ID CX3C1_MOUSE Reviewed; 354 AA. AC Q9Z0D9; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1999, sequence version 1. DT 27-MAR-2024, entry version 179. DE RecName: Full=CX3C chemokine receptor 1 {ECO:0000303|PubMed:9918795}; DE Short=C-X3-C CKR-1 {ECO:0000303|PubMed:9918795}; DE Short=CX3CR1 {ECO:0000303|PubMed:9918795}; DE Short=mCX3CR1 {ECO:0000303|PubMed:9918795}; DE AltName: Full=Fractalkine receptor {ECO:0000303|PubMed:9918795}; GN Name=Cx3cr1 {ECO:0000303|PubMed:9918795}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION. RC STRAIN=129/Sv; RX PubMed=9918795; DOI=10.1006/bbrc.1998.9849; RA Combadiere C., Gao J.-L., Tiffany H.L., Murphy P.M.; RT "Gene cloning, RNA distribution, and functional expression of mCX3CR1, a RT mouse chemotactic receptor for the CX3C chemokine fractalkine."; RL Biochem. Biophys. Res. Commun. 253:728-732(1998). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=129/SvJ; RA Coultas L., McColl S.R.; RT "Cloning and characterization of murine CX3CR1, a receptor for murine RT fractalkine/neurotactin."; RL Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Czech II; TISSUE=Mammary gland; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP FUNCTION, SUBCELLULAR LOCATION, AND MUTAGENESIS OF 127-ASP-ARG-128 AND RP ARG-128. RX PubMed=10187784; DOI=10.1074/jbc.274.15.10053; RA Haskell C.A., Cleary M.D., Charo I.F.; RT "Molecular uncoupling of fractalkine-mediated cell adhesion and signal RT transduction. Rapid flow arrest of CX3CR1-expressing cells is independent RT of G-protein activation."; RL J. Biol. Chem. 274:10053-10058(1999). RN [5] RP TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE. RX PubMed=10805752; DOI=10.1128/mcb.20.11.4106-4114.2000; RA Jung S., Aliberti J., Graemmel P., Sunshine M.J., Kreutzberg G.W., Sher A., RA Littman D.R.; RT "Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion RT and green fluorescent protein reporter gene insertion."; RL Mol. Cell. Biol. 20:4106-4114(2000). RN [6] RP FUNCTION. RX PubMed=11544273; DOI=10.1172/jci12976; RA Haskell C.A., Hancock W.W., Salant D.J., Gao W., Csizmadia V., Peters W., RA Faia K., Fituri O., Rottman J.B., Charo I.F.; RT "Targeted deletion of CX(3)CR1 reveals a role for fractalkine in cardiac RT allograft rejection."; RL J. Clin. Invest. 108:679-688(2001). RN [7] RP FUNCTION, AND TISSUE SPECIFICITY. RX PubMed=12871640; DOI=10.1016/s1074-7613(03)00174-2; RA Geissmann F., Jung S., Littman D.R.; RT "Blood monocytes consist of two principal subsets with distinct migratory RT properties."; RL Immunity 19:71-82(2003). RN [8] RP FUNCTION, AND DISRUPTION PHENOTYPE. RX PubMed=12569158; DOI=10.1172/jci15555; RA Lesnik P., Haskell C.A., Charo I.F.; RT "Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine RT in atherogenesis."; RL J. Clin. Invest. 111:333-340(2003). RN [9] RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE. RX PubMed=15653504; DOI=10.1126/science.1102901; RA Niess J.H., Brand S., Gu X., Landsman L., Jung S., McCormick B.A., RA Vyas J.M., Boes M., Ploegh H.L., Fox J.G., Littman D.R., Reinecker H.C.; RT "CX3CR1-mediated dendritic cell access to the intestinal lumen and RT bacterial clearance."; RL Science 307:254-258(2005). RN [10] RP FUNCTION, AND DISRUPTION PHENOTYPE. RX PubMed=16675847; DOI=10.1096/fj.05-5465com; RA Huang D., Shi F.D., Jung S., Pien G.C., Wang J., Salazar-Mather T.P., RA He T.T., Weaver J.T., Ljunggren H.G., Biron C.A., Littman D.R., RA Ransohoff R.M.; RT "The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells RT that modify experimental autoimmune encephalomyelitis within the central RT nervous system."; RL FASEB J. 20:896-905(2006). RN [11] RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE. RX PubMed=16732273; DOI=10.1038/nn1715; RA Cardona A.E., Pioro E.P., Sasse M.E., Kostenko V., Cardona S.M., RA Dijkstra I.M., Huang D., Kidd G., Dombrowski S., Dutta R., Lee J.C., RA Cook D.N., Jung S., Lira S.A., Littman D.R., Ransohoff R.M.; RT "Control of microglial neurotoxicity by the fractalkine receptor."; RL Nat. Neurosci. 