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Protein

Autoimmune regulator

Gene

Aire

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA) (Probable). Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Mainly expressed by medullary thymic epithelial cells (mTECs), induces the expression of thousands of tissue-restricted proteins, which are presented on major histocompatibility complex class I (MHC-I) and MHC-II molecules to developing T-cells percolating through the thymic medulla (By similarity). Also induces self-tolerance through other mechanisms such as the regulation of the mTEC differentiation program (PubMed:19015306). Controls the medullary accumulation of thymic dendritic cells and the development of regulatory T-cell through the regulation of XCL1 expression (PubMed:21300913). Regulates the production of CCR4 and CCR7 ligands in medullary thymic epithelial cells and alters the coordinated maturation and migration of thymocytes (PubMed:19923453). In thimic B-cells, allows the presentation of licensing-dependent endogenous self-anitgen for negative selection (PubMed:26070482). In secondary lymphoid organs, induces functional inactivation of CD4+ T-cells. Expressed by a distinct bone marrow-derived population, induces self-tolerance through a mechanism that does not require regulatory T-cells and is resitant to innate inflammatory stimuli (PubMed:23993652).By similarity1 Publication5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri298 – 345PHD-type 1PROSITE-ProRule annotationAdd BLAST48
Zinc fingeri434 – 475PHD-type 2PROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

  • central tolerance induction to self antigen Source: UniProtKB
  • chemokine production Source: UniProtKB
  • humoral immune response Source: MGI
  • negative thymic T cell selection Source: MGI
  • peripheral T cell tolerance induction Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of thymocyte migration Source: UniProtKB
  • regulation of transcription, DNA-templated Source: MGI
  • thymus epithelium morphogenesis Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Autoimmune regulator
Alternative name(s):
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog
Short name:
APECED protein homolog
Gene namesi
Name:Aire
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1338803. Aire.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • intracellular Source: MGI
  • nuclear body Source: UniProtKB
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Deficient mice show an altered thymic organization with altered morphology and location of mTECs (PubMed:19015306). They exhibit defective accumulation of thymic dendritic cells in the medullary region and generation of naturally ocurring T cells in the thymus (PubMed:21300913).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi299D → A: Abolishes interaction with histone H3. 1 Publication1
Mutagenesisi303V → M: No effect on interaction with histone H3. 1 Publication1
Mutagenesisi312C → W: Abolishes interaction with histone H3. 1 Publication1
Mutagenesisi313C → Y: Abolishes interaction with histone H3. 1 Publication1
Mutagenesisi328P → L: Reduces interaction with histone H3. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000645141 – 552Autoimmune regulatorAdd BLAST552

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z0E3.
PRIDEiQ9Z0E3.

PTM databases

iPTMnetiQ9Z0E3.
PhosphoSitePlusiQ9Z0E3.

Expressioni

Tissue specificityi

Highly expressed in a few cells in the medulla of the thymus (medullary epithelial cells) (at protein level) (PubMed:23993652). Expressed in thymic but no peripheral B-cells (PubMed:26070482). In secondary lymphoid organs, expressed in a discrete population of bone marrow-derived toleregenic antigen presenting cells (APCs) called extrathymic AIRE expressing cells (eTAC)(at protein level) (PubMed:23993652). Detected at very low levels in thymus, lymph node, liver, brain, ovary, lung, testis, kidney, heart, spleen, bone marrow, skeletal muscle and adrenal gland. Isoforms 1a to 1d predominate, isoforms 2a to 2d are intermediate and isoforms 3a to 3d are expressed at extremely low levels.2 Publications

Developmental stagei

In the thymus, not expressed at E13.5 but present at E16.5 and postnatal day 1.1 Publication

Gene expression databases

BgeeiENSMUSG00000000731.
ExpressionAtlasiQ9Z0E3. baseline and differential.
GenevisibleiQ9Z0E3. MM.

