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Protein

Cystatin-9

Gene

Cst9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Could play an essential role in tissue reorganization during early testis development.

GO - Molecular functioni

  1. cysteine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-9
Alternative name(s):
Testatin
Gene namesi
Name:Cst9
Synonyms:Cresp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1340053. Cst9.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence AnalysisAdd
BLAST
Chaini32 – 137106Cystatin-9PRO_0000006657Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi92 ↔ 102By similarity
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi116 ↔ 136By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9Z0H6.

Expressioni

Tissue specificityi

Expression is restricted to fetal gonads and adult testis.

Gene expression databases

BgeeiQ9Z0H6.
CleanExiMM_CST9.
GenevestigatoriQ9Z0H6.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0H6.
SMRiQ9Z0H6. Positions 47-131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43835.
GeneTreeiENSGT00430000031103.
HOGENOMiHOG000231754.
HOVERGENiHBG096568.
InParanoidiQ9Z0H6.
KOiK13905.
OMAiKEEHAYR.
OrthoDBiEOG74J9B3.
PhylomeDBiQ9Z0H6.

Family and domain databases

InterProiIPR027213. CST9_like.
IPR027214. Cystatin.
IPR000010. Prot_inh_cystat.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 1 hit.
PTHR11413:SF22. PTHR11413:SF22. 1 hit.
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
SMARTiSM00043. CY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0H6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCPLRKKAL PLTMLLLLLS FHVLITPVSK ANKETNRSVH FIPTVEFAVN
60 70 80 90 100
TFNQESQDEY AYRMEHIMSS WREKVNFPTV YSMRLQLRRT ICKKFEESLD
110 120 130
ICPFQESHGL NNTFTCLFTV GTYPWITKFK LFRSVCS
Length:137
Mass (Da):16,094
Last modified:May 1, 1999 - v1
Checksum:iAC1CDE5834C36FB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18243 mRNA. Translation: CAA77090.1.
AB017157 mRNA. Translation: BAA37089.1.
AK006429 mRNA. Translation: BAB24584.1.
AL844519 Genomic DNA. Translation: CAM18692.1.
BC048486 mRNA. Translation: AAH48486.1.
CCDSiCCDS16850.1.
RefSeqiNP_034109.1. NM_009979.1.
UniGeneiMm.21005.

Genome annotation databases

EnsembliENSMUST00000028935; ENSMUSP00000028935; ENSMUSG00000027445.
GeneIDi13013.
KEGGimmu:13013.
UCSCiuc008mtr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18243 mRNA. Translation: CAA77090.1.
AB017157 mRNA. Translation: BAA37089.1.
AK006429 mRNA. Translation: BAB24584.1.
AL844519 Genomic DNA. Translation: CAM18692.1.
BC048486 mRNA. Translation: AAH48486.1.
CCDSiCCDS16850.1.
RefSeqiNP_034109.1. NM_009979.1.
UniGeneiMm.21005.

3D structure databases

ProteinModelPortaliQ9Z0H6.
SMRiQ9Z0H6. Positions 47-131.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9Z0H6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028935; ENSMUSP00000028935; ENSMUSG00000027445.
GeneIDi13013.
KEGGimmu:13013.
UCSCiuc008mtr.1. mouse.

Organism-specific databases

CTDi128822.
MGIiMGI:1340053. Cst9.

Phylogenomic databases

eggNOGiNOG43835.
GeneTreeiENSGT00430000031103.
HOGENOMiHOG000231754.
HOVERGENiHBG096568.
InParanoidiQ9Z0H6.
KOiK13905.
OMAiKEEHAYR.
OrthoDBiEOG74J9B3.
PhylomeDBiQ9Z0H6.

Miscellaneous databases

NextBioi282860.
PROiQ9Z0H6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z0H6.
CleanExiMM_CST9.
GenevestigatoriQ9Z0H6.

Family and domain databases

InterProiIPR027213. CST9_like.
IPR027214. Cystatin.
IPR000010. Prot_inh_cystat.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 1 hit.
PTHR11413:SF22. PTHR11413:SF22. 1 hit.
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
SMARTiSM00043. CY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Testatin: a cystatin-related gene expressed during early testis development."
    Toehoenen V., Oesterlund C., Nordqvist K.
    Proc. Natl. Acad. Sci. U.S.A. 95:14208-14213(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Identification of Cresp, a novel cystatin-related gene."
    Kanno Y., Tamura M., Nakatuji N.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiCST9_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0H6
Secondary accession number(s): Q545L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: January 7, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.