA. Translation: BAB23068.1.
AK029079 mRNA. Translation: BAC26282.1.
BC111105 mRNA. Translation: AAI11106.1.
BC125244 mRNA. Translation: AAI25245.1.
CCDSiCCDS27528.1.
RefSeqiNP_065265.1. NM_020519.1.
UniGeneiMm.27630.

Genome annotation databases

EnsembliENSMUST00000190433; ENSMUSP00000141013; ENSMUSG00000022596.
GeneIDi57277.
KEGGimmu:57277.
UCSCiuc007wft.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132356 Genomic DNA. Translation: CAA10646.1.
AK003904 mRNA. Translation: BAB23068.1.
AK029079 mRNA. Translation: BAC26282.1.
BC111105 mRNA. Translation: AAI11106.1.
BC125244 mRNA. Translation: AAI25245.1.
CCDSiCCDS27528.1.
RefSeqiNP_065265.1. NM_020519.1.
UniGeneiMm.27630.

3D structure databases

ProteinModelPortaliQ9Z0K7.
SMRiQ9Z0K7. Positions 39-100.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023261.

PTM databases

PhosphoSiteiQ9Z0K7.

Proteomic databases

PaxDbiQ9Z0K7.
PRIDEiQ9Z0K7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000190433; ENSMUSP00000141013; ENSMUSG00000022596.
GeneIDi57277.
KEGGimmu:57277.
UCSCiuc007wft.1. mouse.

Organism-specific databases

CTDi57152.
MGIiMGI:1930923. Slurp1.

Phylogenomic databases

eggNOGiENOG410J33S. Eukaryota.
ENOG411196K. LUCA.
GeneTreeiENSGT00510000047304.
HOGENOMiHOG000035114.
HOVERGENiHBG094857.
InParanoidiQ9Z0K7.
OMAiMVTRSCS.
OrthoDBiEOG7P8P9W.
PhylomeDBiQ9Z0K7.
TreeFamiTF336080.

Miscellaneous databases

PROiQ9Z0K7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z0K7.
CleanExiMM_SLURP1.
ExpressionAtlasiQ9Z0K7. baseline and differential.
GenevisibleiQ9Z0K7. MM.

Family and domain databases

InterProiIPR018363. CD59_antigen_CS.
IPR016054. LY6_UPA_recep-like.
IPR027103. SLURP1.
[Graphical view]
PANTHERiPTHR10036:SF10. PTHR10036:SF10. 1 hit.
PfamiPF00021. UPAR_LY6. 1 hit.
[Graphical view]
PROSITEiPS00983. LY6_UPAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of ARS gene, component B, a new member of Ly-6-related family."
    Mastrangeli R., Donini S., Kelton C., Lou S., Serlupi-Crescenzi O., Vaccaro R., Renda T., Bressan A., Micangeli E., Milazzo F., Ciolli V., Biffoni M., El Tayar N., Lisciani R., Borrelli F., Martelli F., Serani S., Papoian R.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/cJ.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Skin.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "ARS component B: structural characterization, tissue expression and regulation of the gene and protein (SLURP-1) associated with Mal de Meleda."
    Mastrangeli R., Donini S., Kelton C.A., He C., Bressan A., Milazzo F., Ciolli V., Borrelli F., Martelli F., Biffoni M., Serlupi-Crescenzi O., Serani S., Micangeli E., El Tayar N., Vaccaro R., Renda T., Lisciani R., Rossi M., Papoian R.
    Eur. J. Dermatol. 13:560-570(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiSLUR1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0K7
Secondary accession number(s): Q2TA55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: May 1, 1999
Last modified: July 6, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.