Q9YUC8 (CAPSD_BFDV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Capsid protein

Gene names

Name:	Cap
ORF Names:	ORF2

Organism

Beak and feather disease virus (BFDV) [Complete proteome]

Taxonomic identifier

77856 [NCBI]

Taxonomic lineage

Viruses › ssDNA viruses › Circoviridae › Circovirus

Virus host

Gracula [TaxID: 116991]
Psittaciformes [TaxID: 9223]

Protein attributes

Sequence length	247 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Self-assembles to form the virion icosahedral capsid with a T=1 symmetry. This very small capsid (17 - 22 nm in diameter) allows the virus to be very stable in the environment and resistant to some disinfectants, including detergents. Essential for the initial attachment to heparan sulfate moities and chondroitin sulfate B of the host cell surface proteoglycans. After attachment, the virus is endocytosed and traffics to the nucleus. The capsid protein binds and transports the viral genome and Rep across the nuclear envelope. Ref.2
Subunit structure	Homomultimer. Assembles in the nucleus, presumably in an immature form, then migrates to the cytoplasm once assembled as mature virion By similarity. Interacts with Rep; this interaction relocates Rep into the nucleus. Ref.2
Subcellular location	Host nucleus. Virion Potential Ref.2.
Sequence similarities	Belongs to the circoviridae capsid protein family.

Ontologies

Keywords
Biological process	Host-virus interaction Viral attachment to host cell Viral penetration into host cytoplasm Viral penetration into host nucleus Virus endocytosis by host Virus entry into host cell
Cellular component	Host nucleus Virion
Ligand	DNA-binding
Molecular function	Capsid protein T=1 icosahedral capsid protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	viral attachment to host cell Inferred from electronic annotation. Source: UniProtKB-KW viral capsid assembly Inferred from electronic annotation. Source: InterPro viral entry into host cell via endocytosis Inferred from electronic annotation. Source: UniProtKB-KW viral penetration into host nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	T=1 icosahedral viral capsid Inferred from electronic annotation. Source: UniProtKB-KW host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 247	247	Capsid protein		PRO_0000319848
Regions
	Region	1 – 40	40	DNA-binding By similarity
	Region	15 – 44	30	Nuclear localization signals Potential
	Compositional bias	15 – 54	40	Arg-rich

Sequences

	Sequence		Length	Mass (Da)
	Q9YUC8 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 25E086A559ABAB7E	FASTA	247	28,942
	10 20 30 40 50 60 MWGTSNCACA KFQIRRRYAR PYRRRHIRRY RRRRRHFRRR RFTTNRVYTL RLTRQFQFKI 70 80 90 100 110 120 QKQTTSVGNL IFNADYITFA LDDFLQAVPN PHALNFEDYR IKLAKMEMRP TGGHYTVQSN 130 140 150 160 170 180 GFGHTAVIQD SRITKFKTTA DQTQDPLAPF DGAKKWFVSR GFKRLLRPKP QITIEDLTTA 190 200 210 220 230 240 NQSAALWLNS ARTGWIPLQG GPNSAGTKVR HYGIAFSFPQ PEQTITYVTK LTLYVQFRQF APNNPST

References

[1]	"Psittacine beak and feather disease virus nucleotide sequence analysis and its relationship to porcine circovirus, plant circoviruses, and chicken anaemia virus." Bassami M.R., Berryman D., Wilcox G.E., Raidal S.R. Virology 249:453-459(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The capsid protein of beak and feather disease virus binds to the viral DNA and is responsible for transporting the replication-associated protein into the nucleus." Heath L., Williamson A.L., Rybicki E.P. J. Virol. 80:7219-7225(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH REP, DNA-BINDING.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF080560 Genomic DNA. Translation: AAC69862.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR003383. Circovirus_capsid. [Graphical view]
Pfam	PF02443. Circo_capsid. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAPSD_BFDV

Accession

Primary (citable) accession number: Q9YUC8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	May 1, 1999
Last modified:	April 3, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program