SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9Z0G0

- GIPC1_MOUSE

UniProt

Q9Z0G0 - GIPC1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
PDZ domain-containing protein GIPC1
Gene
Gipc1, Gipc, Rgs19ip1, Semcap1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibits endothelial cell migartion (in vitro). May be involved in G protein-linked signaling By similarity.

GO - Molecular functioni

  1. GTPase activator activity Source: MGI
  2. actin binding Source: MGI
  3. myosin binding Source: MGI
  4. protein binding Source: IntAct
  5. protein homodimerization activity Source: MGI

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: MGI
  2. endothelial cell migration Source: MGI
  3. glutamate secretion Source: MGI
  4. negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
  5. positive regulation of GTPase activity Source: GOC
  6. positive regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
  7. protein targeting Source: MGI
  8. regulation of protein stability Source: BHF-UCL
  9. regulation of synaptic plasticity Source: MGI
  10. synaptic transmission Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
PDZ domain-containing protein GIPC1
Alternative name(s):
GAIP C-terminus-interacting protein
RGS-GAIP-interacting protein
RGS19-interacting protein 1
SemaF cytoplasmic domain-associated protein 1
Short name:
SEMCAP-1
Synectin
Gene namesi
Name:Gipc1
Synonyms:Gipc, Rgs19ip1, Semcap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1926252. Gipc1.

Subcellular locationi

Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. brush border Source: Ensembl
  2. cell cortex Source: Ensembl
  3. cytoplasm Source: MGI
  4. cytosol Source: MGI
  5. dendritic shaft Source: MGI
  6. dendritic spine Source: MGI
  7. endocytic vesicle Source: Ensembl
  8. membrane Source: MGI
  9. synaptic vesicle Source: MGI
  10. vesicle membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333PDZ domain-containing protein GIPC1
PRO_0000087493Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei225 – 2251Phosphoserine By similarity
Modified residuei232 – 2321Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Z0G0.
PaxDbiQ9Z0G0.
PRIDEiQ9Z0G0.

PTM databases

PhosphoSiteiQ9Z0G0.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Developmental stagei

Detected already at 4.5 dpc, expression peaks at 11.5-12.5 dpc and gradually declines to its adult levels by 18.5 dpc.1 Publication

Gene expression databases

BgeeiQ9Z0G0.
CleanExiMM_GIPC1.
GenevestigatoriQ9Z0G0.

Interactioni

Subunit structurei

Interacts with GLUT1 (C-terminus), ACTN1, KIF1B, MYO6 and PLEKHG5 By similarity. Interacts with RGS19 C-terminus. Interacts with SDC4/syndecan-4 and SEMA4C/semaphorin-4C.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Lrp2A2ARV42EBI-300855,EBI-300875
Sema4cQ641518EBI-300855,EBI-987075

Protein-protein interaction databases

BioGridi212526. 2 interactions.
IntActiQ9Z0G0. 5 interactions.
MINTiMINT-91878.
STRINGi10090.ENSMUSP00000019577.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0G0.
SMRiQ9Z0G0. Positions 127-217.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini133 – 21381PDZ
Add
BLAST

Sequence similaritiesi

Belongs to the GIPC family.
Contains 1 PDZ (DHR) domain.

Phylogenomic databases

eggNOGiNOG313930.
GeneTreeiENSGT00390000003420.
HOGENOMiHOG000293347.
HOVERGENiHBG000898.
InParanoidiQ9Z0G0.
OMAiTHKVDME.
OrthoDBiEOG793B86.
PhylomeDBiQ9Z0G0.
TreeFamiTF313878.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR017379. UCP038083_PDZ.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
PIRSFiPIRSF038083. UCP038083_GIPC. 1 hit.
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z0G0-1 [UniParc]FASTAAdd to Basket

« Hide

MPLGLGRRKK APPLVENEEA EPSRSGLGVG EPGPLGGSAA GESQMGLPPP    50
PAALRPRLVF HTQLAHGSPT GRIEGFTNVK ELYGKIAEAF RLPAAEVMFC 100
TLNTHKVDMD KLLGGQIGLE DFIFAHVKGQ RKEVEVFKSE EALGLTITDN 150
GAGYAFIKRI KEGSVIDHIQ LISVGDMIEA INGQSLLGCR HYEVARLLKE 200
LPRGRTFTLK LTEPRKAFDM ISQRSAGGHP GSGPQLGTGR GTLRLRSRGP 250
ATVEDLPSAF EEKAIEKVDD LLESYMGIRD TELAATMVEL GKDKRNPDEL 300
AEALDERLGD FAFPDEFVFD VWGAIGDAKV GRY 333
Length:333
Mass (Da):36,129
Last modified:May 1, 1999 - v1
Checksum:i52E5ED6092EA9300
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391A → G in AAC67550. 1 Publication
Sequence conflicti53 – 531A → S in AAC67550. 1 Publication
Sequence conflicti141 – 1411E → D in AAC67550. 1 Publication
Sequence conflicti226 – 2261A → S in AAC67550. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF089818 mRNA. Translation: AAC67550.1.
AF104358 mRNA. Translation: AAD12262.1.
AF061263 mRNA. Translation: AAC72311.1.
AK086506 mRNA. Translation: BAC39680.1.
BC003490 mRNA. Translation: AAH03490.1.
CCDSiCCDS22457.1.
RefSeqiNP_061241.1. NM_018771.3.
UniGeneiMm.20945.

Genome annotation databases

EnsembliENSMUST00000019577; ENSMUSP00000019577; ENSMUSG00000019433.
GeneIDi67903.
KEGGimmu:67903.
UCSCiuc009mkr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF089818 mRNA. Translation: AAC67550.1 .
AF104358 mRNA. Translation: AAD12262.1 .
AF061263 mRNA. Translation: AAC72311.1 .
AK086506 mRNA. Translation: BAC39680.1 .
BC003490 mRNA. Translation: AAH03490.1 .
CCDSi CCDS22457.1.
RefSeqi NP_061241.1. NM_018771.3.
UniGenei Mm.20945.

3D structure databases

ProteinModelPortali Q9Z0G0.
SMRi Q9Z0G0. Positions 127-217.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 212526. 2 interactions.
IntActi Q9Z0G0. 5 interactions.
MINTi MINT-91878.
STRINGi 10090.ENSMUSP00000019577.

PTM databases

PhosphoSitei Q9Z0G0.

Proteomic databases

MaxQBi Q9Z0G0.
PaxDbi Q9Z0G0.
PRIDEi Q9Z0G0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000019577 ; ENSMUSP00000019577 ; ENSMUSG00000019433 .
GeneIDi 67903.
KEGGi mmu:67903.
UCSCi uc009mkr.1. mouse.

Organism-specific databases

CTDi 10755.
MGIi MGI:1926252. Gipc1.

Phylogenomic databases

eggNOGi NOG313930.
GeneTreei ENSGT00390000003420.
HOGENOMi HOG000293347.
HOVERGENi HBG000898.
InParanoidi Q9Z0G0.
OMAi THKVDME.
OrthoDBi EOG793B86.
PhylomeDBi Q9Z0G0.
TreeFami TF313878.

Miscellaneous databases

ChiTaRSi GIPC1. mouse.
NextBioi 325906.
PROi Q9Z0G0.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z0G0.
CleanExi MM_GIPC1.
Genevestigatori Q9Z0G0.

Family and domain databases

Gene3Di 2.30.42.10. 1 hit.
InterProi IPR001478. PDZ.
IPR017379. UCP038083_PDZ.
[Graphical view ]
Pfami PF00595. PDZ. 1 hit.
[Graphical view ]
PIRSFi PIRSF038083. UCP038083_GIPC. 1 hit.
SMARTi SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 1 hit.
PROSITEi PS50106. PDZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "GIPC, a PDZ domain containing protein, interacts specifically with the C-terminus of RGS-GAIP."
    De Vries L., Lou X., Zhao G., Zheng B., Farquhar M.G.
    Proc. Natl. Acad. Sci. U.S.A. 95:12340-12345(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH RGS19.
  2. "A PDZ protein regulates the distribution of the transmembrane semaphorin, M-SemF."
    Wang L.-H., Kalb R.G., Strittmatter S.M.
    J. Biol. Chem. 274:14137-14146(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH SEM4C.
  3. "Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migration."
    Gao Y., Li M., Chen W., Simons M.
    J. Cell. Physiol. 184:373-379(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH SDC4.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  6. "Characterization of synectin expression and promoter activity."
    Zhang Y., Chittenden T., Simons M.
    Gene 342:29-34(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiGIPC1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0G0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi