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Q9YUC8

- CAPSD_BFDV

UniProt

Q9YUC8 - CAPSD_BFDV

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Protein

Capsid protein

Gene

Cap

Organism
Beak and feather disease virus (BFDV)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Self-assembles to form the virion icosahedral capsid with a T=1 symmetry. This very small capsid (17 - 22 nm in diameter) allows the virus to be very stable in the environment and resistant to some disinfectants, including detergents. Essential for the initial attachment to heparan sulfate moities and chondroitin sulfate B of the host cell surface proteoglycans. After attachment, the virus is endocytosed and traffics to the nucleus. The capsid protein binds and transports the viral genome and Rep across the nuclear envelope.1 Publication

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. endocytosis involved in viral entry into host cell Source: UniProtKB-KW
  2. viral capsid assembly Source: InterPro
  3. viral penetration into host nucleus Source: UniProtKB-KW
  4. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Viral penetration into host nucleus, Virus endocytosis by host, Virus entry into host cell

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Capsid protein
Gene namesi
Name:Cap
ORF Names:ORF2
OrganismiBeak and feather disease virus (BFDV)
Taxonomic identifieri77856 [NCBI]
Taxonomic lineageiVirusesssDNA virusesCircoviridaeCircovirus
Virus hostiGracula [TaxID: 116991]
Psittaciformes [TaxID: 9223]
ProteomesiUP000007454: Genome

Subcellular locationi

Host nucleus 1 Publication. Virion Curated

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-KW
  2. intracellular Source: GOC
  3. T=1 icosahedral viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host nucleus, T=1 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 247247Capsid proteinPRO_0000319848Add
BLAST

Interactioni

Subunit structurei

Homomultimer. Assembles in the nucleus, presumably in an immature form, then migrates to the cytoplasm once assembled as mature virion (By similarity). Interacts with Rep; this interaction relocates Rep into the nucleus.By similarity1 Publication

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 4040DNA-bindingBy similarityAdd
BLAST
Regioni15 – 4430Nuclear localization signalsSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 5440Arg-richAdd
BLAST

Sequence similaritiesi

Belongs to the circoviridae capsid protein family.Curated

Family and domain databases

InterProiIPR003383. Circovirus_capsid.
[Graphical view]
PfamiPF02443. Circo_capsid. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9YUC8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWGTSNCACA KFQIRRRYAR PYRRRHIRRY RRRRRHFRRR RFTTNRVYTL
60 70 80 90 100
RLTRQFQFKI QKQTTSVGNL IFNADYITFA LDDFLQAVPN PHALNFEDYR
110 120 130 140 150
IKLAKMEMRP TGGHYTVQSN GFGHTAVIQD SRITKFKTTA DQTQDPLAPF
160 170 180 190 200
DGAKKWFVSR GFKRLLRPKP QITIEDLTTA NQSAALWLNS ARTGWIPLQG
210 220 230 240
GPNSAGTKVR HYGIAFSFPQ PEQTITYVTK LTLYVQFRQF APNNPST
Length:247
Mass (Da):28,942
Last modified:May 1, 1999 - v1
Checksum:i25E086A559ABAB7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080560 Genomic DNA. Translation: AAC69862.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080560 Genomic DNA. Translation: AAC69862.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR003383. Circovirus_capsid.
[Graphical view ]
Pfami PF02443. Circo_capsid. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Psittacine beak and feather disease virus nucleotide sequence analysis and its relationship to porcine circovirus, plant circoviruses, and chicken anaemia virus."
    Bassami M.R., Berryman D., Wilcox G.E., Raidal S.R.
    Virology 249:453-459(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The capsid protein of beak and feather disease virus binds to the viral DNA and is responsible for transporting the replication-associated protein into the nucleus."
    Heath L., Williamson A.L., Rybicki E.P.
    J. Virol. 80:7219-7225(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH REP, DNA-BINDING.

Entry informationi

Entry nameiCAPSD_BFDV
AccessioniPrimary (citable) accession number: Q9YUC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3