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Q9YXL6

- Q9YXL6_9INFA

UniProt

Q9YXL6 - Q9YXL6_9INFA

Protein

RNA-directed RNA polymerase catalytic subunit

Gene

PB1

Organism
Influenza A virus H3N2
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. suppression by virus of host RNA polymerase II activity Source: UniProtKB-KW
    2. transcription, DNA-templated Source: InterPro
    3. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymeraseUniRule annotationSAAS annotation, Transferase

    Keywords - Biological processi

    Eukaryotic host gene expression shutoff by virus, Eukaryotic host transcription shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction, Inhibition of host RNA polymerase II by virusSAAS annotation, Viral RNA replicationSAAS annotation

    Keywords - Ligandi

    Nucleotide-bindingSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase catalytic subunitUniRule annotation (EC:2.7.7.48UniRule annotation)
    Gene namesi
    Name:PB1Imported
    OrganismiInfluenza A virus H3N2Imported
    Taxonomic identifieri41857 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4F7PX-ray1.90C496-505[»]
    4F7TX-ray1.70C/F498-505[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains RdRp catalytic domain.SAAS annotation

    Family and domain databases

    InterProiIPR007099. RNA-dir_pol_NSvirus.
    IPR001407. RNA_pol_PB1_influenza.
    [Graphical view]
    PfamiPF00602. Flu_PB1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000827. RdRPol_OMV. 1 hit.
    PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9YXL6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVNPTLLFL KVPAQNAIST TFPYTGDPPY SHGTGTGYTM DTVNRTHQYS    50
    EKGKWTTNTE TGAPQLNPID GPLPEDNEPS GYAQTDCVLE AMAFLEESHP 100
    GIFENSCLET MEVVQQTRVD KLTQGRQTYD WTLNRNQPAA TALANTIEVF 150
    RSNGLTASES GRLIDFLKDV MESMDKEEIE VTTHFQRKRR VRDNMTKKMV 200
    TQRTIGKKKQ RVNKRSYLIR ALTLNTMTKD AERGKLKRRA IATPGMQIRG 250
    FVYFVETLAR SICEKLEQSG LPVGGNEKKA KLANVVRKMM TNSQDTELSF 300
    TITGDNTKWN ENQNPRMFLA MITYITKNQP EWFRNILSIA PIMFSNKMAR 350
    LGKGYMFESK RMKLRTQIPA EMLASIDLKY FNESTRKKIE KIRPLLIDGT 400
    ASLSPGMMMG MFNMLSTVLG VSILNLGQKK YTKTTYWWDG LQSSDDFALI 450
    VNAPNHEGIQ AGVDRFYRTC KLVGINMSKK KSYINKTGTF EFTSFFYRYG 500
    FVANFSMELP SFGVSGVNES ADMSIGVTVI KNNMINNDLG PATAQMALQL 550
    FIKDYRYTYR CHRGDTQIQT RRSFELKKLW DQTQSKAGLL VSDGGPNLYN 600
    IRNLHIPEVC LKWELMDEDY RGRLCNPLNP FVSHKEIESV NNAVVMPAHG 650
    PAKSMEYDAV ATTHSWIPKR NRSILNTSQR GILEDEQMYQ KCCNLFEKFF 700
    PSSSYRRPVG ISSMVEAMVS RARIDARIDF ESGRIKKEEF SEIMKICSTI 750
    EELRRQK 757
    Length:757
    Mass (Da):86,340
    Last modified:May 1, 1999 - v1
    Checksum:i9AEE58B338AA8BC2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF037420 Genomic RNA. Translation: AAC63451.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF037420 Genomic RNA. Translation: AAC63451.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4F7P X-ray 1.90 C 496-505 [» ]
    4F7T X-ray 1.70 C/F 498-505 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR007099. RNA-dir_pol_NSvirus.
    IPR001407. RNA_pol_PB1_influenza.
    [Graphical view ]
    Pfami PF00602. Flu_PB1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000827. RdRPol_OMV. 1 hit.
    PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Phylogenetic analysis of the entire genome of influenza A (H3N2) viruses from Japan: evidence for genetic reassortment of the six internal genes."
      Lindstrom S.E., Hiromoto Y., Nerome R., Omoe K., Sugita S., Yamazaki Y., Takahashi T., Nerome K.
      J. Virol. 72:8021-8031(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: A/Niigata/137/96Imported.
    2. "Cross-allele cytotoxic T lymphocyte responses against 2009 pandemic H1N1 influenza A virus among HLA-A24 and HLA-A3 supertype-positive individuals."
      Liu J., Zhang S., Tan S., Yi Y., Wu B., Cao B., Zhu F., Wang C., Wang H., Qi J., Gao G.F.
      J. Virol. 86:13281-13294(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 498-505.

    Entry informationi

    Entry nameiQ9YXL6_9INFA
    AccessioniPrimary (citable) accession number: Q9YXL6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 1999
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3