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Q9Z0H8

- CLIP2_MOUSE

UniProt

Q9Z0H8 - CLIP2_MOUSE

Protein

CAP-Gly domain-containing linker protein 2

Gene

Clip2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (27 Sep 2005)
      Previous versions | rss
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    Functioni

    Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations By similarity.By similarity

    GO - Molecular functioni

    1. microtubule plus-end binding Source: MGI
    2. protein binding Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CAP-Gly domain-containing linker protein 2
    Alternative name(s):
    Cytoplasmic linker protein 115
    Short name:
    CLIP-115
    Cytoplasmic linker protein 2
    Gene namesi
    Name:Clip2
    Synonyms:Cyln2, Kiaa0291
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1313136. Clip2.

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity
    Note: Associated with the cytoskeleton.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. microtubule Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10471047CAP-Gly domain-containing linker protein 2PRO_0000083516Add
    BLAST

    Proteomic databases

    MaxQBiQ9Z0H8.
    PaxDbiQ9Z0H8.
    PRIDEiQ9Z0H8.

    PTM databases

    PhosphoSiteiQ9Z0H8.

    Expressioni

    Tissue specificityi

    Expressed in the brain, and very low levels in kidneys.1 Publication

    Developmental stagei

    Expressed at E10.5, expression declines until birth after which it suddenly increases. Expression gradually decreases until postnatal day 10, (the day when DLBs start to occur), then again increases and reaches the levels present in adult brain.1 Publication

    Gene expression databases

    BgeeiQ9Z0H8.
    CleanExiMM_CLIP2.
    GenevestigatoriQ9Z0H8.

    Interactioni

    Subunit structurei

    Interacts with CLASP1 and CLASP2.1 Publication

    Protein-protein interaction databases

    BioGridi234703. 1 interaction.
    IntActiQ9Z0H8. 5 interactions.
    MINTiMINT-4128805.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z0H8.
    SMRiQ9Z0H8. Positions 30-156, 174-345, 424-452.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini100 – 14243CAP-Gly 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini240 – 28243CAP-Gly 2PROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili355 – 525171Sequence AnalysisAdd
    BLAST
    Coiled coili564 – 63774Sequence AnalysisAdd
    BLAST
    Coiled coili677 – 1017341Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi315 – 34632Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 2 CAP-Gly domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiCOG5244.
    GeneTreeiENSGT00740000115338.
    HOGENOMiHOG000092755.
    HOVERGENiHBG007123.
    InParanoidiQ9Z0H8.
    KOiK10422.
    OMAiVHKAEWR.
    OrthoDBiEOG7992PN.
    PhylomeDBiQ9Z0H8.
    TreeFamiTF326096.

    Family and domain databases

    Gene3Di2.30.30.190. 2 hits.
    InterProiIPR000938. CAP-Gly_domain.
    IPR028394. CLIP2.
    [Graphical view]
    PANTHERiPTHR18916:SF10. PTHR18916:SF10. 1 hit.
    PfamiPF01302. CAP_GLY. 2 hits.
    [Graphical view]
    SMARTiSM01052. CAP_GLY. 2 hits.
    [Graphical view]
    SUPFAMiSSF74924. SSF74924. 2 hits.
    PROSITEiPS00845. CAP_GLY_1. 2 hits.
    PS50245. CAP_GLY_2. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Z0H8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQKPSGLKPP GRGGKHSSPV GRPSVGSASS SVVASTSGSK EGSPLHKQAS     50
    GPSSSGAATT VSEKPGPKAA EVGDDFLGDF VVGERVWVNG VKPGVVQYLG 100
    ETQFAPGQWA GVVLDDPVGK NDGAVGGVRY FECPALQGIF TRPSKLTRQP 150
    TAEGSGSDTH SVESLTAQNL SLHSGTATPP LTGRVIPLRE SVLNSSVKTG 200
    NESGSNLSDS GSVKRGDKDL HLGDRVLVGG TKTGVVRYVG ETDFAKGEWC 250
    GVELDEPLGK NDGAVAGTRY FQCPPKFGLF APIHKVIRIG FPSTSPAKAK 300
    KTKRMAMGVS ALTHSPSSSS ISSVSSVASS VGGRPSRSGL LTETSSRYAR 350
    KISGTTALQE ALKEKQQHIE QLLAERDLER AEVAKATSHI CEVEKEIALL 400
    KAQHEQYVAE AEEKLQRARL LVENVRKEKV DLSNQLEEER RKVEDLQFRV 450
    EEESITKGDL ETQTQLEHAR IGELEQSLLL EKAQAERLLR ELADNRLTTV 500
    AEKSRVLQLE EELSLRRGEI EELQHCLLQS GPPPADHPEA AETLRLRERL 550
    LSASKEHQRD STLLQDKYEH MLKTYQTEVD KLRAANEKYA QEVADLKAKV 600
    QQATTENMGL MDNWKSKLDS LASDHQKSLE DLKATLNSGP GAQQKEIGEL 650
    KALVEGIKME HQLELGNLQA KHDLETAMHG KEKEGLRQKL QEVQEELAGL 700
    QQHWREQLEE QASQHRLELQ EAQDQCRDAQ LRAQELEGLD VEYRGQAQAI 750
    EFLKEQISLA EKKMLDYEML QRAEAQSRQE AERLREKLLV AENRLQAAES 800
    LCSAQHSHVI ESSDLSEETI RMKETVEGLQ DKLNKRDKEV TALTSQMDML 850
    RAQVSALENK CKSGEKKIDS LLKEKRRLEA ELEAVSRKTH DASGQLVHIS 900
    QELLRKERSL NELRVLLLEA NRHSPGPERD LSREVHKAEW RIKEQKLKDD 950
    IRGLREKLTG LDKEKSLSEQ RRYSLIDPAS PPELLKLQHQ LVSTEDALRD 1000
    ALNQAQQVER LVEALRGCSD RTQTISNSGS ANGIHQPDKA HKQEDKH 1047
    Length:1,047
    Mass (Da):115,910
    Last modified:September 27, 2005 - v2
    Checksum:i8F46948122F58872
    GO
    Isoform 2 (identifier: Q9Z0H8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         462-496: Missing.

