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Q9YYS0

- DUT_ADEG8

UniProt

Q9YYS0 - DUT_ADEG8

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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene
N/A
Organism
Avian adenovirus 8 (strain ATCC A-2A) (FAdV-8) (Fowl adenovirus 8)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.By similarity

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Magnesium.By similarity

Pathwayi

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dUMP biosynthetic process Source: UniProtKB-UniPathway
  2. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
OrganismiAvian adenovirus 8 (strain ATCC A-2A) (FAdV-8) (Fowl adenovirus 8)
Taxonomic identifieri66295 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageAdenoviridaeAviadenovirusFowl aviadenovirus E
Virus hostiGalliformes [TaxID: 8976]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 163163Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182968Add
BLAST

Proteomic databases

PRIDEiQ9YYS0.

Structurei

3D structure databases

ProteinModelPortaliQ9YYS0.
SMRiQ9YYS0. Positions 18-139.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.Curated

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR00576. dut. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9YYS0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFDSGCPPT PPVKLLFKKH SPFAVTPQRA TSGAAGYDLC SSADVVVPPK
60 70 80 90 100
SRSLIPTDLS FQFPRGVYGR IAPRSGLAVK FFIDVGAGVI DSDYRGIVSV
110 120 130 140 150
LLFNFSDHNF NVRRGDRIAQ LILERHLTPD LEERSGLDET ARGAAGFGST
160
GGFDTGVCPS SFS
Length:163
Mass (Da):17,426
Last modified:May 1, 1999 - v1
Checksum:i08DDE78EF8D89419
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF021253 Genomic DNA. Translation: AAC71662.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF021253 Genomic DNA. Translation: AAC71662.1 .

3D structure databases

ProteinModelPortali Q9YYS0.
SMRi Q9YYS0. Positions 18-139.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9YYS0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00610 ; UER00666 .

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
TIGRFAMsi TIGR00576. dut. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequence and transcriptional analysis of terminal regions of the fowl adenovirus type 8 genome."
    Cao J.X., Krell P.J., Nagy E.
    J. Gen. Virol. 79:2507-2516(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiDUT_ADEG8
AccessioniPrimary (citable) accession number: Q9YYS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: October 1, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3