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Protein

B-cell lymphoma/leukemia 10

Gene

Bcl10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in adaptive immune response. Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.By similarity

GO - Molecular functioni

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  • adaptive immune response Source: UniProtKB
  • B cell apoptotic process Source: MGI
  • cell death Source: UniProtKB
  • cellular defense response Source: MGI
  • cellular response to mechanical stimulus Source: Ensembl
  • Fc-epsilon receptor signaling pathway Source: Reactome
  • I-kappaB kinase/NF-kappaB signaling Source: MGI
  • immunoglobulin mediated immune response Source: MGI
  • innate immune response Source: UniProtKB
  • mast cell activation Source: UniProtKB
  • negative regulation of mature B cell apoptotic process Source: UniProtKB
  • neural tube closure Source: UniProtKB
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  • positive regulation of execution phase of apoptosis Source: MGI
  • positive regulation of extrinsic apoptotic signaling pathway Source: MGI
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  • positive regulation of interleukin-8 biosynthetic process Source: UniProtKB
  • positive regulation of NF-kappaB transcription factor activity Source: MGI
  • positive regulation of phosphorylation Source: UniProtKB
  • positive regulation of protein ubiquitination Source: UniProtKB
  • positive regulation of T cell activation Source: MGI
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • protein heterooligomerization Source: Ensembl
  • protein homooligomerization Source: UniProtKB
  • protein oligomerization Source: UniProtKB
  • regulation of T cell receptor signaling pathway Source: MGI
  • response to food Source: UniProtKB
  • response to fungus Source: MGI
  • response to molecule of bacterial origin Source: UniProtKB
  • T cell apoptotic process Source: MGI
  • T cell receptor signaling pathway Source: UniProtKB

Keywordsi

Biological processApoptosis, Immunity

Enzyme and pathway databases

ReactomeiR-MMU-1169091. Activation of NF-kappaB in B cells.
R-MMU-202424. Downstream TCR signaling.
R-MMU-2871837. FCERI mediated NF-kB activation.
R-MMU-5607764. CLEC7A (Dectin-1) signaling.
R-MMU-8866654. E3 ubiquitin ligases ubiquitinate target proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell lymphoma/leukemia 10
Alternative name(s):
B-cell CLL/lymphoma 10
Short name:
Bcl-10
CARD-containing molecule enhancing NF-kappa-B
CARD-like apoptotic protein
Short name:
mCLAP
CED-3/ICH-1 prodomain homologous E10-like regulator
Short name:
mCIPER
Cellular homolog of vCARMEN
Short name:
cCARMEN
Cellular-E10
Short name:
c-E10
Mammalian CARD-containing adapter molecule E10
Short name:
mE10
Gene namesi
Name:Bcl10
Synonyms:Ciper, Clap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1337994. Bcl10.

Subcellular locationi

  • Cytoplasm By similarity
  • Membrane raft By similarity

  • Note: Colocalized with DPP4 in membrane rafts.By similarity

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytoplasmic microtubule Source: UniProtKB
  • cytosol Source: UniProtKB
  • immunological synapse Source: MGI
  • lipopolysaccharide receptor complex Source: Ensembl
  • lysosome Source: UniProtKB
  • membrane raft Source: MGI
  • nucleus Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
  • protein complex Source: UniProtKB
  • T cell receptor complex Source: Ensembl

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440751 – 233B-cell lymphoma/leukemia 10Add BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei138PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by IKBKB/IKKB.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Z0H7.
MaxQBiQ9Z0H7.
PaxDbiQ9Z0H7.
PRIDEiQ9Z0H7.

PTM databases

iPTMnetiQ9Z0H7.
PhosphoSitePlusiQ9Z0H7.

Expressioni

Tissue specificityi

Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Detected in developing brain, olfactory epithelium, tongue, whisker follicles, salivary gland, heart, lung, liver and intestinal epithelia of stage 15 embryos.

Gene expression databases

BgeeiENSMUSG00000028191.
CleanExiMM_BCL10.
ExpressionAtlasiQ9Z0H7. baseline and differential.
GenevisibleiQ9Z0H7. MM.

Interactioni

Subunit structurei

Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Self-associates by CARD-CARD interaction and interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Forms a complex with CARD14 and MALT1; resulting in the formation of a CBM (CARD14-BLC10-MALT1) complex. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2 (By similarity). Interacts with PELI2 and SOCS3; these interactions may be mutually exclusive (PubMed:15213237).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
E10Q666773EBI-8545413,EBI-11709474From Equine herpesvirus 2 (strain 86/87).

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198317. 13 interactors.
DIPiDIP-60309N.
IntActiQ9Z0H7. 2 interactors.
STRINGi10090.ENSMUSP00000029842.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0H7.
SMRiQ9Z0H7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 101CARDPROSITE-ProRule annotationAdd BLAST89

Phylogenomic databases

eggNOGiENOG410IVMM. Eukaryota.
ENOG4111JRA. LUCA.
GeneTreeiENSGT00490000043442.
HOGENOMiHOG000008671.
HOVERGENiHBG050680.
InParanoidiQ9Z0H7.
KOiK07368.
OMAiRHYLCDK.
OrthoDBiEOG091G0UTQ.
PhylomeDBiQ9Z0H7.
TreeFamiTF328636.

Family and domain databases

InterProiView protein in InterPro
IPR033238. BCL10/E10.
IPR001315. CARD.
IPR011029. DEATH-like_dom.
PANTHERiPTHR34920. PTHR34920. 1 hit.
PfamiView protein in Pfam
PF00619. CARD. 1 hit.
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiView protein in PROSITE
PS50209. CARD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z0H7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAPAPSLTE EDLTEVKKDA LENLRVYLCE KIIAERHFDH LRAKKILSRE
60 70 80 90 100
DTEEISCRTS SRKRAGKLLD YLQENPRGLD TLVESIRREK TQSFLIQKIT
110 120 130 140 150
DEVLKLRNIK LEHLKGLKCS SCEPFAAGAT NNLSRCNSDE SNLSEKQRAS
160 170 180 190 200
TVMYHPEGES STAPFFSMAS SLNLPVLEVG RTENSSFSSA TLPRPGDPGA
210 220 230
PPLPPDLRLE EGGSCGNSSE MFLPLRSRAL SRQ
Length:233
Mass (Da):25,948
Last modified:May 1, 1999 - v1
Checksum:iC0539BC97102DBB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006289 mRNA. Translation: CAA06956.1.
AF057701 mRNA. Translation: AAD15801.1.
AF100339 mRNA. Translation: AAD16429.1.
AF127387 mRNA. Translation: AAD32598.1.
AF134396 mRNA. Translation: AAD39148.1.
AK076082 mRNA. Translation: BAC36168.1.
AK140179 mRNA. Translation: BAE24267.1.
AK150883 mRNA. Translation: BAE29930.1.
AK152563 mRNA. Translation: BAE31316.1.
AK152847 mRNA. Translation: BAE31540.1.
AK156890 mRNA. Translation: BAE33885.1.
AK169126 mRNA. Translation: BAE40905.1.
AK172158 mRNA. Translation: BAE42852.1.
BC024379 mRNA. Translation: AAH24379.1.
CCDSiCCDS17897.1.
RefSeqiNP_033870.1. NM_009740.2.
UniGeneiMm.239141.

Genome annotation databases

EnsembliENSMUST00000029842; ENSMUSP00000029842; ENSMUSG00000028191.
GeneIDi12042.
KEGGimmu:12042.
UCSCiuc008rqs.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiBCL10_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0H7
Secondary accession number(s): Q3UBN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 1, 1999
Last modified: July 5, 2017
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot