Q9YW39 (NTP1_MSEPV) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 62.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Nucleoside triphosphatase I EC=3.6.1.15 Alternative name(s): NPH-I Nucleoside triphosphate phosphohydrolase I Short name=NPH I | ||||
| Gene names |
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| Organism | Melanoplus sanguinipes entomopoxvirus (MsEPV) | ||||
| Taxonomic identifier | 83191 [NCBI] | ||||
| Taxonomic lineage | Viruses › dsDNA viruses, no RNA stage › Poxviridae › Entomopoxvirinae › ![]() | ||||
| Virus host | Melanoplus sanguinipes (Migratory grasshopper) [TaxID: 65742] |
Protein attributes
| Sequence length | 647 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | DNA-dependent ATPase required for providing the needed energy to achieve the termination of early transcripts. Acts in concert with the RAP94 subunit of the virion RNA polymerase and the capping enzyme/VTF to catalyze release of UUUUUNU-containing nascent RNA from the elongation complex. NPH-I must bind ssDNA in order to exhibit ATPase activity By similarity. |
| Catalytic activity | NTP + H2O = NDP + phosphate. |
| Subunit structure | Monomer. Interacts (via C-terminus) with RAP94 (via N-terminus). Interacts with the cap-specific mRNA (nucleoside-2'-O-)-methyltransferase By similarity. |
| Subcellular location | Virion By similarity. Note: Virion core enzyme By similarity. |
| Sequence similarities | Belongs to the helicase family. NPH I subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription |
| Cellular component | Virion |
| Ligand | ATP-binding DNA-binding Nucleotide-binding |
| Molecular function | Hydrolase |
| Gene Ontology (GO) | |
| Biological_process | transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular_component | virion Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA bindingInferred from electronic annotation. Source: UniProtKB-KW helicase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 647 | 647 | Nucleoside triphosphatase I | PRO_0000099103 | |||||
Regions | |||||||||
| Domain | 48 – 213 | 166 | Helicase ATP-binding | ||||||
| Domain | 377 – 540 | 164 | Helicase C-terminal | ||||||
| Nucleotide binding | 61 – 68 | 8 | ATP By similarity | ||||||
| Region | 466 – 532 | 67 | Binding to the cap-specific mRNA (nucleoside-2'-O-)-methyltransferase By similarity | ||||||
| Motif | 150 – 153 | 4 | DEXH box | ||||||
Sequences
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References
| [1] | "The genome of Melanoplus sanguinipes entomopoxvirus." Afonso C.L., Tulman E.R., Lu Z., Oma E., Kutish G.F., Rock D.L. J. Virol. 73:533-552(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Isolate Tucson. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF063866 Genomic DNA. Translation: AAC97824.1. |
| PIR | T28214. |
| RefSeq | NP_048124.1. NC_001993.1. |
3D structure databases | |
| ProteinModelPortal | Q9YW39. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1449819. |
Phylogenomic databases | |
| ProtClustDB | CLSP2509799. |
Family and domain databases | |
| InterPro | IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. IPR013676. NPHI_C. IPR000330. SNF2_N. [Graphical view] |
| Pfam | PF00271. Helicase_C. 1 hit. PF08469. NPHI_C. 1 hit. PF00176. SNF2_N. 1 hit. [Graphical view] |
| SMART | SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. [Graphical view] |
| PROSITE | PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | NTP1_MSEPV | ||||||||
| Accession | Primary (citable) accession number: Q9YW39 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Viral Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with
