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Protein

Solute carrier family 22 member 5

Gene

Slc22a5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi218 – 225ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • adult heart development Source: MGI
  • carnitine metabolic process Source: MGI
  • carnitine transport Source: MGI
  • locomotory behavior Source: MGI
  • mitochondrion organization Source: MGI
  • positive regulation of intestinal epithelial structure maintenance Source: MGI
  • quaternary ammonium group transport Source: MGI
  • quorum sensing involved in interaction with host Source: MGI
  • reproductive structure development Source: MGI
  • sodium-dependent organic cation transport Source: MGI
  • sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding, Sodium

Enzyme and pathway databases

ReactomeiR-MMU-549127. Organic cation transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 5
Alternative name(s):
High-affinity sodium-dependent carnitine cotransporter
Organic cation/carnitine transporter 2
Gene namesi
Name:Slc22a5
Synonyms:Octn2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1329012. Slc22a5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 41Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini42 – 142ExtracellularSequence analysisAdd BLAST101
Transmembranei143 – 163Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini164 – 172CytoplasmicSequence analysis9
Transmembranei173 – 193Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini194 – 197ExtracellularSequence analysis4
Transmembranei198 – 218Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini219 – 232CytoplasmicSequence analysisAdd BLAST14
Transmembranei233 – 253Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini254 – 257ExtracellularSequence analysis4
Transmembranei258 – 278Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini279 – 341CytoplasmicSequence analysisAdd BLAST63
Transmembranei342 – 362Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini363 – 373ExtracellularSequence analysisAdd BLAST11
Transmembranei374 – 394Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini395 – 406CytoplasmicSequence analysisAdd BLAST12
Transmembranei407 – 427Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini428 – 430ExtracellularSequence analysis3
Transmembranei431 – 451Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini452 – 462CytoplasmicSequence analysisAdd BLAST11
Transmembranei463 – 483Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini484 – 488ExtracellularSequence analysis5
Transmembranei489 – 509Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini510 – 557CytoplasmicSequence analysisAdd BLAST48

GO - Cellular componenti

  • apical plasma membrane Source: MGI
  • brush border membrane Source: BHF-UCL
  • extracellular exosome Source: MGI
  • integral component of plasma membrane Source: GO_Central
  • membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Slc22a5 are the cause of the juvenile visceral steatosis (JVS) phenotype. JVS is an autosomal recessive animal model of systemic carnitine deficiency.

Keywords - Diseasei

Disease mutation

Chemistry databases

ChEMBLiCHEMBL2073665.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002205011 – 557Solute carrier family 22 member 5Add BLAST557

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...)Sequence analysis1
Glycosylationi64N-linked (GlcNAc...)Sequence analysis1
Glycosylationi91N-linked (GlcNAc...)Sequence analysis1
Modified residuei486PhosphotyrosineBy similarity1
Modified residuei548PhosphoserineCombined sources1
Modified residuei550PhosphothreonineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9Z0E8.
PRIDEiQ9Z0E8.

PTM databases

iPTMnetiQ9Z0E8.
PhosphoSitePlusiQ9Z0E8.

Expressioni

Tissue specificityi

Widely expressed. Expressed in kidney, liver and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000018900.
ExpressionAtlasiQ9Z0E8. baseline and differential.
GenevisibleiQ9Z0E8. MM.

Interactioni

Subunit structurei

Interacts with PDZK1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019044.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0E8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRIE. Eukaryota.
ENOG410XSRI. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234570.
HOVERGENiHBG061545.
InParanoidiQ9Z0E8.
KOiK08202.
OMAiVPRIRTI.
OrthoDBiEOG091G05AC.
PhylomeDBiQ9Z0E8.
TreeFamiTF315847.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR004749. Orgcat_transp/SVOP.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z0E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDYDEVTAF LGEWGPFQRL IFFLLSASII PNGFNGMSIV FLAGTPEHRC
60 70 80 90 100
LVPHTVNLSS AWRNHSIPLE TKDGRQVPQK CRRYRLATIA NFSELGLEPG
110 120 130 140 150
RDVDLEQLEQ ESCLDGWEYD KDVFLSTIVT EWDLVCKDDW KAPLTTSLFF
160 170 180 190 200
VGVLMGSFIS GQLSDRFGRK NVLFLTMGMQ TGFSFLQVFS VNFEMFTVLF
210 220 230 240 250
VLVGMGQISN YVAAFVLGTE ILSKSIRIIF ATLGVCIFYA FGFMVLPLFA
260 270 280 290 300
YFIRDWRMLL LALTVPGVLC GALWWFIPES PRWLISQGRI KEAEVIIRKA
310 320 330 340 350
AKINGIVAPS TIFDPSELQD LNSTKPQLHH IYDLIRTRNI RVITIMSIIL
360 370 380 390 400
WLTISVGYFG LSLDTPNLHG DIYVNCFLLA AVEVPAYVLA WLLLQYLPRR
410 420 430 440 450
YSISAALFLG GSVLLFMQLV PSELFYLSTA LVMVGKFGIT SAYSMVYVYT
460 470 480 490 500
AELYPTVVRN MGVGVSSTAS RLGSILSPYF VYLGAYDRFL PYILMGSLTI
510 520 530 540 550
LTAILTLFFP ESFGVPLPDT IDQMLRVKGI KQWQIQSQTR MQKDGEESPT

VLKSTAF
Length:557
Mass (Da):62,780
Last modified:May 1, 1999 - v1
Checksum:i6093F0EE9612B204
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti352L → R in JVS. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015800 mRNA. Translation: BAA36590.1.
AF111425 mRNA. Translation: AAC99787.1.
AF110417 mRNA. Translation: AAD54060.1.
BC031118 mRNA. Translation: AAH31118.1.
CCDSiCCDS24687.1.
RefSeqiNP_035526.1. NM_011396.3.
UniGeneiMm.42253.

Genome annotation databases

EnsembliENSMUST00000019044; ENSMUSP00000019044; ENSMUSG00000018900.
GeneIDi20520.
KEGGimmu:20520.
UCSCiuc007ixc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015800 mRNA. Translation: BAA36590.1.
AF111425 mRNA. Translation: AAC99787.1.
AF110417 mRNA. Translation: AAD54060.1.
BC031118 mRNA. Translation: AAH31118.1.
CCDSiCCDS24687.1.
RefSeqiNP_035526.1. NM_011396.3.
UniGeneiMm.42253.

3D structure databases

ProteinModelPortaliQ9Z0E8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019044.

Chemistry databases

ChEMBLiCHEMBL2073665.

PTM databases

iPTMnetiQ9Z0E8.
PhosphoSitePlusiQ9Z0E8.

Proteomic databases

PaxDbiQ9Z0E8.
PRIDEiQ9Z0E8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019044; ENSMUSP00000019044; ENSMUSG00000018900.
GeneIDi20520.
KEGGimmu:20520.
UCSCiuc007ixc.2. mouse.

Organism-specific databases

CTDi6584.
MGIiMGI:1329012. Slc22a5.

Phylogenomic databases

eggNOGiENOG410IRIE. Eukaryota.
ENOG410XSRI. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234570.
HOVERGENiHBG061545.
InParanoidiQ9Z0E8.
KOiK08202.
OMAiVPRIRTI.
OrthoDBiEOG091G05AC.
PhylomeDBiQ9Z0E8.
TreeFamiTF315847.

Enzyme and pathway databases

ReactomeiR-MMU-549127. Organic cation transport.

Miscellaneous databases

PROiQ9Z0E8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018900.
ExpressionAtlasiQ9Z0E8. baseline and differential.
GenevisibleiQ9Z0E8. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR004749. Orgcat_transp/SVOP.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS22A5_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0E8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.