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Q9YYS0

- DUT_ADEG8

UniProt

Q9YYS0 - DUT_ADEG8

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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene
N/A
Organism
Avian adenovirus 8 (strain ATCC A-2A) (FAdV-8) (Fowl adenovirus 8)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Magnesium By similarity.

Pathwayi

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dUMP biosynthetic process Source: UniProtKB-UniPathway
  2. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
OrganismiAvian adenovirus 8 (strain ATCC A-2A) (FAdV-8) (Fowl adenovirus 8)
Taxonomic identifieri66295 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageAdenoviridaeAviadenovirusFowl adenovirus E
Virus hostiGalliformes [TaxID: 8976]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 163163Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182968Add
BLAST

Proteomic databases

PRIDEiQ9YYS0.

Structurei

3D structure databases

ProteinModelPortaliQ9YYS0.
SMRiQ9YYS0. Positions 18-139.

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR00576. dut. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9YYS0-1 [UniParc]FASTAAdd to Basket

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MSFDSGCPPT PPVKLLFKKH SPFAVTPQRA TSGAAGYDLC SSADVVVPPK    50
SRSLIPTDLS FQFPRGVYGR IAPRSGLAVK FFIDVGAGVI DSDYRGIVSV 100
LLFNFSDHNF NVRRGDRIAQ LILERHLTPD LEERSGLDET ARGAAGFGST 150
GGFDTGVCPS SFS 163
Length:163
Mass (Da):17,426
Last modified:May 1, 1999 - v1
Checksum:i08DDE78EF8D89419
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF021253 Genomic DNA. Translation: AAC71662.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF021253 Genomic DNA. Translation: AAC71662.1 .

3D structure databases

ProteinModelPortali Q9YYS0.
SMRi Q9YYS0. Positions 18-139.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9YYS0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00610 ; UER00666 .

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
TIGRFAMsi TIGR00576. dut. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequence and transcriptional analysis of terminal regions of the fowl adenovirus type 8 genome."
    Cao J.X., Krell P.J., Nagy E.
    J. Gen. Virol. 79:2507-2516(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiDUT_ADEG8
AccessioniPrimary (citable) accession number: Q9YYS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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