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Protein

Bcl-2-like protein 10

Gene

Bcl2l10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes cell survival. Suppresses apoptosis.

GO - Molecular functioni

  • caspase binding Source: MGI
  • protein heterodimerization activity Source: GO_Central
  • protein homodimerization activity Source: MGI

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-like protein 10
Short name:
Bcl2-L-10
Alternative name(s):
Anti-apoptotic protein Boo
Apoptosis regulator Bcl-B
Bcl-2 homolog Diva
Gene namesi
Name:Bcl2l10
Synonyms:Boo, Diva
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1330841 Bcl2l10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei166 – 183HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001430691 – 191Bcl-2-like protein 10Add BLAST191

Proteomic databases

PaxDbiQ9Z0F3
PRIDEiQ9Z0F3

PTM databases

PhosphoSitePlusiQ9Z0F3

Expressioni

Tissue specificityi

Expressed in multiple embryonic tissues. Restricted to the ovary and testis in adult mice.

Gene expression databases

BgeeiENSMUSG00000032191
CleanExiMM_BCL2L10
GenevisibleiQ9Z0F3 MM

Interactioni

Subunit structurei

Binds to Bcl-2, Bcl-X and BAX. Interacts with APAF1.

Binary interactionsi

WithEntry#Exp.IntActNotes
APAF1O147272EBI-8658693,EBI-446492From Homo sapiens.

GO - Molecular functioni

  • caspase binding Source: MGI
  • protein heterodimerization activity Source: GO_Central
  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

IntActiQ9Z0F3, 1 interactor
MINTiQ9Z0F3
STRINGi10090.ENSMUSP00000034709

Structurei

Secondary structure

1191
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 5Combined sources3
Helixi9 – 24Combined sources16
Helixi37 – 61Combined sources25
Turni62 – 64Combined sources3
Helixi67 – 77Combined sources11
Beta strandi81 – 83Combined sources3
Helixi87 – 100Combined sources14
Helixi120 – 136Combined sources17
Helixi139 – 147Combined sources9
Helixi150 – 157Combined sources8
Beta strandi161 – 163Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KUANMR-A1-165[»]
ProteinModelPortaliQ9Z0F3
SMRiQ9Z0F3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Z0F3

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi79 – 98BH1Add BLAST20
Motifi144 – 155BH2Add BLAST12

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J2PB Eukaryota
ENOG4112AS5 LUCA
GeneTreeiENSGT00640000091607
HOGENOMiHOG000059275
HOVERGENiHBG050646
InParanoidiQ9Z0F3
KOiK18451
OMAiQAQGGWD
OrthoDBiEOG091G0KGL
PhylomeDBiQ9Z0F3
TreeFamiTF334762

Family and domain databases

Gene3Di1.10.437.10, 1 hit
InterProiView protein in InterPro
IPR002475 Bcl2-like
IPR036834 Blc2-like_sf
IPR026298 Blc2_fam
PANTHERiPTHR11256 PTHR11256, 1 hit
PfamiView protein in Pfam
PF00452 Bcl-2, 1 hit
SUPFAMiSSF56854 SSF56854, 1 hit
PROSITEiView protein in PROSITE
PS50062 BCL2_FAMILY, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z0F3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSQDPLHE RTRRLLSDYI FFCAREPDTP EPPPTSVEAA LLRSVTRQIQ
60 70 80 90 100
QEHQEFFSSF CESRGNRLEL VKQMADKLLS KDQDFSWSQL VMLLAFAGTL
110 120 130 140 150
MNQGPYMAVK QKRDLGNRVI VTRDCCLIVN FLYNLLMGRR HRARLEALGG
160 170 180 190
WDGFCRFFKN PLPLGFWRRL LIQAFLSGFF ATAIFFIWKR L
Length:191
Mass (Da):22,302
Last modified:May 1, 1999 - v1
Checksum:i819014E6B2DFE411
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10E → G in AAH52690 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102501 mRNA Translation: AAD08703.1
AF067660 mRNA Translation: AAC83150.1
AK136172 mRNA Translation: BAE22856.1
AK145385 mRNA Translation: BAE26403.1
AK162127 mRNA Translation: BAE36742.1
CH466522 Genomic DNA Translation: EDL26315.1
BC052690 mRNA Translation: AAH52690.1
CCDSiCCDS23341.1
RefSeqiNP_038507.1, NM_013479.2
UniGeneiMm.25988

Genome annotation databases

EnsembliENSMUST00000034709; ENSMUSP00000034709; ENSMUSG00000032191
GeneIDi12049
KEGGimmu:12049
UCSCiuc012gwy.1 mouse

Similar proteinsi

Entry informationi

Entry nameiB2L10_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0F3
Secondary accession number(s): Q3ULP5, Q7TPY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health