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Protein

Growth/differentiation factor 15

Gene

Gdf15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Growth/differentiation factor 15
Short name:
GDF-15
Gene namesi
Name:Gdf15
Synonyms:Sbf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1346047. Gdf15.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence analysisAdd
BLAST
Propeptidei31 – 188158Sequence analysisPRO_0000033994Add
BLAST
Chaini189 – 303115Growth/differentiation factor 15PRO_0000033995Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence analysis
Disulfide bondi206 ↔ 269By similarity
Disulfide bondi235 ↔ 300By similarity
Disulfide bondi239 ↔ 302By similarity
Disulfide bondi268 – 268InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9Z0J7.
PaxDbiQ9Z0J7.
PRIDEiQ9Z0J7.

PTM databases

PhosphoSiteiQ9Z0J7.

Expressioni

Tissue specificityi

Highly expressed in liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000038508.
CleanExiMM_GDF15.
GenevisibleiQ9Z0J7. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000003808.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0J7.
SMRiQ9Z0J7. Positions 204-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00740000114888.
HOGENOMiHOG000143379.
HOVERGENiHBG051718.
InParanoidiQ9Z0J7.
KOiK05504.
OMAiSWDVTRP.
OrthoDBiEOG091G0IUS.
TreeFamiTF351787.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 2 hits.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPALQAQP PGGSQLRFLL FLLLLLLLLS WPSQGDALAM PEQRPSGPES
60 70 80 90 100
QLNADELRGR FQDLLSRLHA NQSREDSNSE PSPDPAVRIL SPEVRLGSHG
110 120 130 140 150
QLLLRVNRAS LSQGLPEAYR VHRALLLLTP TARPWDITRP LKRALSLRGP
160 170 180 190 200
RAPALRLRLT PPPDLAMLPS GGTQLELRLR VAAGRGRRSA HAHPRDSCPL
210 220 230 240 250
GPGRCCHLET VQATLEDLGW SDWVLSPRQL QLSMCVGECP HLYRSANTHA
260 270 280 290 300
QIKARLHGLQ PDKVPAPCCV PSSYTPVVLM HRTDSGVSLQ TYDDLVARGC

HCA
Length:303
Mass (Da):33,225
Last modified:October 3, 2012 - v2
Checksum:iCD021EBEF598D3D0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451P → R in CAA09890 (Ref. 1) Curated
Sequence conflicti45 – 451P → R in AAD41410 (PubMed:10779363).Curated
Sequence conflicti132 – 1321A → T in CAA09890 (Ref. 1) Curated
Sequence conflicti132 – 1321A → T in AAD41410 (PubMed:10779363).Curated
Sequence conflicti148 – 1481R → Q in CAA09890 (Ref. 1) Curated
Sequence conflicti148 – 1481R → Q in AAD41410 (PubMed:10779363).Curated
Sequence conflicti173 – 1731T → A in CAA09890 (Ref. 1) Curated
Sequence conflicti173 – 1731T → A in AAD41410 (PubMed:10779363).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011967, AJ011968 Genomic DNA. Translation: CAA09890.1.
AF159571 mRNA. Translation: AAD41410.1.
AK159242 mRNA. Translation: BAE34924.1.
AC157774 Genomic DNA. No translation available.
CH466569 Genomic DNA. Translation: EDL28851.1.
BC067248 mRNA. Translation: AAH67248.1.
CCDSiCCDS22376.1.
RefSeqiNP_035949.2. NM_011819.2.
UniGeneiMm.31325.

Genome annotation databases

EnsembliENSMUST00000003808; ENSMUSP00000003808; ENSMUSG00000038508.
ENSMUST00000110103; ENSMUSP00000105730; ENSMUSG00000038508.
GeneIDi23886.
KEGGimmu:23886.
UCSCiuc009mba.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011967, AJ011968 Genomic DNA. Translation: CAA09890.1.
AF159571 mRNA. Translation: AAD41410.1.
AK159242 mRNA. Translation: BAE34924.1.
AC157774 Genomic DNA. No translation available.
CH466569 Genomic DNA. Translation: EDL28851.1.
BC067248 mRNA. Translation: AAH67248.1.
CCDSiCCDS22376.1.
RefSeqiNP_035949.2. NM_011819.2.
UniGeneiMm.31325.

3D structure databases

ProteinModelPortaliQ9Z0J7.
SMRiQ9Z0J7. Positions 204-303.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000003808.

PTM databases

PhosphoSiteiQ9Z0J7.

Proteomic databases

MaxQBiQ9Z0J7.
PaxDbiQ9Z0J7.
PRIDEiQ9Z0J7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003808; ENSMUSP00000003808; ENSMUSG00000038508.
ENSMUST00000110103; ENSMUSP00000105730; ENSMUSG00000038508.
GeneIDi23886.
KEGGimmu:23886.
UCSCiuc009mba.2. mouse.

Organism-specific databases

CTDi9518.
MGIiMGI:1346047. Gdf15.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00740000114888.
HOGENOMiHOG000143379.
HOVERGENiHBG051718.
InParanoidiQ9Z0J7.
KOiK05504.
OMAiSWDVTRP.
OrthoDBiEOG091G0IUS.
TreeFamiTF351787.

Miscellaneous databases

PROiQ9Z0J7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038508.
CleanExiMM_GDF15.
GenevisibleiQ9Z0J7. MM.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 2 hits.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGDF15_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0J7
Secondary accession number(s): Q6NX63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 3, 2012
Last modified: September 7, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.