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Q9Z0D9 (CX3C1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CX3C chemokine receptor 1

Short name=C-X3-C CKR-1
Short name=CX3CR1
Alternative name(s):
Fractalkine receptor
Gene names
Name:Cx3cr1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Post-translational modification

This protein is not N-glycosylated which is unusual for G-protein-coupled receptors.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: InterPro

cellular response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

cellular response to transforming growth factor beta stimulus

Inferred from electronic annotation. Source: Ensembl

cerebral cortex cell migration

Inferred from mutant phenotype PubMed 16732273. Source: MGI

chemotaxis

Inferred from electronic annotation. Source: InterPro

cytokine-mediated signaling pathway

Inferred from mutant phenotype PubMed 18971423. Source: GOC

macrophage chemotaxis

Inferred from mutant phenotype PubMed 18322241. Source: MGI

microglial cell activation involved in immune response

Inferred from mutant phenotype PubMed 16732273. Source: MGI

negative regulation of angiogenesis

Inferred from mutant phenotype PubMed 18322241. Source: MGI

negative regulation of cell migration

Inferred from electronic annotation. Source: Ensembl

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Inferred from mutant phenotype PubMed 18971423. Source: MGI

positive regulation of angiogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

neuron projection

Inferred from electronic annotation. Source: Ensembl

neuronal cell body membrane

Inferred from electronic annotation. Source: Ensembl

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionC-X3-C chemokine receptor activity

Inferred from electronic annotation. Source: Ensembl

cytokine receptor activity

Inferred from mutant phenotype PubMed 18971423. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354CX3C chemokine receptor 1
PRO_0000069327

Regions

Topological domain1 – 3232Extracellular Potential
Transmembrane33 – 6028Helical; Name=1; Potential
Topological domain61 – 7010Cytoplasmic Potential
Transmembrane71 – 9121Helical; Name=2; Potential
Topological domain92 – 10413Extracellular Potential
Transmembrane105 – 12622Helical; Name=3; Potential
Topological domain127 – 14317Cytoplasmic Potential
Transmembrane144 – 16825Helical; Name=4; Potential
Topological domain169 – 19628Extracellular Potential
Transmembrane197 – 21620Helical; Name=5; Potential
Topological domain217 – 23216Cytoplasmic Potential
Transmembrane233 – 25725Helical; Name=6; Potential
Topological domain258 – 27417Extracellular Potential
Transmembrane275 – 29824Helical; Name=7; Potential
Topological domain299 – 35456Cytoplasmic Potential

Amino acid modifications

Disulfide bond103 ↔ 176 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9Z0D9 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 12C745E8E3755CA9

FASTA35440,266
        10         20         30         40         50         60 
MSTSFPELDL ENFEYDDSAE ACYLGDIVAF GTIFLSVFYA LVFTFGLVGN LLVVLALTNS 

        70         80         90        100        110        120 
RKPKSITDIY LLNLALSDLL FVATLPFWTH YLISHEGLHN AMCKLTTAFF FIGFFGGIFF 

       130        140        150        160        170        180 
ITVISIDRYL AIVLAANSMN NRTVQHGVTI SLGVWAAAIL VASPQFMFTK RKDNECLGDY 

       190        200        210        220        230        240 
PEVLQEMWPV LRNSEVNILG FALPLLIMSF CYFRIIQTLF SCKNRKKARA VRLILLVVFA 

       250        260        270        280        290        300 
FFLFWTPYNI MIFLETLKFY NFFPSCDMKR DLRLALSVTE TVAFSHCCLN PFIYAFAGEK 

       310        320        330        340        350 
FRRYLGHLYR KCLAVLCGHP VHTGFSPESQ RSRQDSILSS FTHYTSEGDG SLLL 

« Hide

References

« Hide 'large scale' references
[1]"Gene cloning, RNA distribution, and functional expression of mCX3CR1, a mouse chemotactic receptor for the CX3C chemokine fractalkine."
Combadiere C., Gao J.-L., Tiffany H.L., Murphy P.M.
Biochem. Biophys. Res. Commun. 253:728-732(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
[2]"Cloning and characterization of murine CX3CR1, a receptor for murine fractalkine/neurotactin."
Coultas L., McColl S.R.
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129/SvJ.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF074912 Genomic DNA. Translation: AAD08665.1.
AF102269 mRNA. Translation: AAC72408.1.
BC012653 mRNA. Translation: AAH12653.1.
RefSeqNP_034117.3. NM_009987.4.
UniGeneMm.44065.

3D structure databases

ProteinModelPortalQ9Z0D9.
SMRQ9Z0D9. Positions 34-305.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY74.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9Z0D9.

Proteomic databases

PaxDbQ9Z0D9.
PRIDEQ9Z0D9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000064165; ENSMUSP00000063986; ENSMUSG00000052336.
ENSMUST00000177637; ENSMUSP00000136413; ENSMUSG00000052336.
GeneID13051.
KEGGmmu:13051.
UCSCuc009sbz.1. mouse.

Organism-specific databases

CTD1524.
MGIMGI:1333815. Cx3cr1.

Phylogenomic databases

eggNOGNOG151350.
GeneTreeENSGT00700000104407.
HOGENOMHOG000234122.
HOVERGENHBG106917.
InParanoidQ9Z0D9.
KOK04192.
OMATMTETIL.
OrthoDBEOG7327P9.
PhylomeDBQ9Z0D9.
TreeFamTF330966.

Gene expression databases

ArrayExpressQ9Z0D9.
BgeeQ9Z0D9.
CleanExMM_CX3CR1.
GenevestigatorQ9Z0D9.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR005387. Chemokine_CX3CR1.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01562. FRACTALKINER.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio282966.
PROQ9Z0D9.
SOURCESearch...

Entry information

Entry nameCX3C1_MOUSE
AccessionPrimary (citable) accession number: Q9Z0D9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries