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Protein

WNT1-inducible-signaling pathway protein 2

Gene

Wisp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production (By similarity).By similarity

GO - Molecular functioni

  1. growth factor activity Source: MGI
  2. heparin binding Source: GO_Central
  3. integrin binding Source: GO_Central

GO - Biological processi

  1. cell adhesion Source: GO_Central
  2. cell-cell signaling Source: GO_Central
  3. negative regulation of cell death Source: GO_Central
  4. regulation of cell growth Source: MGI
  5. signal transduction Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
WNT1-inducible-signaling pathway protein 2
Short name:
WISP-2
Alternative name(s):
CCN family member 5
Connective tissue growth factor-like protein
Short name:
CTGF-L
Gene namesi
Name:Wisp2
Synonyms:Ccn5, Ctgfl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1328326. Wisp2.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular space Source: MGI
  2. extracellular vesicular exosome Source: MGI
  3. plasma membrane Source: MGI
  4. proteinaceous extracellular matrix Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 251228WNT1-inducible-signaling pathway protein 2PRO_0000014410Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9Z0G4.

PTM databases

PhosphoSiteiQ9Z0G4.

Expressioni

Gene expression databases

CleanExiMM_WISP2.
GenevestigatoriQ9Z0G4.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029188.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0G4.
SMRiQ9Z0G4. Positions 33-133.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 9471IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini98 – 16467VWFCPROSITE-ProRule annotationAdd
BLAST
Domaini195 – 23945TSP type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CCN family.Curated
Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
Contains 1 VWFC domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG82184.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiQ9Z0G4.
PhylomeDBiQ9Z0G4.

Family and domain databases

InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0G4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRGNPLIHLL AISFLCILSM VYSQLCPAPC ACPWTPPQCP PGVPLVLDGC
60 70 80 90 100
GCCRVCARRL GESCDHLHVC DPSQGLVCQP GAGPSGRGAV CLFEEDDGSC
110 120 130 140 150
EVNGRRYLDG ETFKPNCRVL CRCDDGGFTC LPLCSEDVRL PSWDCPRPRR
160 170 180 190 200
IQVPGRCCPE WVCDQAVMQP AIQPSSAQGH QLSALVTPAS ADGPCPNWST
210 220 230 240 250
AWGPCSTTCG LGIATRVSNQ NRFCQLEIQR RLCLSRPCLA SRSHGSWNSA

F
Length:251
Mass (Da):27,095
Last modified:May 1, 1999 - v1
Checksum:i893E1633F6E5C7FC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231S → A in AAH32877. (PubMed:15489334)Curated
Sequence conflicti71 – 711D → N in AAH32877. (PubMed:15489334)Curated
Sequence conflicti89 – 891A → V in AAH32877. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100778 mRNA. Translation: AAC96320.1.
AF126063 mRNA. Translation: AAD18058.1.
BC032877 mRNA. Translation: AAH32877.1.
CCDSiCCDS17016.1.
RefSeqiNP_058569.2. NM_016873.2.
UniGeneiMm.13828.

Genome annotation databases

GeneIDi22403.
KEGGimmu:22403.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100778 mRNA. Translation: AAC96320.1.
AF126063 mRNA. Translation: AAD18058.1.
BC032877 mRNA. Translation: AAH32877.1.
CCDSiCCDS17016.1.
RefSeqiNP_058569.2. NM_016873.2.
UniGeneiMm.13828.

3D structure databases

ProteinModelPortaliQ9Z0G4.
SMRiQ9Z0G4. Positions 33-133.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029188.

PTM databases

PhosphoSiteiQ9Z0G4.

Proteomic databases

PRIDEiQ9Z0G4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi22403.
KEGGimmu:22403.

Organism-specific databases

CTDi8839.
MGIiMGI:1328326. Wisp2.

Phylogenomic databases

eggNOGiNOG82184.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiQ9Z0G4.
PhylomeDBiQ9Z0G4.

Miscellaneous databases

NextBioi302785.
PROiQ9Z0G4.
SOURCEiSearch...

Gene expression databases

CleanExiMM_WISP2.
GenevestigatoriQ9Z0G4.

Family and domain databases

InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors."
    Pennica D., Swanson T.A., Welsh J.W., Roy M.A., Lawrence D.A., Lee J., Brush J., Taneyhill L.A., Deuel B., Lew M., Watanabe C., Cohen R.L., Melham M.F., Finley G.G., Quirke P., Goddard A.D., Hillan K.J., Gurney A.L., Botstein D., Levine A.J.
    Proc. Natl. Acad. Sci. U.S.A. 95:14717-14722(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Mammary gland.
  2. "Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions."
    Kumar S., Hand A.T., Connor J.R., Dodds R.A., Ryan P.J., Trill J.J., Fisher S.M., Nuttall M.E., Lipshutz D.B., Zou C., Hwang S.M., Votta B.J., James I.E., Rieman D.J., Gowen M., Lee J.C.
    J. Biol. Chem. 274:17123-17131(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiWISP2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0G4
Secondary accession number(s): Q8CIC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: May 1, 1999
Last modified: February 4, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.