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Protein

PDZ domain-containing protein GIPC1

Gene

Gipc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits endothelial cell migration (in vitro). May be involved in G protein-linked signaling (By similarity).By similarity

GO - Molecular functioni

  • actin binding Source: MGI
  • cadherin binding Source: MGI
  • GTPase activator activity Source: MGI
  • myosin binding Source: MGI
  • PDZ domain binding Source: Ensembl
  • protein homodimerization activity Source: MGI
  • receptor binding Source: MGI

GO - Biological processi

  • chemical synaptic transmission Source: MGI
  • endothelial cell migration Source: MGI
  • glutamate secretion Source: MGI
  • G-protein coupled receptor signaling pathway Source: MGI
  • negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
  • positive regulation of cytokinesis Source: MGI
  • positive regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
  • protein targeting Source: MGI
  • regulation of protein stability Source: BHF-UCL
  • regulation of synaptic plasticity Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
PDZ domain-containing protein GIPC1
Alternative name(s):
GAIP C-terminus-interacting protein
RGS-GAIP-interacting protein
RGS19-interacting protein 1
SemaF cytoplasmic domain-associated protein 1
Short name:
SEMCAP-1
Synectin
Gene namesi
Name:Gipc1
Synonyms:Gipc, Rgs19ip1, Semcap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1926252. Gipc1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000874931 – 333PDZ domain-containing protein GIPC1Add BLAST333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei68PhosphoserineBy similarity1
Modified residuei222PhosphoserineBy similarity1
Modified residuei225PhosphoserineBy similarity1
Modified residuei232PhosphoserineBy similarity1
Modified residuei242PhosphothreonineBy similarity1
Modified residuei247PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Z0G0.
MaxQBiQ9Z0G0.
PaxDbiQ9Z0G0.
PeptideAtlasiQ9Z0G0.
PRIDEiQ9Z0G0.

PTM databases

iPTMnetiQ9Z0G0.
PhosphoSitePlusiQ9Z0G0.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Developmental stagei

Detected already at 4.5 dpc, expression peaks at 11.5-12.5 dpc and gradually declines to its adult levels by 18.5 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000019433.
CleanExiMM_GIPC1.
ExpressionAtlasiQ9Z0G0. baseline and differential.
GenevisibleiQ9Z0G0. MM.

Interactioni

Subunit structurei

Interacts with GLUT1 (C-terminus), ACTN1, KIF1B, MYO6 and PLEKHG5 (By similarity). Interacts with RGS19 C-terminus. Interacts with SDC4/syndecan-4 and SEMA4C/semaphorin-4C.By similarity3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • actin binding Source: MGI
  • cadherin binding Source: MGI
  • myosin binding Source: MGI
  • PDZ domain binding Source: Ensembl
  • protein homodimerization activity Source: MGI
  • receptor binding Source: MGI

Protein-protein interaction databases

BioGridi212526. 3 interactors.
CORUMiQ9Z0G0.
DIPiDIP-33281N.
ELMiQ9Z0G0.
IntActiQ9Z0G0. 6 interactors.
MINTiMINT-91878.
STRINGi10090.ENSMUSP00000019577.

Structurei

Secondary structure

1333
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi60 – 64Combined sources5
Beta strandi71 – 73Combined sources3
Helixi79 – 89Combined sources11
Helixi94 – 96Combined sources3
Beta strandi97 – 103Combined sources7
Helixi109 – 111Combined sources3
Beta strandi115 – 118Combined sources4
Beta strandi123 – 137Combined sources15
Beta strandi145 – 149Combined sources5
Beta strandi151 – 153Combined sources3
Beta strandi155 – 160Combined sources6
Turni165 – 168Combined sources4
Beta strandi177 – 181Combined sources5
Helixi191 – 199Combined sources9
Beta strandi206 – 214Combined sources9
Beta strandi241 – 245Combined sources5
Beta strandi247 – 249Combined sources3
Beta strandi251 – 255Combined sources5
Helixi259 – 276Combined sources18
Helixi281 – 291Combined sources11
Helixi297 – 308Combined sources12
Turni309 – 311Combined sources3
Helixi315 – 324Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5V6BX-ray1.90A/B52-327[»]
5V6EX-ray3.51A/C/E/G/I258-333[»]
5V6TX-ray3.19B52-333[»]
ProteinModelPortaliQ9Z0G0.
SMRiQ9Z0G0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 213PDZPROSITE-ProRule annotationAdd BLAST81

Sequence similaritiesi

Belongs to the GIPC family.Curated

Phylogenomic databases

eggNOGiKOG3938. Eukaryota.
ENOG410XQ87. LUCA.
GeneTreeiENSGT00390000003420.
HOGENOMiHOG000293347.
HOVERGENiHBG000898.
InParanoidiQ9Z0G0.
KOiK20056.
OMAiMIESING.
OrthoDBiEOG091G0D3X.
PhylomeDBiQ9Z0G0.
TreeFamiTF313878.

Family and domain databases

InterProiView protein in InterPro
IPR017379. GIPC1/2/3.
IPR001478. PDZ.
IPR036034. PDZ_sf.
PANTHERiPTHR12259. PTHR12259. 1 hit.
PfamiView protein in Pfam
PF00595. PDZ. 1 hit.
PIRSFiPIRSF038083. UCP038083_GIPC. 1 hit.
SMARTiView protein in SMART
SM00228. PDZ. 1 hit.
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiView protein in PROSITE
PS50106. PDZ. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z0G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLGLGRRKK APPLVENEEA EPSRSGLGVG EPGPLGGSAA GESQMGLPPP
60 70 80 90 100
PAALRPRLVF HTQLAHGSPT GRIEGFTNVK ELYGKIAEAF RLPAAEVMFC
110 120 130 140 150
TLNTHKVDMD KLLGGQIGLE DFIFAHVKGQ RKEVEVFKSE EALGLTITDN
160 170 180 190 200
GAGYAFIKRI KEGSVIDHIQ LISVGDMIEA INGQSLLGCR HYEVARLLKE
210 220 230 240 250
LPRGRTFTLK LTEPRKAFDM ISQRSAGGHP GSGPQLGTGR GTLRLRSRGP
260 270 280 290 300
ATVEDLPSAF EEKAIEKVDD LLESYMGIRD TELAATMVEL GKDKRNPDEL
310 320 330
AEALDERLGD FAFPDEFVFD VWGAIGDAKV GRY
Length:333
Mass (Da):36,129
Last modified:May 1, 1999 - v1
Checksum:i52E5ED6092EA9300
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39A → G in AAC67550 (PubMed:9770488).Curated1
Sequence conflicti53A → S in AAC67550 (PubMed:9770488).Curated1
Sequence conflicti141E → D in AAC67550 (PubMed:9770488).Curated1
Sequence conflicti226A → S in AAC67550 (PubMed:9770488).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089818 mRNA. Translation: AAC67550.1.
AF104358 mRNA. Translation: AAD12262.1.
AF061263 mRNA. Translation: AAC72311.1.
AK086506 mRNA. Translation: BAC39680.1.
BC003490 mRNA. Translation: AAH03490.1.
CCDSiCCDS22457.1.
RefSeqiNP_061241.1. NM_018771.3.
UniGeneiMm.20945.

Genome annotation databases

EnsembliENSMUST00000019577; ENSMUSP00000019577; ENSMUSG00000019433.
GeneIDi67903.
KEGGimmu:67903.
UCSCiuc009mkr.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiGIPC1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0G0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 1999
Last modified: October 25, 2017
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families