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Protein

Cystatin-9

Gene

Cst9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in testis development (PubMed:9826679). May play a role in hematopoietic differentiation or inflammation (By similarity). Has immunomodulatory and antimicrobial functions against Francisella tularensis, a Gram-negative bacteria (PubMed:23922243).By similarity1 Publication1 Publication

GO - Molecular functioni

GO - Biological processi

  • antimicrobial humoral response Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Protease inhibitor, Thiol protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-9
Alternative name(s):
Testatin1 Publication
Gene namesi
Name:Cst9
Synonyms:Cresp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1340053. Cst9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

No visible phenotype; probably due to redundancy with other family members.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence analysisAdd
BLAST
Chaini32 – 137106Cystatin-9PRO_0000006657Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence analysis
Disulfide bondi92 ↔ 102By similarity
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence analysis
Disulfide bondi116 ↔ 136By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Z0H6.
PRIDEiQ9Z0H6.

PTM databases

PhosphoSiteiQ9Z0H6.

Expressioni

Tissue specificityi

Expression is restricted to fetal gonads and adult testis.1 Publication

Developmental stagei

Expressed during testis cord formation in pre-Sertoli cells, at a time immediately after the peak of SRY expression.1 Publication

Gene expression databases

BgeeiENSMUSG00000027445.
CleanExiMM_CST9.
GenevisibleiQ9Z0H6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028935.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0H6.
SMRiQ9Z0H6. Positions 47-131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1WW. Eukaryota.
ENOG4111DUC. LUCA.
GeneTreeiENSGT00430000031103.
HOGENOMiHOG000231754.
HOVERGENiHBG096568.
InParanoidiQ9Z0H6.
KOiK13905.
OMAiRRTICKK.
OrthoDBiEOG091G0YM0.
PhylomeDBiQ9Z0H6.

Family and domain databases

InterProiIPR027213. CST9-like.
IPR027214. Cystatin.
IPR000010. Cystatin_dom.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 1 hit.
PTHR11413:SF22. PTHR11413:SF22. 1 hit.
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0H6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCPLRKKAL PLTMLLLLLS FHVLITPVSK ANKETNRSVH FIPTVEFAVN
60 70 80 90 100
TFNQESQDEY AYRMEHIMSS WREKVNFPTV YSMRLQLRRT ICKKFEESLD
110 120 130
ICPFQESHGL NNTFTCLFTV GTYPWITKFK LFRSVCS
Length:137
Mass (Da):16,094
Last modified:May 1, 1999 - v1
Checksum:iAC1CDE5834C36FB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18243 mRNA. Translation: CAA77090.1.
AB017157 mRNA. Translation: BAA37089.1.
AK006429 mRNA. Translation: BAB24584.1.
AL844519 Genomic DNA. Translation: CAM18692.1.
BC048486 mRNA. Translation: AAH48486.1.
CCDSiCCDS16850.1.
RefSeqiNP_034109.1. NM_009979.1.
UniGeneiMm.21005.

Genome annotation databases

EnsembliENSMUST00000028935; ENSMUSP00000028935; ENSMUSG00000027445.
GeneIDi13013.
KEGGimmu:13013.
UCSCiuc008mtr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18243 mRNA. Translation: CAA77090.1.
AB017157 mRNA. Translation: BAA37089.1.
AK006429 mRNA. Translation: BAB24584.1.
AL844519 Genomic DNA. Translation: CAM18692.1.
BC048486 mRNA. Translation: AAH48486.1.
CCDSiCCDS16850.1.
RefSeqiNP_034109.1. NM_009979.1.
UniGeneiMm.21005.

3D structure databases

ProteinModelPortaliQ9Z0H6.
SMRiQ9Z0H6. Positions 47-131.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028935.

PTM databases

PhosphoSiteiQ9Z0H6.

Proteomic databases

PaxDbiQ9Z0H6.
PRIDEiQ9Z0H6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028935; ENSMUSP00000028935; ENSMUSG00000027445.
GeneIDi13013.
KEGGimmu:13013.
UCSCiuc008mtr.1. mouse.

Organism-specific databases

CTDi128822.
MGIiMGI:1340053. Cst9.

Phylogenomic databases

eggNOGiENOG410J1WW. Eukaryota.
ENOG4111DUC. LUCA.
GeneTreeiENSGT00430000031103.
HOGENOMiHOG000231754.
HOVERGENiHBG096568.
InParanoidiQ9Z0H6.
KOiK13905.
OMAiRRTICKK.
OrthoDBiEOG091G0YM0.
PhylomeDBiQ9Z0H6.

Miscellaneous databases

PROiQ9Z0H6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027445.
CleanExiMM_CST9.
GenevisibleiQ9Z0H6. MM.

Family and domain databases

InterProiIPR027213. CST9-like.
IPR027214. Cystatin.
IPR000010. Cystatin_dom.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 1 hit.
PTHR11413:SF22. PTHR11413:SF22. 1 hit.
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCST9_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0H6
Secondary accession number(s): Q545L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.