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Q9Z0G4

- WISP2_MOUSE

UniProt

Q9Z0G4 - WISP2_MOUSE

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Protein

WNT1-inducible-signaling pathway protein 2

Gene

Wisp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production By similarity.By similarity

GO - Molecular functioni

  1. growth factor activity Source: MGI

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. regulation of cell growth Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
WNT1-inducible-signaling pathway protein 2
Short name:
WISP-2
Alternative name(s):
CCN family member 5
Connective tissue growth factor-like protein
Short name:
CTGF-L
Gene namesi
Name:Wisp2
Synonyms:Ccn5, Ctgfl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1328326. Wisp2.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 251228WNT1-inducible-signaling pathway protein 2PRO_0000014410Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9Z0G4.

PTM databases

PhosphoSiteiQ9Z0G4.

Expressioni

Gene expression databases

CleanExiMM_WISP2.
GenevestigatoriQ9Z0G4.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029188.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0G4.
SMRiQ9Z0G4. Positions 33-133.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 9471IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini98 – 16467VWFCPROSITE-ProRule annotationAdd
BLAST
Domaini195 – 23945TSP type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CCN family.Curated
Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
Contains 1 VWFC domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG82184.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiQ9Z0G4.
PhylomeDBiQ9Z0G4.

Family and domain databases

InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0G4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRGNPLIHLL AISFLCILSM VYSQLCPAPC ACPWTPPQCP PGVPLVLDGC
60 70 80 90 100
GCCRVCARRL GESCDHLHVC DPSQGLVCQP GAGPSGRGAV CLFEEDDGSC
110 120 130 140 150
EVNGRRYLDG ETFKPNCRVL CRCDDGGFTC LPLCSEDVRL PSWDCPRPRR
160 170 180 190 200
IQVPGRCCPE WVCDQAVMQP AIQPSSAQGH QLSALVTPAS ADGPCPNWST
210 220 230 240 250
AWGPCSTTCG LGIATRVSNQ NRFCQLEIQR RLCLSRPCLA SRSHGSWNSA

F
Length:251
Mass (Da):27,095
Last modified:May 1, 1999 - v1
Checksum:i893E1633F6E5C7FC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231S → A in AAH32877. (PubMed:15489334)Curated
Sequence conflicti71 – 711D → N in AAH32877. (PubMed:15489334)Curated
Sequence conflicti89 – 891A → V in AAH32877. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF100778 mRNA. Translation: AAC96320.1.
AF126063 mRNA. Translation: AAD18058.1.
BC032877 mRNA. Translation: AAH32877.1.
CCDSiCCDS17016.1.
RefSeqiNP_058569.2. NM_016873.2.
UniGeneiMm.13828.

Genome annotation databases

GeneIDi22403.
KEGGimmu:22403.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF100778 mRNA. Translation: AAC96320.1 .
AF126063 mRNA. Translation: AAD18058.1 .
BC032877 mRNA. Translation: AAH32877.1 .
CCDSi CCDS17016.1.
RefSeqi NP_058569.2. NM_016873.2.
UniGenei Mm.13828.

3D structure databases

ProteinModelPortali Q9Z0G4.
SMRi Q9Z0G4. Positions 33-133.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000029188.

PTM databases

PhosphoSitei Q9Z0G4.

Proteomic databases

PRIDEi Q9Z0G4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 22403.
KEGGi mmu:22403.

Organism-specific databases

CTDi 8839.
MGIi MGI:1328326. Wisp2.

Phylogenomic databases

eggNOGi NOG82184.
HOGENOMi HOG000231462.
HOVERGENi HBG000635.
InParanoidi Q9Z0G4.
PhylomeDBi Q9Z0G4.

Miscellaneous databases

NextBioi 302785.
PROi Q9Z0G4.
SOURCEi Search...

Gene expression databases

CleanExi MM_WISP2.
Genevestigatori Q9Z0G4.

Family and domain databases

InterProi IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view ]
SMARTi SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEi PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors."
    Pennica D., Swanson T.A., Welsh J.W., Roy M.A., Lawrence D.A., Lee J., Brush J., Taneyhill L.A., Deuel B., Lew M., Watanabe C., Cohen R.L., Melham M.F., Finley G.G., Quirke P., Goddard A.D., Hillan K.J., Gurney A.L., Botstein D., Levine A.J.
    Proc. Natl. Acad. Sci. U.S.A. 95:14717-14722(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Mammary gland.
  2. "Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions."
    Kumar S., Hand A.T., Connor J.R., Dodds R.A., Ryan P.J., Trill J.J., Fisher S.M., Nuttall M.E., Lipshutz D.B., Zou C., Hwang S.M., Votta B.J., James I.E., Rieman D.J., Gowen M., Lee J.C.
    J. Biol. Chem. 274:17123-17131(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiWISP2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0G4
Secondary accession number(s): Q8CIC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3