9:917-924(2006). RN [12] RP FUNCTION. RX PubMed=18322241; DOI=10.4049/jimmunol.180.6.4283; RA Lu P., Li L., Kuno K., Wu Y., Baba T., Li Y.Y., Zhang X., Mukaida N.; RT "Protective roles of the fractalkine/CX3CL1-CX3CR1 interactions in alkali- RT induced corneal neovascularization through enhanced antiangiogenic factor RT expression."; RL J. Immunol. 180:4283-4291(2008). RN [13] RP FUNCTION. RX PubMed=18971423; DOI=10.1182/blood-2008-07-170787; RA Landsman L., Bar-On L., Zernecke A., Kim K.W., Krauthgamer R., RA Shagdarsuren E., Lira S.A., Weissman I.L., Weber C., Jung S.; RT "CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting RT cell survival."; RL Blood 113:963-972(2009). RN [14] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-345, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Brain; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [15] RP FUNCTION. RX PubMed=21037587; DOI=10.1038/nm.2253; RA Mionnet C., Buatois V., Kanda A., Milcent V., Fleury S., Lair D., RA Langelot M., Lacoeuille Y., Hessel E., Coffman R., Magnan A., RA Dombrowicz D., Glaichenhaus N., Julia V.; RT "CX3CR1 is required for airway inflammation by promoting T helper cell RT survival and maintenance in inflamed lung."; RL Nat. Med. 16:1305-1312(2010). RN [16] RP FUNCTION, AND DISRUPTION PHENOTYPE. RX PubMed=21778362; DOI=10.1126/science.1202529; RA Paolicelli R.C., Bolasco G., Pagani F., Maggi L., Scianni M., RA Panzanelli P., Giustetto M., Ferreira T.A., Guiducci E., Dumas L., RA Ragozzino D., Gross C.T.; RT "Synaptic pruning by microglia is necessary for normal brain development."; RL Science 333:1456-1458(2011). RN [17] RP FUNCTION, AND DISRUPTION PHENOTYPE. RX PubMed=24487234; DOI=10.1038/nn.3641; RA Zhan Y., Paolicelli R.C., Sforazzini F., Weinhard L., Bolasco G., RA Pagani F., Vyssotski A.L., Bifone A., Gozzi A., Ragozzino D., Gross C.T.; RT "Deficient neuron-microglia signaling results in impaired functional brain RT connectivity and social behavior."; RL Nat. Neurosci. 17:400-406(2014). RN [18] RP FUNCTION, AND DISRUPTION PHENOTYPE. RX PubMed=29326275; DOI=10.1126/science.aao1503; RA Leonardi I., Li X., Semon A., Li D., Doron I., Putzel G., Bar A., RA Prieto D., Rescigno M., McGovern D.P.B., Pla J., Iliev I.D.; RT "CX3CR1+ mononuclear phagocytes control immunity to intestinal fungi."; RL Science 359:232-236(2018). RN [19] RP FUNCTION. RX PubMed=33548172; DOI=10.1016/j.cell.2021.01.016; RA Doron I., Leonardi I., Li X.V., Fiers W.D., Semon A., Bialt-DeCelie M., RA Migaud M., Gao I.H., Lin W.Y., Kusakabe T., Puel A., Iliev I.D.; RT "Human gut mycobiota tune immunity via CARD9-dependent induction of anti- RT fungal IgG antibodies."; RL Cell 0:0-0(2021). CC -!- FUNCTION: Receptor for the C-X3-C chemokine fractalkine (CX3CL1) CC present on many early leukocyte cells; CX3CR1-CX3CL1 signaling exerts CC distinct functions in different tissue compartments, such as immune CC response, inflammation, cell adhesion and chemotaxis (PubMed:9918795, CC PubMed:10187784). CX3CR1-CX3CL1 signaling mediates cell migratory CC functions (PubMed:11544273, PubMed:12871640, PubMed:16675847, CC PubMed:18322241). Responsible for the recruitment of natural killer CC (NK) cells to inflamed tissues (PubMed:11544273, PubMed:16675847). Acts CC as a regulator of inflammation process leading to atherogenesis by CC mediating macrophage and monocyte recruitment to inflamed CC atherosclerotic plaques, promoting cell survival (PubMed:12569158, CC PubMed:18971423). Involved in airway inflammation by promoting CC interleukin 2-producing T helper (Th2) cell survival in inflamed lung CC (PubMed:21037587). Involved in the migration of circulating monocytes CC to non-inflamed tissues, where they differentiate into macrophages and CC dendritic cells (PubMed:12871640). Acts as a negative regulator of CC angiogenesis, probably by promoting macrophage chemotaxis CC (PubMed:18322241). Plays a key role in brain microglia by regulating CC inflammatory response in the central nervous system (CNS) and CC regulating synapse maturation (PubMed:16732273, PubMed:21778362, CC PubMed:24487234). Required to restrain the microglial inflammatory CC response in the CNS and the resulting parenchymal damage in response to CC pathological stimuli (PubMed:16732273). Involved in brain development CC by participating in synaptic pruning, a natural process during which CC brain microglia eliminates extra synapses during postnatal development CC (PubMed:21778362). Synaptic pruning by microglia is required to promote CC the maturation of circuit connectivity during brain development CC (PubMed:24487234). Acts as an important regulator of the gut microbiota CC by controlling immunity to intestinal bacteria and fungi CC (PubMed:15653504, PubMed:29326275). Expressed in lamina propria CC dendritic cells in the small intestine, which form transepithelial CC dendrites capable of taking up bacteria in order to provide defense CC against pathogenic bacteria (PubMed:15653504). Required to initiate CC innate and adaptive immune responses against dissemination of commensal CC fungi (mycobiota) component of the gut: expressed in mononuclear CC phagocytes (MNPs) and acts by promoting induction of antifungal IgG CC antibodies response to confer protection against disseminated CC C.albicans or C.auris infection (PubMed:29326275, PubMed:33548172). CC Also acts as a receptor for C-C motif chemokine CCL26, inducing cell CC chemotaxis (By similarity). {ECO:0000250|UniProtKB:P49238, CC ECO:0000269|PubMed:10187784, ECO:0000269|PubMed:11544273, CC ECO:0000269|PubMed:12569158, ECO:0000269|PubMed:12871640, CC ECO:0000269|PubMed:15653504, ECO:0000269|PubMed:16675847, CC ECO:0000269|PubMed:16732273, ECO:0000269|PubMed:18322241, CC ECO:0000269|PubMed:18971423, ECO:0000269|PubMed:21037587, CC ECO:0000269|PubMed:21778362, ECO:0000269|PubMed:24487234, CC ECO:0000269|PubMed:29326275, ECO:0000269|PubMed:33548172, CC ECO:0000269|PubMed:9918795}. CC -!- SUBUNIT: Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or CC ITGA4:ITGB1. {ECO:0000250|UniProtKB:P49238}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10187784}; CC Multi-pass membrane protein {ECO:0000255}. CC -!- TISSUE SPECIFICITY: Specifically expressed in subsets of leukocytes: CC expressed in monocytes, subsets of T-cells and natural killer (NK) CC cells in the circulation, dendritic cells, as well as in microglia in CC the central nervous system (CNS) (PubMed:10805752, PubMed:12871640, CC PubMed:16732273). Expression level subdivides blood monocytes into two CC major functional subsets; CD14(+)CD16(-)-CX3CR1(low) inflammatory CC monocytes and CD14(low)CD16(+)CX3CR1(high) homeostatic monocytes CC (PubMed:12871640). Expressed in myeloid-derived mucosal dendritic CC cells, which populate the entire lamina propria of the small intestine CC (PubMed:15653504). {ECO:0000269|PubMed:10805752, CC ECO:0000269|PubMed:12871640, ECO:0000269|PubMed:15653504, CC ECO:0000269|PubMed:16732273}. CC -!- PTM: This protein is not N-glycosylated which is unusual for G-protein- CC coupled receptors. {ECO:0000250|UniProtKB:P35411}. CC -!- DISRUPTION PHENOTYPE: No visible phenotype in normal conditions; mice CC develop normally and are fertile (PubMed:10805752). Mice lacking both CC Cx3cr1 and Apoe show decreased atherogenesis (PubMed:12569158). In CC experimental autoimmune encephalomyelitis (EAE) model mice, recruitment CC of natural killer (NK) cells in the inflamed central nervous system CC (CNS) is impaired, leading to increased EAE-related mortality, CC nonremitting spastic paraplegia and hemorrhagic inflammatory lesions CC (PubMed:16675847). Mice show an increased microglial inflammatory CC response and neuronal death in several models of CNS insult CC (PubMed:16732273). Mice display reduced airway inflammation in lung CC after allergen sensitization (PubMed:21037587). Mice display a CC transient decrease in microglia density, leading to synaptic deficits CC characterized by an excess of weak excitatory synapses: defects are CC caused by a failure to eliminate immature synaptic connections during CC the second and third postnatal weeks (PubMed:21778362). Deficient CC synaptic pruning is associated with weak synaptic transmission, CC decreased functional brain connectivity, deficits in social interaction CC and increased repetitive-behavior phenotypes (PubMed:24487234). Defects CC of lamina propria dendritic cells are observed, leading to impair the CC sampling of bacteria from the intestinal lumen and affect their ability CC to take up invasive pathogens (PubMed:15653504). Mice are more CC susceptible to severe colitis that is rescued by antifungal treatment CC and display changes in gut fungal communities (PubMed:29326275). CC {ECO:0000269|PubMed:10805752, ECO:0000269|PubMed:12569158, CC ECO:0000269|PubMed:15653504, ECO:0000269|PubMed:16675847, CC ECO:0000269|PubMed:16732273, ECO:0000269|PubMed:21037587, CC ECO:0000269|PubMed:21778362, ECO:0000269|PubMed:24487234, CC ECO:0000269|PubMed:29326275}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF074912; AAD08665.1; -; Genomic_DNA. DR EMBL; AF102269; AAC72408.1; -; mRNA. DR EMBL; BC012653; AAH12653.1; -; mRNA. DR CCDS; CCDS40806.1; -. DR RefSeq; NP_034117.3; NM_009987.4. DR AlphaFoldDB; Q9Z0D9; -. DR SMR; Q9Z0D9; -. DR STRING; 10090.ENSMUSP00000150463; -. DR iPTMnet; Q9Z0D9; -. DR PhosphoSitePlus; Q9Z0D9; -. DR SwissPalm; Q9Z0D9; -. DR PaxDb; 10090-ENSMUSP00000063986; -. DR ProteomicsDB; 285403; -. DR Antibodypedia; 6554; 864 antibodies from 46 providers. DR DNASU; 13051; -. DR Ensembl; ENSMUST00000064165.5; ENSMUSP00000063986.4; ENSMUSG00000052336.8. DR Ensembl; ENSMUST00000177637.2; ENSMUSP00000136413.2; ENSMUSG00000052336.8. DR Ensembl; ENSMUST00000215016.2; ENSMUSP00000150463.2; ENSMUSG00000052336.8. DR GeneID; 13051; -. DR KEGG; mmu:13051; -. DR UCSC; uc009sbz.2; mouse. DR AGR; MGI:1333815; -. DR CTD; 1524; -. DR MGI; MGI:1333815; Cx3cr1. DR VEuPathDB; HostDB:ENSMUSG00000052336; -. DR eggNOG; ENOG502QVQK; Eukaryota. DR GeneTree; ENSGT01020000230359; -. DR HOGENOM; CLU_009579_8_3_1; -. DR InParanoid; Q9Z0D9; -. DR OMA; TDIQEFG; -. DR OrthoDB; 4604454at2759; -. DR PhylomeDB; Q9Z0D9; -. DR TreeFam; TF330966; -. DR Reactome; R-MMU-380108; Chemokine receptors bind chemokines. DR