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Q9Z0E2

- CHRD_MOUSE

UniProt

Q9Z0E2 - CHRD_MOUSE

Protein

Chordin

Gene

Chrd

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.

    GO - Molecular functioni

    1. heparin binding Source: MGI
    2. syndecan binding Source: MGI

    GO - Biological processi

    1. BMP signaling pathway involved in spinal cord dorsal/ventral patterning Source: Ensembl
    2. central nervous system development Source: MGI
    3. dorsal/ventral pattern formation Source: MGI
    4. forebrain development Source: MGI
    5. gastrulation with mouth forming second Source: MGI
    6. mesoderm formation Source: MGI
    7. negative regulation of BMP signaling pathway Source: MGI
    8. negative regulation of cell migration Source: Ensembl
    9. negative regulation of osteoblast differentiation Source: MGI
    10. osteoblast differentiation Source: MGI
    11. pattern specification process Source: MGI
    12. positive regulation of cell adhesion Source: Ensembl
    13. positive regulation of mesenchymal cell proliferation Source: Ensembl
    14. skeletal system development Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chordin
    Gene namesi
    Name:Chrd
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1313268. Chrd.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 948922ChordinPRO_0000005365Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi430 – 4301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi877 – 8771N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Cleaved by tolloid proteases; cleavage participates in dorsoventral patterning during early development.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9Z0E2.

    PTM databases

    PhosphoSiteiQ9Z0E2.

    Miscellaneous databases

    PMAP-CutDBQ9Z0E2.

    Expressioni

    Developmental stagei

    Detected at high levels of a in 7 dpc mouse embryos; its level decrease at later developmental stages and in adult tissues.

    Gene expression databases

    BgeeiQ9Z0E2.
    CleanExiMM_CHRD.
    GenevestigatoriQ9Z0E2.

    Interactioni

    Subunit structurei

    Interacts with TWSG1 and/or BMP4.1 Publication

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000007171.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z0E2.
    SMRiQ9Z0E2. Positions 46-131, 696-763, 774-851, 862-933.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini49 – 12678VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini168 – 277110CHRD 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini279 – 398120CHRD 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini399 – 520122CHRD 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini526 – 646121CHRD 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini699 – 75961VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini779 – 84567VWFC 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini867 – 92761VWFC 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the chordin family.Curated
    Contains 4 CHRD domains.PROSITE-ProRule annotation
    Contains 4 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG85639.
    GeneTreeiENSGT00730000110792.
    HOVERGENiHBG005330.
    InParanoidiQ9Z0E2.
    KOiK04657.
    OMAiRDPGEGC.
    OrthoDBiEOG7QNVK7.
    TreeFamiTF106451.

    Family and domain databases

    InterProiIPR016353. Chordin.
    IPR010895. CHRD.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF07452. CHRD. 4 hits.
    PF00093. VWC. 3 hits.
    [Graphical view]
    PIRSFiPIRSF002496. Chordin. 1 hit.
    SMARTiSM00754. CHRD. 4 hits.
    SM00214. VWC. 4 hits.
    [Graphical view]
    PROSITEiPS50933. CHRD. 4 hits.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Z0E2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSLPAPPAP RLLLGLLLLG SRPASGTGPE PPALPIRSEK EPLPVRGAAG    50
    CSFGGKVYAL DETWHPDLGE PFGVMRCVLC ACEAPQWARR GRGPGRVSCK 100
    NIKPQCPTLA CRQPRQLPGH CCQTCPQERS NLDPQPAGLV FEYPRDPEHR 150
    SYSDRGEPGV GERTRADGHT DFVALLTGPR SQAVARARVS LLRSSLRFSV 200
    SYQRLDRPSR VRFTDPTGNI LFEHPATPTQ DGLVCGVWRA VPRLSVRLLR 250
    AEQLRVALVT STHPSGEVWG PLIWQGALAA ETFSAILTLE DPLQRGVGGI 300
    ALLTLSDTED SLHFLLLFRG LLGGLAQAPL KLQILHQGQL LRELQANTSA 350
    QEPGFAEVLP SLTDQEMDWL ELGELQMVLE KAGGPELRIS GYITTRQSCD 400
    VLQSVLCGAD ALIPVQTGAA GSASFILLGN GSLIYQVQVV GTGSEVVAMT 450
    LETKPQRKNQ RTVLCHMAGL QPGGHMAVGM CSGLGARGAH MLLQNELFLN 500
    VGTKDFPDGE LRGHVTALCY SGHSARYDRL PVPLAGALVL PPVRSQAAGH 550
    AWLSLDTHCH LHYEVLLAGL GGSEQGTVTA HLLGPPGMPG PQRLLKGFYG 600
    SEAQGVVKDL EPVLLRHLAQ GTASLLITTK SSPRGELRGQ VHIASQCEAG 650
    GLRLASEGVQ MPLAPNGEAA TSPMLPAGPG PEAPVPAKHG SPGRPRDPNT 700
    CFFEGQQRPH GARWAPNYDP LCSLCICQRR TVICDPVVCP PPSCPHPVQA 750
    LDQCCPVCPE KQRSRDLPSL PNLEPGEGCY FDGDRSWRAA GTRWHPVVPP 800
    FGLIKCAVCT CKGATGEVHC EKVQCPRLAC AQPVRANPTD CCKQCPVGSG 850
    TNAKLGDPMQ ADGPRGCRFA GQWFPENQSW HPSVPPFGEM SCITCRCGAG 900
    VPHCERDDCS PPLSCGSGKE SRCCSHCTAQ RSSETRTLPE LEKEAEHS 948
    Length:948
    Mass (Da):101,513
    Last modified:May 1, 1999 - v1
    Checksum:i4DC2DA01D9BD2147
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF096276 mRNA. Translation: AAD19895.1.
    AF069501 mRNA. Translation: AAC68867.1.
    CCDSiCCDS28059.1.
    RefSeqiNP_001264970.1. NM_001278041.1.
    NP_034023.1. NM_009893.2.
    UniGeneiMm.20457.

    Genome annotation databases

    EnsembliENSMUST00000007171; ENSMUSP00000007171; ENSMUSG00000006958.
    GeneIDi12667.
    KEGGimmu:12667.
    UCSCiuc007yre.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF096276 mRNA. Translation: AAD19895.1 .
    AF069501 mRNA. Translation: AAC68867.1 .
    CCDSi CCDS28059.1.
    RefSeqi NP_001264970.1. NM_001278041.1.
    NP_034023.1. NM_009893.2.
    UniGenei Mm.20457.

    3D structure databases

    ProteinModelPortali Q9Z0E2.
    SMRi Q9Z0E2. Positions 46-131, 696-763, 774-851, 862-933.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000007171.

    PTM databases

    PhosphoSitei Q9Z0E2.

    Proteomic databases

    PRIDEi Q9Z0E2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000007171 ; ENSMUSP00000007171 ; ENSMUSG00000006958 .
    GeneIDi 12667.
    KEGGi mmu:12667.
    UCSCi uc007yre.2. mouse.

    Organism-specific databases

    CTDi 8646.
    MGIi MGI:1313268. Chrd.

    Phylogenomic databases

    eggNOGi NOG85639.
    GeneTreei ENSGT00730000110792.
    HOVERGENi HBG005330.
    InParanoidi Q9Z0E2.
    KOi K04657.
    OMAi RDPGEGC.
    OrthoDBi EOG7QNVK7.
    TreeFami TF106451.

    Miscellaneous databases

    NextBioi 281902.
    PMAP-CutDB Q9Z0E2.
    PROi Q9Z0E2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Z0E2.
    CleanExi MM_CHRD.
    Genevestigatori Q9Z0E2.

    Family and domain databases

    InterProi IPR016353. Chordin.
    IPR010895. CHRD.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF07452. CHRD. 4 hits.
    PF00093. VWC. 3 hits.
    [Graphical view ]
    PIRSFi PIRSF002496. Chordin. 1 hit.
    SMARTi SM00754. CHRD. 4 hits.
    SM00214. VWC. 4 hits.
    [Graphical view ]
    PROSITEi PS50933. CHRD. 4 hits.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "BMP-binding domains in the chordin secreted protein."
      Lu B., Bachiller D., Agius E., Piccolo S., De Robertis E.M.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: B6SJL/F1.
    2. "Coding sequence and expression patterns of mouse chordin and mapping of the cognate mouse chrd and human CHRD genes."
      Pappano W.N., Scott I.C., Clark T.G., Eddy R.L., Shows T.B., Greenspan D.S.
      Genomics 52:236-239(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling."
      Scott I.C., Blitz I.L., Pappano W.N., Maas S.A., Cho K.W.Y., Greenspan D.S.
      Nature 410:475-478(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TWSG1 AND BMP4.

    Entry informationi

    Entry nameiCHRD_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z0E2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3