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Protein

Chordin

Gene

Chrd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.

GO - Molecular functioni

  • heparin binding Source: MGI
  • syndecan binding Source: MGI

GO - Biological processi

  • BMP signaling pathway involved in spinal cord dorsal/ventral patterning Source: MGI
  • central nervous system development Source: MGI
  • dorsal/ventral pattern formation Source: MGI
  • forebrain development Source: MGI
  • gastrulation with mouth forming second Source: MGI
  • mesoderm formation Source: MGI
  • negative regulation of BMP signaling pathway Source: MGI
  • negative regulation of cell migration Source: MGI
  • negative regulation of osteoblast differentiation Source: MGI
  • osteoblast differentiation Source: MGI
  • pattern specification process Source: MGI
  • positive regulation of cell adhesion Source: MGI
  • positive regulation of mesenchymal cell proliferation Source: MGI
  • skeletal system development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Chordin
Gene namesi
Name:Chrd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1313268. Chrd.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000000536527 – 948ChordinAdd BLAST922

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi347N-linked (GlcNAc...)Sequence analysis1
Glycosylationi430N-linked (GlcNAc...)Sequence analysis1
Glycosylationi877N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Cleaved by tolloid proteases; cleavage participates in dorsoventral patterning during early development.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9Z0E2.
PaxDbiQ9Z0E2.
PRIDEiQ9Z0E2.

PTM databases

PhosphoSitePlusiQ9Z0E2.

Miscellaneous databases

PMAP-CutDBQ9Z0E2.

Expressioni

Developmental stagei

Detected at high levels of a in 7 dpc mouse embryos; its level decrease at later developmental stages and in adult tissues.

Gene expression databases

BgeeiENSMUSG00000006958.
CleanExiMM_CHRD.
ExpressionAtlasiQ9Z0E2. baseline and differential.
GenevisibleiQ9Z0E2. MM.

Interactioni

Subunit structurei

Interacts with TWSG1 and/or BMP4.1 Publication

GO - Molecular functioni

  • syndecan binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000007171.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0E2.
SMRiQ9Z0E2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 126VWFC 1PROSITE-ProRule annotationAdd BLAST78
Domaini168 – 277CHRD 1PROSITE-ProRule annotationAdd BLAST110
Domaini279 – 398CHRD 2PROSITE-ProRule annotationAdd BLAST120
Domaini399 – 520CHRD 3PROSITE-ProRule annotationAdd BLAST122
Domaini526 – 646CHRD 4PROSITE-ProRule annotationAdd BLAST121
Domaini699 – 759VWFC 2PROSITE-ProRule annotationAdd BLAST61
Domaini779 – 845VWFC 3PROSITE-ProRule annotationAdd BLAST67
Domaini867 – 927VWFC 4PROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Belongs to the chordin family.Curated
Contains 4 CHRD domains.PROSITE-ProRule annotation
Contains 4 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IEDE. Eukaryota.
ENOG410XSBA. LUCA.
GeneTreeiENSGT00730000110792.
HOVERGENiHBG005330.
InParanoidiQ9Z0E2.
KOiK04657.
OMAiCKQCPVG.
OrthoDBiEOG091G11A0.
TreeFamiTF106451.

