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Protein

B-cell lymphoma/leukemia 10

Gene

Bcl10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in adaptive immune response. Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.By similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase activator activity involved in apoptotic process Source: MGI
  2. enzyme binding Source: MGI
  3. kinase activator activity Source: Ensembl
  4. kinase binding Source: UniProtKB
  5. NF-kappaB binding Source: UniProtKB
  6. protease binding Source: MGI
  7. protein C-terminus binding Source: UniProtKB
  8. protein heterodimerization activity Source: MGI
  9. protein homodimerization activity Source: MGI
  10. protein kinase B binding Source: UniProtKB
  11. protein kinase binding Source: UniProtKB
  12. protein self-association Source: UniProtKB
  13. transcription coactivator activity Source: UniProtKB
  14. transcription factor binding Source: UniProtKB
  15. ubiquitin binding Source: UniProtKB
  16. ubiquitin protein ligase binding Source: UniProtKB

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  2. adaptive immune response Source: UniProtKB
  3. B cell apoptotic process Source: MGI
  4. cell death Source: UniProtKB
  5. cellular defense response Source: MGI
  6. cellular response to mechanical stimulus Source: Ensembl
  7. I-kappaB kinase/NF-kappaB signaling Source: MGI
  8. immunoglobulin mediated immune response Source: MGI
  9. innate immune response Source: UniProtKB
  10. mast cell activation Source: UniProtKB
  11. negative regulation of mature B cell apoptotic process Source: UniProtKB
  12. neural tube closure Source: UniProtKB
  13. positive regulation of apoptotic process Source: MGI
  14. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  15. positive regulation of execution phase of apoptosis Source: MGI
  16. positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
  17. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  18. positive regulation of interleukin-8 biosynthetic process Source: UniProtKB
  19. positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
  20. positive regulation of phosphorylation Source: UniProtKB
  21. positive regulation of protein ubiquitination Source: UniProtKB
  22. positive regulation of T cell activation Source: MGI
  23. positive regulation of transcription, DNA-templated Source: UniProtKB
  24. protein homooligomerization Source: UniProtKB
  25. protein oligomerization Source: UniProtKB
  26. regulation of T cell receptor signaling pathway Source: MGI
  27. response to food Source: UniProtKB
  28. response to fungus Source: MGI
  29. response to molecule of bacterial origin Source: UniProtKB
  30. T cell apoptotic process Source: MGI
  31. T cell receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Immunity

Enzyme and pathway databases

ReactomeiREACT_199121. Activation of NF-kappaB in B cells.
REACT_205561. FCERI mediated NF-kB activation.
REACT_225145. Downstream TCR signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell lymphoma/leukemia 10
Alternative name(s):
B-cell CLL/lymphoma 10
Short name:
Bcl-10
CARD-containing molecule enhancing NF-kappa-B
CARD-like apoptotic protein
Short name:
mCLAP
CED-3/ICH-1 prodomain homologous E10-like regulator
Short name:
mCIPER
Cellular homolog of vCARMEN
Short name:
cCARMEN
Cellular-E10
Short name:
c-E10
Mammalian CARD-containing adapter molecule E10
Short name:
mE10
Gene namesi
Name:Bcl10
Synonyms:Ciper, Clap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1337994. Bcl10.

Subcellular locationi

Cytoplasm By similarity. Membrane raft By similarity
Note: Colocalized with DPP4 in membrane rafts.By similarity

GO - Cellular componenti

  1. CBM complex Source: GO_Central
  2. cytoplasm Source: UniProtKB
  3. cytoplasmic microtubule Source: UniProtKB
  4. cytosol Source: UniProtKB
  5. immunological synapse Source: MGI
  6. lipopolysaccharide receptor complex Source: Ensembl
  7. lysosome Source: UniProtKB
  8. membrane raft Source: MGI
  9. nucleus Source: UniProtKB
  10. perinuclear region of cytoplasm Source: UniProtKB
  11. protein complex Source: UniProtKB
  12. T cell receptor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233B-cell lymphoma/leukemia 10PRO_0000144075Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei138 – 1381PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated by IKBKB/IKKB.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9Z0H7.
PaxDbiQ9Z0H7.
PRIDEiQ9Z0H7.

PTM databases

PhosphoSiteiQ9Z0H7.

Expressioni

Tissue specificityi

Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Detected in developing brain, olfactory epithelium, tongue, whisker follicles, salivary gland, heart, lung, liver and intestinal epithelia of stage 15 embryos.

Gene expression databases

BgeeiQ9Z0H7.
CleanExiMM_BCL10.
ExpressionAtlasiQ9Z0H7. baseline and differential.
GenevestigatoriQ9Z0H7.

Interactioni

Subunit structurei

Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Self-associates by CARD-CARD interaction and interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2 (By similarity). Interacts with PELI2 and SOCS3; these interactions may be mutually exclusive.By similarity1 Publication

