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Protein

Cell division cycle 7-related protein kinase

Gene

Cdc7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei84 – 841ATPPROSITE-ProRule annotation
Active sitei171 – 1711Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi58 – 669ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 3474.
ReactomeiR-MMU-176187. Activation of ATR in response to replication stress.
R-MMU-68962. Activation of the pre-replicative complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle 7-related protein kinase (EC:2.7.11.1)
Short name:
CDC7-related kinase
Short name:
muCdc7
Gene namesi
Name:Cdc7
Synonyms:Cdc7l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1309511. Cdc7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 564564Cell division cycle 7-related protein kinasePRO_0000085764Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Z0H0.
MaxQBiQ9Z0H0.
PaxDbiQ9Z0H0.
PRIDEiQ9Z0H0.

PTM databases

iPTMnetiQ9Z0H0.
PhosphoSiteiQ9Z0H0.

Expressioni

Gene expression databases

BgeeiQ9Z0H0.
CleanExiMM_CDC7.
ExpressionAtlasiQ9Z0H0. baseline and differential.
GenevisibleiQ9Z0H0. MM.

Interactioni

Subunit structurei

Forms a complex with either DBF4/DBF4A or DBF4B, leading to the activation of the kinase activity.

Protein-protein interaction databases

BioGridi198629. 1 interaction.
STRINGi10090.ENSMUSP00000031221.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0H0.
SMRiQ9Z0H0. Positions 5-214, 356-496, 525-562.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 564513Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1167. Eukaryota.
ENOG410YKCM. LUCA.
GeneTreeiENSGT00550000075011.
HOGENOMiHOG000193450.
HOVERGENiHBG003991.
InParanoidiQ9Z0H0.
KOiK02214.
OMAiHESPDGR.
OrthoDBiEOG7VMP6J.
TreeFamiTF101052.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 2 hits.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 3 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9Z0H0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEPMAFSSL RGSDRCPADD SLKKYEQSVK LSGIKRDIEE LCEAVPQLVN
60 70 80 90 100
VFKIKDKIGE GTFSSVYLAT AQLQEGHEEK IALKHLIPTS HPMRIAAELQ
110 120 130 140 150
CLTVAGGQDN VMGLKYCFRK NDHVVIAMPY LEHESFLDIL NSLSFQEVRE
160 170 180 190 200
YMYNLFVALK RIHQFGIVHR DVKPSNFLYN RRLKKYALVD FGLAQGTRDT
210 220 230 240 250
KIELLKFVQS EAQQEDCSRN KYHGVVGHKG LLSRPAPKTV DQQCTPKTSV
260 270 280 290 300
KRSYTQVHIK QGKDGKERSV GLSVQRSVFG ERNFNIHSSI SHESPAEKLI
310 320 330 340 350
KQSKTVDIIS RKLATKKTAI STKAMNSVMR ETARSCPAVL TCDCYGSDRV
360 370 380 390 400
CSVCLSRRQQ VAPRAGTPGF RAPEVLTKCP DQTTAIDMWS AGVIFLSLLS
410 420 430 440 450
GRYPFYKASD DLTALAQIMT IRGSRETIQA AKAFGKSVLC SKEVPAQDLR
460 470 480 490 500
ALCERLRGLD STTPRSASGP PGNASYDPAA SKNTDHKASR VQAAQAQHSE
510 520 530 540 550
DSLYKRDNDG YWSHPKDCTS NSEGWDSVPD EAYDLLDKLL DLNPASRITA
560
EAALLHAFFK DMCS
Length:564
Mass (Da):62,770
Last modified:July 27, 2011 - v2
Checksum:i82BD6617F70FB240
GO
Isoform 2 (identifier: Q9Z0H0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     267-298: Missing.

Show »
Length:532
Mass (Da):59,203
Checksum:i9376E9C74AC603C6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381I → F in BAA34347 (PubMed:9722556).Curated
Sequence conflicti38 – 381I → F in BAA33881 (PubMed:9722556).Curated
Sequence conflicti38 – 381I → F in BAA33880 (PubMed:9722556).Curated
Sequence conflicti42 – 421C → G in BAA34347 (PubMed:9722556).Curated
Sequence conflicti42 – 421C → G in BAA33881 (PubMed:9722556).Curated
Sequence conflicti42 – 421C → G in BAA33880 (PubMed:9722556).Curated
Sequence conflicti52 – 521F → S in BAA34347 (PubMed:9722556).Curated
Sequence conflicti52 – 521F → S in BAA33881 (PubMed:9722556).Curated
Sequence conflicti52 – 521F → S in BAA33880 (PubMed:9722556).Curated
Sequence conflicti348 – 3481D → N in BAA34347 (PubMed:9722556).Curated
Sequence conflicti348 – 3481D → N in BAA33881 (PubMed:9722556).Curated
Sequence conflicti348 – 3481D → N in BAA33880 (PubMed:9722556).Curated
Sequence conflicti516 – 5161K → R in BAA34347 (PubMed:9722556).Curated
Sequence conflicti516 – 5161K → R in BAA33881 (PubMed:9722556).Curated
Sequence conflicti516 – 5161K → R in BAA33880 (PubMed:9722556).Curated
Sequence conflicti557 – 5571A → V in BAA34347 (PubMed:9722556).Curated
Sequence conflicti557 – 5571A → V in BAA33881 (PubMed:9722556).Curated
Sequence conflicti557 – 5571A → V in BAA33880 (PubMed:9722556).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei267 – 29832Missing in isoform 2. 1 PublicationVSP_004864Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019388 Genomic DNA. Translation: BAA34347.1.
AB018575 mRNA. Translation: BAA33881.1.
AB018574 mRNA. Translation: BAA33880.1.
AJ007661 mRNA. Translation: CAB40539.1.
AK145921 mRNA. Translation: BAE26752.1.
CH466529 Genomic DNA. Translation: EDL20174.1.
BC072666 mRNA. Translation: AAH72666.1.
CCDSiCCDS19498.1. [Q9Z0H0-1]
CCDS71628.1. [Q9Z0H0-2]
RefSeqiNP_001258495.1. NM_001271566.1. [Q9Z0H0-1]
NP_001258496.1. NM_001271567.1. [Q9Z0H0-2]
NP_001258497.1. NM_001271568.1.
NP_033993.2. NM_009863.3. [Q9Z0H0-1]
UniGeneiMm.20842.

