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Q9Z0E2

- CHRD_MOUSE

UniProt

Q9Z0E2 - CHRD_MOUSE

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Protein

Chordin

Gene

Chrd

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.

GO - Molecular functioni

  1. heparin binding Source: MGI
  2. syndecan binding Source: MGI

GO - Biological processi

  1. BMP signaling pathway involved in spinal cord dorsal/ventral patterning Source: Ensembl
  2. central nervous system development Source: MGI
  3. dorsal/ventral pattern formation Source: MGI
  4. forebrain development Source: MGI
  5. gastrulation with mouth forming second Source: MGI
  6. mesoderm formation Source: MGI
  7. negative regulation of BMP signaling pathway Source: MGI
  8. negative regulation of cell migration Source: Ensembl
  9. negative regulation of osteoblast differentiation Source: MGI
  10. osteoblast differentiation Source: MGI
  11. pattern specification process Source: MGI
  12. positive regulation of cell adhesion Source: Ensembl
  13. positive regulation of mesenchymal cell proliferation Source: Ensembl
  14. skeletal system development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Chordin
Gene namesi
Name:Chrd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1313268. Chrd.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 948922ChordinPRO_0000005365Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi430 – 4301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi877 – 8771N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Cleaved by tolloid proteases; cleavage participates in dorsoventral patterning during early development.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9Z0E2.

PTM databases

PhosphoSiteiQ9Z0E2.

Miscellaneous databases

PMAP-CutDBQ9Z0E2.

Expressioni

Developmental stagei

Detected at high levels of a in 7 dpc mouse embryos; its level decrease at later developmental stages and in adult tissues.

Gene expression databases

BgeeiQ9Z0E2.
CleanExiMM_CHRD.
ExpressionAtlasiQ9Z0E2. baseline.
GenevestigatoriQ9Z0E2.

Interactioni

Subunit structurei

Interacts with TWSG1 and/or BMP4.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000007171.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0E2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 12678VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini168 – 277110CHRD 1PROSITE-ProRule annotationAdd
BLAST
Domaini279 – 398120CHRD 2PROSITE-ProRule annotationAdd
BLAST
Domaini399 – 520122CHRD 3PROSITE-ProRule annotationAdd
BLAST
Domaini526 – 646121CHRD 4PROSITE-ProRule annotationAdd
BLAST
Domaini699 – 75961VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini779 – 84567VWFC 3PROSITE-ProRule annotationAdd
BLAST
Domaini867 – 92761VWFC 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the chordin family.Curated
Contains 4 CHRD domains.PROSITE-ProRule annotation
Contains 4 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG85639.
GeneTreeiENSGT00730000110792.
HOVERGENiHBG005330.
InParanoidiQ9Z0E2.
KOiK04657.
OMAiRDPGEGC.
OrthoDBiEOG7QNVK7.
TreeFamiTF106451.

