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Q9Z0H8

- CLIP2_MOUSE

UniProt

Q9Z0H8 - CLIP2_MOUSE

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Protein

CAP-Gly domain-containing linker protein 2

Gene
Clip2, Cyln2, Kiaa0291
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations By similarity.

GO - Molecular functioni

  1. microtubule plus-end binding Source: MGI
  2. protein binding Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
CAP-Gly domain-containing linker protein 2
Alternative name(s):
Cytoplasmic linker protein 115
Short name:
CLIP-115
Cytoplasmic linker protein 2
Gene namesi
Name:Clip2
Synonyms:Cyln2, Kiaa0291
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1313136. Clip2.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity
Note: Associated with the cytoskeleton By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10471047CAP-Gly domain-containing linker protein 2PRO_0000083516Add
BLAST

Proteomic databases

MaxQBiQ9Z0H8.
PaxDbiQ9Z0H8.
PRIDEiQ9Z0H8.

PTM databases

PhosphoSiteiQ9Z0H8.

Expressioni

Tissue specificityi

Expressed in the brain, and very low levels in kidneys.1 Publication

Developmental stagei

Expressed at E10.5, expression declines until birth after which it suddenly increases. Expression gradually decreases until postnatal day 10, (the day when DLBs start to occur), then again increases and reaches the levels present in adult brain.1 Publication

Gene expression databases

BgeeiQ9Z0H8.
CleanExiMM_CLIP2.
GenevestigatoriQ9Z0H8.

Interactioni

Subunit structurei

Interacts with CLASP1 and CLASP2.1 Publication

Protein-protein interaction databases

BioGridi234703. 1 interaction.
IntActiQ9Z0H8. 5 interactions.
MINTiMINT-4128805.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0H8.
SMRiQ9Z0H8. Positions 30-156, 174-345, 424-452.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini100 – 14243CAP-Gly 1Add
BLAST
Domaini240 – 28243CAP-Gly 2Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili355 – 525171 Reviewed predictionAdd
BLAST
Coiled coili564 – 63774 Reviewed predictionAdd
BLAST
Coiled coili677 – 1017341 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi315 – 34632Ser-richAdd
BLAST

Sequence similaritiesi

Contains 2 CAP-Gly domains.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG5244.
GeneTreeiENSGT00740000115338.
HOGENOMiHOG000092755.
HOVERGENiHBG007123.
InParanoidiQ9Z0H8.
KOiK10422.
OMAiVHKAEWR.
OrthoDBiEOG7992PN.
PhylomeDBiQ9Z0H8.
TreeFamiTF326096.

Family and domain databases

Gene3Di2.30.30.190. 2 hits.
InterProiIPR000938. CAP-Gly_domain.
IPR028394. CLIP2.
[Graphical view]
PANTHERiPTHR18916:SF10. PTHR18916:SF10. 1 hit.
PfamiPF01302. CAP_GLY. 2 hits.
[Graphical view]
SMARTiSM01052. CAP_GLY. 2 hits.
[Graphical view]
SUPFAMiSSF74924. SSF74924. 2 hits.
PROSITEiPS00845. CAP_GLY_1. 2 hits.
PS50245. CAP_GLY_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Z0H8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQKPSGLKPP GRGGKHSSPV GRPSVGSASS SVVASTSGSK EGSPLHKQAS     50
GPSSSGAATT VSEKPGPKAA EVGDDFLGDF VVGERVWVNG VKPGVVQYLG 100
ETQFAPGQWA GVVLDDPVGK NDGAVGGVRY FECPALQGIF TRPSKLTRQP 150
TAEGSGSDTH SVESLTAQNL SLHSGTATPP LTGRVIPLRE SVLNSSVKTG 200
NESGSNLSDS GSVKRGDKDL HLGDRVLVGG TKTGVVRYVG ETDFAKGEWC 250
GVELDEPLGK NDGAVAGTRY FQCPPKFGLF APIHKVIRIG FPSTSPAKAK 300
KTKRMAMGVS ALTHSPSSSS ISSVSSVASS VGGRPSRSGL LTETSSRYAR 350
KISGTTALQE ALKEKQQHIE QLLAERDLER AEVAKATSHI CEVEKEIALL 400
KAQHEQYVAE AEEKLQRARL LVENVRKEKV DLSNQLEEER RKVEDLQFRV 450
EEESITKGDL ETQTQLEHAR IGELEQSLLL EKAQAERLLR ELADNRLTTV 500
AEKSRVLQLE EELSLRRGEI EELQHCLLQS GPPPADHPEA AETLRLRERL 550
LSASKEHQRD STLLQDKYEH MLKTYQTEVD KLRAANEKYA QEVADLKAKV 600
QQATTENMGL MDNWKSKLDS LASDHQKSLE DLKATLNSGP GAQQKEIGEL 650
KALVEGIKME HQLELGNLQA KHDLETAMHG KEKEGLRQKL QEVQEELAGL 700
QQHWREQLEE QASQHRLELQ EAQDQCRDAQ LRAQELEGLD VEYRGQAQAI 750
EFLKEQISLA EKKMLDYEML QRAEAQSRQE AERLREKLLV AENRLQAAES 800
LCSAQHSHVI ESSDLSEETI RMKETVEGLQ DKLNKRDKEV TALTSQMDML 850
RAQVSALENK CKSGEKKIDS LLKEKRRLEA ELEAVSRKTH DASGQLVHIS 900
QELLRKERSL NELRVLLLEA NRHSPGPERD LSREVHKAEW RIKEQKLKDD 950
IRGLREKLTG LDKEKSLSEQ RRYSLIDPAS PPELLKLQHQ LVSTEDALRD 1000
ALNQAQQVER LVEALRGCSD RTQTISNSGS ANGIHQPDKA HKQEDKH 1047
Length:1,047
Mass (Da):115,910
Last modified:September 27, 2005 - v2
Checksum:i8F46948122F58872
GO
Isoform 2 (identifier: Q9Z0H8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     462-496: Missing.

Show »
Length:1,012
Mass (Da):111,855
Checksum:i5CD0F481CFE7CFB0
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei462 – 49635Missing in isoform 2. VSP_015683Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251V → I in AAH39162. 1 Publication
Sequence conflicti59 – 591T → A in CAA13068. 1 Publication
Sequence conflicti59 – 591T → A in CAA13069. 1 Publication
Sequence conflicti79 – 791D → H in CAA13068. 1 Publication
Sequence conflicti79 – 791D → H in CAA13069. 1 Publication
Sequence conflicti127 – 1271G → A in CAA13068. 1 Publication
Sequence conflicti127 – 1271G → A in CAA13069. 1 Publication
Sequence conflicti334 – 3352RP → PA in CAA13068. 1 Publication
Sequence conflicti334 – 3352RP → PA in CAA13069. 1 Publication
Sequence conflicti356 – 3561T → I in CAA13068. 1 Publication
Sequence conflicti356 – 3561T → I in CAA13069. 1 Publication
Sequence conflicti559 – 5591R → D in CAA13068. 1 Publication
Sequence conflicti559 – 5591R → D in CAA13069. 1 Publication
Sequence conflicti713 – 7197SQHRLEL → AASAEA in CAA13068. 1 Publication
Sequence conflicti733 – 7331A → V in CAA13068. 1 Publication
Sequence conflicti733 – 7331A → V in CAA13069. 1 Publication
Sequence conflicti856 – 8561A → V in CAA13068. 1 Publication
Sequence conflicti856 – 8561A → V in CAA13069. 1 Publication
Sequence conflicti1003 – 10031N → D in AAH39162. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ228863 Genomic DNA. Translation: CAA13068.1.
AJ228865
, AJ228868, AJ228869, AJ228870, AJ228872, AJ228876, AJ228880, AJ228867, AJ228875, AJ228871, AJ228873, AJ228877, AJ228866, AJ228879, AJ228878, AJ228874 Genomic DNA. Translation: CAA13069.1.
AF289667 Genomic DNA. Translation: AAF99340.1.
AF289664 Genomic DNA. Translation: AAF99333.1.
BC039162 mRNA. Translation: AAH39162.1.
BC053048 mRNA. Translation: AAH53048.1.
CCDSiCCDS39309.1. [Q9Z0H8-2]
CCDS39310.1. [Q9Z0H8-1]
PIRiT42720.
RefSeqiNP_001034251.1. NM_001039162.2. [Q9Z0H8-2]
NP_034120.2. NM_009990.3. [Q9Z0H8-1]
UniGeneiMm.255138.

