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Protein

CX3C chemokine receptor 1

Gene

Cx3cr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the CX3C chemokine fractalkine (CX3CL1); binds to CX3CL1 and mediates both its adhesive and migratory functions.1 Publication

GO - Molecular functioni

  • C-X3-C chemokine binding Source: MGI
  • C-X3-C chemokine receptor activity Source: Ensembl
  • cytokine receptor activity Source: MGI

GO - Biological processi

  • cell adhesion Source: InterPro
  • cellular response to lipopolysaccharide Source: Ensembl
  • cellular response to transforming growth factor beta stimulus Source: Ensembl
  • cerebral cortex cell migration Source: MGI
  • cytokine-mediated signaling pathway Source: MGI
  • macrophage chemotaxis Source: MGI
  • memory Source: Ensembl
  • microglial cell activation involved in immune response Source: MGI
  • negative regulation of angiogenesis Source: MGI
  • negative regulation of cell migration Source: Ensembl
  • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  • negative regulation of long-term synaptic potentiation Source: Ensembl
  • positive regulation of angiogenesis Source: Ensembl
  • positive regulation of neuroblast proliferation Source: Ensembl

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
CX3C chemokine receptor 1
Short name:
C-X3-C CKR-1
Short name:
CX3CR1
Alternative name(s):
Fractalkine receptor
Gene namesi
Name:Cx3cr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1333815 Cx3cr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 60Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini61 – 70CytoplasmicSequence analysis10
Transmembranei71 – 91Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini92 – 104ExtracellularSequence analysisAdd BLAST13
Transmembranei105 – 126Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini127 – 143CytoplasmicSequence analysisAdd BLAST17
Transmembranei144 – 168Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini169 – 196ExtracellularSequence analysisAdd BLAST28
Transmembranei197 – 216Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini217 – 232CytoplasmicSequence analysisAdd BLAST16
Transmembranei233 – 257Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini258 – 274ExtracellularSequence analysisAdd BLAST17
Transmembranei275 – 298Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini299 – 354CytoplasmicSequence analysisAdd BLAST56

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693271 – 354CX3C chemokine receptor 1Add BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi103 ↔ 176PROSITE-ProRule annotation
Modified residuei345PhosphothreonineCombined sources1

Post-translational modificationi

This protein is not N-glycosylated which is unusual for G-protein-coupled receptors.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ9Z0D9
PRIDEiQ9Z0D9

PTM databases

iPTMnetiQ9Z0D9
PhosphoSitePlusiQ9Z0D9

Expressioni

Gene expression databases

BgeeiENSMUSG00000052336
CleanExiMM_CX3CR1
ExpressionAtlasiQ9Z0D9 baseline and differential
GenevisibleiQ9Z0D9 MM

Interactioni

Subunit structurei

Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063986

Structurei

3D structure databases

ProteinModelPortaliQ9Z0D9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGZ8 Eukaryota
ENOG41118PP LUCA
GeneTreeiENSGT00760000118785
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiQ9Z0D9
KOiK04192
OMAiPQFMFTK
OrthoDBiEOG091G0D5U
PhylomeDBiQ9Z0D9
TreeFamiTF330966

Family and domain databases

CDDicd15186 7tmA_CX3CR1, 1 hit
InterProiView protein in InterPro
IPR005387 Chemokine_CX3CR1
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01562 FRACTALKINER
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z0D9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSFPELDL ENFEYDDSAE ACYLGDIVAF GTIFLSVFYA LVFTFGLVGN
60 70 80 90 100
LLVVLALTNS RKPKSITDIY LLNLALSDLL FVATLPFWTH YLISHEGLHN
110 120 130 140 150
AMCKLTTAFF FIGFFGGIFF ITVISIDRYL AIVLAANSMN NRTVQHGVTI
160 170 180 190 200
SLGVWAAAIL VASPQFMFTK RKDNECLGDY PEVLQEMWPV LRNSEVNILG
210 220 230 240 250
FALPLLIMSF CYFRIIQTLF SCKNRKKARA VRLILLVVFA FFLFWTPYNI
260 270 280 290 300
MIFLETLKFY NFFPSCDMKR DLRLALSVTE TVAFSHCCLN PFIYAFAGEK
310 320 330 340 350
FRRYLGHLYR KCLAVLCGHP VHTGFSPESQ RSRQDSILSS FTHYTSEGDG

SLLL
Length:354
Mass (Da):40,266
Last modified:May 1, 1999 - v1
Checksum:i12C745E8E3755CA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074912 Genomic DNA Translation: AAD08665.1
AF102269 mRNA Translation: AAC72408.1
BC012653 mRNA Translation: AAH12653.1
CCDSiCCDS40806.1
RefSeqiNP_034117.3, NM_009987.4
UniGeneiMm.44065

Genome annotation databases

EnsembliENSMUST00000064165; ENSMUSP00000063986; ENSMUSG00000052336
ENSMUST00000177637; ENSMUSP00000136413; ENSMUSG00000052336
ENSMUST00000215016; ENSMUSP00000150463; ENSMUSG00000052336
GeneIDi13051
KEGGimmu:13051
UCSCiuc009sbz.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCX3C1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0D9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: February 28, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome