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Q9Z0G4 (WISP2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
WNT1-inducible-signaling pathway protein 2

Short name=WISP-2
Alternative name(s):
CCN family member 5
Connective tissue growth factor-like protein
Short name=CTGF-L
Gene names
Name:Wisp2
Synonyms:Ccn5, Ctgfl
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length251 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production By similarity.

Subcellular location

Secreted Probable.

Sequence similarities

Belongs to the CCN family.

Contains 1 IGFBP N-terminal domain.

Contains 1 TSP type-1 domain.

Contains 1 VWFC domain.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentSecreted
   DomainSignal
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

regulation of cell growth

Inferred from direct assay PubMed 9742130. Source: MGI

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from direct assay PubMed 9742130. Source: MGI

   Molecular_functiongrowth factor activity

Inferred from sequence alignment PubMed 9742130. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 251228WNT1-inducible-signaling pathway protein 2
PRO_0000014410

Regions

Domain24 – 9471IGFBP N-terminal
Domain98 – 16467VWFC
Domain195 – 23945TSP type-1

Amino acid modifications

Glycosylation1971N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict231S → A in AAH32877. Ref.3
Sequence conflict711D → N in AAH32877. Ref.3
Sequence conflict891A → V in AAH32877. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9Z0G4 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 893E1633F6E5C7FC

FASTA25127,095
        10         20         30         40         50         60 
MRGNPLIHLL AISFLCILSM VYSQLCPAPC ACPWTPPQCP PGVPLVLDGC GCCRVCARRL 

        70         80         90        100        110        120 
GESCDHLHVC DPSQGLVCQP GAGPSGRGAV CLFEEDDGSC EVNGRRYLDG ETFKPNCRVL 

       130        140        150        160        170        180 
CRCDDGGFTC LPLCSEDVRL PSWDCPRPRR IQVPGRCCPE WVCDQAVMQP AIQPSSAQGH 

       190        200        210        220        230        240 
QLSALVTPAS ADGPCPNWST AWGPCSTTCG LGIATRVSNQ NRFCQLEIQR RLCLSRPCLA 

       250 
SRSHGSWNSA F 

« Hide

References

« Hide 'large scale' references
[1]"WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors."
Pennica D., Swanson T.A., Welsh J.W., Roy M.A., Lawrence D.A., Lee J., Brush J., Taneyhill L.A., Deuel B., Lew M., Watanabe C., Cohen R.L., Melham M.F., Finley G.G., Quirke P., Goddard A.D., Hillan K.J., Gurney A.L., Botstein D., Levine A.J.
Proc. Natl. Acad. Sci. U.S.A. 95:14717-14722(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Mammary gland.
[2]"Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions."
Kumar S., Hand A.T., Connor J.R., Dodds R.A., Ryan P.J., Trill J.J., Fisher S.M., Nuttall M.E., Lipshutz D.B., Zou C., Hwang S.M., Votta B.J., James I.E., Rieman D.J., Gowen M., Lee J.C.
J. Biol. Chem. 274:17123-17131(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF100778 mRNA. Translation: AAC96320.1.
AF126063 mRNA. Translation: AAD18058.1.
BC032877 mRNA. Translation: AAH32877.1.
CCDSCCDS17016.1.
RefSeqNP_058569.2. NM_016873.2.
UniGeneMm.13828.

3D structure databases

ProteinModelPortalQ9Z0G4.
SMRQ9Z0G4. Positions 31-83, 198-240.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000029188.

PTM databases

PhosphoSiteQ9Z0G4.

Proteomic databases

PRIDEQ9Z0G4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID22403.
KEGGmmu:22403.

Organism-specific databases

CTD8839.
MGIMGI:1328326. Wisp2.

Phylogenomic databases

eggNOGNOG82184.
HOGENOMHOG000231462.
HOVERGENHBG000635.
InParanoidQ9Z0G4.
PhylomeDBQ9Z0G4.

Gene expression databases

CleanExMM_WISP2.
GenevestigatorQ9Z0G4.

Family and domain databases

InterProIPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamPF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTSM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio302785.
PROQ9Z0G4.
SOURCESearch...

Entry information

Entry nameWISP2_MOUSE
AccessionPrimary (citable) accession number: Q9Z0G4
Secondary accession number(s): Q8CIC8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot