Q9Z0H7 (BCL10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
B-cell lymphoma/leukemia 10

Alternative name(s):
B-cell CLL/lymphoma 10
Short name=Bcl-10
CARD-containing molecule enhancing NF-kappa-B
CARD-like apoptotic protein
Short name=mCLAP
CED-3/ICH-1 prodomain homologous E10-like regulator
Short name=mCIPER
Cellular homolog of vCARMEN
Short name=cCARMEN
Cellular-E10
Short name=c-E10
Mammalian CARD-containing adapter molecule E10
Short name=mE10

Gene names

Name:	Bcl10
Synonyms:	Ciper, Clap

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	233 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex By similarity. Is a substrate for MALT1 By similarity.
Subunit structure	Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Self-associates by CARD-CARD interaction and interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2 By similarity. Interacts with PELI2 and SOCS3; these interactions may be mutually exclusive. Ref.8
Subcellular location	Cytoplasm By similarity. Membrane raft By similarity. Note: Colocalized with DPP4 in membrane rafts By similarity.
Tissue specificity	Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Detected in developing brain, olfactory epithelium, tongue, whisker follicles, salivary gland, heart, lung, liver and intestinal epithelia of stage 15 embryos.
Post-translational modification	Phosphorylated by IKBKB/IKKB By similarity.
Sequence similarities	Contains 1 CARD domain.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cytoplasm Membrane
Disease	Tumor suppressor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	I-kappaB kinase/NF-kappaB cascade Inferred from mutant phenotype PubMed 11163238. Source: MGI T cell receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB cellular defense response Inferred from mutant phenotype PubMed 11163238. Source: MGI cellular response to mechanical stimulus Inferred from electronic annotation. Source: Compara immunoglobulin mediated immune response Inferred from mutant phenotype PubMed 11163238. Source: MGI induction of apoptosis Inferred from sequence alignment Ref.5Ref.1. Source: MGI innate immune response Inferred from sequence or structural similarity. Source: UniProtKB mast cell activation Non-traceable author statement PubMed 16432253. Source: UniProtKB negative regulation of mature B cell apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB neural tube closure Inferred from mutant phenotype PubMed 11163238. Source: UniProtKB positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of NF-kappaB transcription factor activity Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of T cell activation Inferred from mutant phenotype PubMed 14614861. Source: MGI positive regulation of interleukin-8 biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of phosphorylation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of protein ubiquitination Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of transcription, DNA-dependent Inferred from sequence or structural similarity. Source: UniProtKB protein homooligomerization Inferred from mutant phenotype PubMed 16831874. Source: UniProtKB regulation of T cell receptor signaling pathway Inferred from mutant phenotype PubMed 14614861. Source: MGI response to fungus Inferred from mutant phenotype PubMed 16862125. Source: MGI response to molecule of bacterial origin Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	T cell receptor complex Inferred from electronic annotation. Source: Compara cytoplasmic microtubule Inferred from sequence or structural similarity. Source: UniProtKB cytosol Inferred from direct assay PubMed 16831874. Source: UniProtKB immunological synapse Inferred from direct assay PubMed 14724296. Source: MGI lipopolysaccharide receptor complex Inferred from electronic annotation. Source: Compara lysosome Inferred from sequence or structural similarity. Source: UniProtKB membrane raft Inferred from direct assay PubMed 12867038. Source: MGI nucleus Inferred from sequence or structural similarity. Source: UniProtKB perinuclear region of cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	NF-kappaB binding Inferred from sequence or structural similarity. Source: UniProtKB cysteine-type endopeptidase activator activity involved in apoptotic process Inferred from sequence alignment Ref.4. Source: MGI kinase activator activity Inferred from electronic annotation. Source: Compara protein C-terminus binding Inferred from sequence or structural similarity. Source: UniProtKB protein heterodimerization activity Inferred from sequence alignment Ref.5. Source: MGI protein homodimerization activity Inferred from sequence alignment Ref.5. Source: MGI protein kinase B binding Inferred from sequence or structural similarity. Source: UniProtKB protein self-association Inferred from sequence or structural similarity. Source: UniProtKB transcription coactivator activity Inferred from sequence or structural similarity. Source: UniProtKB ubiquitin binding Inferred from sequence or structural similarity. Source: UniProtKB ubiquitin protein ligase binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 233	233	B-cell lymphoma/leukemia 10		PRO_0000144075
