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Q9Z0G0

- GIPC1_MOUSE

UniProt

Q9Z0G0 - GIPC1_MOUSE

Protein

PDZ domain-containing protein GIPC1

Gene

Gipc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Inhibits endothelial cell migartion (in vitro). May be involved in G protein-linked signaling By similarity.By similarity

    GO - Molecular functioni

    1. actin binding Source: MGI
    2. GTPase activator activity Source: MGI
    3. myosin binding Source: MGI
    4. protein binding Source: IntAct
    5. protein homodimerization activity Source: MGI

    GO - Biological processi

    1. endothelial cell migration Source: MGI
    2. glutamate secretion Source: MGI
    3. G-protein coupled receptor signaling pathway Source: MGI
    4. negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
    5. positive regulation of GTPase activity Source: GOC
    6. positive regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
    7. protein targeting Source: MGI
    8. regulation of protein stability Source: BHF-UCL
    9. regulation of synaptic plasticity Source: MGI
    10. synaptic transmission Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PDZ domain-containing protein GIPC1
    Alternative name(s):
    GAIP C-terminus-interacting protein
    RGS-GAIP-interacting protein
    RGS19-interacting protein 1
    SemaF cytoplasmic domain-associated protein 1
    Short name:
    SEMCAP-1
    Synectin
    Gene namesi
    Name:Gipc1
    Synonyms:Gipc, Rgs19ip1, Semcap1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1926252. Gipc1.

    Subcellular locationi

    Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. brush border Source: Ensembl
    2. cell cortex Source: Ensembl
    3. cytoplasm Source: MGI
    4. cytosol Source: MGI
    5. dendritic shaft Source: MGI
    6. dendritic spine Source: MGI
    7. endocytic vesicle Source: Ensembl
    8. membrane Source: MGI
    9. synaptic vesicle Source: MGI
    10. vesicle membrane Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 333333PDZ domain-containing protein GIPC1PRO_0000087493Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei225 – 2251PhosphoserineBy similarity
    Modified residuei232 – 2321PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9Z0G0.
    PaxDbiQ9Z0G0.
    PRIDEiQ9Z0G0.

    PTM databases

    PhosphoSiteiQ9Z0G0.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Developmental stagei

    Detected already at 4.5 dpc, expression peaks at 11.5-12.5 dpc and gradually declines to its adult levels by 18.5 dpc.1 Publication

    Gene expression databases

    BgeeiQ9Z0G0.
    CleanExiMM_GIPC1.
    GenevestigatoriQ9Z0G0.

    Interactioni

    Subunit structurei

    Interacts with GLUT1 (C-terminus), ACTN1, KIF1B, MYO6 and PLEKHG5 By similarity. Interacts with RGS19 C-terminus. Interacts with SDC4/syndecan-4 and SEMA4C/semaphorin-4C.By similarity3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Lrp2A2ARV42EBI-300855,EBI-300875
    Sema4cQ641518EBI-300855,EBI-987075

    Protein-protein interaction databases

    BioGridi212526. 2 interactions.
    IntActiQ9Z0G0. 5 interactions.
    MINTiMINT-91878.
    STRINGi10090.ENSMUSP00000019577.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z0G0.
    SMRiQ9Z0G0. Positions 127-217.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini133 – 21381PDZPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GIPC family.Curated
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG313930.
    GeneTreeiENSGT00390000003420.
    HOGENOMiHOG000293347.
    HOVERGENiHBG000898.
    InParanoidiQ9Z0G0.
    OMAiTHKVDME.
    OrthoDBiEOG793B86.
    PhylomeDBiQ9Z0G0.
    TreeFamiTF313878.