Interactioni

Subunit structurei

Homodimer and homotetramer. Interacts with CREBBP. Interacts preferentially with histone H3 that is not methylated at 'Lys-4'. Binds with lower affinity to histone H3 that is monomethylated at 'Lys-4'. Trimethylation of histone H3 at 'Lys-4' or phosphorylation at 'Thr-3' abolish the interaction. Binds with lower affinity to histone H3 that is acetylated at 'Lys-4', or that is acetylated at 'Lys-9' or trimethylated at 'Lys-9'. Binds histone H3 that is dimethylated at 'Arg-2' with very low affinity (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-80858,EBI-80858

GO - Molecular functioni

  • histone binding Source: UniProtKB
  • identical protein binding Source: IntAct

Protein-protein interaction databases

DIPiDIP-31030N.
IntActiQ9Z0E3. 90 interactors.
STRINGi10090.ENSMUSP00000114904.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0E3.
SMRiQ9Z0E3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 106HSRPROSITE-ProRule annotationAdd BLAST106
Domaini182 – 282SANDPROSITE-ProRule annotationAdd BLAST101

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi8 – 12LXXLL motif 15
Motifi64 – 68LXXLL motif 25
Motifi114 – 134Nuclear localization signalSequence analysisAdd BLAST21
Motifi414 – 418LXXLL motif 35
Motifi520 – 524LXXLL motif 45

Domaini

Interacts via the first PHD domain with the N-terminus of histone H3 that is not methylated at 'Lys-4'. Disruption of the first PHD domain has been shown to lead to reduced transcriptional activity and to localization of the protein mainly in the cytoplasm in small granules. While the PHD zinc fingers are necessary for the transactivation capacity of the protein, other regions also modulate this function (By similarity).By similarity
The L-X-X-L-L repeats may be implicated in binding to nuclear receptors.
The N-terminal HSR domain is required for localization on tubular structures.By similarity

Sequence similaritiesi

Contains 1 HSR domain.PROSITE-ProRule annotation
Contains 2 PHD-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SAND domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri298 – 345PHD-type 1PROSITE-ProRule annotationAdd BLAST48
Zinc fingeri434 – 475PHD-type 2PROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IRE7. Eukaryota.
ENOG410XQQA. LUCA.
GeneTreeiENSGT00530000062982.
HOVERGENiHBG014961.
InParanoidiQ9Z0E3.
KOiK10603.
OMAiLLSEHTF.
OrthoDBiEOG091G055U.
PhylomeDBiQ9Z0E3.
TreeFamiTF336193.

Family and domain databases

Gene3Di3.10.390.10. 1 hit.
3.30.40.10. 2 hits.
InterProiIPR008087. AIRE.
IPR004865. HSR_dom.
IPR000770. SAND_dom.
IPR010919. SAND_dom-like.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF03172. HSR. 1 hit.
PF00628. PHD. 1 hit.
PF01342. SAND. 1 hit.
[Graphical view]
PRINTSiPR01711. AIREGULATOR.
SMARTiSM00249. PHD. 2 hits.
SM00258. SAND. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 2 hits.
SSF63763. SSF63763. 1 hit.
PROSITEiPS51414. HSR. 1 hit.
PS50864. SAND. 1 hit.
PS01359. ZF_PHD_1. 2 hits.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequences (12)i

Sequence statusi: Complete.

This entry describes 12 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1a (identifier: Q9Z0E3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGGDGMLRR LLRLHRTEIA VAIDSAFPLL HALADHDVVP EDKFQETLRL
60 70 80 90 100
KEKEGCPQAF HALLSWLLTR DSGAILDFWR ILFKDYNLER YSRLHSILDG
110 120 130 140 150
FPKDVDLNQS RKGRKPLAGP KAAVLPPRPP TKRKALEEPR ATPPATLASK
160 170 180 190 200
SVSSPGSHLK TKPPKKPDGN LESQHLPLGN GIQTMAASVQ RAVTVASGDV
210 220 230 240 250
PGTRGAVEGI LIQQVFESGR SKKCIQVGGE FYTPNKFEDP SGNLKNKARS
260 270 280 290 300
GSSLKPVVRA KGAQVTIPGR DEQKVGQQCG VPPLPSLPSE PQVNQKNEDE
310 320 330 340 350
CAVCHDGGEL ICCDGCPRAF HLACLSPPLQ EIPSGLWRCS CCLQGRVQQN
360 370 380 390 400
LSQPEVSRPP ELPAETPILV GLRSASEKTR GPSRELKASS DAAVTYVNLL
410 420 430 440 450
APHPAAPLLE PSALCPLLSA GNEGRPGPAP SARCSVCGDG TEVLRCAHCA
460 470 480 490 500
AAFHWRCHFP TAAARPGTNL RCKSCSADST PTPGTPGEAV PTSGPRPAPG
510 520 530 540 550
LAKVGDDSAS HDPVLHRDDL ESLLNEHSFD GILQWAIQSM SRPLAETPPF

