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Q9Z0G4

- WISP2_MOUSE

UniProt

Q9Z0G4 - WISP2_MOUSE

Protein

WNT1-inducible-signaling pathway protein 2

Gene

Wisp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production By similarity.By similarity

    GO - Molecular functioni

    1. growth factor activity Source: MGI

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. regulation of cell growth Source: MGI

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WNT1-inducible-signaling pathway protein 2
    Short name:
    WISP-2
    Alternative name(s):
    CCN family member 5
    Connective tissue growth factor-like protein
    Short name:
    CTGF-L
    Gene namesi
    Name:Wisp2
    Synonyms:Ccn5, Ctgfl
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1328326. Wisp2.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 251228WNT1-inducible-signaling pathway protein 2PRO_0000014410Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9Z0G4.

    PTM databases

    PhosphoSiteiQ9Z0G4.

    Expressioni

    Gene expression databases

    CleanExiMM_WISP2.
    GenevestigatoriQ9Z0G4.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000029188.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z0G4.
    SMRiQ9Z0G4. Positions 31-83, 198-240.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 9471IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini98 – 16467VWFCPROSITE-ProRule annotationAdd
    BLAST
    Domaini195 – 23945TSP type-1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CCN family.Curated
    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
    Contains 1 VWFC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG82184.
    HOGENOMiHOG000231462.
    HOVERGENiHBG000635.
    InParanoidiQ9Z0G4.
    PhylomeDBiQ9Z0G4.

    Family and domain databases

    InterProiIPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view]
    SMARTiSM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEiPS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Z0G4-1 [UniParc]FASTAAdd to Basket

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    MRGNPLIHLL AISFLCILSM VYSQLCPAPC ACPWTPPQCP PGVPLVLDGC    50
    GCCRVCARRL GESCDHLHVC DPSQGLVCQP GAGPSGRGAV CLFEEDDGSC 100
    EVNGRRYLDG ETFKPNCRVL CRCDDGGFTC LPLCSEDVRL PSWDCPRPRR 150
    IQVPGRCCPE WVCDQAVMQP AIQPSSAQGH QLSALVTPAS ADGPCPNWST 200
    AWGPCSTTCG LGIATRVSNQ NRFCQLEIQR RLCLSRPCLA SRSHGSWNSA 250
    F 251
    Length:251
    Mass (Da):27,095
    Last modified:May 1, 1999 - v1
    Checksum:i893E1633F6E5C7FC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti23 – 231S → A in AAH32877. (PubMed:15489334)Curated
    Sequence conflicti71 – 711D → N in AAH32877. (PubMed:15489334)Curated
    Sequence conflicti89 – 891A → V in AAH32877. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF100778 mRNA. Translation: AAC96320.1.
    AF126063 mRNA. Translation: AAD18058.1.
    BC032877 mRNA. Translation: AAH32877.1.
    CCDSiCCDS17016.1.
    RefSeqiNP_058569.2. NM_016873.2.
    UniGeneiMm.13828.

    Genome annotation databases

    GeneIDi22403.
    KEGGimmu:22403.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF100778 mRNA. Translation: AAC96320.1 .
    AF126063 mRNA. Translation: AAD18058.1 .
    BC032877 mRNA. Translation: AAH32877.1 .
    CCDSi CCDS17016.1.
    RefSeqi NP_058569.2. NM_016873.2.
    UniGenei Mm.13828.

    3D structure databases

    ProteinModelPortali Q9Z0G4.
    SMRi Q9Z0G4. Positions 31-83, 198-240.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000029188.

    PTM databases

    PhosphoSitei Q9Z0G4.

    Proteomic databases

    PRIDEi Q9Z0G4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 22403.
    KEGGi mmu:22403.

    Organism-specific databases

    CTDi 8839.
    MGIi MGI:1328326. Wisp2.

    Phylogenomic databases

    eggNOGi NOG82184.
    HOGENOMi HOG000231462.
    HOVERGENi HBG000635.
    InParanoidi Q9Z0G4.
    PhylomeDBi Q9Z0G4.

    Miscellaneous databases

    NextBioi 302785.
    PROi Q9Z0G4.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_WISP2.
    Genevestigatori Q9Z0G4.

    Family and domain databases

    InterProi IPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view ]
    SMARTi SM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEi PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors."
      Pennica D., Swanson T.A., Welsh J.W., Roy M.A., Lawrence D.A., Lee J., Brush J., Taneyhill L.A., Deuel B., Lew M., Watanabe C., Cohen R.L., Melham M.F., Finley G.G., Quirke P., Goddard A.D., Hillan K.J., Gurney A.L., Botstein D., Levine A.J.
      Proc. Natl. Acad. Sci. U.S.A. 95:14717-14722(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Mammary gland.
    2. "Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions."
      Kumar S., Hand A.T., Connor J.R., Dodds R.A., Ryan P.J., Trill J.J., Fisher S.M., Nuttall M.E., Lipshutz D.B., Zou C., Hwang S.M., Votta B.J., James I.E., Rieman D.J., Gowen M., Lee J.C.
      J. Biol. Chem. 274:17123-17131(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiWISP2_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z0G4
    Secondary accession number(s): Q8CIC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3