Regions
	Domain	13 – 101	89	CARD
Amino acid modifications
	Modified residue	138	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9Z0H7 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: C0539BC97102DBB8	FASTA	233	25,948
	10 20 30 40 50 60 MEAPAPSLTE EDLTEVKKDA LENLRVYLCE KIIAERHFDH LRAKKILSRE DTEEISCRTS 70 80 90 100 110 120 SRKRAGKLLD YLQENPRGLD TLVESIRREK TQSFLIQKIT DEVLKLRNIK LEHLKGLKCS 130 140 150 160 170 180 SCEPFAAGAT NNLSRCNSDE SNLSEKQRAS TVMYHPEGES STAPFFSMAS SLNLPVLEVG 190 200 210 220 230 RTENSSFSSA TLPRPGDPGA PPLPPDLRLE EGGSCGNSSE MFLPLRSRAL SRQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types." Willis T.G., Jadayel D.M., Du M.-Q., Peng H., Perry A.R., Abdul-Rauf M., Price H., Karran L., Majekodunmi O., Wlodarska I., Pan L., Crook T., Hamoudi R., Isaacson P., Dyer M.J.S. Cell 96:35-45(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10." Koseki T., Inohara N., Chen S., Carrio R., Merino J., Hottiger M.O., Nabel G.J., Nunez G. J. Biol. Chem. 274:9955-9961(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase." Thome M., Martinon F., Hofmann K., Rubio V., Steiner V., Schneider P., Mattmann C., Tschopp J. J. Biol. Chem. 274:9962-9968(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"mE10, a novel caspase recruitment domain-containing proapoptotic molecule." Yan M., Lee J., Schilbach S., Goddard A., Dixit V.M. J. Biol. Chem. 274:10287-10292(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Embryo.
[5]	"CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis." Srinivasula S.M., Ahmad M., Lin J.-H., Poyet J.-L., Fernandes-Alnemri T., Tsichlis P.N., Alnemri E.S. J. Biol. Chem. 274:17946-17954(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J and NOD. Tissue: Bone marrow, Corpora quadrigemina, Liver and Spleen.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]	"BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2." Liu Y., Dong W., Chen L., Xiang R., Xiao H., De G., Wang Z., Qi Y. J. Biol. Chem. 279:37436-37444(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PELI2 AND SOCS3.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ006289 mRNA. Translation: CAA06956.1. AF057701 mRNA. Translation: AAD15801.1. AF100339 mRNA. Translation: AAD16429.1. AF127387 mRNA. Translation: AAD32598.1. AF134396 mRNA. Translation: AAD39148.1. AK076082 mRNA. Translation: BAC36168.1. AK140179 mRNA. Translation: BAE24267.1. AK150883 mRNA. Translation: BAE29930.1. AK152563 mRNA. Translation: BAE31316.1. AK152847 mRNA. Translation: BAE31540.1. AK156890 mRNA. Translation: BAE33885.1. AK169126 mRNA. Translation: BAE40905.1. AK172158 mRNA. Translation: BAE42852.1. BC024379 mRNA. Translation: AAH24379.1.
IPI	IPI00129152.
RefSeq	NP_033870.1. NM_009740.1.
UniGene	Mm.239141.
3D structure databases
ProteinModelPortal	Q9Z0H7.
SMR	Q9Z0H7. Positions 16-101.
ModBase	Search...
PTM databases
PhosphoSite	Q9Z0H7.
Proteomic databases
PaxDb	Q9Z0H7.
PRIDE	Q9Z0H7.
Protocols and materials databases
DNASU	12042.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000029842; ENSMUSP00000029842; ENSMUSG00000028191.
GeneID	12042.
KEGG	mmu:12042.
UCSC	uc008rqs.1. mouse.
Organism-specific databases
CTD	8915.
MGI	MGI:1337994. Bcl10.
Phylogenomic databases
eggNOG	NOG44778.
GeneTree	ENSGT00490000043442.
HOGENOM	HOG000008671.
HOVERGEN	HBG050680.
InParanoid	Q9Z0H7.
KO	K07368.
OMA	ASTVIYH.
OrthoDB	EOG41JZD7.
Gene expression databases
ArrayExpress	Q9Z0H7.
Bgee	Q9Z0H7.
CleanEx	MM_BCL10.
Genevestigator	Q9Z0H7.
GermOnline	ENSMUSG00000028191. Mus musculus.
Family and domain databases
Gene3D	1.10.533.10. 1 hit.
InterPro	IPR001315. CARD. IPR011029. DEATH-like_dom. [Graphical view]
Pfam	PF00619. CARD. 1 hit. [Graphical view]
SUPFAM	SSF47986. DEATH_like. 1 hit.
PROSITE	PS50209. CARD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	280309.
SOURCE	Search...

Entry information

Entry name

BCL10_MOUSE

Accession

Primary (citable) accession number: Q9Z0H7
Secondary accession number(s): Q3UBN4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	May 1, 1999
Last modified:	May 29, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program