Q9YXL3 (Q9YXL3_9INFA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
PA polymerase subunit EMBL AAC63456.1

Gene names

Name:

PA EMBL AAC63456.1

Organism

Influenza A virus H3N2 EMBL AAC63456.1

Taxonomic identifier

41857 [NCBI]

Taxonomic lineage

Viruses › ssRNA viruses › ssRNA negative-strand viruses › Orthomyxoviridae › Influenzavirus A › Influenza A virus › H3N2 subtype

Protein attributes

Sequence length	716 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Implicated in endonuclease cleavage of capped RNA primers. Displays an elongation factor activity in viral RNA synthesis. Dispensable for viral transcription, but not replication By similarity. SAAS SAAS001009
Subunit structure	Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA By similarity. SAAS SAAS001009

Ontologies

Keywords
Technical term	3D-structure PDB 4F7M
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Molecular_function	RNA binding Inferred from electronic annotation. Source: InterPro RNA-directed RNA polymerase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9YXL3 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 1F2D03926A52ACCD	FASTA	716	82,765
	10 20 30 40 50 60 MEDFVRQCFN PMIVELAEKA MKEYGEDLKI ETNKFAAICT HLEVCFMYSD FHFINEQGES 70 80 90 100 110 120 IVVELDDPNA LLKHRFEIIE GRDRTMAWTV VNSICNTTGA EKPKFLPDLY DYKENRFIEI 130 140 150 160 170 180 GVTRREVHIY YLEKANKIKS ENTHIHIFSF TGEEMATKAD YTLDEESRAR IKTRLFTIRQ 190 200 210 220 230 240 EMANRGLWDS FRQSERGEET IEEKFEISGT MRRLADQSLP PNFSCLENFR AYVDGFEPNG 250 260 270 280 290 300 CIEGKLSQMS KEVNAKIEPF LKTTPRPIKL PNGPPCYQRS KFLLMDALKL SIEDPSHEGE 310 320 330 340 350 360 GIPLYDAIKC IRTFFGWKEP YIVKPHEKGI NSNYLLSWKQ VLAELQDIET EEKIPRTKNM 370 380 390 400 410 420 KKTSQLKWAL GENMAPEKVD FDNCRDISDL KQYDSDEPEL RSLSSWIQNE FNKACELTDS 430 440 450 460 470 480 IWIELDEIGE DIAPIEHIAS MRRNYFTAEV SHCRATEYIM KGVYINTALL NASCAAMDDF 490 500 510 520 530 540 QLIPMISKCR TKEGRRKTNL YGFIIKGRSH LRNDTDVVNF VSMEFSLTDP RLEPHKWEKY 550 560 570 580 590 600 CVLEIGDMLL RSAIGQMSRP MFLYVRTNGT SKIKMKWGME MRRCLLQSLQ QIESMIEAES 610 620 630 640 650 660 SVKEKDMTKE FFENKSEAWP IGESPKGVEE GSIGKVCRTL LAKSVFNSLY ASPQLEGFSA 670 680 690 700 710 ESRKLLLVVQ ALRDNLEPGT FDLGGLYEAI EECLINDPWV LLNASWFNSF LKHALK

References

[1]	"Phylogenetic analysis of the entire genome of influenza A (H3N2) viruses from Japan: evidence for genetic reassortment of the six internal genes." Lindstrom S.E., Hiromoto Y., Nerome R., Omoe K., Sugita S., Yamazaki Y., Takahashi T., Nerome K. J. Virol. 72:8021-8031(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: A/Tochigi/44/95 EMBL AAC63456.1.
[2]	"Cross-allele cytotoxic T lymphocyte responses against 2009 pandemic H1N1 influenza A virus among HLA-A24 and HLA-A3 supertype-positive individuals." Liu J., Zhang S., Tan S., Yi Y., Wu B., Cao B., Zhu F., Wang C., Wang H., Qi J., Gao G.F. J. Virol. 86:13281-13294(2012) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 649-658.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF037425 Genomic RNA. Translation: AAC63456.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4F7M	X-ray	2.40	C/F	649-658	[»]

ModBase

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Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR001009. RNA-dir_pol_influenzavirus.
[Graphical view]

Pfam

PF00603. Flu_PA. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q9YXL3_9INFA

Accession

Primary (citable) accession number: Q9YXL3

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 1999
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)