Reactome; R-MMU-418594; G alpha (i) signalling events. DR BioGRID-ORCS; 13051; 3 hits in 76 CRISPR screens. DR ChiTaRS; Cx3cr1; mouse. DR PRO; PR:Q9Z0D9; -. DR Proteomes; UP000000589; Chromosome 9. DR RNAct; Q9Z0D9; Protein. DR Bgee; ENSMUSG00000052336; Expressed in lumbar subsegment of spinal cord and 177 other cell types or tissues. DR ExpressionAtlas; Q9Z0D9; baseline and differential. DR GO; GO:0009986; C:cell surface; IDA:ARUK-UCL. DR GO; GO:0097447; C:dendritic tree; ISO:MGI. DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central. DR GO; GO:0032809; C:neuronal cell body membrane; ISO:MGI. DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI. DR GO; GO:0005886; C:plasma membrane; ISO:MGI. DR GO; GO:0019957; F:C-C chemokine binding; IBA:GO_Central. DR GO; GO:0016493; F:C-C chemokine receptor activity; IBA:GO_Central. DR GO; GO:0019960; F:C-X3-C chemokine binding; IPI:ARUK-UCL. DR GO; GO:0016495; F:C-X3-C chemokine receptor activity; IDA:UniProtKB. DR GO; GO:0004950; F:chemokine receptor activity; ISO:MGI. DR GO; GO:0031737; F:CX3C chemokine receptor binding; ISO:MGI. DR GO; GO:0004896; F:cytokine receptor activity; IMP:MGI. DR GO; GO:0004930; F:G protein-coupled receptor activity; IMP:ARUK-UCL. DR GO; GO:0002250; P:adaptive immune response; IMP:UniProtKB. DR GO; GO:0061760; P:antifungal innate immune response; IMP:UniProtKB. DR GO; GO:0035425; P:autocrine signaling; ISO:MGI. DR GO; GO:0007420; P:brain development; IMP:UniProtKB. DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central. DR GO; GO:0007155; P:cell adhesion; IPI:ARUK-UCL. DR GO; GO:0060326; P:cell chemotaxis; ISO:MGI. DR GO; GO:0098609; P:cell-cell adhesion; ISO:MGI. DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IGI:ARUK-UCL. DR GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Ensembl. DR GO; GO:0071356; P:cellular response to tumor necrosis factor; ISO:MGI. DR GO; GO:0021626; P:central nervous system maturation; IMP:ARUK-UCL. DR GO; GO:0070098; P:chemokine-mediated signaling pathway; ISO:MGI. DR GO; GO:0006935; P:chemotaxis; ISO:MGI. DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISO:MGI. DR GO; GO:0048874; P:host-mediated regulation of intestinal microbiota composition; IMP:UniProtKB. DR GO; GO:0006955; P:immune response; IMP:UniProtKB. DR GO; GO:0045087; P:innate immune response; IC:ARUK-UCL. DR GO; GO:0030595; P:leukocyte chemotaxis; IMP:UniProtKB. DR GO; GO:0050901; P:leukocyte tethering or rolling; IGI:ARUK-UCL. DR GO; GO:0007613; P:memory; ISO:MGI. DR GO; GO:0001774; P:microglial cell activation; ISO:MGI. DR GO; GO:0002282; P:microglial cell activation involved in immune response; IMP:UniProtKB. DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IMP:ARUK-UCL. DR GO; GO:0150090; P:multiple spine synapse organization, single dendrite; IMP:ARUK-UCL. DR GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; ISO:MGI. DR GO; GO:0030336; P:negative regulation of cell migration; ISO:MGI. DR GO; GO:0002881; P:negative regulation of chronic inflammatory response to non-antigenic stimulus; ISO:MGI. DR GO; GO:0110091; P:negative regulation of hippocampal neuron apoptotic process; ISO:MGI. DR GO; GO:0032691; P:negative regulation of interleukin-1 beta production; ISO:MGI. DR GO; GO:1900272; P:negative regulation of long-term synaptic potentiation; ISO:MGI. DR GO; GO:1904150; P:negative regulation of microglial cell mediated cytotoxicity; IMP:UniProtKB. DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IMP:ARUK-UCL. DR GO; GO:0045766; P:positive regulation of