Genome annotation databases

EnsembliENSMUST00000031221; ENSMUSP00000031221; ENSMUSG00000029283. [Q9Z0H0-1]
ENSMUST00000117196; ENSMUSP00000112392; ENSMUSG00000029283. [Q9Z0H0-2]
ENSMUST00000118261; ENSMUSP00000113385; ENSMUSG00000029283. [Q9Z0H0-1]
GeneIDi12545.
KEGGimmu:12545.
UCSCiuc008ylw.2. mouse. [Q9Z0H0-1]
uc008ylx.2. mouse. [Q9Z0H0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019388 Genomic DNA. Translation: BAA34347.1.
AB018575 mRNA. Translation: BAA33881.1.
AB018574 mRNA. Translation: BAA33880.1.
AJ007661 mRNA. Translation: CAB40539.1.
AK145921 mRNA. Translation: BAE26752.1.
CH466529 Genomic DNA. Translation: EDL20174.1.
BC072666 mRNA. Translation: AAH72666.1.
CCDSiCCDS19498.1. [Q9Z0H0-1]
CCDS71628.1. [Q9Z0H0-2]
RefSeqiNP_001258495.1. NM_001271566.1. [Q9Z0H0-1]
NP_001258496.1. NM_001271567.1. [Q9Z0H0-2]
NP_001258497.1. NM_001271568.1.
NP_033993.2. NM_009863.3. [Q9Z0H0-1]
UniGeneiMm.20842.

3D structure databases

ProteinModelPortaliQ9Z0H0.
SMRiQ9Z0H0. Positions 5-214, 356-496, 525-562.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198629. 1 interaction.
STRINGi10090.ENSMUSP00000031221.

PTM databases

iPTMnetiQ9Z0H0.
PhosphoSiteiQ9Z0H0.

Proteomic databases

EPDiQ9Z0H0.
MaxQBiQ9Z0H0.
PaxDbiQ9Z0H0.
PRIDEiQ9Z0H0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031221; ENSMUSP00000031221; ENSMUSG00000029283. [Q9Z0H0-1]
ENSMUST00000117196; ENSMUSP00000112392; ENSMUSG00000029283. [Q9Z0H0-2]
ENSMUST00000118261; ENSMUSP00000113385; ENSMUSG00000029283. [Q9Z0H0-1]
GeneIDi12545.
KEGGimmu:12545.
UCSCiuc008ylw.2. mouse. [Q9Z0H0-1]
uc008ylx.2. mouse. [Q9Z0H0-2]

Organism-specific databases

CTDi8317.
MGIiMGI:1309511. Cdc7.

Phylogenomic databases

eggNOGiKOG1167. Eukaryota.
ENOG410YKCM. LUCA.
GeneTreeiENSGT00550000075011.
HOGENOMiHOG000193450.
HOVERGENiHBG003991.
InParanoidiQ9Z0H0.
KOiK02214.
OMAiHESPDGR.
OrthoDBiEOG7VMP6J.
TreeFamiTF101052.

Enzyme and pathway databases

BRENDAi2.7.11.1. 3474.
ReactomeiR-MMU-176187. Activation of ATR in response to replication stress.
R-MMU-68962. Activation of the pre-replicative complex.

Miscellaneous databases

PROiQ9Z0H0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z0H0.
CleanExiMM_CDC7.
ExpressionAtlasiQ9Z0H0. baseline and differential.
GenevisibleiQ9Z0H0. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 2 hits.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 3 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Growth regulation of the expression of mouse cDNA and gene encoding a serine/threonine kinase related to Saccharomyces cerevisiae CDC7 essential for G1/S transition. Structure, chromosomal localization, and expression of mouse gene for s. cerevisiae Cdc7-related kinase."
    Kim J., Sato N., Yamada M., Arai K., Masai H.
    J. Biol. Chem. 273:23248-23257(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2).
    Tissue: Liver.
  2. "Identification and characterization of mouse homologue to yeast Cdc7 protein and chromosomal localization of the cognate mouse gene Cdc7l."
    Faul T., Staib C., Nanda I., Schmid M., Grummt F.
    Chromosoma 108:26-31(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Placenta.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Eye.
  6. "Identification, characterization and chromosomal localization of the cognate human and murine DBF4 genes."
    Lepke M., Puetter V., Staib C., Kneissl M., Berger C., Hoehn K., Nanda I., Schmid M., Grummt F.
    Mol. Gen. Genet. 262:220-229(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DBF4.
    Strain: C57BL/6J.
    Tissue: Egg and Embryo.

Entry informationi

Entry nameiCDC7_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0H0
Secondary accession number(s): Q9WUV1, Q9Z2Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 27, 2011
Last modified: July 6, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.