Genome annotation databases

EnsembliENSMUST00000036999; ENSMUSP00000037431; ENSMUSG00000063146. [Q9Z0H8-2]
ENSMUST00000100647; ENSMUSP00000098212; ENSMUSG00000063146. [Q9Z0H8-1]
GeneIDi269713.
KEGGimmu:269713.
UCSCiuc008zwi.1. mouse. [Q9Z0H8-1]
uc008zwj.1. mouse. [Q9Z0H8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ228863 Genomic DNA. Translation: CAA13068.1 .
AJ228865
, AJ228868 , AJ228869 , AJ228870 , AJ228872 , AJ228876 , AJ228880 , AJ228867 , AJ228875 , AJ228871 , AJ228873 , AJ228877 , AJ228866 , AJ228879 , AJ228878 , AJ228874 Genomic DNA. Translation: CAA13069.1 .
AF289667 Genomic DNA. Translation: AAF99340.1 .
AF289664 Genomic DNA. Translation: AAF99333.1 .
BC039162 mRNA. Translation: AAH39162.1 .
BC053048 mRNA. Translation: AAH53048.1 .
CCDSi CCDS39309.1. [Q9Z0H8-2 ]
CCDS39310.1. [Q9Z0H8-1 ]
PIRi T42720.
RefSeqi NP_001034251.1. NM_001039162.2. [Q9Z0H8-2 ]
NP_034120.2. NM_009990.3. [Q9Z0H8-1 ]
UniGenei Mm.255138.

3D structure databases

ProteinModelPortali Q9Z0H8.
SMRi Q9Z0H8. Positions 30-156, 174-345, 424-452.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 234703. 1 interaction.
IntActi Q9Z0H8. 5 interactions.
MINTi MINT-4128805.

PTM databases

PhosphoSitei Q9Z0H8.

Proteomic databases

MaxQBi Q9Z0H8.
PaxDbi Q9Z0H8.
PRIDEi Q9Z0H8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036999 ; ENSMUSP00000037431 ; ENSMUSG00000063146 . [Q9Z0H8-2 ]
ENSMUST00000100647 ; ENSMUSP00000098212 ; ENSMUSG00000063146 . [Q9Z0H8-1 ]
GeneIDi 269713.
KEGGi mmu:269713.
UCSCi uc008zwi.1. mouse. [Q9Z0H8-1 ]
uc008zwj.1. mouse. [Q9Z0H8-2 ]

Organism-specific databases

CTDi 7461.
MGIi MGI:1313136. Clip2.
Rougei Search...

Phylogenomic databases

eggNOGi COG5244.
GeneTreei ENSGT00740000115338.
HOGENOMi HOG000092755.
HOVERGENi HBG007123.
InParanoidi Q9Z0H8.
KOi K10422.
OMAi VHKAEWR.
OrthoDBi EOG7992PN.
PhylomeDBi Q9Z0H8.
TreeFami TF326096.

Miscellaneous databases

NextBioi 393005.
PROi Q9Z0H8.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z0H8.
CleanExi MM_CLIP2.
Genevestigatori Q9Z0H8.

Family and domain databases

Gene3Di 2.30.30.190. 2 hits.
InterProi IPR000938. CAP-Gly_domain.
IPR028394. CLIP2.
[Graphical view ]
PANTHERi PTHR18916:SF10. PTHR18916:SF10. 1 hit.
Pfami PF01302. CAP_GLY. 2 hits.
[Graphical view ]
SMARTi SM01052. CAP_GLY. 2 hits.
[Graphical view ]
SUPFAMi SSF74924. SSF74924. 2 hits.
PROSITEi PS00845. CAP_GLY_1. 2 hits.
PS50245. CAP_GLY_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The murine CYLN2 gene: genomic organization, chromosome localization, and comparison to the human gene that is located within the 7q11.23 Williams syndrome critical region."
    Hoogenraad C.C., Eussen B.H.J., Langeveld A., van Haperen R., Winterberg S., Wouters C.H., Grosveld F., de Zeeuw C.I., Galjart N.
    Genomics 53:348-358(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
  2. Green E.D.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6 and FVB/N.
    Tissue: Brain and Mammary tumor.
  4. "Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts."
    Akhmanova A., Hoogenraad C.C., Drabek K., Stepanova T., Dortland B., Verkerk T., Vermeulen W., Burgering B.M., de Zeeuw C.I., Grosveld F., Galjart N.
    Cell 104:923-935(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CLASP1 AND CLASP2.
  5. "CLIP-115, a novel brain specific cytoplasmic linker protein, mediates the localisation of dendritic lamellar bodies."
    de Zeeuw C.I., Hoogenraad C.C., Goedknegt E., Hertzberg E., Neubauer A., Grosveld F.G., Galjart N.J.
    Neuron 19:1187-1199(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiCLIP2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0H8
Secondary accession number(s): Q7TSI9, Q8CHU1, Q9EP81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: September 27, 2005
Last modified: September 3, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi