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Q9Z0H6

- CST9_MOUSE

UniProt

Q9Z0H6 - CST9_MOUSE

Protein

Cystatin-9

Gene

Cst9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Could play an essential role in tissue reorganization during early testis development.

    GO - Molecular functioni

    1. cysteine-type endopeptidase inhibitor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Protease inhibitor, Thiol protease inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cystatin-9
    Alternative name(s):
    Testatin
    Gene namesi
    Name:Cst9
    Synonyms:Cresp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1340053. Cst9.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3131Sequence AnalysisAdd
    BLAST
    Chaini32 – 137106Cystatin-9PRO_0000006657Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi92 ↔ 102By similarity
    Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi116 ↔ 136By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9Z0H6.

    Expressioni

    Tissue specificityi

    Expression is restricted to fetal gonads and adult testis.

    Gene expression databases

    BgeeiQ9Z0H6.
    CleanExiMM_CST9.
    GenevestigatoriQ9Z0H6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z0H6.
    SMRiQ9Z0H6. Positions 47-131.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cystatin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG43835.
    GeneTreeiENSGT00430000031103.
    HOGENOMiHOG000231754.
    HOVERGENiHBG096568.
    InParanoidiQ9Z0H6.
    KOiK13905.
    OMAiKEEHAYR.
    OrthoDBiEOG74J9B3.
    PhylomeDBiQ9Z0H6.

    Family and domain databases

    InterProiIPR027213. CST9_like.
    IPR027214. Cystatin.
    IPR000010. Prot_inh_cystat.
    [Graphical view]
    PANTHERiPTHR11413. PTHR11413. 1 hit.
    PTHR11413:SF22. PTHR11413:SF22. 1 hit.
    PfamiPF00031. Cystatin. 1 hit.
    [Graphical view]
    SMARTiSM00043. CY. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Z0H6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSCPLRKKAL PLTMLLLLLS FHVLITPVSK ANKETNRSVH FIPTVEFAVN    50
    TFNQESQDEY AYRMEHIMSS WREKVNFPTV YSMRLQLRRT ICKKFEESLD 100
    ICPFQESHGL NNTFTCLFTV GTYPWITKFK LFRSVCS 137
    Length:137
    Mass (Da):16,094
    Last modified:May 1, 1999 - v1
    Checksum:iAC1CDE5834C36FB7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y18243 mRNA. Translation: CAA77090.1.
    AB017157 mRNA. Translation: BAA37089.1.
    AK006429 mRNA. Translation: BAB24584.1.
    AL844519 Genomic DNA. Translation: CAM18692.1.
    BC048486 mRNA. Translation: AAH48486.1.
    CCDSiCCDS16850.1.
    RefSeqiNP_034109.1. NM_009979.1.
    UniGeneiMm.21005.

    Genome annotation databases

    EnsembliENSMUST00000028935; ENSMUSP00000028935; ENSMUSG00000027445.
    GeneIDi13013.
    KEGGimmu:13013.
    UCSCiuc008mtr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y18243 mRNA. Translation: CAA77090.1 .
    AB017157 mRNA. Translation: BAA37089.1 .
    AK006429 mRNA. Translation: BAB24584.1 .
    AL844519 Genomic DNA. Translation: CAM18692.1 .
    BC048486 mRNA. Translation: AAH48486.1 .
    CCDSi CCDS16850.1.
    RefSeqi NP_034109.1. NM_009979.1.
    UniGenei Mm.21005.

    3D structure databases

    ProteinModelPortali Q9Z0H6.
    SMRi Q9Z0H6. Positions 47-131.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9Z0H6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028935 ; ENSMUSP00000028935 ; ENSMUSG00000027445 .
    GeneIDi 13013.
    KEGGi mmu:13013.
    UCSCi uc008mtr.1. mouse.

    Organism-specific databases

    CTDi 128822.
    MGIi MGI:1340053. Cst9.

    Phylogenomic databases

    eggNOGi NOG43835.
    GeneTreei ENSGT00430000031103.
    HOGENOMi HOG000231754.
    HOVERGENi HBG096568.
    InParanoidi Q9Z0H6.
    KOi K13905.
    OMAi KEEHAYR.
    OrthoDBi EOG74J9B3.
    PhylomeDBi Q9Z0H6.

    Miscellaneous databases

    NextBioi 282860.
    PROi Q9Z0H6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Z0H6.
    CleanExi MM_CST9.
    Genevestigatori Q9Z0H6.

    Family and domain databases

    InterProi IPR027213. CST9_like.
    IPR027214. Cystatin.
    IPR000010. Prot_inh_cystat.
    [Graphical view ]
    PANTHERi PTHR11413. PTHR11413. 1 hit.
    PTHR11413:SF22. PTHR11413:SF22. 1 hit.
    Pfami PF00031. Cystatin. 1 hit.
    [Graphical view ]
    SMARTi SM00043. CY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Testatin: a cystatin-related gene expressed during early testis development."
      Toehoenen V., Oesterlund C., Nordqvist K.
      Proc. Natl. Acad. Sci. U.S.A. 95:14208-14213(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "Identification of Cresp, a novel cystatin-related gene."
      Kanno Y., Tamura M., Nakatuji N.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Testis.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiCST9_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z0H6
    Secondary accession number(s): Q545L7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3