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Protein

CX3C chemokine receptor 1

Gene

Cx3cr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions.

GO - Molecular functioni

  1. C-X3-C chemokine receptor activity Source: Ensembl
  2. cytokine receptor activity Source: MGI

GO - Biological processi

  1. cell adhesion Source: InterPro
  2. cellular response to lipopolysaccharide Source: Ensembl
  3. cellular response to transforming growth factor beta stimulus Source: Ensembl
  4. cerebral cortex cell migration Source: MGI
  5. cytokine-mediated signaling pathway Source: MGI
  6. macrophage chemotaxis Source: MGI
  7. microglial cell activation involved in immune response Source: MGI
  8. negative regulation of angiogenesis Source: MGI
  9. negative regulation of cell migration Source: Ensembl
  10. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  11. positive regulation of angiogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
CX3C chemokine receptor 1
Short name:
C-X3-C CKR-1
Short name:
CX3CR1
Alternative name(s):
Fractalkine receptor
Gene namesi
Name:Cx3cr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1333815. Cx3cr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
BLAST
Transmembranei33 – 6028Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini61 – 7010CytoplasmicSequence Analysis
Transmembranei71 – 9121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini92 – 10413ExtracellularSequence AnalysisAdd
BLAST
Transmembranei105 – 12622Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini127 – 14317CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei144 – 16825Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini169 – 19628ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 21620Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini217 – 23216CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei233 – 25725Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini258 – 27417ExtracellularSequence AnalysisAdd
BLAST
Transmembranei275 – 29824Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini299 – 35456CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. neuronal cell body membrane Source: Ensembl
  3. neuron projection Source: Ensembl
  4. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354CX3C chemokine receptor 1PRO_0000069327Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi103 ↔ 176PROSITE-ProRule annotation

Post-translational modificationi

This protein is not N-glycosylated which is unusual for G-protein-coupled receptors.

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9Z0D9.
PRIDEiQ9Z0D9.

PTM databases

PhosphoSiteiQ9Z0D9.

Expressioni

Gene expression databases

BgeeiQ9Z0D9.
CleanExiMM_CX3CR1.
ExpressionAtlasiQ9Z0D9. baseline and differential.
GenevestigatoriQ9Z0D9.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0D9.
SMRiQ9Z0D9. Positions 34-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG151350.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ9Z0D9.
KOiK04192.
OMAiTMTETIL.
OrthoDBiEOG7327P9.
PhylomeDBiQ9Z0D9.
TreeFamiTF330966.

Family and domain databases

InterProiIPR005387. Chemokine_CX3CR1.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01562. FRACTALKINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z0D9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSFPELDL ENFEYDDSAE ACYLGDIVAF GTIFLSVFYA LVFTFGLVGN
60 70 80 90 100
LLVVLALTNS RKPKSITDIY LLNLALSDLL FVATLPFWTH YLISHEGLHN
110 120 130 140 150
AMCKLTTAFF FIGFFGGIFF ITVISIDRYL AIVLAANSMN NRTVQHGVTI
160 170 180 190 200
SLGVWAAAIL VASPQFMFTK RKDNECLGDY PEVLQEMWPV LRNSEVNILG
210 220 230 240 250
FALPLLIMSF CYFRIIQTLF SCKNRKKARA VRLILLVVFA FFLFWTPYNI
260 270 280 290 300
MIFLETLKFY NFFPSCDMKR DLRLALSVTE TVAFSHCCLN PFIYAFAGEK
310 320 330 340 350
FRRYLGHLYR KCLAVLCGHP VHTGFSPESQ RSRQDSILSS FTHYTSEGDG

SLLL
Length:354
Mass (Da):40,266
Last modified:April 30, 1999 - v1
Checksum:i12C745E8E3755CA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074912 Genomic DNA. Translation: AAD08665.1.
AF102269 mRNA. Translation: AAC72408.1.
BC012653 mRNA. Translation: AAH12653.1.
CCDSiCCDS40806.1.
RefSeqiNP_034117.3. NM_009987.4.
UniGeneiMm.44065.

Genome annotation databases

EnsembliENSMUST00000064165; ENSMUSP00000063986; ENSMUSG00000052336.
ENSMUST00000177637; ENSMUSP00000136413; ENSMUSG00000052336.
GeneIDi13051.
KEGGimmu:13051.
UCSCiuc009sbz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074912 Genomic DNA. Translation: AAD08665.1.
AF102269 mRNA. Translation: AAC72408.1.
BC012653 mRNA. Translation: AAH12653.1.
CCDSiCCDS40806.1.
RefSeqiNP_034117.3. NM_009987.4.
UniGeneiMm.44065.

3D structure databases

ProteinModelPortaliQ9Z0D9.
SMRiQ9Z0D9. Positions 34-305.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

GuidetoPHARMACOLOGYi74.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9Z0D9.

Proteomic databases

PaxDbiQ9Z0D9.
PRIDEiQ9Z0D9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064165; ENSMUSP00000063986; ENSMUSG00000052336.
ENSMUST00000177637; ENSMUSP00000136413; ENSMUSG00000052336.
GeneIDi13051.
KEGGimmu:13051.
UCSCiuc009sbz.1. mouse.

Organism-specific databases

CTDi1524.
MGIiMGI:1333815. Cx3cr1.

Phylogenomic databases

eggNOGiNOG151350.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ9Z0D9.
KOiK04192.
OMAiTMTETIL.
OrthoDBiEOG7327P9.
PhylomeDBiQ9Z0D9.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.

Miscellaneous databases

NextBioi282966.
PROiQ9Z0D9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z0D9.
CleanExiMM_CX3CR1.
ExpressionAtlasiQ9Z0D9. baseline and differential.
GenevestigatoriQ9Z0D9.

Family and domain databases

InterProiIPR005387. Chemokine_CX3CR1.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01562. FRACTALKINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Gene cloning, RNA distribution, and functional expression of mCX3CR1, a mouse chemotactic receptor for the CX3C chemokine fractalkine."
    Combadiere C., Gao J.-L., Tiffany H.L., Murphy P.M.
    Biochem. Biophys. Res. Commun. 253:728-732(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  2. "Cloning and characterization of murine CX3CR1, a receptor for murine fractalkine/neurotactin."
    Coultas L., McColl S.R.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/SvJ.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary gland.

Entry informationi

Entry nameiCX3C1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0D9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2000
Last sequence update: April 30, 1999
Last modified: March 31, 2015
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.