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Q9Z0D9

- CX3C1_MOUSE

UniProt

Q9Z0D9 - CX3C1_MOUSE

Protein

CX3C chemokine receptor 1

Gene

Cx3cr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions.

    GO - Molecular functioni

    1. C-X3-C chemokine receptor activity Source: Ensembl
    2. cytokine receptor activity Source: MGI

    GO - Biological processi

    1. cell adhesion Source: InterPro
    2. cellular response to lipopolysaccharide Source: Ensembl
    3. cellular response to transforming growth factor beta stimulus Source: Ensembl
    4. cerebral cortex cell migration Source: MGI
    5. cytokine-mediated signaling pathway Source: MGI
    6. macrophage chemotaxis Source: MGI
    7. microglial cell activation involved in immune response Source: MGI
    8. negative regulation of angiogenesis Source: MGI
    9. negative regulation of cell migration Source: Ensembl
    10. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
    11. positive regulation of angiogenesis Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CX3C chemokine receptor 1
    Short name:
    C-X3-C CKR-1
    Short name:
    CX3CR1
    Alternative name(s):
    Fractalkine receptor
    Gene namesi
    Name:Cx3cr1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1333815. Cx3cr1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. neuronal cell body membrane Source: Ensembl
    3. neuron projection Source: Ensembl
    4. perinuclear region of cytoplasm Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 354354CX3C chemokine receptor 1PRO_0000069327Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi103 ↔ 176PROSITE-ProRule annotation

    Post-translational modificationi

    This protein is not N-glycosylated which is unusual for G-protein-coupled receptors.

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ9Z0D9.
    PRIDEiQ9Z0D9.

    PTM databases

    PhosphoSiteiQ9Z0D9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Z0D9.
    BgeeiQ9Z0D9.
    CleanExiMM_CX3CR1.
    GenevestigatoriQ9Z0D9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z0D9.
    SMRiQ9Z0D9. Positions 34-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini61 – 7010CytoplasmicSequence Analysis
    Topological domaini92 – 10413ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini127 – 14317CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini169 – 19628ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini217 – 23216CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini258 – 27417ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini299 – 35456CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 6028Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei71 – 9121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei105 – 12622Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei144 – 16825Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 21620Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei233 – 25725Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei275 – 29824Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG151350.
    GeneTreeiENSGT00700000104407.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiQ9Z0D9.
    KOiK04192.
    OMAiTMTETIL.
    OrthoDBiEOG7327P9.
    PhylomeDBiQ9Z0D9.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR005387. Chemokine_CX3CR1.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01562. FRACTALKINER.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z0D9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTSFPELDL ENFEYDDSAE ACYLGDIVAF GTIFLSVFYA LVFTFGLVGN    50
    LLVVLALTNS RKPKSITDIY LLNLALSDLL FVATLPFWTH YLISHEGLHN 100
    AMCKLTTAFF FIGFFGGIFF ITVISIDRYL AIVLAANSMN NRTVQHGVTI 150
    SLGVWAAAIL VASPQFMFTK RKDNECLGDY PEVLQEMWPV LRNSEVNILG 200
    FALPLLIMSF CYFRIIQTLF SCKNRKKARA VRLILLVVFA FFLFWTPYNI 250
    MIFLETLKFY NFFPSCDMKR DLRLALSVTE TVAFSHCCLN PFIYAFAGEK 300
    FRRYLGHLYR KCLAVLCGHP VHTGFSPESQ RSRQDSILSS FTHYTSEGDG 350
    SLLL 354
    Length:354
    Mass (Da):40,266
    Last modified:May 1, 1999 - v1
    Checksum:i12C745E8E3755CA9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF074912 Genomic DNA. Translation: AAD08665.1.
    AF102269 mRNA. Translation: AAC72408.1.
    BC012653 mRNA. Translation: AAH12653.1.
    CCDSiCCDS40806.1.
    RefSeqiNP_034117.3. NM_009987.4.
    UniGeneiMm.44065.

    Genome annotation databases

    EnsembliENSMUST00000064165; ENSMUSP00000063986; ENSMUSG00000052336.
    ENSMUST00000177637; ENSMUSP00000136413; ENSMUSG00000052336.
    GeneIDi13051.
    KEGGimmu:13051.
    UCSCiuc009sbz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF074912 Genomic DNA. Translation: AAD08665.1 .
    AF102269 mRNA. Translation: AAC72408.1 .
    BC012653 mRNA. Translation: AAH12653.1 .
    CCDSi CCDS40806.1.
    RefSeqi NP_034117.3. NM_009987.4.
    UniGenei Mm.44065.

    3D structure databases

    ProteinModelPortali Q9Z0D9.
    SMRi Q9Z0D9. Positions 34-305.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 74.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9Z0D9.

    Proteomic databases

    PaxDbi Q9Z0D9.
    PRIDEi Q9Z0D9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000064165 ; ENSMUSP00000063986 ; ENSMUSG00000052336 .
    ENSMUST00000177637 ; ENSMUSP00000136413 ; ENSMUSG00000052336 .
    GeneIDi 13051.
    KEGGi mmu:13051.
    UCSCi uc009sbz.1. mouse.

    Organism-specific databases

    CTDi 1524.
    MGIi MGI:1333815. Cx3cr1.

    Phylogenomic databases

    eggNOGi NOG151350.
    GeneTreei ENSGT00700000104407.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi Q9Z0D9.
    KOi K04192.
    OMAi TMTETIL.
    OrthoDBi EOG7327P9.
    PhylomeDBi Q9Z0D9.
    TreeFami TF330966.

    Miscellaneous databases

    NextBioi 282966.
    PROi Q9Z0D9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Z0D9.
    Bgeei Q9Z0D9.
    CleanExi MM_CX3CR1.
    Genevestigatori Q9Z0D9.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR005387. Chemokine_CX3CR1.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01562. FRACTALKINER.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gene cloning, RNA distribution, and functional expression of mCX3CR1, a mouse chemotactic receptor for the CX3C chemokine fractalkine."
      Combadiere C., Gao J.-L., Tiffany H.L., Murphy P.M.
      Biochem. Biophys. Res. Commun. 253:728-732(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    2. "Cloning and characterization of murine CX3CR1, a receptor for murine fractalkine/neurotactin."
      Coultas L., McColl S.R.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/SvJ.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiCX3C1_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z0D9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3