    Show »
    Length:1,012
    Mass (Da):111,855
    Checksum:i5CD0F481CFE7CFB0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti25 – 251V → I in AAH39162. (PubMed:15489334)Curated
    Sequence conflicti59 – 591T → A in CAA13068. (PubMed:9799601)Curated
    Sequence conflicti59 – 591T → A in CAA13069. (PubMed:9799601)Curated
    Sequence conflicti79 – 791D → H in CAA13068. (PubMed:9799601)Curated
    Sequence conflicti79 – 791D → H in CAA13069. (PubMed:9799601)Curated
    Sequence conflicti127 – 1271G → A in CAA13068. (PubMed:9799601)Curated
    Sequence conflicti127 – 1271G → A in CAA13069. (PubMed:9799601)Curated
    Sequence conflicti334 – 3352RP → PA in CAA13068. (PubMed:9799601)Curated
    Sequence conflicti334 – 3352RP → PA in CAA13069. (PubMed:9799601)Curated
    Sequence conflicti356 – 3561T → I in CAA13068. (PubMed:9799601)Curated
    Sequence conflicti356 – 3561T → I in CAA13069. (PubMed:9799601)Curated
    Sequence conflicti559 – 5591R → D in CAA13068. (PubMed:9799601)Curated
    Sequence conflicti559 – 5591R → D in CAA13069. (PubMed:9799601)Curated
    Sequence conflicti713 – 7197SQHRLEL → AASAEA in CAA13068. (PubMed:9799601)Curated
    Sequence conflicti733 – 7331A → V in CAA13068. (PubMed:9799601)Curated
    Sequence conflicti733 – 7331A → V in CAA13069. (PubMed:9799601)Curated
    Sequence conflicti856 – 8561A → V in CAA13068. (PubMed:9799601)Curated
    Sequence conflicti856 – 8561A → V in CAA13069. (PubMed:9799601)Curated
    Sequence conflicti1003 – 10031N → D in AAH39162. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei462 – 49635Missing in isoform 2. 1 PublicationVSP_015683Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ228863 Genomic DNA. Translation: CAA13068.1.
    AJ228865
    , AJ228868, AJ228869, AJ228870, AJ228872, AJ228876, AJ228880, AJ228867, AJ228875, AJ228871, AJ228873, AJ228877, AJ228866, AJ228879, AJ228878, AJ228874 Genomic DNA. Translation: CAA13069.1.
    AF289667 Genomic DNA. Translation: AAF99340.1.
    AF289664 Genomic DNA. Translation: AAF99333.1.
    BC039162 mRNA. Translation: AAH39162.1.
    BC053048 mRNA. Translation: AAH53048.1.
    CCDSiCCDS39309.1. [Q9Z0H8-2]
    CCDS39310.1. [Q9Z0H8-1]
    PIRiT42720.
    RefSeqiNP_001034251.1. NM_001039162.2. [Q9Z0H8-2]
    NP_034120.2. NM_009990.3. [Q9Z0H8-1]
    UniGeneiMm.255138.

