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Q9Z0G9

- CLD3_MOUSE

UniProt

Q9Z0G9 - CLD3_MOUSE

Protein

Claudin-3

Gene

Cldn3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.1 Publication

    GO - Molecular functioni

    1. identical protein binding Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. structural molecule activity Source: InterPro

    GO - Biological processi

    1. calcium-independent cell-cell adhesion Source: UniProtKB
    2. response to hypoxia Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Claudin-3
    Alternative name(s):
    Clostridium perfringens enterotoxin receptor 2
    Short name:
    CPE-R 2
    Short name:
    CPE-receptor 2
    Gene namesi
    Name:Cldn3
    Synonyms:Cpetr2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1329044. Cldn3.

    Subcellular locationi

    Cell junctiontight junction 1 Publication. Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. lateral plasma membrane Source: MGI
    3. tight junction Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Tight junction

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 219219Claudin-3PRO_0000144739Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei197 – 1971Phosphotyrosine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9Z0G9.
    PRIDEiQ9Z0G9.

    PTM databases

    PhosphoSiteiQ9Z0G9.

    Expressioni

    Tissue specificityi

    Expressed at high levels in liver and lung and, at lower levels, in kidney and testis.1 Publication

    Gene expression databases

    ArrayExpressiQ9Z0G9.
    BgeeiQ9Z0G9.
    CleanExiMM_CLDN3.
    GenevestigatoriQ9Z0G9.

    Interactioni

    Subunit structurei

    Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.2 Publications

    Protein-protein interaction databases

    MINTiMINT-113483.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 88CytoplasmicSequence Analysis
    Topological domaini30 – 8051ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini102 – 11514CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini137 – 15923ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini181 – 21939CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei81 – 10121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei116 – 13621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei160 – 18021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni218 – 2192Interactions with TJP1, TJP2 and TJP3By similarity

    Sequence similaritiesi

    Belongs to the claudin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG281814.
    GeneTreeiENSGT00740000115238.
    HOGENOMiHOG000220937.
    HOVERGENiHBG000643.
    InParanoidiQ9Z0G9.
    KOiK06087.
    OMAiVPDAQKR.
    OrthoDBiEOG79KPGQ.
    PhylomeDBiQ9Z0G9.
    TreeFamiTF331936.

    Family and domain databases

    InterProiIPR006187. Claudin.
    IPR003549. Claudin3.
    IPR017974. Claudin_CS.
    IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view]
    PANTHERiPTHR12002. PTHR12002. 1 hit.
    PfamiPF00822. PMP22_Claudin. 1 hit.
    [Graphical view]
    PRINTSiPR01077. CLAUDIN.
    PR01378. CLAUDIN3.
    PROSITEiPS01346. CLAUDIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Z0G9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSMGLEITGT SLAVLGWLCT IVCCALPMWR VSAFIGSSII TAQITWEGLW    50
    MNCVVQSTGQ MQCKMYDSLL ALPQDLQAAR ALIVVSILLA AFGLLVALVG 100
    AQCTNCVQDE TAKAKITIVA GVLFLLAALL TLVPVSWSAN TIIRDFYNPL 150
    VPEAQKREMG AGLYVGWAAA ALQLLGGALL CCSCPPRDKY APTKILYSAP 200
    RSTGPGTGTG TAYDRKDYV 219
    Length:219
    Mass (Da):23,285
    Last modified:May 1, 1999 - v1
    Checksum:i62F67810D9B9BD37
    GO
    Isoform 2 (identifier: Q9Z0G9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         72-91: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:199
    Mass (Da):21,227
    Checksum:iE6F917AAE0098772
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei72 – 9120Missing in isoform 2. 1 PublicationVSP_001101Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF095905 mRNA. Translation: AAD14608.1.
    AF087821 mRNA. Translation: AAD09756.1.
    BC012650 mRNA. Translation: AAH12650.1.
    CCDSiCCDS19729.1. [Q9Z0G9-1]
    RefSeqiNP_034032.1. NM_009902.4. [Q9Z0G9-1]
    UniGeneiMm.158662.

    Genome annotation databases

    EnsembliENSMUST00000094245; ENSMUSP00000091799; ENSMUSG00000070473. [Q9Z0G9-1]
    GeneIDi12739.
    KEGGimmu:12739.
    UCSCiuc008zxe.2. mouse. [Q9Z0G9-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF095905 mRNA. Translation: AAD14608.1 .
    AF087821 mRNA. Translation: AAD09756.1 .
    BC012650 mRNA. Translation: AAH12650.1 .
    CCDSi CCDS19729.1. [Q9Z0G9-1 ]
    RefSeqi NP_034032.1. NM_009902.4. [Q9Z0G9-1 ]
    UniGenei Mm.158662.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-113483.

    PTM databases

    PhosphoSitei Q9Z0G9.

    Proteomic databases

    PaxDbi Q9Z0G9.
    PRIDEi Q9Z0G9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000094245 ; ENSMUSP00000091799 ; ENSMUSG00000070473 . [Q9Z0G9-1 ]
    GeneIDi 12739.
    KEGGi mmu:12739.
    UCSCi uc008zxe.2. mouse. [Q9Z0G9-1 ]

    Organism-specific databases

    CTDi 1365.
    MGIi MGI:1329044. Cldn3.

    Phylogenomic databases

    eggNOGi NOG281814.
    GeneTreei ENSGT00740000115238.
    HOGENOMi HOG000220937.
    HOVERGENi HBG000643.
    InParanoidi Q9Z0G9.
    KOi K06087.
    OMAi VPDAQKR.
    OrthoDBi EOG79KPGQ.
    PhylomeDBi Q9Z0G9.
    TreeFami TF331936.

    Miscellaneous databases

    NextBioi 282050.
    PROi Q9Z0G9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Z0G9.
    Bgeei Q9Z0G9.
    CleanExi MM_CLDN3.
    Genevestigatori Q9Z0G9.

    Family and domain databases

    InterProi IPR006187. Claudin.
    IPR003549. Claudin3.
    IPR017974. Claudin_CS.
    IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view ]
    PANTHERi PTHR12002. PTHR12002. 1 hit.
    Pfami PF00822. PMP22_Claudin. 1 hit.
    [Graphical view ]
    PRINTSi PR01077. CLAUDIN.
    PR01378. CLAUDIN3.
    PROSITEi PS01346. CLAUDIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genes for the CPE receptor (CPETR1) and the human homolog of RVP1 (CPETR2) are localized within the Williams-Beuren syndrome deletion."
      Paperna T., Peoples R., Wang Y.K., Kaplan P., Francke U.
      Genomics 54:453-459(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands."
      Morita K., Furuse M., Fujimoto K., Tsukita S.
      Proc. Natl. Acad. Sci. U.S.A. 96:511-516(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Liver.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Colon.
    4. "Ca(2+)-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions."
      Kubota K., Furuse M., Sasaki H., Sonoda N., Fujita K., Nagafuchi A., Tsukita S.
      Curr. Biol. 9:1035-1038(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Manner of interaction of heterogeneous claudin species within and between tight junction strands."
      Furuse M., Sasaki H., Tsukita S.
      J. Cell Biol. 147:891-903(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CLDN1 AND CLDN2.
    6. "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins."
      Itoh M., Furuse M., Morita K., Kubota K., Saitou M., Tsukita S.
      J. Cell Biol. 147:1351-1363(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TJP1; TJP2 AND TJP3.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-197, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiCLD3_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z0G9
    Secondary accession number(s): Q91X40
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3