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Protein

Natural cytotoxicity triggering receptor 1

Gene

Ncr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.By similarity

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Natural cytotoxicity triggering receptor 1
Alternative name(s):
Activating receptor 1
Short name:
rAR-1
Lymphocyte antigen 94 homolog
NK receptor KILR-1
NKACTR
Natural killer cell p46-related protein
Short name:
NK-p46
Short name:
NKp46
CD_antigen: CD335
Gene namesi
Name:Ncr1
Synonyms:Ar1, Kilr1, Ly94
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621288. Ncr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 258242ExtracellularSequence analysisAdd
BLAST
Transmembranei259 – 27921HelicalSequence analysisAdd
BLAST
Topological domaini280 – 32546CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 325309Natural cytotoxicity triggering receptor 1PRO_0000015030Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 98By similarity
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence analysis
Disulfide bondi144 ↔ 190By similarity
Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Z0H5.
PRIDEiQ9Z0H5.

Expressioni

Tissue specificityi

Weakly expressed in spleen, heart and lung.1 Publication

Gene expression databases

GenevisibleiQ9Z0H5. RN.

Interactioni

Subunit structurei

Interacts with CD3Z and FCER1G.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025080.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0H5.
SMRiQ9Z0H5. Positions 25-212.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 10059Ig-like 1Add
BLAST
Domaini137 – 19256Ig-like 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IX2G. Eukaryota.
ENOG4111ACT. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiQ9Z0H5.
KOiK06741.
OMAiYAWSFPS.
OrthoDBiEOG78SQGZ.
PhylomeDBiQ9Z0H5.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0H5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPTLTALLC LGLCLSQRIN TEKQTLPKPI IWAKPSIMVT KGNSVNIWCQ
60 70 80 90 100
GAQSASEYQL YFEGSFFALE RPKSSRSMNK VKFFISQMTS HTAGIYTCFY
110 120 130 140 150
QSGELWSESS NPLKLVVTGL YDTPTLWVHP GPEVTLGENV TFSCHLKTAT
160 170 180 190 200
SKFFLLKERE SNHIQHKYGN IQAEFPMGPV TRAHRGTYRC FGSYNDYAWS
210 220 230 240 250
FPSEPVTLLI TGEVENTSLA PTDPVSSLDY WEFDLSTKES GLQKDSAFWD
260 270 280 290 300
HTAQNLIRIG LACIIVMALV WLLAEDWLSR RKDHEKLNRL TSWECRGRRR
310 320
MHRYHEEEQR DAISMRELKA TPGDM
Length:325
Mass (Da):37,178
Last modified:May 1, 1999 - v1
Checksum:i502C10AA02F65FA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ012741 mRNA. Translation: CAA10161.1.
AF082533 mRNA. Translation: AAC69890.1.
RefSeqiNP_476547.1. NM_057199.1.
UniGeneiRn.30049.

Genome annotation databases

EnsembliENSRNOT00000025080; ENSRNOP00000025080; ENSRNOG00000018458.
GeneIDi117547.
KEGGirno:117547.
UCSCiRGD:621288. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ012741 mRNA. Translation: CAA10161.1.
AF082533 mRNA. Translation: AAC69890.1.
RefSeqiNP_476547.1. NM_057199.1.
UniGeneiRn.30049.

3D structure databases

ProteinModelPortaliQ9Z0H5.
SMRiQ9Z0H5. Positions 25-212.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025080.

Proteomic databases

PaxDbiQ9Z0H5.
PRIDEiQ9Z0H5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025080; ENSRNOP00000025080; ENSRNOG00000018458.
GeneIDi117547.
KEGGirno:117547.
UCSCiRGD:621288. rat.

Organism-specific databases

CTDi9437.
RGDi621288. Ncr1.

Phylogenomic databases

eggNOGiENOG410IX2G. Eukaryota.
ENOG4111ACT. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiQ9Z0H5.
KOiK06741.
OMAiYAWSFPS.
OrthoDBiEOG78SQGZ.
PhylomeDBiQ9Z0H5.
TreeFamiTF336644.

Miscellaneous databases

PROiQ9Z0H5.

Gene expression databases

GenevisibleiQ9Z0H5. RN.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Identification of the rat homologue of the human NKp46 triggering receptor."
    Falco M., Cantoni C., Bottino C., Moretta A., Biassoni R.
    Immunol. Lett. 68:411-414(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Lymphoid tissue.
  2. "Molecular characterization of KILR-1, a novel immunoglobulin-like gene in the rat, expressed by NK cells."
    Berg S.F., Dissen E., Westgaard I.H., Fossum S.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: PVG.

Entry informationi

Entry nameiNCTR1_RAT
AccessioniPrimary (citable) accession number: Q9Z0H5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 1, 1999
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.