    Family and domain databases

    Gene3Di2.30.42.10. 1 hit.
    InterProiIPR001478. PDZ.
    IPR017379. UCP038083_PDZ.
    [Graphical view]
    PfamiPF00595. PDZ. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038083. UCP038083_GIPC. 1 hit.
    SMARTiSM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    PROSITEiPS50106. PDZ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z0G0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLGLGRRKK APPLVENEEA EPSRSGLGVG EPGPLGGSAA GESQMGLPPP    50
    PAALRPRLVF HTQLAHGSPT GRIEGFTNVK ELYGKIAEAF RLPAAEVMFC 100
    TLNTHKVDMD KLLGGQIGLE DFIFAHVKGQ RKEVEVFKSE EALGLTITDN 150
    GAGYAFIKRI KEGSVIDHIQ LISVGDMIEA INGQSLLGCR HYEVARLLKE 200
    LPRGRTFTLK LTEPRKAFDM ISQRSAGGHP GSGPQLGTGR GTLRLRSRGP 250
    ATVEDLPSAF EEKAIEKVDD LLESYMGIRD TELAATMVEL GKDKRNPDEL 300
    AEALDERLGD FAFPDEFVFD VWGAIGDAKV GRY 333
    Length:333
    Mass (Da):36,129
    Last modified:May 1, 1999 - v1
    Checksum:i52E5ED6092EA9300
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti39 – 391A → G in AAC67550. (PubMed:9770488)Curated
    Sequence conflicti53 – 531A → S in AAC67550. (PubMed:9770488)Curated
    Sequence conflicti141 – 1411E → D in AAC67550. (PubMed:9770488)Curated
    Sequence conflicti226 – 2261A → S in AAC67550. (PubMed:9770488)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF089818 mRNA. Translation: AAC67550.1.
    AF104358 mRNA. Translation: AAD12262.1.
    AF061263 mRNA. Translation: AAC72311.1.
    AK086506 mRNA. Translation: BAC39680.1.
    BC003490 mRNA. Translation: AAH03490.1.
    CCDSiCCDS22457.1.
    RefSeqiNP_061241.1. NM_018771.3.
    UniGeneiMm.20945.

    Genome annotation databases

    EnsembliENSMUST00000019577; ENSMUSP00000019577; ENSMUSG00000019433.
    GeneIDi67903.
    KEGGimmu:67903.
    UCSCiuc009mkr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF089818 mRNA. Translation: AAC67550.1 .
    AF104358 mRNA. Translation: AAD12262.1 .
    AF061263 mRNA. Translation: AAC72311.1 .
    AK086506 mRNA. Translation: BAC39680.1 .
    BC003490 mRNA. Translation: AAH03490.1 .
    CCDSi CCDS22457.1.
    RefSeqi NP_061241.1. NM_018771.3.
    UniGenei Mm.20945.

    3D structure databases

    ProteinModelPortali Q9Z0G0.
    SMRi Q9Z0G0. Positions 127-217.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 212526. 2 interactions.
    IntActi Q9Z0G0. 5 interactions.
    MINTi MINT-91878.
    STRINGi 10090.ENSMUSP00000019577.

    PTM databases

    PhosphoSitei Q9Z0G0.

    Proteomic databases

    MaxQBi Q9Z0G0.
    PaxDbi Q9Z0G0.
    PRIDEi Q9Z0G0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019577 ; ENSMUSP00000019577 ; ENSMUSG00000019433 .
    GeneIDi 67903.
    KEGGi mmu:67903.
    UCSCi uc009mkr.1. mouse.

    Organism-specific databases

    CTDi 10755.
    MGIi MGI:1926252. Gipc1.

    Phylogenomic databases

    eggNOGi NOG313930.
    GeneTreei ENSGT00390000003420.
    HOGENOMi HOG000293347.
    HOVERGENi HBG000898.
    InParanoidi Q9Z0G0.
    OMAi THKVDME.
    OrthoDBi EOG793B86.
    PhylomeDBi Q9Z0G0.
    TreeFami TF313878.

    Miscellaneous databases

    ChiTaRSi GIPC1. mouse.
    NextBioi 325906.
    PROi Q9Z0G0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Z0G0.
    CleanExi MM_GIPC1.
    Genevestigatori Q9Z0G0.

    Family and domain databases

    Gene3Di 2.30.42.10. 1 hit.
    InterProi IPR001478. PDZ.
    IPR017379. UCP038083_PDZ.
    [Graphical view ]
    Pfami PF00595. PDZ. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038083. UCP038083_GIPC. 1 hit.
    SMARTi SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    PROSITEi PS50106. PDZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "GIPC, a PDZ domain containing protein, interacts specifically with the C-terminus of RGS-GAIP."
      De Vries L., Lou X., Zhao G., Zheng B., Farquhar M.G.
      Proc. Natl. Acad. Sci. U.S.A. 95:12340-12345(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH RGS19.
    2. "A PDZ protein regulates the distribution of the transmembrane semaphorin, M-SemF."
      Wang L.-H., Kalb R.G., Strittmatter S.M.
      J. Biol. Chem. 274:14137-14146(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH SEM4C.
    3. "Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migration."
      Gao Y., Li M., Chen W., Simons M.
      J. Cell. Physiol. 184:373-379(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH SDC4.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.
    6. "Characterization of synectin expression and promoter activity."
      Zhang Y., Chittenden T., Simons M.
      Gene 342:29-34(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiGIPC1_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z0G0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3