Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9Z0G0 (GIPC1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
PDZ domain-containing protein GIPC1
Alternative name(s):
GAIP C-terminus-interacting protein
RGS-GAIP-interacting protein
RGS19-interacting protein 1
SemaF cytoplasmic domain-associated protein 1
Short name=SEMCAP-1
Synectin
Gene names
Name:Gipc1
Synonyms:Gipc, Rgs19ip1, Semcap1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibits endothelial cell migartion (in vitro). May be involved in G protein-linked signaling By similarity.

Subunit structure

Interacts with GLUT1 (C-terminus), ACTN1, KIF1B, MYO6 and PLEKHG5 By similarity. Interacts with RGS19 C-terminus. Interacts with SDC4/syndecan-4 and SEMA4C/semaphorin-4C. Ref.1 Ref.2 Ref.3

Subcellular location

Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity.

Tissue specificity

Widely expressed. Ref.6

Developmental stage

Detected already at 4.5 dpc, expression peaks at 11.5-12.5 dpc and gradually declines to its adult levels by 18.5 dpc. Ref.6

Sequence similarities

Belongs to the GIPC family.

Contains 1 PDZ (DHR) domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Membrane
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Traceable author statement PubMed 11342430. Source: MGI

endothelial cell migration

Inferred from mutant phenotype PubMed 16467373. Source: MGI

glutamate secretion

Inferred from mutant phenotype PubMed 16819522. Source: MGI

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

Inferred from direct assay PubMed 11546783. Source: BHF-UCL

positive regulation of GTPase activity

Traceable author statement PubMed 11342430. Source: GOC

positive regulation of transforming growth factor beta receptor signaling pathway

Inferred from direct assay PubMed 11546783. Source: BHF-UCL

protein targeting

Inferred from mutant phenotype PubMed 16467373. Source: MGI

regulation of protein stability

Inferred from direct assay PubMed 11546783. Source: BHF-UCL

regulation of synaptic plasticity

Inferred from mutant phenotype PubMed 16819522. Source: MGI

synaptic transmission

Inferred from mutant phenotype PubMed 16819522. Source: MGI

   Cellular_componentbrush border

Inferred from electronic annotation. Source: Ensembl

cell cortex

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from direct assay PubMed 16819522. Source: MGI

cytosol

Inferred from direct assay Ref.1. Source: MGI

dendritic shaft

Inferred from direct assay PubMed 16819522. Source: MGI

dendritic spine

Inferred from direct assay PubMed 16819522. Source: MGI

endocytic vesicle

Inferred from electronic annotation. Source: Ensembl

membrane

Inferred from direct assay Ref.1. Source: MGI

synaptic vesicle

Inferred from direct assay PubMed 16819522. Source: MGI

vesicle membrane

Inferred from direct assay PubMed 15975910. Source: MGI

   Molecular_functionGTPase activator activity

Traceable author statement PubMed 11342430. Source: MGI

actin binding

Inferred from physical interaction PubMed 15975910. Source: MGI

myosin binding

Inferred from physical interaction PubMed 16908842. Source: MGI

protein binding

Inferred from physical interaction Ref.2PubMed 10827173. Source: IntAct

protein homodimerization activity

Inferred from physical interaction PubMed 15975910. Source: MGI

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Lrp2A2ARV42EBI-300855,EBI-300875
Sema4cQ641518EBI-300855,EBI-987075

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 333333PDZ domain-containing protein GIPC1
PRO_0000087493

Regions

Domain133 – 21381PDZ

Amino acid modifications

Modified residue2251Phosphoserine By similarity
Modified residue2321Phosphoserine By similarity

Experimental info

Sequence conflict391A → G in AAC67550. Ref.1
Sequence conflict531A → S in AAC67550. Ref.1
Sequence conflict1411E → D in AAC67550. Ref.1
Sequence conflict2261A → S in AAC67550. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9Z0G0 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 52E5ED6092EA9300

FASTA33336,129
        10         20         30         40         50         60 
MPLGLGRRKK APPLVENEEA EPSRSGLGVG EPGPLGGSAA GESQMGLPPP PAALRPRLVF 

        70         80         90        100        110        120 
HTQLAHGSPT GRIEGFTNVK ELYGKIAEAF RLPAAEVMFC TLNTHKVDMD KLLGGQIGLE 

       130        140        150        160        170        180 
DFIFAHVKGQ RKEVEVFKSE EALGLTITDN GAGYAFIKRI KEGSVIDHIQ LISVGDMIEA 

       190        200        210        220        230        240 
INGQSLLGCR HYEVARLLKE LPRGRTFTLK LTEPRKAFDM ISQRSAGGHP GSGPQLGTGR 

       250        260        270        280        290        300 
GTLRLRSRGP ATVEDLPSAF EEKAIEKVDD LLESYMGIRD TELAATMVEL GKDKRNPDEL 

       310        320        330 
AEALDERLGD FAFPDEFVFD VWGAIGDAKV GRY 

« Hide

References

« Hide 'large scale' references
[1]"GIPC, a PDZ domain containing protein, interacts specifically with the C-terminus of RGS-GAIP."
De Vries L., Lou X., Zhao G., Zheng B., Farquhar M.G.
Proc. Natl. Acad. Sci. U.S.A. 95:12340-12345(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH RGS19.
[2]"A PDZ protein regulates the distribution of the transmembrane semaphorin, M-SemF."
Wang L.-H., Kalb R.G., Strittmatter S.M.
J. Biol. Chem. 274:14137-14146(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH SEM4C.
[3]"Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migration."
Gao Y., Li M., Chen W., Simons M.
J. Cell. Physiol. 184:373-379(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH SDC4.
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Head.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
[6]"Characterization of synectin expression and promoter activity."
Zhang Y., Chittenden T., Simons M.
Gene 342:29-34(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF089818 mRNA. Translation: AAC67550.1.
AF104358 mRNA. Translation: AAD12262.1.
AF061263 mRNA. Translation: AAC72311.1.
AK086506 mRNA. Translation: BAC39680.1.
BC003490 mRNA. Translation: AAH03490.1.
CCDSCCDS22457.1.
RefSeqNP_061241.1. NM_018771.3.
UniGeneMm.20945.

3D structure databases

ProteinModelPortalQ9Z0G0.
SMRQ9Z0G0. Positions 127-217.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid212526. 2 interactions.
IntActQ9Z0G0. 5 interactions.
MINTMINT-91878.
STRING10090.ENSMUSP00000019577.

PTM databases

PhosphoSiteQ9Z0G0.

Proteomic databases

MaxQBQ9Z0G0.
PaxDbQ9Z0G0.
PRIDEQ9Z0G0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000019577; ENSMUSP00000019577; ENSMUSG00000019433.
GeneID67903.
KEGGmmu:67903.
UCSCuc009mkr.1. mouse.

Organism-specific databases

CTD10755.
MGIMGI:1926252. Gipc1.

Phylogenomic databases

eggNOGNOG313930.
GeneTreeENSGT00390000003420.
HOGENOMHOG000293347.
HOVERGENHBG000898.
InParanoidQ9Z0G0.
OMATHKVDME.
OrthoDBEOG793B86.
PhylomeDBQ9Z0G0.
TreeFamTF313878.

Gene expression databases

BgeeQ9Z0G0.
CleanExMM_GIPC1.
GenevestigatorQ9Z0G0.

Family and domain databases

Gene3D2.30.42.10. 1 hit.
InterProIPR001478. PDZ.
IPR017379. UCP038083_PDZ.
[Graphical view]
PfamPF00595. PDZ. 1 hit.
[Graphical view]
PIRSFPIRSF038083. UCP038083_GIPC. 1 hit.
SMARTSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMSSF50156. SSF50156. 1 hit.
PROSITEPS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGIPC1. mouse.
NextBio325906.
PROQ9Z0G0.
SOURCESearch...

Entry information

Entry nameGIPC1_MOUSE
AccessionPrimary (citable) accession number: Q9Z0G0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot