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Q9YUC8 (CAPSD_BFDV) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Capsid protein
Gene names
Name:Cap
ORF Names:ORF2
OrganismBeak and feather disease virus (BFDV) [Complete proteome]
Taxonomic identifier77856 [NCBI]
Taxonomic lineageVirusesssDNA virusesCircoviridaeCircovirus
Virus hostGracula [TaxID: 116991]
Psittaciformes [TaxID: 9223]

Protein attributes

Sequence length247 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Self-assembles to form the virion icosahedral capsid with a T=1 symmetry. This very small capsid (17 - 22 nm in diameter) allows the virus to be very stable in the environment and resistant to some disinfectants, including detergents. Essential for the initial attachment to heparan sulfate moities and chondroitin sulfate B of the host cell surface proteoglycans. After attachment, the virus is endocytosed and traffics to the nucleus. The capsid protein binds and transports the viral genome and Rep across the nuclear envelope. Ref.2

Subunit structure

Homomultimer. Assembles in the nucleus, presumably in an immature form, then migrates to the cytoplasm once assembled as mature virion By similarity. Interacts with Rep; this interaction relocates Rep into the nucleus. Ref.2

Subcellular location

Host nucleus. Virion Potential Ref.2.

Sequence similarities

Belongs to the circoviridae capsid protein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 247247Capsid protein
PRO_0000319848

Regions

Region1 – 4040DNA-binding By similarity
Region15 – 4430Nuclear localization signals Potential
Compositional bias15 – 5440Arg-rich

Sequences

Sequence LengthMass (Da)Tools
Q9YUC8 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 25E086A559ABAB7E

FASTA24728,942
        10         20         30         40         50         60 
MWGTSNCACA KFQIRRRYAR PYRRRHIRRY RRRRRHFRRR RFTTNRVYTL RLTRQFQFKI 

        70         80         90        100        110        120 
QKQTTSVGNL IFNADYITFA LDDFLQAVPN PHALNFEDYR IKLAKMEMRP TGGHYTVQSN 

       130        140        150        160        170        180 
GFGHTAVIQD SRITKFKTTA DQTQDPLAPF DGAKKWFVSR GFKRLLRPKP QITIEDLTTA 

       190        200        210        220        230        240 
NQSAALWLNS ARTGWIPLQG GPNSAGTKVR HYGIAFSFPQ PEQTITYVTK LTLYVQFRQF 


APNNPST 

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References

[1]"Psittacine beak and feather disease virus nucleotide sequence analysis and its relationship to porcine circovirus, plant circoviruses, and chicken anaemia virus."
Bassami M.R., Berryman D., Wilcox G.E., Raidal S.R.
Virology 249:453-459(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The capsid protein of beak and feather disease virus binds to the viral DNA and is responsible for transporting the replication-associated protein into the nucleus."
Heath L., Williamson A.L., Rybicki E.P.
J. Virol. 80:7219-7225(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH REP, DNA-BINDING.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF080560 Genomic DNA. Translation: AAC69862.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR003383. Circovirus_capsid.
[Graphical view]
PfamPF02443. Circo_capsid. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCAPSD_BFDV
AccessionPrimary (citable) accession number: Q9YUC8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 1, 1999
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families