Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

CAP-Gly domain-containing linker protein 2

Gene

Clip2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity).By similarity

GO - Molecular functioni

  • microtubule plus-end binding Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
CAP-Gly domain-containing linker protein 2
Alternative name(s):
Cytoplasmic linker protein 115
Short name:
CLIP-115
Cytoplasmic linker protein 2
Gene namesi
Name:Clip2
Synonyms:Cyln2, Kiaa0291
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1313136. Clip2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10471047CAP-Gly domain-containing linker protein 2PRO_0000083516Add
BLAST

Proteomic databases

MaxQBiQ9Z0H8.
PaxDbiQ9Z0H8.
PRIDEiQ9Z0H8.

PTM databases

PhosphoSiteiQ9Z0H8.

Expressioni

Tissue specificityi

Expressed in the brain, and very low levels in kidneys.1 Publication

Developmental stagei

Expressed at E10.5, expression declines until birth after which it suddenly increases. Expression gradually decreases until postnatal day 10, (the day when DLBs start to occur), then again increases and reaches the levels present in adult brain.1 Publication

Gene expression databases

BgeeiQ9Z0H8.
CleanExiMM_CLIP2.
GenevisibleiQ9Z0H8. MM.

Interactioni

Subunit structurei

Interacts with CLASP1 and CLASP2.1 Publication

Protein-protein interaction databases

BioGridi234703. 1 interaction.
IntActiQ9Z0H8. 5 interactions.
MINTiMINT-4128805.
STRINGi10090.ENSMUSP00000098212.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0H8.
SMRiQ9Z0H8. Positions 69-156, 174-345.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini100 – 14243CAP-Gly 1PROSITE-ProRule annotationAdd
BLAST
Domaini240 – 28243CAP-Gly 2PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili355 – 525171Sequence AnalysisAdd
BLAST
Coiled coili564 – 63774Sequence AnalysisAdd
BLAST
Coiled coili677 – 1017341Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi315 – 34632Ser-richAdd
BLAST

Sequence similaritiesi

Contains 2 CAP-Gly domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG5244.
GeneTreeiENSGT00760000119173.
HOGENOMiHOG000092755.
HOVERGENiHBG007123.
InParanoidiQ9Z0H8.
KOiK10422.
OMAiHWRAQLE.
OrthoDBiEOG7992PN.
PhylomeDBiQ9Z0H8.
TreeFamiTF326096.

Family and domain databases

Gene3Di2.30.30.190. 2 hits.
InterProiIPR000938. CAP-Gly_domain.
IPR028394. CLIP2.
[Graphical view]
PANTHERiPTHR18916:SF10. PTHR18916:SF10. 1 hit.
PfamiPF01302. CAP_GLY. 2 hits.
[Graphical view]
SMARTiSM01052. CAP_GLY. 2 hits.
[Graphical view]
SUPFAMiSSF74924. SSF74924. 2 hits.
PROSITEiPS00845. CAP_GLY_1. 2 hits.
PS50245. CAP_GLY_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Z0H8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQKPSGLKPP GRGGKHSSPV GRPSVGSASS SVVASTSGSK EGSPLHKQAS
60 70 80 90 100
GPSSSGAATT VSEKPGPKAA EVGDDFLGDF VVGERVWVNG VKPGVVQYLG
110 120 130 140 150
ETQFAPGQWA GVVLDDPVGK NDGAVGGVRY FECPALQGIF TRPSKLTRQP
160 170 180 190 200
TAEGSGSDTH SVESLTAQNL SLHSGTATPP LTGRVIPLRE SVLNSSVKTG
210 220 230 240 250
NESGSNLSDS GSVKRGDKDL HLGDRVLVGG TKTGVVRYVG ETDFAKGEWC
260 270 280 290 300
GVELDEPLGK NDGAVAGTRY FQCPPKFGLF APIHKVIRIG FPSTSPAKAK
310 320 330 340 350
KTKRMAMGVS ALTHSPSSSS ISSVSSVASS VGGRPSRSGL LTETSSRYAR
360 370 380 390 400
KISGTTALQE ALKEKQQHIE QLLAERDLER AEVAKATSHI CEVEKEIALL
410 420 430 440 450
KAQHEQYVAE AEEKLQRARL LVENVRKEKV DLSNQLEEER RKVEDLQFRV
460 470 480 490 500
EEESITKGDL ETQTQLEHAR IGELEQSLLL EKAQAERLLR ELADNRLTTV
510 520 530 540 550
AEKSRVLQLE EELSLRRGEI EELQHCLLQS GPPPADHPEA AETLRLRERL
560 570 580 590 600
LSASKEHQRD STLLQDKYEH MLKTYQTEVD KLRAANEKYA QEVADLKAKV
610 620 630 640 650
QQATTENMGL MDNWKSKLDS LASDHQKSLE DLKATLNSGP GAQQKEIGEL
660 670 680 690 700
KALVEGIKME HQLELGNLQA KHDLETAMHG KEKEGLRQKL QEVQEELAGL
710 720 730 740 750
QQHWREQLEE QASQHRLELQ EAQDQCRDAQ LRAQELEGLD VEYRGQAQAI
760 770 780 790 800
EFLKEQISLA EKKMLDYEML QRAEAQSRQE AERLREKLLV AENRLQAAES
810 820 830 840 850
LCSAQHSHVI ESSDLSEETI RMKETVEGLQ DKLNKRDKEV TALTSQMDML
860 870 880 890 900
RAQVSALENK CKSGEKKIDS LLKEKRRLEA ELEAVSRKTH DASGQLVHIS
910 920 930 940 950
QELLRKERSL NELRVLLLEA NRHSPGPERD LSREVHKAEW RIKEQKLKDD
960 970 980 990 1000
IRGLREKLTG LDKEKSLSEQ RRYSLIDPAS PPELLKLQHQ LVSTEDALRD
1010 1020 1030 1040
ALNQAQQVER LVEALRGCSD RTQTISNSGS ANGIHQPDKA HKQEDKH
Length:1,047
Mass (Da):115,910
Last modified:September 27, 2005 - v2
Checksum:i8F46948122F58872
GO
Isoform 2 (identifier: Q9Z0H8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     462-496: Missing.

