Q9YYS0 (DUT_ADEG8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Deoxyuridine 5'-triphosphate nucleotidohydrolase Short name=dUTPase EC=3.6.1.23 Alternative name(s): dUTP pyrophosphatase
Organism	Avian adenovirus 8 (strain ATCC A-2A) (FAdV-8) (Fowl adenovirus 8)
Taxonomic identifier	66295 [NCBI]
Taxonomic lineage	Viruses › dsDNA viruses, no RNA stage › Adenoviridae › Aviadenovirus › Fowl adenovirus E
Virus host	Galliformes [TaxID: 8976]

Protein attributes

Sequence length	163 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.
Catalytic activity	dUTP + H2O = dUMP + diphosphate.
Cofactor	Magnesium By similarity.
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.
Sequence similarities	Belongs to the dUTPase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Gene Ontology (GO)
Biological_process	dUMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	dUTP diphosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 163	163	Deoxyuridine 5'-triphosphate nucleotidohydrolase		PRO_0000182968

Sequences

	Sequence		Length	Mass (Da)
	Q9YYS0 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 08DDE78EF8D89419	FASTA	163	17,426
	10 20 30 40 50 60 MSFDSGCPPT PPVKLLFKKH SPFAVTPQRA TSGAAGYDLC SSADVVVPPK SRSLIPTDLS 70 80 90 100 110 120 FQFPRGVYGR IAPRSGLAVK FFIDVGAGVI DSDYRGIVSV LLFNFSDHNF NVRRGDRIAQ 130 140 150 160 LILERHLTPD LEERSGLDET ARGAAGFGST GGFDTGVCPS SFS

References

[1]	"Sequence and transcriptional analysis of terminal regions of the fowl adenovirus type 8 genome." Cao J.X., Krell P.J., Nagy E. J. Gen. Virol. 79:2507-2516(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF021253 Genomic DNA. Translation: AAC71662.1.
3D structure databases
ProteinModelPortal	Q9YYS0.
SMR	Q9YYS0. Positions 18-139.
ModBase	Search...
Proteomic databases
PRIDE	Q9YYS0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00610; UER00666.
Family and domain databases
InterPro	IPR008180. dUTP_pyroPase. IPR008181. dUTP_pyroPase_sf. [Graphical view]
PANTHER	PTHR11241. PTHR11241. 1 hit.
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00576. dut. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DUT_ADEG8

Accession

Primary (citable) accession number: Q9YYS0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	April 3, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program