Family and domain databases

InterProiIPR016353. Chordin.
IPR010895. CHRD.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF07452. CHRD. 2 hits.
PF00093. VWC. 3 hits.
[Graphical view]
PIRSFiPIRSF002496. Chordin. 1 hit.
SMARTiSM00754. CHRD. 4 hits.
SM00214. VWC. 4 hits.
[Graphical view]
PROSITEiPS50933. CHRD. 4 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0E2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSLPAPPAP RLLLGLLLLG SRPASGTGPE PPALPIRSEK EPLPVRGAAG
60 70 80 90 100
CSFGGKVYAL DETWHPDLGE PFGVMRCVLC ACEAPQWARR GRGPGRVSCK
110 120 130 140 150
NIKPQCPTLA CRQPRQLPGH CCQTCPQERS NLDPQPAGLV FEYPRDPEHR
160 170 180 190 200
SYSDRGEPGV GERTRADGHT DFVALLTGPR SQAVARARVS LLRSSLRFSV
210 220 230 240 250
SYQRLDRPSR VRFTDPTGNI LFEHPATPTQ DGLVCGVWRA VPRLSVRLLR
260 270 280 290 300
AEQLRVALVT STHPSGEVWG PLIWQGALAA ETFSAILTLE DPLQRGVGGI
310 320 330 340 350
ALLTLSDTED SLHFLLLFRG LLGGLAQAPL KLQILHQGQL LRELQANTSA
360 370 380 390 400
QEPGFAEVLP SLTDQEMDWL ELGELQMVLE KAGGPELRIS GYITTRQSCD
410 420 430 440 450
VLQSVLCGAD ALIPVQTGAA GSASFILLGN GSLIYQVQVV GTGSEVVAMT
460 470 480 490 500
LETKPQRKNQ RTVLCHMAGL QPGGHMAVGM CSGLGARGAH MLLQNELFLN
510 520 530 540 550
VGTKDFPDGE LRGHVTALCY SGHSARYDRL PVPLAGALVL PPVRSQAAGH
560 570 580 590 600
AWLSLDTHCH LHYEVLLAGL GGSEQGTVTA HLLGPPGMPG PQRLLKGFYG
610 620 630 640 650
SEAQGVVKDL EPVLLRHLAQ GTASLLITTK SSPRGELRGQ VHIASQCEAG
660 670 680 690 700
GLRLASEGVQ MPLAPNGEAA TSPMLPAGPG PEAPVPAKHG SPGRPRDPNT
710 720 730 740 750
CFFEGQQRPH GARWAPNYDP LCSLCICQRR TVICDPVVCP PPSCPHPVQA
760 770 780 790 800
LDQCCPVCPE KQRSRDLPSL PNLEPGEGCY FDGDRSWRAA GTRWHPVVPP
810 820 830 840 850
FGLIKCAVCT CKGATGEVHC EKVQCPRLAC AQPVRANPTD CCKQCPVGSG
860 870 880 890 900
TNAKLGDPMQ ADGPRGCRFA GQWFPENQSW HPSVPPFGEM SCITCRCGAG
910 920 930 940
VPHCERDDCS PPLSCGSGKE SRCCSHCTAQ RSSETRTLPE LEKEAEHS
Length:948
Mass (Da):101,513
Last modified:May 1, 1999 - v1
Checksum:i4DC2DA01D9BD2147
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF096276 mRNA. Translation: AAD19895.1.
AF069501 mRNA. Translation: AAC68867.1.
CCDSiCCDS28059.1.
RefSeqiNP_001264970.1. NM_001278041.1.
NP_034023.1. NM_009893.2.
UniGeneiMm.20457.

Genome annotation databases

EnsembliENSMUST00000007171; ENSMUSP00000007171; ENSMUSG00000006958.
GeneIDi12667.
KEGGimmu:12667.
UCSCiuc007yre.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF096276 mRNA. Translation: AAD19895.1.
AF069501 mRNA. Translation: AAC68867.1.
CCDSiCCDS28059.1.
RefSeqiNP_001264970.1. NM_001278041.1.
NP_034023.1. NM_009893.2.
UniGeneiMm.20457.

3D structure databases

ProteinModelPortaliQ9Z0E2.
SMRiQ9Z0E2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000007171.

PTM databases

PhosphoSitePlusiQ9Z0E2.

Proteomic databases

MaxQBiQ9Z0E2.
PaxDbiQ9Z0E2.
PRIDEiQ9Z0E2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000007171; ENSMUSP00000007171; ENSMUSG00000006958.
GeneIDi12667.
KEGGimmu:12667.
UCSCiuc007yre.2. mouse.

Organism-specific databases

CTDi8646.
MGIiMGI:1313268. Chrd.

Phylogenomic databases

eggNOGiENOG410IEDE. Eukaryota.
ENOG410XSBA. LUCA.
GeneTreeiENSGT00730000110792.
HOVERGENiHBG005330.
InParanoidiQ9Z0E2.
KOiK04657.
OMAiCKQCPVG.
OrthoDBiEOG091G11A0.
TreeFamiTF106451.

Miscellaneous databases

PMAP-CutDBQ9Z0E2.
PROiQ9Z0E2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006958.
CleanExiMM_CHRD.
ExpressionAtlasiQ9Z0E2. baseline and differential.
GenevisibleiQ9Z0E2. MM.

Family and domain databases

InterProiIPR016353. Chordin.
IPR010895. CHRD.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF07452. CHRD. 2 hits.
PF00093. VWC. 3 hits.
[Graphical view]
PIRSFiPIRSF002496. Chordin. 1 hit.
SMARTiSM00754. CHRD. 4 hits.
SM00214. VWC. 4 hits.
[Graphical view]
PROSITEiPS50933. CHRD. 4 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHRD_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0E2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.