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Q9Z0G2

- SRPK3_MOUSE

UniProt

Q9Z0G2 - SRPK3_MOUSE

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Protein

SRSF protein kinase 3

Gene

Srpk3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei107 – 1071ATPPROSITE-ProRule annotation
Active sitei211 – 2111Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi84 – 929ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: MGI

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. muscle tissue development Source: UniProtKB
  3. protein phosphorylation Source: MGI
  4. skeletal muscle tissue development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Differentiation, Myogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
SRSF protein kinase 3 (EC:2.7.11.1)
Alternative name(s):
Muscle-specific serine kinase 1
Short name:
MSSK-1
Serine/arginine-rich protein-specific kinase 3
Short name:
SR-protein-specific kinase 3
Serine/threonine-protein kinase 23
Gene namesi
Name:Srpk3
Synonyms:Mssk1, Stk23
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1891338. Srpk3.

Pathology & Biotechi

Disruption phenotypei

Mice are viable to adulthood but display defects in skeletal muscle growth including reduced muscle mass, marked increase in centrally placed nuclei and disorganized intermyofibrillar network.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 565565SRSF protein kinase 3PRO_0000086710Add
BLAST

Proteomic databases

PaxDbiQ9Z0G2.
PRIDEiQ9Z0G2.

PTM databases

PhosphoSiteiQ9Z0G2.

Expressioni

Tissue specificityi

Exclusively expressed in skeletal and heart muscle.1 Publication

Developmental stagei

Expressed from embryogenesis to adulthood.1 Publication

Gene expression databases

BgeeiQ9Z0G2.
CleanExiMM_SRPK3.
ExpressionAtlasiQ9Z0G2. baseline and differential.
GenevestigatoriQ9Z0G2.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002081.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0G2.
SMRiQ9Z0G2. Positions 64-260, 348-564.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini78 – 563486Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi16 – 205Poly-Ser

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG266081.
GeneTreeiENSGT00530000063566.
HOGENOMiHOG000171558.
HOVERGENiHBG108512.
InParanoidiQ9Z0G2.
KOiK08832.
OMAiSSQTSCG.
OrthoDBiEOG70S74X.
PhylomeDBiQ9Z0G2.
TreeFamiTF105334.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 2 hits.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z0G2 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSANAGGSGS VDCGGSSSSS QTSCGPESSG SELTPATPAP RLLQGLLGSD
60 70 80 90 100
DEEQEDPKDY CKGGYYPVKI GDLFNGRYHV VRKLGWGHFS TVWLCWDIQR
110 120 130 140 150
KRFVALKVVK SAGHYTETAV DEIKLLKCVR DSDPSDPKRE TIVQLIDDFR
160 170 180 190 200
ISGVNGVHVC MVLEVLGHQL LKWIIKSNYQ GLPVPCVKSI VRQVLHGLDY
210 220 230 240 250
LHTKCKIIHT DIKPENILLC VGDAYIRRLA AEATEWQQSG AQPPSRSTVS
260 270 280 290 300
TAPQEVLIGK LSKNKRKKMR RKRKQQKRLL EERLRDLQRL EAMEAAVQAE
310 320 330 340 350
DSSSRLERGS GSTSSSGCHP EGTRAGPSPA SSSPVPGGER SLSPSSQTSG
360 370 380 390 400
FSGSLFSTAS CSILSGSSNQ RETGGLLSPS TPFGASNLLV NPLEPQNADK
410 420 430 440 450
IKIKIADLGN ACWVHKHFTE DIQTRQYRAV EVLIGAEYGP PADIWSTACM
460 470 480 490 500
AFELATGDYL FEPHSGEDYS RDEDHIAHIV ELLGDIPPAF ALSGRYSREF
510 520 530 540 550
FNRRGELRHI PNLKHWGLYE VLMEKYEWPL EQATQFSAFL LPMMEYIPEK
560
RASAADCLQH PWLNP
Length:565
Mass (Da):62,365
Last modified:May 1, 1999 - v1
Checksum:i34976D08141C5DC8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF043289 Genomic DNA. Translation: AAD02248.1.
AF043288 mRNA. Translation: AAD02247.1.
AF133093 Genomic DNA. No translation available.
CCDSiCCDS30211.1.
RefSeqiNP_062658.1. NM_019684.1.
UniGeneiMm.111904.

Genome annotation databases

EnsembliENSMUST00000002081; ENSMUSP00000002081; ENSMUSG00000002007.
GeneIDi56504.
KEGGimmu:56504.
UCSCiuc009tmo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF043289 Genomic DNA. Translation: AAD02248.1 .
AF043288 mRNA. Translation: AAD02247.1 .
AF133093 Genomic DNA. No translation available.
CCDSi CCDS30211.1.
RefSeqi NP_062658.1. NM_019684.1.
UniGenei Mm.111904.

3D structure databases

ProteinModelPortali Q9Z0G2.
SMRi Q9Z0G2. Positions 64-260, 348-564.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000002081.

PTM databases

PhosphoSitei Q9Z0G2.

Proteomic databases

PaxDbi Q9Z0G2.
PRIDEi Q9Z0G2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000002081 ; ENSMUSP00000002081 ; ENSMUSG00000002007 .
GeneIDi 56504.
KEGGi mmu:56504.
UCSCi uc009tmo.1. mouse.

Organism-specific databases

CTDi 26576.
MGIi MGI:1891338. Srpk3.

Phylogenomic databases

eggNOGi NOG266081.
GeneTreei ENSGT00530000063566.
HOGENOMi HOG000171558.
HOVERGENi HBG108512.
InParanoidi Q9Z0G2.
KOi K08832.
OMAi SSQTSCG.
OrthoDBi EOG70S74X.
PhylomeDBi Q9Z0G2.
TreeFami TF105334.

Miscellaneous databases

NextBioi 312802.
PROi Q9Z0G2.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z0G2.
CleanExi MM_SRPK3.
ExpressionAtlasi Q9Z0G2. baseline and differential.
Genevestigatori Q9Z0G2.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 2 hits.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequencing of a new muscle-specific serine kinase gene in human and mouse."
    Brenner V., Rosenthal A.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Muscle.
  2. "Comparative sequence analysis of the mouse L1cam locus and the corresponding region of human Xq28."
    Platzer M., Brenner V., Reichwald K., Wiehe T., Oksche A., Rosenthal A.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2."
    Nakagawa O., Arnold M., Nakagawa M., Hamada H., Shelton J.M., Kusano H., Harris T.M., Childs G., Campbell K.P., Richardson J.A., Nishino I., Olson E.N.
    Genes Dev. 19:2066-2077(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiSRPK3_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0G2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3