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Protein

Growth/differentiation factor 15

Gene

Gdf15

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Growth/differentiation factor 15
Short name:
GDF-15
Gene namesi
Name:Gdf15
Synonyms:Sbf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2674 Gdf15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
PropeptideiPRO_000003399631 – 188Sequence analysisAdd BLAST158
ChainiPRO_0000033997189 – 303Growth/differentiation factor 15Add BLAST115

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi206 ↔ 269By similarity
Disulfide bondi235 ↔ 300By similarity
Disulfide bondi239 ↔ 302By similarity
Disulfide bondi268InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Z0J6
PRIDEiQ9Z0J6

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026652

Structurei

3D structure databases

ProteinModelPortaliQ9Z0J6
SMRiQ9Z0J6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
HOGENOMiHOG000143379
HOVERGENiHBG051718
InParanoidiQ9Z0J6
KOiK05504
PhylomeDBiQ9Z0J6

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR015615 TGF-beta-rel
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0J6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRALHAQP TGGPQLRFLL FLLLLLLLLS WPSQGDALAL PEQRRSLSES
60 70 80 90 100
QLNPDELRGR FQDLLSRLHA NQSREDSNSE PTPDPAVRIL SPEVRLGSHG
110 120 130 140 150
RLLLRVNRAS LTQGLPEAYR VHRALLLLTP SSRPWDITRP LQRAISLQGP
160 170 180 190 200
HARALRLRLA PPPDLAVLPS GGARLELHLR SAAGRGRRSA HLHPRDSCPL
210 220 230 240 250
GPGRCCHLET VQATLEDLGW SDWVLSPRQL QLSMCVGECP HLYRSANTHA
260 270 280 290 300
LIKARLHGLQ PDRVPAPCCV PSSYTPVVLM HRTDSGVSLQ TYDDLVAQGC

HCA
Length:303
Mass (Da):33,439
Last modified:May 1, 1999 - v1
Checksum:iFA828BE79C1052C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011969, AJ011970 Genomic DNA Translation: CAA09891.1
RefSeqiNP_062089.1, NM_019216.2
UniGeneiRn.44228

Genome annotation databases

GeneIDi29455
KEGGirno:29455
UCSCiRGD:2674 rat

Similar proteinsi

Entry informationi

Entry nameiGDF15_RAT
AccessioniPrimary (citable) accession number: Q9Z0J6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 1999
Last modified: April 25, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health