    Genome annotation databases

    EnsembliENSMUST00000036999; ENSMUSP00000037431; ENSMUSG00000063146. [Q9Z0H8-2]
    ENSMUST00000100647; ENSMUSP00000098212; ENSMUSG00000063146. [Q9Z0H8-1]
    GeneIDi269713.
    KEGGimmu:269713.
    UCSCiuc008zwi.1. mouse. [Q9Z0H8-1]
    uc008zwj.1. mouse. [Q9Z0H8-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ228863 Genomic DNA. Translation: CAA13068.1 .
    AJ228865
    , AJ228868 , AJ228869 , AJ228870 , AJ228872 , AJ228876 , AJ228880 , AJ228867 , AJ228875 , AJ228871 , AJ228873 , AJ228877 , AJ228866 , AJ228879 , AJ228878 , AJ228874 Genomic DNA. Translation: CAA13069.1 .
    AF289667 Genomic DNA. Translation: AAF99340.1 .
    AF289664 Genomic DNA. Translation: AAF99333.1 .
    BC039162 mRNA. Translation: AAH39162.1 .
    BC053048 mRNA. Translation: AAH53048.1 .
    CCDSi CCDS39309.1. [Q9Z0H8-2 ]
    CCDS39310.1. [Q9Z0H8-1 ]
    PIRi T42720.
    RefSeqi NP_001034251.1. NM_001039162.2. [Q9Z0H8-2 ]
    NP_034120.2. NM_009990.3. [Q9Z0H8-1 ]
    UniGenei Mm.255138.

    3D structure databases

    ProteinModelPortali Q9Z0H8.
    SMRi Q9Z0H8. Positions 30-156, 174-345, 424-452.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 234703. 1 interaction.
    IntActi Q9Z0H8. 5 interactions.
    MINTi MINT-4128805.

    PTM databases

    PhosphoSitei Q9Z0H8.

    Proteomic databases

    MaxQBi Q9Z0H8.
    PaxDbi Q9Z0H8.
    PRIDEi Q9Z0H8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000036999 ; ENSMUSP00000037431 ; ENSMUSG00000063146 . [Q9Z0H8-2 ]
    ENSMUST00000100647 ; ENSMUSP00000098212 ; ENSMUSG00000063146 . [Q9Z0H8-1 ]
    GeneIDi 269713.
    KEGGi mmu:269713.
    UCSCi uc008zwi.1. mouse. [Q9Z0H8-1 ]
    uc008zwj.1. mouse. [Q9Z0H8-2 ]

    Organism-specific databases

    CTDi 7461.
    MGIi MGI:1313136. Clip2.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG5244.
    GeneTreei ENSGT00740000115338.
    HOGENOMi HOG000092755.
    HOVERGENi HBG007123.
    InParanoidi Q9Z0H8.
    KOi K10422.
    OMAi VHKAEWR.
    OrthoDBi EOG7992PN.
    PhylomeDBi Q9Z0H8.
    TreeFami TF326096.

    Miscellaneous databases

    NextBioi 393005.
    PROi Q9Z0H8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Z0H8.
    CleanExi MM_CLIP2.
    Genevestigatori Q9Z0H8.

    Family and domain databases

    Gene3Di 2.30.30.190. 2 hits.
    InterProi IPR000938. CAP-Gly_domain.
    IPR028394. CLIP2.
    [Graphical view ]
    PANTHERi PTHR18916:SF10. PTHR18916:SF10. 1 hit.
    Pfami PF01302. CAP_GLY. 2 hits.
    [Graphical view ]
    SMARTi SM01052. CAP_GLY. 2 hits.
    [Graphical view ]
    SUPFAMi SSF74924. SSF74924. 2 hits.
    PROSITEi PS00845. CAP_GLY_1. 2 hits.
    PS50245. CAP_GLY_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The murine CYLN2 gene: genomic organization, chromosome localization, and comparison to the human gene that is located within the 7q11.23 Williams syndrome critical region."
      Hoogenraad C.C., Eussen B.H.J., Langeveld A., van Haperen R., Winterberg S., Wouters C.H., Grosveld F., de Zeeuw C.I., Galjart N.
      Genomics 53:348-358(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129.
    2. Green E.D.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6 and FVB/N.
      Tissue: Brain and Mammary tumor.
    4. "Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts."
      Akhmanova A., Hoogenraad C.C., Drabek K., Stepanova T., Dortland B., Verkerk T., Vermeulen W., Burgering B.M., de Zeeuw C.I., Grosveld F., Galjart N.
      Cell 104:923-935(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CLASP1 AND CLASP2.
    5. "CLIP-115, a novel brain specific cytoplasmic linker protein, mediates the localisation of dendritic lamellar bodies."
      de Zeeuw C.I., Hoogenraad C.C., Goedknegt E., Hertzberg E., Neubauer A., Grosveld F.G., Galjart N.J.
      Neuron 19:1187-1199(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiCLIP2_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z0H8
    Secondary accession number(s): Q7TSI9, Q8CHU1, Q9EP81
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: September 27, 2005
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3