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Protein

Neurochondrin

Gene

Ncdn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca2+-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth.3 Publications

GO - Biological processi

  • bone resorption Source: MGI
  • neuron projection development Source: UniProtKB
  • regulation of neuronal synaptic plasticity Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Neurochondrin
Alternative name(s):
M-Sema F-associating protein of 75 kDa
Norbin
Gene namesi
Name:Ncdn
Synonyms:Kiaa0607, Sfap75
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1347351. Ncdn.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • dendrite Source: UniProtKB
  • membrane Source: MGI
  • neuronal cell body Source: UniProtKB
  • neuron projection Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Death between 3.5 and 6.5 dpc. Heterozygous mutant do not display gross anatomic abnormalities. They however show abnormalities in developing cartilage. Nervous system-specific gene disruption by conditional knockout results in epileptic seizure. Displays no overt neurite outgrowth phenotype (PubMed:15790563). Shows a behavioral phenotype associated with a rodent model of schizophrenia, as observed in alterations in both sensorimotor gating and psychotomimetic-induced locomotor activity.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 729728NeurochondrinPRO_0000324618Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei448 – 4481PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Z0E0.
MaxQBiQ9Z0E0.
PaxDbiQ9Z0E0.
PRIDEiQ9Z0E0.

PTM databases

iPTMnetiQ9Z0E0.
PhosphoSiteiQ9Z0E0.
SwissPalmiQ9Z0E0.

Expressioni

Tissue specificityi

Expressed in the neuronal, chondral and bone tissues. Expressed in dendrites. Enriched in the brain in the surface layer I-IV. In brains, protein level increases in male but decreases in female with advancing age (at protein level). In adult brains, it is highly expressed in the forebrain and hindbrain. Highly expressed in the hippocampus, piriform cortex, septum, amygdaloid complex, medial geniculate nucleus, inferior colliculus, cerebellar nuclei and the nuclei of the Vth, VIIth, and XIIth cranial nerves. In bone tissues, it is expressed in osteoblasts and osteocytes.4 Publications

Developmental stagei

In the developing brain, it is first expressed in the hindbrain and spinal cord at E10.5 followed by expression in the midbrain at E11.5. By E18 it is also expressed in the diencephalon and telencephalon, with a strongest expression in the hindbrain. Highly expressed in the developing olfactory bulb and in the lateral choroid plexus.3 Publications

Gene expression databases

BgeeiQ9Z0E0.
CleanExiMM_NCDN.
GenevisibleiQ9Z0E0. MM.

Interactioni

Subunit structurei

Interacts with MCHR1 and GRM5 (By similarity). Interacts with SEMA4C and DIAPH1 (via FH3 domain).By similarity2 Publications

Protein-protein interaction databases

IntActiQ9Z0E0. 4 interactions.
MINTiMINT-4131225.
STRINGi10090.ENSMUSP00000030637.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0E0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the neurochondrin family.Curated

Phylogenomic databases

eggNOGiKOG2611. Eukaryota.
ENOG410XRYT. LUCA.
GeneTreeiENSGT00390000013601.
HOGENOMiHOG000113742.
HOVERGENiHBG097452.
InParanoidiQ9Z0E0.
OMAiATIRFLW.
OrthoDBiEOG72ZCDD.
PhylomeDBiQ9Z0E0.
TreeFamiTF323752.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR008709. Neurochondrin.
[Graphical view]
PANTHERiPTHR13109. PTHR13109. 1 hit.
PfamiPF05536. Neurochondrin. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Z0E0-1) [UniParc]FASTAAdd to basket

Also known as: Neurochondrin-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSCCDLAAAG QLGKAGIMAS DCEPALNQAE SRNPTLERYL GALREAKNDS
60 70 80 90 100
EQFAALLLVT KAVKAGDIDA KTRRRIFDAV GFTFPNRLLT TKEAPDGCPD
110 120 130 140 150
HVLRALGVAL LACFCSDPEL ASHPQVLNKI PILSTFLTAR GDPDDAARRS
160 170 180 190 200
MIDDTYQCLT AVAGTPRGPR HLIAGGTVSA LCQAYLGHGY GFDQALALLV
210 220 230 240 250
GLLAAAETQC WKEAEPDLLA VLRGLSEDFQ RAEDASKFEL CQLLPLFLPP
260 270 280 290 300
TTVPPECHRD LQAGLARILG SKLSSWQRNP ALKLAARLAH ACGSDWIPVG
310 320 330 340 350
SSGSKFLALL VNLACVEVRL ALEETGTEVK EDVVTACYAL MELGIQECTR
360 370 380 390 400
CEQSLLKEPQ KVQLVSIMKE AIGAVIHYLL QVGPEKQKEP FVFASVRILG
410 420 430 440 450
AWLAEETSSL RKEVCQLLPF LVRYAKTLYE EAEEASDISQ QVANLAISPT
460 470 480 490 500
TPGPSWPGDA LRLLLPGWCH LTVEDGPREI LIKEGAPSLL CKYFLQQWEL
510 520 530 540 550
TSPGHDTSVL PDSVEIGLQT CCHIFLNLVV TAPGLIKRDA CFTSLMNTLM
560 570 580 590 600
TSLPSLVQQQ GRLLLAANVA TLGLLMARLL STSPALQGTP ASRGFFAAAI
610 620 630 640 650
LFLSQSHVAR ATPGSDQAVL ALSPDYEGIW ADLQELWFLG MQAFTGCVPL
660 670 680 690 700
LPWLAPAALR SRWPQELLQL LGSVSPNSVK PEMVAAYQGV LVELARANRL
710 720
CREAMRLQAG EETASHYRMA ALEQCLSEP
Length:729
Mass (Da):78,895
Last modified:May 1, 1999 - v1
Checksum:iF23C439BDE1EDD9C
GO
Isoform 2 (identifier: Q9Z0E0-2) [UniParc]FASTAAdd to basket

Also known as: Neurochondrin-2

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: Missing.

Show »
Length:712
Mass (Da):77,304
Checksum:i3622A879C105341E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti109 – 1091A → S in AAH17126 (PubMed:12693553).Curated
Sequence conflicti164 – 1641G → D in BAE41841 (PubMed:19468303).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1717Missing in isoform 2. CuratedVSP_032317Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017608 Genomic DNA. Translation: BAA75226.1.
AB017609 Genomic DNA. Translation: BAA75227.1.
AB019041 Genomic DNA. Translation: BAA75228.1.
AB019041 Genomic DNA. Translation: BAA75229.1.
AK002938 mRNA. Translation: BAB22468.2.
AK154889 mRNA. Translation: BAE32905.1.
AK170502 mRNA. Translation: BAE41841.1.
AL606908 Genomic DNA. Translation: CAM19265.1.
BC017126 mRNA. Translation: AAH17126.1.
AK122327 mRNA. Translation: BAC65609.1.
CCDSiCCDS18659.1. [Q9Z0E0-1]
RefSeqiNP_036116.3. NM_011986.4. [Q9Z0E0-1]
XP_006503181.1. XM_006503118.2. [Q9Z0E0-2]
XP_006503182.1. XM_006503119.2. [Q9Z0E0-2]
XP_011238841.1. XM_011240539.1. [Q9Z0E0-1]
UniGeneiMm.206206.
Mm.456184.

Genome annotation databases

EnsembliENSMUST00000030637; ENSMUSP00000030637; ENSMUSG00000028833. [Q9Z0E0-1]
ENSMUST00000106116; ENSMUSP00000101722; ENSMUSG00000028833. [Q9Z0E0-1]
GeneIDi26562.
KEGGimmu:26562.
UCSCiuc008utt.2. mouse. [Q9Z0E0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017608 Genomic DNA. Translation: BAA75226.1.
AB017609 Genomic DNA. Translation: BAA75227.1.
AB019041 Genomic DNA. Translation: BAA75228.1.
AB019041 Genomic DNA. Translation: BAA75229.1.
AK002938 mRNA. Translation: BAB22468.2.
AK154889 mRNA. Translation: BAE32905.1.
AK170502 mRNA. Translation: BAE41841.1.
AL606908 Genomic DNA. Translation: CAM19265.1.
BC017126 mRNA. Translation: AAH17126.1.
AK122327 mRNA. Translation: BAC65609.1.
CCDSiCCDS18659.1. [Q9Z0E0-1]
RefSeqiNP_036116.3. NM_011986.4. [Q9Z0E0-1]
XP_006503181.1. XM_006503118.2. [Q9Z0E0-2]
XP_006503182.1. XM_006503119.2. [Q9Z0E0-2]
XP_011238841.1. XM_011240539.1. [Q9Z0E0-1]
UniGeneiMm.206206.
Mm.456184.

3D structure databases

ProteinModelPortaliQ9Z0E0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z0E0. 4 interactions.
MINTiMINT-4131225.
STRINGi10090.ENSMUSP00000030637.

PTM databases

iPTMnetiQ9Z0E0.
PhosphoSiteiQ9Z0E0.
SwissPalmiQ9Z0E0.

Proteomic databases

EPDiQ9Z0E0.
MaxQBiQ9Z0E0.
PaxDbiQ9Z0E0.
PRIDEiQ9Z0E0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030637; ENSMUSP00000030637; ENSMUSG00000028833. [Q9Z0E0-1]
ENSMUST00000106116; ENSMUSP00000101722; ENSMUSG00000028833. [Q9Z0E0-1]
GeneIDi26562.
KEGGimmu:26562.
UCSCiuc008utt.2. mouse. [Q9Z0E0-1]

Organism-specific databases

CTDi23154.
MGIiMGI:1347351. Ncdn.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2611. Eukaryota.
ENOG410XRYT. LUCA.
GeneTreeiENSGT00390000013601.
HOGENOMiHOG000113742.
HOVERGENiHBG097452.
InParanoidiQ9Z0E0.
OMAiATIRFLW.
OrthoDBiEOG72ZCDD.
PhylomeDBiQ9Z0E0.
TreeFamiTF323752.

Miscellaneous databases

ChiTaRSiNcdn. mouse.
PROiQ9Z0E0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z0E0.
CleanExiMM_NCDN.
GenevisibleiQ9Z0E0. MM.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR008709. Neurochondrin.
[Graphical view]
PANTHERiPTHR13109. PTHR13109. 1 hit.
PfamiPF05536. Neurochondrin. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Induction of hydroxyapatite resorptive activity in bone marrow cell populations resistant to bafilomycin A1 by a factor with restricted expression to bone and brain, neurochondrin."
    Ishiduka Y., Mochizuki R., Yanai K., Takatsuka M., Nonomura T., Niida S., Horiguchi H., Maeda N., Fukamizu A.
    Biochim. Biophys. Acta 1450:92-98(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS 1 AND 2).
    Strain: C57BL/6N.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J and NOD.
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary tumor.
  5. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 78-729.
    Tissue: Brain.
  6. "Semaphorin 4C, a transmembrane semaphorin, associates with a neurite-outgrowth-related protein, SFAP75."
    Ohoka Y., Hirotani M., Sugimoto H., Fujioka S., Furuyama T., Inagaki S.
    Biochem. Biophys. Res. Commun. 280:237-243(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INTERACTION WITH SEMA4C.
  7. "Age- and sex-related expression of norbin in the brain cortex of mice."
    Mani S.T., Kumar R.C., Thakur M.K.
    Neurosci. Lett. 308:57-59(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  8. Erratum
    Ohoka Y., Hirotani M., Sugimoto H., Fujioka S., Furuyama T., Inagaki S.
    Biochem. Biophys. Res. Commun. 281:266-266(2001)
  9. "Targeted disruption of the neurochondrin/norbin gene results in embryonic lethality."
    Mochizuki R., Dateki M., Yanai K., Ishizuka Y., Amizuka N., Kawashima H., Koga Y., Ozawa H., Fukamizu A.
    Biochem. Biophys. Res. Commun. 310:1219-1226(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE.
  10. "Expression of neurochondrin in the developing and adult mouse brain."
    Istvanffy R., Vogt Weisenhorn D.M., Floss T., Wurst W.
    Dev. Genes Evol. 214:206-209(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  11. "Neurochondrin negatively regulates CaMKII phosphorylation, and nervous system-specific gene disruption results in epileptic seizure."
    Dateki M., Horii T., Kasuya Y., Mochizuki R., Nagao Y., Ishida J., Sugiyama F., Tanimoto K., Yagami K., Imai H., Fukamizu A.
    J. Biol. Chem. 280:20503-20508(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  12. "Identification of Neurochondrin as a new interaction partner of the FH3 domain of the Diaphanous-related formin Dia1."
    Schwaibold E.M., Brandt D.T.
    Biochem. Biophys. Res. Commun. 373:366-372(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DIAPH1.
  13. "Norbin is an endogenous regulator of metabotropic glutamate receptor 5 signaling."
    Wang H., Westin L., Nong Y., Birnbaum S., Bendor J., Brismar H., Nestler E., Aperia A., Flajolet M., Greengard P.
    Science 326:1554-1557(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Lung, Spleen and Testis.

Entry informationi

Entry nameiNCDN_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0E0
Secondary accession number(s): Q3TCW4
, Q80TW1, Q91YH7, Q9CW81, Q9QUQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 1, 1999
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.