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Q9Z0G9

- CLD3_MOUSE

UniProt

Q9Z0G9 - CLD3_MOUSE

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Protein
Claudin-3
Gene
Cldn3, Cpetr2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.1 Publication

GO - Molecular functioni

  1. identical protein binding Source: UniProtKB
  2. protein binding Source: UniProtKB
  3. structural molecule activity Source: InterPro

GO - Biological processi

  1. calcium-independent cell-cell adhesion Source: UniProtKB
  2. response to hypoxia Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-3
Alternative name(s):
Clostridium perfringens enterotoxin receptor 2
Short name:
CPE-R 2
Short name:
CPE-receptor 2
Gene namesi
Name:Cldn3
Synonyms:Cpetr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1329044. Cldn3.

Subcellular locationi

Cell junctiontight junction. Cell membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88Cytoplasmic Reviewed prediction
Transmembranei9 – 2921Helical; Reviewed prediction
Add
BLAST
Topological domaini30 – 8051Extracellular Reviewed prediction
Add
BLAST
Transmembranei81 – 10121Helical; Reviewed prediction
Add
BLAST
Topological domaini102 – 11514Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei116 – 13621Helical; Reviewed prediction
Add
BLAST
Topological domaini137 – 15923Extracellular Reviewed prediction
Add
BLAST
Transmembranei160 – 18021Helical; Reviewed prediction
Add
BLAST
Topological domaini181 – 21939Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. lateral plasma membrane Source: MGI
  3. tight junction Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Claudin-3
PRO_0000144739Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei197 – 1971Phosphotyrosine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z0G9.
PRIDEiQ9Z0G9.

PTM databases

PhosphoSiteiQ9Z0G9.

Expressioni

Tissue specificityi

Expressed at high levels in liver and lung and, at lower levels, in kidney and testis.1 Publication

Gene expression databases

ArrayExpressiQ9Z0G9.
BgeeiQ9Z0G9.
CleanExiMM_CLDN3.
GenevestigatoriQ9Z0G9.

Interactioni

Subunit structurei

Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.2 Publications

Protein-protein interaction databases

MINTiMINT-113483.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni218 – 2192Interactions with TJP1, TJP2 and TJP3 By similarity

Sequence similaritiesi

Belongs to the claudin family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG281814.
GeneTreeiENSGT00740000115238.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiQ9Z0G9.
KOiK06087.
OMAiVPDAQKR.
OrthoDBiEOG79KPGQ.
PhylomeDBiQ9Z0G9.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003549. Claudin3.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01077. CLAUDIN.
PR01378. CLAUDIN3.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Z0G9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSMGLEITGT SLAVLGWLCT IVCCALPMWR VSAFIGSSII TAQITWEGLW    50
MNCVVQSTGQ MQCKMYDSLL ALPQDLQAAR ALIVVSILLA AFGLLVALVG 100
AQCTNCVQDE TAKAKITIVA GVLFLLAALL TLVPVSWSAN TIIRDFYNPL 150
VPEAQKREMG AGLYVGWAAA ALQLLGGALL CCSCPPRDKY APTKILYSAP 200
RSTGPGTGTG TAYDRKDYV 219
Length:219
Mass (Da):23,285
Last modified:May 1, 1999 - v1
Checksum:i62F67810D9B9BD37
GO
Isoform 2 (identifier: Q9Z0G9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-91: Missing.

Note: No experimental confirmation available.

Show »
Length:199
Mass (Da):21,227
Checksum:iE6F917AAE0098772
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei72 – 9120Missing in isoform 2.
VSP_001101Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF095905 mRNA. Translation: AAD14608.1.
AF087821 mRNA. Translation: AAD09756.1.
BC012650 mRNA. Translation: AAH12650.1.
CCDSiCCDS19729.1. [Q9Z0G9-1]
RefSeqiNP_034032.1. NM_009902.4. [Q9Z0G9-1]
UniGeneiMm.158662.

Genome annotation databases

EnsembliENSMUST00000094245; ENSMUSP00000091799; ENSMUSG00000070473. [Q9Z0G9-1]
GeneIDi12739.
KEGGimmu:12739.
UCSCiuc008zxe.2. mouse. [Q9Z0G9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF095905 mRNA. Translation: AAD14608.1 .
AF087821 mRNA. Translation: AAD09756.1 .
BC012650 mRNA. Translation: AAH12650.1 .
CCDSi CCDS19729.1. [Q9Z0G9-1 ]
RefSeqi NP_034032.1. NM_009902.4. [Q9Z0G9-1 ]
UniGenei Mm.158662.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-113483.

PTM databases

PhosphoSitei Q9Z0G9.

Proteomic databases

PaxDbi Q9Z0G9.
PRIDEi Q9Z0G9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000094245 ; ENSMUSP00000091799 ; ENSMUSG00000070473 . [Q9Z0G9-1 ]
GeneIDi 12739.
KEGGi mmu:12739.
UCSCi uc008zxe.2. mouse. [Q9Z0G9-1 ]

Organism-specific databases

CTDi 1365.
MGIi MGI:1329044. Cldn3.

Phylogenomic databases

eggNOGi NOG281814.
GeneTreei ENSGT00740000115238.
HOGENOMi HOG000220937.
HOVERGENi HBG000643.
InParanoidi Q9Z0G9.
KOi K06087.
OMAi VPDAQKR.
OrthoDBi EOG79KPGQ.
PhylomeDBi Q9Z0G9.
TreeFami TF331936.

Miscellaneous databases

NextBioi 282050.
PROi Q9Z0G9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Z0G9.
Bgeei Q9Z0G9.
CleanExi MM_CLDN3.
Genevestigatori Q9Z0G9.

Family and domain databases

InterProi IPR006187. Claudin.
IPR003549. Claudin3.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view ]
PANTHERi PTHR12002. PTHR12002. 1 hit.
Pfami PF00822. PMP22_Claudin. 1 hit.
[Graphical view ]
PRINTSi PR01077. CLAUDIN.
PR01378. CLAUDIN3.
PROSITEi PS01346. CLAUDIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genes for the CPE receptor (CPETR1) and the human homolog of RVP1 (CPETR2) are localized within the Williams-Beuren syndrome deletion."
    Paperna T., Peoples R., Wang Y.K., Kaplan P., Francke U.
    Genomics 54:453-459(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands."
    Morita K., Furuse M., Fujimoto K., Tsukita S.
    Proc. Natl. Acad. Sci. U.S.A. 96:511-516(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Colon.
  4. "Ca(2+)-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions."
    Kubota K., Furuse M., Sasaki H., Sonoda N., Fujita K., Nagafuchi A., Tsukita S.
    Curr. Biol. 9:1035-1038(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Manner of interaction of heterogeneous claudin species within and between tight junction strands."
    Furuse M., Sasaki H., Tsukita S.
    J. Cell Biol. 147:891-903(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CLDN1 AND CLDN2.
  6. "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins."
    Itoh M., Furuse M., Morita K., Kubota K., Saitou M., Tsukita S.
    J. Cell Biol. 147:1351-1363(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TJP1; TJP2 AND TJP3.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-197, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCLD3_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0G9
Secondary accession number(s): Q91X40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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