Protein-protein interaction databases

BioGridi198317. 12 interactions.
DIPiDIP-60309N.
IntActiQ9Z0H7. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0H7.
SMRiQ9Z0H7. Positions 10-115.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 10189CARDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CARD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG44778.
GeneTreeiENSGT00490000043442.
HOGENOMiHOG000008671.
HOVERGENiHBG050680.
InParanoidiQ9Z0H7.
KOiK07368.
OMAiPYLCDKI.
OrthoDBiEOG79W97M.
PhylomeDBiQ9Z0H7.
TreeFamiTF328636.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z0H7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAPAPSLTE EDLTEVKKDA LENLRVYLCE KIIAERHFDH LRAKKILSRE
60 70 80 90 100
DTEEISCRTS SRKRAGKLLD YLQENPRGLD TLVESIRREK TQSFLIQKIT
110 120 130 140 150
DEVLKLRNIK LEHLKGLKCS SCEPFAAGAT NNLSRCNSDE SNLSEKQRAS
160 170 180 190 200
TVMYHPEGES STAPFFSMAS SLNLPVLEVG RTENSSFSSA TLPRPGDPGA
210 220 230
PPLPPDLRLE EGGSCGNSSE MFLPLRSRAL SRQ
Length:233
Mass (Da):25,948
Last modified:May 1, 1999 - v1
Checksum:iC0539BC97102DBB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006289 mRNA. Translation: CAA06956.1.
AF057701 mRNA. Translation: AAD15801.1.
AF100339 mRNA. Translation: AAD16429.1.
AF127387 mRNA. Translation: AAD32598.1.
AF134396 mRNA. Translation: AAD39148.1.
AK076082 mRNA. Translation: BAC36168.1.
AK140179 mRNA. Translation: BAE24267.1.
AK150883 mRNA. Translation: BAE29930.1.
AK152563 mRNA. Translation: BAE31316.1.
AK152847 mRNA. Translation: BAE31540.1.
AK156890 mRNA. Translation: BAE33885.1.
AK169126 mRNA. Translation: BAE40905.1.
AK172158 mRNA. Translation: BAE42852.1.
BC024379 mRNA. Translation: AAH24379.1.
CCDSiCCDS17897.1.
RefSeqiNP_033870.1. NM_009740.2.
UniGeneiMm.239141.

Genome annotation databases

EnsembliENSMUST00000029842; ENSMUSP00000029842; ENSMUSG00000028191.
GeneIDi12042.
KEGGimmu:12042.
UCSCiuc008rqs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006289 mRNA. Translation: CAA06956.1.
AF057701 mRNA. Translation: AAD15801.1.
AF100339 mRNA. Translation: AAD16429.1.
AF127387 mRNA. Translation: AAD32598.1.
AF134396 mRNA. Translation: AAD39148.1.
AK076082 mRNA. Translation: BAC36168.1.
AK140179 mRNA. Translation: BAE24267.1.
AK150883 mRNA. Translation: BAE29930.1.
AK152563 mRNA. Translation: BAE31316.1.
AK152847 mRNA. Translation: BAE31540.1.
AK156890 mRNA. Translation: BAE33885.1.
AK169126 mRNA. Translation: BAE40905.1.
AK172158 mRNA. Translation: BAE42852.1.
BC024379 mRNA. Translation: AAH24379.1.
CCDSiCCDS17897.1.
RefSeqiNP_033870.1. NM_009740.2.
UniGeneiMm.239141.

3D structure databases

ProteinModelPortaliQ9Z0H7.
SMRiQ9Z0H7. Positions 10-115.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198317. 12 interactions.
DIPiDIP-60309N.
IntActiQ9Z0H7. 1 interaction.

PTM databases

PhosphoSiteiQ9Z0H7.

Proteomic databases

MaxQBiQ9Z0H7.
PaxDbiQ9Z0H7.
PRIDEiQ9Z0H7.

Protocols and materials databases

DNASUi12042.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029842; ENSMUSP00000029842; ENSMUSG00000028191.
GeneIDi12042.
KEGGimmu:12042.
UCSCiuc008rqs.1. mouse.

Organism-specific databases

CTDi8915.
MGIiMGI:1337994. Bcl10.

Phylogenomic databases

eggNOGiNOG44778.
GeneTreeiENSGT00490000043442.
HOGENOMiHOG000008671.
HOVERGENiHBG050680.
InParanoidiQ9Z0H7.
KOiK07368.
OMAiPYLCDKI.
OrthoDBiEOG79W97M.
PhylomeDBiQ9Z0H7.
TreeFamiTF328636.

Enzyme and pathway databases

ReactomeiREACT_199121. Activation of NF-kappaB in B cells.
REACT_205561. FCERI mediated NF-kB activation.
REACT_225145. Downstream TCR signaling.

Miscellaneous databases

ChiTaRSiBcl10. mouse.
NextBioi280309.
PROiQ9Z0H7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z0H7.
CleanExiMM_BCL10.
ExpressionAtlasiQ9Z0H7. baseline and differential.
GenevestigatoriQ9Z0H7.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types."
    Willis T.G., Jadayel D.M., Du M.-Q., Peng H., Perry A.R., Abdul-Rauf M., Price H., Karran L., Majekodunmi O., Wlodarska I., Pan L., Crook T., Hamoudi R., Isaacson P., Dyer M.J.S.
    Cell 96:35-45(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10."
    Koseki T., Inohara N., Chen S., Carrio R., Merino J., Hottiger M.O., Nabel G.J., Nunez G.
    J. Biol. Chem. 274:9955-9961(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase."
    Thome M., Martinon F., Hofmann K., Rubio V., Steiner V., Schneider P., Mattmann C., Tschopp J.
    J. Biol. Chem. 274:9962-9968(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "mE10, a novel caspase recruitment domain-containing proapoptotic molecule."
    Yan M., Lee J., Schilbach S., Goddard A., Dixit V.M.
    J. Biol. Chem. 274:10287-10292(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  5. "CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis."
    Srinivasula S.M., Ahmad M., Lin J.-H., Poyet J.-L., Fernandes-Alnemri T., Tsichlis P.N., Alnemri E.S.
    J. Biol. Chem. 274:17946-17954(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Bone marrow, Corpora quadrigemina, Liver and Spleen.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2."
    Liu Y., Dong W., Chen L., Xiang R., Xiao H., De G., Wang Z., Qi Y.
    J. Biol. Chem. 279:37436-37444(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PELI2 AND SOCS3.

Entry informationi

Entry nameiBCL10_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0H7
Secondary accession number(s): Q3UBN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 1, 1999
Last modified: March 4, 2015
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.