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Protein

Claudin-3

Gene

Cldn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.1 Publication

GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • structural molecule activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-3
Alternative name(s):
Clostridium perfringens enterotoxin receptor 2
Short name:
CPE-R 2
Short name:
CPE-receptor 2
Gene namesi
Name:Cldn3
Synonyms:Cpetr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1329044. Cldn3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Topological domaini30 – 80ExtracellularSequence analysisAdd BLAST51
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 115CytoplasmicSequence analysisAdd BLAST14
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 159ExtracellularSequence analysisAdd BLAST23
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 219CytoplasmicSequence analysisAdd BLAST39

GO - Cellular componenti

  • apicolateral plasma membrane Source: UniProtKB
  • bicellular tight junction Source: UniProtKB
  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB
  • lateral plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447391 – 219Claudin-3Add BLAST219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei197PhosphotyrosineCombined sources1
Modified residuei198PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z0G9.
PRIDEiQ9Z0G9.

PTM databases

iPTMnetiQ9Z0G9.
PhosphoSitePlusiQ9Z0G9.

Expressioni

Tissue specificityi

Expressed at high levels in liver and lung and, at lower levels, in kidney and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000070473.
CleanExiMM_CLDN3.
ExpressionAtlasiQ9Z0G9. baseline and differential.
GenevisibleiQ9Z0G9. MM.

Interactioni

Subunit structurei

Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.2 Publications

GO - Molecular functioni

  • identical protein binding Source: UniProtKB

Protein-protein interaction databases

DIPiDIP-40779N.
IntActiQ9Z0G9. 1 interactor.
MINTiMINT-113483.
STRINGi10090.ENSMUSP00000091799.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0G9.
SMRiQ9Z0G9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni218 – 219Interactions with TJP1, TJP2 and TJP3By similarity2

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIJR. Eukaryota.
ENOG410YA61. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiQ9Z0G9.
KOiK06087.
OMAiVPDAQKR.
OrthoDBiEOG091G0MMR.
PhylomeDBiQ9Z0G9.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003549. Claudin3.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01378. CLAUDIN3.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Z0G9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSMGLEITGT SLAVLGWLCT IVCCALPMWR VSAFIGSSII TAQITWEGLW
60 70 80 90 100
MNCVVQSTGQ MQCKMYDSLL ALPQDLQAAR ALIVVSILLA AFGLLVALVG
110 120 130 140 150
AQCTNCVQDE TAKAKITIVA GVLFLLAALL TLVPVSWSAN TIIRDFYNPL
160 170 180 190 200
VPEAQKREMG AGLYVGWAAA ALQLLGGALL CCSCPPRDKY APTKILYSAP
210
RSTGPGTGTG TAYDRKDYV
Length:219
Mass (Da):23,285
Last modified:May 1, 1999 - v1
Checksum:i62F67810D9B9BD37
GO
Isoform 2 (identifier: Q9Z0G9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-91: Missing.

Note: No experimental confirmation available.
Show »
Length:199
Mass (Da):21,227
Checksum:iE6F917AAE0098772
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00110172 – 91Missing in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095905 mRNA. Translation: AAD14608.1.
AF087821 mRNA. Translation: AAD09756.1.
BC012650 mRNA. Translation: AAH12650.1.
CCDSiCCDS19729.1. [Q9Z0G9-1]
RefSeqiNP_034032.1. NM_009902.4. [Q9Z0G9-1]
UniGeneiMm.158662.

Genome annotation databases

EnsembliENSMUST00000094245; ENSMUSP00000091799; ENSMUSG00000070473. [Q9Z0G9-1]
GeneIDi12739.
KEGGimmu:12739.
UCSCiuc008zxe.2. mouse. [Q9Z0G9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095905 mRNA. Translation: AAD14608.1.
AF087821 mRNA. Translation: AAD09756.1.
BC012650 mRNA. Translation: AAH12650.1.
CCDSiCCDS19729.1. [Q9Z0G9-1]
RefSeqiNP_034032.1. NM_009902.4. [Q9Z0G9-1]
UniGeneiMm.158662.

3D structure databases

ProteinModelPortaliQ9Z0G9.
SMRiQ9Z0G9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-40779N.
IntActiQ9Z0G9. 1 interactor.
MINTiMINT-113483.
STRINGi10090.ENSMUSP00000091799.

PTM databases

iPTMnetiQ9Z0G9.
PhosphoSitePlusiQ9Z0G9.

Proteomic databases

PaxDbiQ9Z0G9.
PRIDEiQ9Z0G9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094245; ENSMUSP00000091799; ENSMUSG00000070473. [Q9Z0G9-1]
GeneIDi12739.
KEGGimmu:12739.
UCSCiuc008zxe.2. mouse. [Q9Z0G9-1]

Organism-specific databases

CTDi1365.
MGIiMGI:1329044. Cldn3.

Phylogenomic databases

eggNOGiENOG410IIJR. Eukaryota.
ENOG410YA61. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiQ9Z0G9.
KOiK06087.
OMAiVPDAQKR.
OrthoDBiEOG091G0MMR.
PhylomeDBiQ9Z0G9.
TreeFamiTF331936.

Miscellaneous databases

PROiQ9Z0G9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070473.
CleanExiMM_CLDN3.
ExpressionAtlasiQ9Z0G9. baseline and differential.
GenevisibleiQ9Z0G9. MM.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003549. Claudin3.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01378. CLAUDIN3.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLD3_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0G9
Secondary accession number(s): Q91X40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.