Show »
Length:1,012
Mass (Da):111,855
Checksum:i5CD0F481CFE7CFB0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251V → I in AAH39162 (PubMed:15489334).Curated
Sequence conflicti59 – 591T → A in CAA13068 (PubMed:9799601).Curated
Sequence conflicti59 – 591T → A in CAA13069 (PubMed:9799601).Curated
Sequence conflicti79 – 791D → H in CAA13068 (PubMed:9799601).Curated
Sequence conflicti79 – 791D → H in CAA13069 (PubMed:9799601).Curated
Sequence conflicti127 – 1271G → A in CAA13068 (PubMed:9799601).Curated
Sequence conflicti127 – 1271G → A in CAA13069 (PubMed:9799601).Curated
Sequence conflicti334 – 3352RP → PA in CAA13068 (PubMed:9799601).Curated
Sequence conflicti334 – 3352RP → PA in CAA13069 (PubMed:9799601).Curated
Sequence conflicti356 – 3561T → I in CAA13068 (PubMed:9799601).Curated
Sequence conflicti356 – 3561T → I in CAA13069 (PubMed:9799601).Curated
Sequence conflicti559 – 5591R → D in CAA13068 (PubMed:9799601).Curated
Sequence conflicti559 – 5591R → D in CAA13069 (PubMed:9799601).Curated
Sequence conflicti713 – 7197SQHRLEL → AASAEA in CAA13068 (PubMed:9799601).Curated
Sequence conflicti733 – 7331A → V in CAA13068 (PubMed:9799601).Curated
Sequence conflicti733 – 7331A → V in CAA13069 (PubMed:9799601).Curated
Sequence conflicti856 – 8561A → V in CAA13068 (PubMed:9799601).Curated
Sequence conflicti856 – 8561A → V in CAA13069 (PubMed:9799601).Curated
Sequence conflicti1003 – 10031N → D in AAH39162 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei462 – 49635Missing in isoform 2. 1 PublicationVSP_015683Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ228863 Genomic DNA. Translation: CAA13068.1.
AJ228865
, AJ228868, AJ228869, AJ228870, AJ228872, AJ228876, AJ228880, AJ228867, AJ228875, AJ228871, AJ228873, AJ228877, AJ228866, AJ228879, AJ228878, AJ228874 Genomic DNA. Translation: CAA13069.1.
AF289667 Genomic DNA. Translation: AAF99340.1.
AF289664 Genomic DNA. Translation: AAF99333.1.
BC039162 mRNA. Translation: AAH39162.1.
BC053048 mRNA. Translation: AAH53048.1.
CCDSiCCDS39309.1. [Q9Z0H8-2]
CCDS39310.1. [Q9Z0H8-1]
PIRiT42720.
RefSeqiNP_001034251.1. NM_001039162.2. [Q9Z0H8-2]
NP_034120.2. NM_009990.3. [Q9Z0H8-1]
UniGeneiMm.255138.

Genome annotation databases

EnsembliENSMUST00000036999; ENSMUSP00000037431; ENSMUSG00000063146. [Q9Z0H8-2]
ENSMUST00000100647; ENSMUSP00000098212; ENSMUSG00000063146. [Q9Z0H8-1]
GeneIDi269713.
KEGGimmu:269713.
UCSCiuc008zwi.1. mouse. [Q9Z0H8-1]
uc008zwj.1. mouse. [Q9Z0H8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ228863 Genomic DNA. Translation: CAA13068.1.
AJ228865
, AJ228868, AJ228869, AJ228870, AJ228872, AJ228876, AJ228880, AJ228867, AJ228875, AJ228871, AJ228873, AJ228877, AJ228866, AJ228879, AJ228878, AJ228874 Genomic DNA. Translation: CAA13069.1.
AF289667 Genomic DNA. Translation: AAF99340.1.
AF289664 Genomic DNA. Translation: AAF99333.1.
BC039162 mRNA. Translation: AAH39162.1.
BC053048 mRNA. Translation: AAH53048.1.
CCDSiCCDS39309.1. [Q9Z0H8-2]
CCDS39310.1. [Q9Z0H8-1]
PIRiT42720.
RefSeqiNP_001034251.1. NM_001039162.2. [Q9Z0H8-2]
NP_034120.2. NM_009990.3. [Q9Z0H8-1]
UniGeneiMm.255138.

3D structure databases

ProteinModelPortaliQ9Z0H8.
SMRiQ9Z0H8. Positions 69-156, 174-345.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi234703. 1 interaction.
IntActiQ9Z0H8. 5 interactions.
MINTiMINT-4128805.
STRINGi10090.ENSMUSP00000098212.

PTM databases

PhosphoSiteiQ9Z0H8.

Proteomic databases

MaxQBiQ9Z0H8.
PaxDbiQ9Z0H8.
PRIDEiQ9Z0H8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036999; ENSMUSP00000037431; ENSMUSG00000063146. [Q9Z0H8-2]
ENSMUST00000100647; ENSMUSP00000098212; ENSMUSG00000063146. [Q9Z0H8-1]
GeneIDi269713.
KEGGimmu:269713.
UCSCiuc008zwi.1. mouse. [Q9Z0H8-1]
uc008zwj.1. mouse. [Q9Z0H8-2]

Organism-specific databases

CTDi7461.
MGIiMGI:1313136. Clip2.
RougeiSearch...

Phylogenomic databases

eggNOGiCOG5244.
GeneTreeiENSGT00760000119173.
HOGENOMiHOG000092755.
HOVERGENiHBG007123.
InParanoidiQ9Z0H8.
KOiK10422.
OMAiHWRAQLE.
OrthoDBiEOG7992PN.
PhylomeDBiQ9Z0H8.
TreeFamiTF326096.

Miscellaneous databases

NextBioi393005.
PROiQ9Z0H8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z0H8.
CleanExiMM_CLIP2.
GenevisibleiQ9Z0H8. MM.

Family and domain databases

Gene3Di2.30.30.190. 2 hits.
InterProiIPR000938. CAP-Gly_domain.
IPR028394. CLIP2.
[Graphical view]
PANTHERiPTHR18916:SF10. PTHR18916:SF10. 1 hit.
PfamiPF01302. CAP_GLY. 2 hits.
[Graphical view]
SMARTiSM01052. CAP_GLY. 2 hits.
[Graphical view]
SUPFAMiSSF74924. SSF74924. 2 hits.
PROSITEiPS00845. CAP_GLY_1. 2 hits.
PS50245. CAP_GLY_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The murine CYLN2 gene: genomic organization, chromosome localization, and comparison to the human gene that is located within the 7q11.23 Williams syndrome critical region."
    Hoogenraad C.C., Eussen B.H.J., Langeveld A., van Haperen R., Winterberg S., Wouters C.H., Grosveld F., de Zeeuw C.I., Galjart N.
    Genomics 53:348-358(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
  2. Green E.D.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6 and FVB/N.
    Tissue: Brain and Mammary tumor.
  4. "Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts."
    Akhmanova A., Hoogenraad C.C., Drabek K., Stepanova T., Dortland B., Verkerk T., Vermeulen W., Burgering B.M., de Zeeuw C.I., Grosveld F., Galjart N.
    Cell 104:923-935(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CLASP1 AND CLASP2.
  5. "CLIP-115, a novel brain specific cytoplasmic linker protein, mediates the localisation of dendritic lamellar bodies."
    de Zeeuw C.I., Hoogenraad C.C., Goedknegt E., Hertzberg E., Neubauer A., Grosveld F.G., Galjart N.J.
    Neuron 19:1187-1199(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiCLIP2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0H8
Secondary accession number(s): Q7TSI9, Q8CHU1, Q9EP81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: September 27, 2005
Last modified: June 24, 2015
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.