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Q9Z0G2

- SRPK3_MOUSE

UniProt

Q9Z0G2 - SRPK3_MOUSE

Protein

SRSF protein kinase 3

Gene

Srpk3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development.1 Publication

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei107 – 1071ATPPROSITE-ProRule annotation
    Active sitei211 – 2111Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi84 – 929ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: MGI

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. muscle tissue development Source: UniProtKB
    3. protein phosphorylation Source: MGI
    4. skeletal muscle tissue development Source: MGI

    Keywords - Molecular functioni

    Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Differentiation, Myogenesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SRSF protein kinase 3 (EC:2.7.11.1)
    Alternative name(s):
    Muscle-specific serine kinase 1
    Short name:
    MSSK-1
    Serine/arginine-rich protein-specific kinase 3
    Short name:
    SR-protein-specific kinase 3
    Serine/threonine-protein kinase 23
    Gene namesi
    Name:Srpk3
    Synonyms:Mssk1, Stk23
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1891338. Srpk3.

    Pathology & Biotechi

    Disruption phenotypei

    Mice are viable to adulthood but display defects in skeletal muscle growth including reduced muscle mass, marked increase in centrally placed nuclei and disorganized intermyofibrillar network.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 565565SRSF protein kinase 3PRO_0000086710Add
    BLAST

    Proteomic databases

    PaxDbiQ9Z0G2.
    PRIDEiQ9Z0G2.

    PTM databases

    PhosphoSiteiQ9Z0G2.

    Expressioni

    Tissue specificityi

    Exclusively expressed in skeletal and heart muscle.1 Publication

    Developmental stagei

    Expressed from embryogenesis to adulthood.1 Publication

    Gene expression databases

    ArrayExpressiQ9Z0G2.
    BgeeiQ9Z0G2.
    CleanExiMM_SRPK3.
    GenevestigatoriQ9Z0G2.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000002081.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z0G2.
    SMRiQ9Z0G2. Positions 64-260, 348-564.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini78 – 563486Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi16 – 205Poly-Ser

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG266081.
    GeneTreeiENSGT00530000063566.
    HOGENOMiHOG000171558.
    HOVERGENiHBG108512.
    InParanoidiQ9Z0G2.
    KOiK08832.
    OMAiSSQTSCG.
    OrthoDBiEOG70S74X.
    PhylomeDBiQ9Z0G2.
    TreeFamiTF105334.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 2 hits.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z0G2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSANAGGSGS VDCGGSSSSS QTSCGPESSG SELTPATPAP RLLQGLLGSD    50
    DEEQEDPKDY CKGGYYPVKI GDLFNGRYHV VRKLGWGHFS TVWLCWDIQR 100
    KRFVALKVVK SAGHYTETAV DEIKLLKCVR DSDPSDPKRE TIVQLIDDFR 150
    ISGVNGVHVC MVLEVLGHQL LKWIIKSNYQ GLPVPCVKSI VRQVLHGLDY 200
    LHTKCKIIHT DIKPENILLC VGDAYIRRLA AEATEWQQSG AQPPSRSTVS 250
    TAPQEVLIGK LSKNKRKKMR RKRKQQKRLL EERLRDLQRL EAMEAAVQAE 300
    DSSSRLERGS GSTSSSGCHP EGTRAGPSPA SSSPVPGGER SLSPSSQTSG 350
    FSGSLFSTAS CSILSGSSNQ RETGGLLSPS TPFGASNLLV NPLEPQNADK 400
    IKIKIADLGN ACWVHKHFTE DIQTRQYRAV EVLIGAEYGP PADIWSTACM 450
    AFELATGDYL FEPHSGEDYS RDEDHIAHIV ELLGDIPPAF ALSGRYSREF 500
    FNRRGELRHI PNLKHWGLYE VLMEKYEWPL EQATQFSAFL LPMMEYIPEK 550
    RASAADCLQH PWLNP 565
    Length:565
    Mass (Da):62,365
    Last modified:May 1, 1999 - v1
    Checksum:i34976D08141C5DC8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF043289 Genomic DNA. Translation: AAD02248.1.
    AF043288 mRNA. Translation: AAD02247.1.
    AF133093 Genomic DNA. No translation available.
    CCDSiCCDS30211.1.
    RefSeqiNP_062658.1. NM_019684.1.
    UniGeneiMm.111904.

    Genome annotation databases

    EnsembliENSMUST00000002081; ENSMUSP00000002081; ENSMUSG00000002007.
    GeneIDi56504.
    KEGGimmu:56504.
    UCSCiuc009tmo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF043289 Genomic DNA. Translation: AAD02248.1 .
    AF043288 mRNA. Translation: AAD02247.1 .
    AF133093 Genomic DNA. No translation available.
    CCDSi CCDS30211.1.
    RefSeqi NP_062658.1. NM_019684.1.
    UniGenei Mm.111904.

    3D structure databases

    ProteinModelPortali Q9Z0G2.
    SMRi Q9Z0G2. Positions 64-260, 348-564.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000002081.

    PTM databases

    PhosphoSitei Q9Z0G2.

    Proteomic databases

    PaxDbi Q9Z0G2.
    PRIDEi Q9Z0G2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000002081 ; ENSMUSP00000002081 ; ENSMUSG00000002007 .
    GeneIDi 56504.
    KEGGi mmu:56504.
    UCSCi uc009tmo.1. mouse.

    Organism-specific databases

    CTDi 26576.
    MGIi MGI:1891338. Srpk3.

    Phylogenomic databases

    eggNOGi NOG266081.
    GeneTreei ENSGT00530000063566.
    HOGENOMi HOG000171558.
    HOVERGENi HBG108512.
    InParanoidi Q9Z0G2.
    KOi K08832.
    OMAi SSQTSCG.
    OrthoDBi EOG70S74X.
    PhylomeDBi Q9Z0G2.
    TreeFami TF105334.

    Miscellaneous databases

    NextBioi 312802.
    PROi Q9Z0G2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Z0G2.
    Bgeei Q9Z0G2.
    CleanExi MM_SRPK3.
    Genevestigatori Q9Z0G2.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of a new muscle-specific serine kinase gene in human and mouse."
      Brenner V., Rosenthal A.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Tissue: Muscle.
    2. "Comparative sequence analysis of the mouse L1cam locus and the corresponding region of human Xq28."
      Platzer M., Brenner V., Reichwald K., Wiehe T., Oksche A., Rosenthal A.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2."
      Nakagawa O., Arnold M., Nakagawa M., Hamada H., Shelton J.M., Kusano H., Harris T.M., Childs G., Campbell K.P., Richardson J.A., Nishino I., Olson E.N.
      Genes Dev. 19:2066-2077(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiSRPK3_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z0G2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2002
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3