SS
Length:552
Mass (Da):59,042
Last modified:May 1, 1999 - v1
Checksum:iBF30F8F66B71239A
GO
Isoform 1b (identifier: Q9Z0E3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     296-296: Missing.

Show »
Length:551
Mass (Da):58,914
Checksum:i77C75E773B48B72C
GO
Isoform 1c (identifier: Q9Z0E3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     265-268: Missing.

Show »
Length:548
Mass (Da):58,632
Checksum:i0B0524A3C5EDCBE6
GO
Isoform 1d (identifier: Q9Z0E3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     265-268: Missing.
     296-296: Missing.

Show »
Length:547
Mass (Da):58,504
Checksum:i421B0BD9A7A0CBEC
GO
Isoform 2a (identifier: Q9Z0E3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     367-425: Missing.

Show »
Length:493
Mass (Da):52,996
Checksum:i13307FC59268E06E
GO
Isoform 2b (identifier: Q9Z0E3-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     296-296: Missing.
     367-425: Missing.

Show »
Length:492
Mass (Da):52,868
Checksum:i9BE6428E275E5781
GO
Isoform 2c (identifier: Q9Z0E3-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     265-268: Missing.
     367-425: Missing.

Show »
Length:489
Mass (Da):52,586
Checksum:iBA09175B96C9824A
GO
Isoform 2d (identifier: Q9Z0E3-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     265-268: Missing.
     296-296: Missing.
     367-425: Missing.

Show »
Length:488
Mass (Da):52,458
Checksum:i628EDC8A863C7355
GO
Isoform 3a (identifier: Q9Z0E3-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-409: ILVGLRSASE...LAPHPAAPLL → DQSPLQILLC...WACQGRGRLC
     410-552: Missing.

Note: Probably inactive.
Show »
Length:409
Mass (Da):44,571
Checksum:i4F95F6914E91E109
GO
Isoform 3b (identifier: Q9Z0E3-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     296-296: Missing.
     368-409: ILVGLRSASE...LAPHPAAPLL → DQSPLQILLC...WACQGRGRLC
     410-552: Missing.

Note: Probably inactive.
Show »
Length:408
Mass (Da):44,443
Checksum:i36857622FFED94C8
GO
Isoform 3c (identifier: Q9Z0E3-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     265-268: Missing.
     368-409: ILVGLRSASE...LAPHPAAPLL → DQSPLQILLC...WACQGRGRLC
     410-552: Missing.

Note: Probably inactive.
Show »
Length:405
Mass (Da):44,161
Checksum:i4D820E9642824F3A
GO
Isoform 3d (identifier: Q9Z0E3-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     265-268: Missing.
     296-296: Missing.
     368-409: ILVGLRSASE...LAPHPAAPLL → DQSPLQILLC...WACQGRGRLC
     410-552: Missing.

Note: Probably inactive.
Show »
Length:404
Mass (Da):44,032
Checksum:iF17D712EEC43A7CB
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004091265 – 268Missing in isoform 1c, isoform 1d, isoform 2c, isoform 2d, isoform 3c and isoform 3d. 1 Publication4
Alternative sequenceiVSP_004092296Missing in isoform 1b, isoform 1d, isoform 2b, isoform 2d, isoform 3b and isoform 3d. 1 Publication1
Alternative sequenceiVSP_004093367 – 425Missing in isoform 2a, isoform 2b, isoform 2c and isoform 2d. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_004094368 – 409ILVGL…AAPLL → DQSPLQILLCRLDSHARHTG RSCTHLWAPSSTWACQGRGR LC in isoform 3a, isoform 3b, isoform 3c and isoform 3d. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_004095410 – 552Missing in isoform 3a, isoform 3b, isoform 3c and isoform 3d. 1 PublicationAdd BLAST143

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105002 Genomic DNA. Translation: AAD46421.1.
AF128772 mRNA. Translation: AAF36481.1.
AF128773 mRNA. Translation: AAF36482.1.
AJ007715 Genomic DNA. Translation: CAA07620.1.
AF079536 mRNA. Translation: AAD20444.1.
AJ132243 mRNA. Translation: CAB36909.1.
AF128115 mRNA. Translation: AAF36460.1.
AF128116 mRNA. Translation: AAF36461.1.
AF128117 mRNA. Translation: AAF36462.1.
AF128118 mRNA. Translation: AAF36463.1.
AF128119 mRNA. Translation: AAF36464.1.
AF128120 mRNA. Translation: AAF36465.1.
AF128121 mRNA. Translation: AAF36466.1.
AF128122 mRNA. Translation: AAF36467.1.
AF128123 mRNA. Translation: AAF36468.1.
AF128124 mRNA. Translation: AAF36469.1.
AF128125 mRNA. Translation: AAF36470.1.
AJ243821 mRNA. Translation: CAB66141.1.
CCDSiCCDS23961.1. [Q9Z0E3-1]
CCDS70051.1. [Q9Z0E3-10]
CCDS70052.1. [Q9Z0E3-6]
CCDS70053.1. [Q9Z0E3-2]
CCDS70054.1. [Q9Z0E3-9]
CCDS70055.1. [Q9Z0E3-5]
CCDS70056.1. [Q9Z0E3-12]
CCDS70057.1. [Q9Z0E3-8]
CCDS70058.1. [Q9Z0E3-4]
CCDS70059.1. [Q9Z0E3-11]
CCDS70060.1. [Q9Z0E3-3]
RefSeqiNP_001258478.1. NM_001271549.1. [Q9Z0E3-2]
NP_001258479.1. NM_001271550.1. [Q9Z0E3-3]
NP_001258480.1. NM_001271551.1. [Q9Z0E3-4]
NP_001258481.1. NM_001271552.1. [Q9Z0E3-5]
NP_001258482.1. NM_001271553.1. [Q9Z0E3-6]
NP_001258483.1. NM_001271554.1. [Q9Z0E3-7]
NP_001258484.1. NM_001271555.1. [Q9Z0E3-8]
NP_001258485.1. NM_001271556.1. [Q9Z0E3-9]
NP_001258486.1. NM_001271557.1. [Q9Z0E3-10]
NP_001258487.1. NM_001271558.1. [Q9Z0E3-11]
NP_001258488.1. NM_001271559.1. [Q9Z0E3-12]
NP_033776.1. NM_009646.2. [Q9Z0E3-1]
UniGeneiMm.35300.

Genome annotation databases

EnsembliENSMUST00000019257; ENSMUSP00000019257; ENSMUSG00000000731. [Q9Z0E3-2]
ENSMUST00000105395; ENSMUSP00000101034; ENSMUSG00000000731. [Q9Z0E3-9]
ENSMUST00000105396; ENSMUSP00000101035; ENSMUSG00000000731. [Q9Z0E3-6]
ENSMUST00000128241; ENSMUSP00000114904; ENSMUSG00000000731. [Q9Z0E3-1]
ENSMUST00000130972; ENSMUSP00000122659; ENSMUSG00000000731. [Q9Z0E3-4]
ENSMUST00000140636; ENSMUSP00000121477; ENSMUSG00000000731. [Q9Z0E3-12]
ENSMUST00000145975; ENSMUSP00000120150; ENSMUSG00000000731. [Q9Z0E3-3]
ENSMUST00000148469; ENSMUSP00000118317; ENSMUSG00000000731. [Q9Z0E3-11]
ENSMUST00000154374; ENSMUSP00000117094; ENSMUSG00000000731. [Q9Z0E3-5]
ENSMUST00000155021; ENSMUSP00000122190; ENSMUSG00000000731. [Q9Z0E3-8]
ENSMUST00000156417; ENSMUSP00000115162; ENSMUSG00000000731. [Q9Z0E3-10]
GeneIDi11634.
KEGGimmu:11634.
UCSCiuc007fwr.2. mouse. [Q9Z0E3-1]
uc007fws.2. mouse. [Q9Z0E3-4]
uc007fwt.2. mouse. [Q9Z0E3-10]
uc007fwu.2. mouse. [Q9Z0E3-6]
uc007fwv.2. mouse. [Q9Z0E3-12]
uc007fww.2. mouse. [Q9Z0E3-8]
uc007fwx.2. mouse. [Q9Z0E3-3]
uc007fwz.2. mouse. [Q9Z0E3-9]
uc007fxa.2. mouse. [Q9Z0E3-11]
uc007fxb.2. mouse. [Q9Z0E3-7]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105002 Genomic DNA. Translation: AAD46421.1.
AF128772 mRNA. Translation: AAF36481.1.
AF128773 mRNA. Translation: AAF36482.1.
AJ007715 Genomic DNA. Translation: CAA07620.1.
AF079536 mRNA. Translation: AAD20444.1.
AJ132243 mRNA. Translation: CAB36909.1.
AF128115 mRNA. Translation: AAF36460.1.
AF128116 mRNA. Translation: AAF36461.1.
AF128117 mRNA. Translation: AAF36462.1.
AF128118 mRNA. Translation: AAF36463.1.
AF128119 mRNA. Translation: AAF36464.1.
AF128120 mRNA. Translation: AAF36465.1.
AF128121 mRNA. Translation: AAF36466.1.
AF128122 mRNA. Translation: AAF36467.1.
AF128123 mRNA. Translation: AAF36468.1.
AF128124 mRNA. Translation: AAF36469.1.
AF128125 mRNA. Translation: AAF36470.1.
AJ243821 mRNA. Translation: CAB66141.1.
CCDSiCCDS23961.1. [Q9Z0E3-1]
CCDS70051.1. [Q9Z0E3-10]
CCDS70052.1. [Q9Z0E3-6]
CCDS70053.1. [Q9Z0E3-2]
CCDS70054.1. [Q9Z0E3-9]
CCDS70055.1. [Q9Z0E3-5]
CCDS70056.1. [Q9Z0E3-12]
CCDS70057.1. [Q9Z0E3-8]
CCDS70058.1. [Q9Z0E3-4]
CCDS70059.1. [Q9Z0E3-11]
CCDS70060.1. [Q9Z0E3-3]
RefSeqiNP_001258478.1. NM_001271549.1. [Q9Z0E3-2]
NP_001258479.1. NM_001271550.1. [Q9Z0E3-3]
NP_001258480.1. NM_001271551.1. [Q9Z0E3-4]
NP_001258481.1. NM_001271552.1. [Q9Z0E3-5]
NP_001258482.1. NM_001271553.1. [Q9Z0E3-6]
NP_001258483.1. NM_001271554.1. [Q9Z0E3-7]
NP_001258484.1. NM_001271555.1. [Q9Z0E3-8]
NP_001258485.1. NM_001271556.1. [Q9Z0E3-9]
NP_001258486.1. NM_001271557.1. [Q9Z0E3-10]
NP_001258487.1. NM_001271558.1. [Q9Z0E3-11]
NP_001258488.1. NM_001271559.1. [Q9Z0E3-12]
NP_033776.1. NM_009646.2. [Q9Z0E3-1]
UniGeneiMm.35300.

3D structure databases

ProteinModelPortaliQ9Z0E3.
SMRiQ9Z0E3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-31030N.
IntActiQ9Z0E3. 90 interactors.
STRINGi10090.ENSMUSP00000114904.