angiogenesis; ISO:MGI. DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; ISO:MGI. DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central. DR GO; GO:1903721; P:positive regulation of I-kappaB phosphorylation; ISO:MGI. DR GO; GO:1904141; P:positive regulation of microglial cell migration; ISO:MGI. DR GO; GO:0090026; P:positive regulation of monocyte chemotaxis; IMP:UniProtKB. DR GO; GO:0002052; P:positive regulation of neuroblast proliferation; ISO:MGI. DR GO; GO:0050769; P:positive regulation of neurogenesis; IMP:ARUK-UCL. DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; ISO:MGI. DR GO; GO:0045428; P:regulation of nitric oxide biosynthetic process; IGI:ARUK-UCL. DR GO; GO:0032680; P:regulation of tumor necrosis factor production; IGI:ARUK-UCL. DR GO; GO:0002931; P:response to ischemia; ISO:MGI. DR GO; GO:0035176; P:social behavior; IMP:ARUK-UCL. DR GO; GO:0060074; P:synapse maturation; IMP:ARUK-UCL. DR GO; GO:0098883; P:synapse pruning; IMP:UniProtKB. DR CDD; cd15186; 7tmA_CX3CR1; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR005387; Chemokine_CX3CR1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR PANTHER; PTHR10489; CELL ADHESION MOLECULE; 1. DR PANTHER; PTHR10489:SF947; CX3C CHEMOKINE RECEPTOR 1; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01562; FRACTALKINER. DR PRINTS; PR00237; GPCRRHODOPSN. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR Genevisible; Q9Z0D9; MM. PE 1: Evidence at protein level; KW Adaptive immunity; Cell membrane; Disulfide bond; KW G-protein coupled receptor; Immunity; Inflammatory response; KW Innate immunity; Membrane; Phosphoprotein; Receptor; Reference proteome; KW Transducer; Transmembrane; Transmembrane helix. FT CHAIN 1..354 FT /note="CX3C chemokine receptor 1" FT /id="PRO_0000069327" FT TOPO_DOM 1..32 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 33..60 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 61..70 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 71..91 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 92..104 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 105..126 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 127..143 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 144..168 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 169..196 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 197..216 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 217..232 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 233..257 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 258..274 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 275..298 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 299..354 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT MOD_RES 345 FT /note="Phosphothreonine" FT /evidence="ECO:0007744|PubMed:21183079" FT DISULFID 103..176 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" FT MUTAGEN 127..128 FT /note="DR->NN: In DR/NN; abolished activity without FT affecting avility to bind CX3CL1." FT /evidence="ECO:0000269|PubMed:10187784" FT MUTAGEN 128 FT /note="R->N: Abolished activity without affecting avility FT to bind CX3CL1." FT /evidence="ECO:0000269|PubMed:10187784" SQ SEQUENCE 354 AA; 40266 MW; 12C745E8E3755CA9 CRC64; MSTSFPELDL ENFEYDDSAE ACYLGDIVAF GTIFLSVFYA LVFTFGLVGN LLVVLALTNS RKPKSITDIY LLNLALSDLL FVATLPFWTH YLISHEGLHN AMCKLTTAFF FIGFFGGIFF ITVISIDRYL AIVLAANSMN NRTVQHGVTI SLGVWAAAIL VASPQFMFTK RKDNECLGDY PEVLQEMWPV LRNSEVNILG FALPLLIMSF CYFRIIQTLF SCKNRKKARA VRLILLVVFA FFLFWTPYNI MIFLETLKFY NFFPSCDMKR DLRLALSVTE TVAFSHCCLN PFIYAFAGEK FRRYLGHLYR KCLAVLCGHP VHTGFSPESQ RSRQDSILSS FTHYTSEGDG SLLL //