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Protein

Bcl-2-like protein 10

Gene

Bcl2l10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes cell survival. Suppresses apoptosis.

GO - Molecular functioni

  • protein heterodimerization activity Source: GO_Central
  • protein homodimerization activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-like protein 10
Short name:
Bcl2-L-10
Alternative name(s):
Anti-apoptotic protein Boo
Apoptosis regulator Bcl-B
Bcl-2 homolog Diva
Gene namesi
Name:Bcl2l10
Synonyms:Boo, Diva
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1330841. Bcl2l10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei166 – 18318HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 191191Bcl-2-like protein 10PRO_0000143069Add
BLAST

Proteomic databases

PaxDbiQ9Z0F3.
PRIDEiQ9Z0F3.

PTM databases

PhosphoSiteiQ9Z0F3.

Expressioni

Tissue specificityi

Expressed in multiple embryonic tissues. Restricted to the ovary and testis in adult mice.

Gene expression databases

BgeeiQ9Z0F3.
CleanExiMM_BCL2L10.
GenevisibleiQ9Z0F3. MM.

Interactioni

Subunit structurei

Binds to Bcl-2, Bcl-X and BAX. Interacts with APAF1.

GO - Molecular functioni

  • protein heterodimerization activity Source: GO_Central
  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

MINTiMINT-104414.
STRINGi10090.ENSMUSP00000034709.

Structurei

Secondary structure

1
191
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 53Combined sources
Helixi9 – 2416Combined sources
Helixi37 – 6125Combined sources
Turni62 – 643Combined sources
Helixi67 – 7711Combined sources
Beta strandi81 – 833Combined sources
Helixi87 – 10014Combined sources
Helixi120 – 13617Combined sources
Helixi139 – 1479Combined sources
Helixi150 – 1578Combined sources
Beta strandi161 – 1633Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KUANMR-A1-165[»]
ProteinModelPortaliQ9Z0F3.
SMRiQ9Z0F3. Positions 1-165.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Z0F3.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi79 – 9820BH1Add
BLAST
Motifi144 – 15512BH2Add
BLAST

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J2PB. Eukaryota.
ENOG4112AS5. LUCA.
GeneTreeiENSGT00640000091607.
HOGENOMiHOG000059275.
HOVERGENiHBG050646.
InParanoidiQ9Z0F3.
KOiK18451.
OMAiGYPGNRV.
OrthoDBiEOG7Q5HFF.
PhylomeDBiQ9Z0F3.
TreeFamiTF334762.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z0F3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSQDPLHE RTRRLLSDYI FFCAREPDTP EPPPTSVEAA LLRSVTRQIQ
60 70 80 90 100
QEHQEFFSSF CESRGNRLEL VKQMADKLLS KDQDFSWSQL VMLLAFAGTL
110 120 130 140 150
MNQGPYMAVK QKRDLGNRVI VTRDCCLIVN FLYNLLMGRR HRARLEALGG
160 170 180 190
WDGFCRFFKN PLPLGFWRRL LIQAFLSGFF ATAIFFIWKR L
Length:191
Mass (Da):22,302
Last modified:May 1, 1999 - v1
Checksum:i819014E6B2DFE411
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101E → G in AAH52690 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102501 mRNA. Translation: AAD08703.1.
AF067660 mRNA. Translation: AAC83150.1.
AK136172 mRNA. Translation: BAE22856.1.
AK145385 mRNA. Translation: BAE26403.1.
AK162127 mRNA. Translation: BAE36742.1.
CH466522 Genomic DNA. Translation: EDL26315.1.
BC052690 mRNA. Translation: AAH52690.1.
CCDSiCCDS23341.1.
RefSeqiNP_038507.1. NM_013479.2.
UniGeneiMm.25988.

Genome annotation databases

EnsembliENSMUST00000034709; ENSMUSP00000034709; ENSMUSG00000032191.
GeneIDi12049.
KEGGimmu:12049.
UCSCiuc012gwy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102501 mRNA. Translation: AAD08703.1.
AF067660 mRNA. Translation: AAC83150.1.
AK136172 mRNA. Translation: BAE22856.1.
AK145385 mRNA. Translation: BAE26403.1.
AK162127 mRNA. Translation: BAE36742.1.
CH466522 Genomic DNA. Translation: EDL26315.1.
BC052690 mRNA. Translation: AAH52690.1.
CCDSiCCDS23341.1.
RefSeqiNP_038507.1. NM_013479.2.
UniGeneiMm.25988.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KUANMR-A1-165[»]
ProteinModelPortaliQ9Z0F3.
SMRiQ9Z0F3. Positions 1-165.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-104414.
STRINGi10090.ENSMUSP00000034709.

PTM databases

PhosphoSiteiQ9Z0F3.

Proteomic databases

PaxDbiQ9Z0F3.
PRIDEiQ9Z0F3.

Protocols and materials databases

DNASUi12049.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034709; ENSMUSP00000034709; ENSMUSG00000032191.
GeneIDi12049.
KEGGimmu:12049.
UCSCiuc012gwy.1. mouse.

Organism-specific databases

CTDi10017.
MGIiMGI:1330841. Bcl2l10.

Phylogenomic databases

eggNOGiENOG410J2PB. Eukaryota.
ENOG4112AS5. LUCA.
GeneTreeiENSGT00640000091607.
HOGENOMiHOG000059275.
HOVERGENiHBG050646.
InParanoidiQ9Z0F3.
KOiK18451.
OMAiGYPGNRV.
OrthoDBiEOG7Q5HFF.
PhylomeDBiQ9Z0F3.
TreeFamiTF334762.

Miscellaneous databases

EvolutionaryTraceiQ9Z0F3.
PROiQ9Z0F3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z0F3.
CleanExiMM_BCL2L10.
GenevisibleiQ9Z0F3. MM.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Boo, a novel negative regulator of cell death, interacts with Apaf-1."
    Song Q.Z., Kuang Y.P., Dixit V.M., Vincenz C.
    EMBO J. 18:167-178(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X DBA/2.
    Tissue: Ovary.
  2. "Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death."
    Inohara N., Gourley T.S., Carrio R., Muniz M., Merino J., Garcia I., Koseki T., Hu Y., Chen S., Nunez G.
    J. Biol. Chem. 273:32479-32486(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X DBA/2.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Egg.

Entry informationi

Entry nameiB2L10_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0F3
Secondary accession number(s): Q3ULP5, Q7TPY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 1, 1999
Last modified: July 6, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.