PTM databases

iPTMnetiQ9Z0E3.
PhosphoSitePlusiQ9Z0E3.

Proteomic databases

PaxDbiQ9Z0E3.
PRIDEiQ9Z0E3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019257; ENSMUSP00000019257; ENSMUSG00000000731. [Q9Z0E3-2]
ENSMUST00000105395; ENSMUSP00000101034; ENSMUSG00000000731. [Q9Z0E3-9]
ENSMUST00000105396; ENSMUSP00000101035; ENSMUSG00000000731. [Q9Z0E3-6]
ENSMUST00000128241; ENSMUSP00000114904; ENSMUSG00000000731. [Q9Z0E3-1]
ENSMUST00000130972; ENSMUSP00000122659; ENSMUSG00000000731. [Q9Z0E3-4]
ENSMUST00000140636; ENSMUSP00000121477; ENSMUSG00000000731. [Q9Z0E3-12]
ENSMUST00000145975; ENSMUSP00000120150; ENSMUSG00000000731. [Q9Z0E3-3]
ENSMUST00000148469; ENSMUSP00000118317; ENSMUSG00000000731. [Q9Z0E3-11]
ENSMUST00000154374; ENSMUSP00000117094; ENSMUSG00000000731. [Q9Z0E3-5]
ENSMUST00000155021; ENSMUSP00000122190; ENSMUSG00000000731. [Q9Z0E3-8]
ENSMUST00000156417; ENSMUSP00000115162; ENSMUSG00000000731. [Q9Z0E3-10]
GeneIDi11634.
KEGGimmu:11634.
UCSCiuc007fwr.2. mouse. [Q9Z0E3-1]
uc007fws.2. mouse. [Q9Z0E3-4]
uc007fwt.2. mouse. [Q9Z0E3-10]
uc007fwu.2. mouse. [Q9Z0E3-6]
uc007fwv.2. mouse. [Q9Z0E3-12]
uc007fww.2. mouse. [Q9Z0E3-8]
uc007fwx.2. mouse. [Q9Z0E3-3]
uc007fwz.2. mouse. [Q9Z0E3-9]
uc007fxa.2. mouse. [Q9Z0E3-11]
uc007fxb.2. mouse. [Q9Z0E3-7]

Organism-specific databases

CTDi326.
MGIiMGI:1338803. Aire.

Phylogenomic databases

eggNOGiENOG410IRE7. Eukaryota.
ENOG410XQQA. LUCA.
GeneTreeiENSGT00530000062982.
HOVERGENiHBG014961.
InParanoidiQ9Z0E3.
KOiK10603.
OMAiLLSEHTF.
OrthoDBiEOG091G055U.
PhylomeDBiQ9Z0E3.
TreeFamiTF336193.

Miscellaneous databases

ChiTaRSiAire. mouse.
PROiQ9Z0E3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000731.
ExpressionAtlasiQ9Z0E3. baseline and differential.
GenevisibleiQ9Z0E3. MM.

Family and domain databases

Gene3Di3.10.390.10. 1 hit.
3.30.40.10. 2 hits.
InterProiIPR008087. AIRE.
IPR004865. HSR_dom.
IPR000770. SAND_dom.
IPR010919. SAND_dom-like.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF03172. HSR. 1 hit.
PF00628. PHD. 1 hit.
PF01342. SAND. 1 hit.
[Graphical view]
PRINTSiPR01711. AIREGULATOR.
SMARTiSM00249. PHD. 2 hits.
SM00258. SAND. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 2 hits.
SSF63763. SSF63763. 1 hit.
PROSITEiPS51414. HSR. 1 hit.
PS50864. SAND. 1 hit.
PS01359. ZF_PHD_1. 2 hits.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAIRE_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0E3
Secondary accession number(s): Q9JLW0
, Q9JLW1, Q9JLW2, Q9JLW3, Q9JLW4, Q9JLW5, Q9JLW6, Q9JLW7, Q9JLW8, Q9JLW9, Q9JLX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.