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Protein

Growth/differentiation factor 15

Gene

Gdf15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Growth/differentiation factor 15
Short name:
GDF-15
Gene namesi
Name:Gdf15
Synonyms:Sbf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1346047 Gdf15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
PropeptideiPRO_000003399431 – 188Sequence analysisAdd BLAST158
ChainiPRO_0000033995189 – 303Growth/differentiation factor 15Add BLAST115

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi206 ↔ 269By similarity
Disulfide bondi235 ↔ 300By similarity
Disulfide bondi239 ↔ 302By similarity
Disulfide bondi268InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9Z0J7
PaxDbiQ9Z0J7
PRIDEiQ9Z0J7

PTM databases

PhosphoSitePlusiQ9Z0J7

Expressioni

Tissue specificityi

Highly expressed in liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000038508
CleanExiMM_GDF15
GenevisibleiQ9Z0J7 MM

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000003808

Structurei

3D structure databases

ProteinModelPortaliQ9Z0J7
SMRiQ9Z0J7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00910000143982
HOGENOMiHOG000143379
HOVERGENiHBG051718
InParanoidiQ9Z0J7
KOiK05504
OMAiLGWADWV
OrthoDBiEOG091G0IUS
TreeFamiTF351787

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR015615 TGF-beta-rel
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPALQAQP PGGSQLRFLL FLLLLLLLLS WPSQGDALAM PEQRPSGPES
60 70 80 90 100
QLNADELRGR FQDLLSRLHA NQSREDSNSE PSPDPAVRIL SPEVRLGSHG
110 120 130 140 150
QLLLRVNRAS LSQGLPEAYR VHRALLLLTP TARPWDITRP LKRALSLRGP
160 170 180 190 200
RAPALRLRLT PPPDLAMLPS GGTQLELRLR VAAGRGRRSA HAHPRDSCPL
210 220 230 240 250
GPGRCCHLET VQATLEDLGW SDWVLSPRQL QLSMCVGECP HLYRSANTHA
260 270 280 290 300
QIKARLHGLQ PDKVPAPCCV PSSYTPVVLM HRTDSGVSLQ TYDDLVARGC

HCA
Length:303
Mass (Da):33,225
Last modified:October 3, 2012 - v2
Checksum:iCD021EBEF598D3D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45P → R in CAA09890 (Ref. 1) Curated1
Sequence conflicti45P → R in AAD41410 (PubMed:10779363).Curated1
Sequence conflicti132A → T in CAA09890 (Ref. 1) Curated1
Sequence conflicti132A → T in AAD41410 (PubMed:10779363).Curated1
Sequence conflicti148R → Q in CAA09890 (Ref. 1) Curated1
Sequence conflicti148R → Q in AAD41410 (PubMed:10779363).Curated1
Sequence conflicti173T → A in CAA09890 (Ref. 1) Curated1
Sequence conflicti173T → A in AAD41410 (PubMed:10779363).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011967, AJ011968 Genomic DNA Translation: CAA09890.1
AF159571 mRNA Translation: AAD41410.1
AK159242 mRNA Translation: BAE34924.1
AC157774 Genomic DNA No translation available.
CH466569 Genomic DNA Translation: EDL28851.1
BC067248 mRNA Translation: AAH67248.1
CCDSiCCDS22376.1
RefSeqiNP_001317616.1, NM_001330687.1
NP_035949.2, NM_011819.3
UniGeneiMm.31325

Genome annotation databases

EnsembliENSMUST00000003808; ENSMUSP00000003808; ENSMUSG00000038508
ENSMUST00000110103; ENSMUSP00000105730; ENSMUSG00000038508
GeneIDi23886
KEGGimmu:23886
UCSCiuc009mba.2 mouse

Similar proteinsi

Entry informationi

Entry nameiGDF15_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0J7
Secondary accession number(s): Q6NX63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 3, 2012
Last modified: March 28, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health