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Protein

CX3C chemokine receptor 1

Gene

Cx3cr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the CX3C chemokine fractalkine (CX3CL1); binds to CX3CL1 and mediates both its adhesive and migratory functions.1 Publication

GO - Molecular functioni

  • C-X3-C chemokine binding Source: MGI
  • C-X3-C chemokine receptor activity Source: Ensembl
  • cytokine receptor activity Source: MGI

GO - Biological processi

  • cell adhesion Source: InterPro
  • cellular response to lipopolysaccharide Source: Ensembl
  • cellular response to transforming growth factor beta stimulus Source: Ensembl
  • cerebral cortex cell migration Source: MGI
  • cytokine-mediated signaling pathway Source: MGI
  • macrophage chemotaxis Source: MGI
  • memory Source: Ensembl
  • microglial cell activation involved in immune response Source: MGI
  • negative regulation of angiogenesis Source: MGI
  • negative regulation of cell migration Source: Ensembl
  • negative regulation of chronic inflammatory response to non-antigenic stimulus Source: Ensembl
  • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  • negative regulation of long-term synaptic potentiation Source: Ensembl
  • positive regulation of angiogenesis Source: Ensembl
  • positive regulation of neuroblast proliferation Source: Ensembl

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
CX3C chemokine receptor 1
Short name:
C-X3-C CKR-1
Short name:
CX3CR1
Alternative name(s):
Fractalkine receptor
Gene namesi
Name:Cx3cr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1333815. Cx3cr1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 60Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini61 – 70CytoplasmicSequence analysis10
Transmembranei71 – 91Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini92 – 104ExtracellularSequence analysisAdd BLAST13
Transmembranei105 – 126Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini127 – 143CytoplasmicSequence analysisAdd BLAST17
Transmembranei144 – 168Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini169 – 196ExtracellularSequence analysisAdd BLAST28
Transmembranei197 – 216Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini217 – 232CytoplasmicSequence analysisAdd BLAST16
Transmembranei233 – 257Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini258 – 274ExtracellularSequence analysisAdd BLAST17
Transmembranei275 – 298Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini299 – 354CytoplasmicSequence analysisAdd BLAST56

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693271 – 354CX3C chemokine receptor 1Add BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi103 ↔ 176PROSITE-ProRule annotation
Modified residuei345PhosphothreonineCombined sources1

Post-translational modificationi

This protein is not N-glycosylated which is unusual for G-protein-coupled receptors.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ9Z0D9.
PRIDEiQ9Z0D9.

PTM databases

iPTMnetiQ9Z0D9.
PhosphoSitePlusiQ9Z0D9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000052336.
CleanExiMM_CX3CR1.
ExpressionAtlasiQ9Z0D9. baseline and differential.
GenevisibleiQ9Z0D9. MM.

Interactioni

Subunit structurei

Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063986.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0D9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGZ8. Eukaryota.
ENOG41118PP. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ9Z0D9.
KOiK04192.
OMAiPQFMFTK.
OrthoDBiEOG091G0D5U.
PhylomeDBiQ9Z0D9.
TreeFamiTF330966.

Family and domain databases

InterProiView protein in InterPro
IPR005387. Chemokine_CX3CR1.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR01562. FRACTALKINER.
PR00237. GPCRRHODOPSN.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z0D9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSFPELDL ENFEYDDSAE ACYLGDIVAF GTIFLSVFYA LVFTFGLVGN
60 70 80 90 100
LLVVLALTNS RKPKSITDIY LLNLALSDLL FVATLPFWTH YLISHEGLHN
110 120 130 140 150
AMCKLTTAFF FIGFFGGIFF ITVISIDRYL AIVLAANSMN NRTVQHGVTI
160 170 180 190 200
SLGVWAAAIL VASPQFMFTK RKDNECLGDY PEVLQEMWPV LRNSEVNILG
210 220 230 240 250
FALPLLIMSF CYFRIIQTLF SCKNRKKARA VRLILLVVFA FFLFWTPYNI
260 270 280 290 300
MIFLETLKFY NFFPSCDMKR DLRLALSVTE TVAFSHCCLN PFIYAFAGEK
310 320 330 340 350
FRRYLGHLYR KCLAVLCGHP VHTGFSPESQ RSRQDSILSS FTHYTSEGDG

SLLL
Length:354
Mass (Da):40,266
Last modified:May 1, 1999 - v1
Checksum:i12C745E8E3755CA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074912 Genomic DNA. Translation: AAD08665.1.
AF102269 mRNA. Translation: AAC72408.1.
BC012653 mRNA. Translation: AAH12653.1.
CCDSiCCDS40806.1.
RefSeqiNP_034117.3. NM_009987.4.
UniGeneiMm.44065.

Genome annotation databases

EnsembliENSMUST00000064165; ENSMUSP00000063986; ENSMUSG00000052336.
ENSMUST00000177637; ENSMUSP00000136413; ENSMUSG00000052336.
ENSMUST00000215016; ENSMUSP00000150463; ENSMUSG00000052336.
GeneIDi13051.
KEGGimmu:13051.
UCSCiuc009sbz.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCX3C1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0D9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: July 5, 2017
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families