Family and domain databases

InterProiIPR016353. Chordin.
IPR010895. CHRD.
IPR001007. VWF_C.
[Graphical view]
PfamiPF07452. CHRD. 4 hits.
PF00093. VWC. 3 hits.
[Graphical view]
PIRSFiPIRSF002496. Chordin. 1 hit.
SMARTiSM00754. CHRD. 4 hits.
SM00214. VWC. 4 hits.
[Graphical view]
PROSITEiPS50933. CHRD. 4 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0E2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSLPAPPAP RLLLGLLLLG SRPASGTGPE PPALPIRSEK EPLPVRGAAG
60 70 80 90 100
CSFGGKVYAL DETWHPDLGE PFGVMRCVLC ACEAPQWARR GRGPGRVSCK
110 120 130 140 150
NIKPQCPTLA CRQPRQLPGH CCQTCPQERS NLDPQPAGLV FEYPRDPEHR
160 170 180 190 200
SYSDRGEPGV GERTRADGHT DFVALLTGPR SQAVARARVS LLRSSLRFSV
210 220 230 240 250
SYQRLDRPSR VRFTDPTGNI LFEHPATPTQ DGLVCGVWRA VPRLSVRLLR
260 270 280 290 300
AEQLRVALVT STHPSGEVWG PLIWQGALAA ETFSAILTLE DPLQRGVGGI
310 320 330 340 350
ALLTLSDTED SLHFLLLFRG LLGGLAQAPL KLQILHQGQL LRELQANTSA
360 370 380 390 400
QEPGFAEVLP SLTDQEMDWL ELGELQMVLE KAGGPELRIS GYITTRQSCD
410 420 430 440 450
VLQSVLCGAD ALIPVQTGAA GSASFILLGN GSLIYQVQVV GTGSEVVAMT
460 470 480 490 500
LETKPQRKNQ RTVLCHMAGL QPGGHMAVGM CSGLGARGAH MLLQNELFLN
510 520 530 540 550
VGTKDFPDGE LRGHVTALCY SGHSARYDRL PVPLAGALVL PPVRSQAAGH
560 570 580 590 600
AWLSLDTHCH LHYEVLLAGL GGSEQGTVTA HLLGPPGMPG PQRLLKGFYG
610 620 630 640 650
SEAQGVVKDL EPVLLRHLAQ GTASLLITTK SSPRGELRGQ VHIASQCEAG
660 670 680 690 700
GLRLASEGVQ MPLAPNGEAA TSPMLPAGPG PEAPVPAKHG SPGRPRDPNT
710 720 730 740 750
CFFEGQQRPH GARWAPNYDP LCSLCICQRR TVICDPVVCP PPSCPHPVQA
760 770 780 790 800
LDQCCPVCPE KQRSRDLPSL PNLEPGEGCY FDGDRSWRAA GTRWHPVVPP
810 820 830 840 850
FGLIKCAVCT CKGATGEVHC EKVQCPRLAC AQPVRANPTD CCKQCPVGSG
860 870 880 890 900
TNAKLGDPMQ ADGPRGCRFA GQWFPENQSW HPSVPPFGEM SCITCRCGAG
910 920 930 940
VPHCERDDCS PPLSCGSGKE SRCCSHCTAQ RSSETRTLPE LEKEAEHS
Length:948
Mass (Da):101,513
Last modified:May 1, 1999 - v1
Checksum:i4DC2DA01D9BD2147
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF096276 mRNA. Translation: AAD19895.1.
AF069501 mRNA. Translation: AAC68867.1.
CCDSiCCDS28059.1.
RefSeqiNP_001264970.1. NM_001278041.1.
NP_034023.1. NM_009893.2.
UniGeneiMm.20457.

Genome annotation databases

EnsembliENSMUST00000007171; ENSMUSP00000007171; ENSMUSG00000006958.
GeneIDi12667.
KEGGimmu:12667.
UCSCiuc007yre.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF096276 mRNA. Translation: AAD19895.1 .
AF069501 mRNA. Translation: AAC68867.1 .
CCDSi CCDS28059.1.
RefSeqi NP_001264970.1. NM_001278041.1.
NP_034023.1. NM_009893.2.
UniGenei Mm.20457.

3D structure databases

ProteinModelPortali Q9Z0E2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000007171.

PTM databases

PhosphoSitei Q9Z0E2.

Proteomic databases

PRIDEi Q9Z0E2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000007171 ; ENSMUSP00000007171 ; ENSMUSG00000006958 .
GeneIDi 12667.
KEGGi mmu:12667.
UCSCi uc007yre.2. mouse.

Organism-specific databases

CTDi 8646.
MGIi MGI:1313268. Chrd.

Phylogenomic databases

eggNOGi NOG85639.
GeneTreei ENSGT00730000110792.
HOVERGENi HBG005330.
InParanoidi Q9Z0E2.
KOi K04657.
OMAi RDPGEGC.
OrthoDBi EOG7QNVK7.
TreeFami TF106451.

Miscellaneous databases

NextBioi 281902.
PMAP-CutDB Q9Z0E2.
PROi Q9Z0E2.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z0E2.
CleanExi MM_CHRD.
ExpressionAtlasi Q9Z0E2. baseline.
Genevestigatori Q9Z0E2.

Family and domain databases

InterProi IPR016353. Chordin.
IPR010895. CHRD.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF07452. CHRD. 4 hits.
PF00093. VWC. 3 hits.
[Graphical view ]
PIRSFi PIRSF002496. Chordin. 1 hit.
SMARTi SM00754. CHRD. 4 hits.
SM00214. VWC. 4 hits.
[Graphical view ]
PROSITEi PS50933. CHRD. 4 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "BMP-binding domains in the chordin secreted protein."
    Lu B., Bachiller D., Agius E., Piccolo S., De Robertis E.M.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: B6SJL/F1.
  2. "Coding sequence and expression patterns of mouse chordin and mapping of the cognate mouse chrd and human CHRD genes."
    Pappano W.N., Scott I.C., Clark T.G., Eddy R.L., Shows T.B., Greenspan D.S.
    Genomics 52:236-239(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling."
    Scott I.C., Blitz I.L., Pappano W.N., Maas S.A., Cho K.W.Y., Greenspan D.S.
    Nature 410:475-478(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TWSG1 AND BMP4.

Entry informationi

Entry nameiCHRD_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0E2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3