Reviewed, UniProtKB/Swiss-Prot Q9YYS0 (DUT_ADEG8)

Names and origin

Protein names	Recommended name:     Deoxyuridine 5'-triphosphate nucleotidohydrolase       Short name=dUTPase     EC=3.6.1.23 Alternative name(s):     dUTP pyrophosphatase
Organism	Avian adenovirus 8 (strain ATCC A-2A) (FAdV-8) (Fowl adenovirus 8)
Taxonomic identifier	66295 [NCBI]
Taxonomic lineage	Viruses › dsDNA viruses, no RNA stage › Adenoviridae › Aviadenovirus › Fowl adenovirus E
Virus host	Galliformes [TaxID: 8976]

Protein attributes

Sequence length	163 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.
Catalytic activity	dUTP + H2O = dUMP + diphosphate.
Cofactor	Magnesium By similarity.
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.
Sequence similarities	Belongs to the dUTPase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	dUTP diphosphatase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 163	163	Deoxyuridine 5'-triphosphate nucleotidohydrolase		PRO_0000182968

Sequences

	Sequence		Length	Mass (Da)
	Q9YYS0-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 08DDE78EF8D89419	FASTA	163	17,426
	10 20 30 40 50 60 MSFDSGCPPT PPVKLLFKKH SPFAVTPQRA TSGAAGYDLC SSADVVVPPK SRSLIPTDLS 70 80 90 100 110 120 FQFPRGVYGR IAPRSGLAVK FFIDVGAGVI DSDYRGIVSV LLFNFSDHNF NVRRGDRIAQ 130 140 150 160 LILERHLTPD LEERSGLDET ARGAAGFGST GGFDTGVCPS SFS

References

[1]	"Sequence and transcriptional analysis of terminal regions of the fowl adenovirus type 8 genome." Cao J.X., Krell P.J., Nagy E. J. Gen. Virol. 79:2507-2516(1998) [PubMed: 9780058] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF021253 Genomic DNA. Translation: AAC71662.1.
3D structure databases
HSSP	HSSP built from PDB template 1MQ7 based on UniProtKB O07199.
ModBase	Search...
Family and domain databases
InterPro	IPR008180. DeoxyUTP_pyroPase_dom. IPR008181. dUTP_pyrophosphatase_subfam_1. [Graphical view]
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
ProDom	PD004900. dCTP_deaminase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00576. dut. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DUT_ADEG8

Accession

Primary (citable) accession number: Q9YYS0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	September 22, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)