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Q9YUC8

- CAPSD_BFDV

UniProt

Q9YUC8 - CAPSD_BFDV

Protein

Capsid protein

Gene

Cap

Organism
Beak and feather disease virus (BFDV)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Self-assembles to form the virion icosahedral capsid with a T=1 symmetry. This very small capsid (17 - 22 nm in diameter) allows the virus to be very stable in the environment and resistant to some disinfectants, including detergents. Essential for the initial attachment to heparan sulfate moities and chondroitin sulfate B of the host cell surface proteoglycans. After attachment, the virus is endocytosed and traffics to the nucleus. The capsid protein binds and transports the viral genome and Rep across the nuclear envelope.1 Publication

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. endocytosis involved in viral entry into host cell Source: UniProtKB-KW
    2. viral capsid assembly Source: InterPro
    3. viral penetration into host nucleus Source: UniProtKB-KW
    4. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Viral penetration into host nucleus, Virus endocytosis by host, Virus entry into host cell

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Capsid protein
    Gene namesi
    Name:Cap
    ORF Names:ORF2
    OrganismiBeak and feather disease virus (BFDV)
    Taxonomic identifieri77856 [NCBI]
    Taxonomic lineageiVirusesssDNA virusesCircoviridaeCircovirus
    Virus hostiGracula [TaxID: 116991]
    Psittaciformes [TaxID: 9223]
    ProteomesiUP000007454: Genome

    Subcellular locationi

    Host nucleus 1 Publication. Virion Curated

    GO - Cellular componenti

    1. host cell nucleus Source: UniProtKB-SubCell
    2. intracellular Source: GOC
    3. T=1 icosahedral viral capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Host nucleus, T=1 icosahedral capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 247247Capsid proteinPRO_0000319848Add
    BLAST

    Interactioni

    Subunit structurei

    Homomultimer. Assembles in the nucleus, presumably in an immature form, then migrates to the cytoplasm once assembled as mature virion By similarity. Interacts with Rep; this interaction relocates Rep into the nucleus.By similarity1 Publication

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 4040DNA-bindingBy similarityAdd
    BLAST
    Regioni15 – 4430Nuclear localization signalsSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi15 – 5440Arg-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the circoviridae capsid protein family.Curated

    Family and domain databases

    InterProiIPR003383. Circovirus_capsid.
    [Graphical view]
    PfamiPF02443. Circo_capsid. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9YUC8-1 [UniParc]FASTAAdd to Basket

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    MWGTSNCACA KFQIRRRYAR PYRRRHIRRY RRRRRHFRRR RFTTNRVYTL    50
    RLTRQFQFKI QKQTTSVGNL IFNADYITFA LDDFLQAVPN PHALNFEDYR 100
    IKLAKMEMRP TGGHYTVQSN GFGHTAVIQD SRITKFKTTA DQTQDPLAPF 150
    DGAKKWFVSR GFKRLLRPKP QITIEDLTTA NQSAALWLNS ARTGWIPLQG 200
    GPNSAGTKVR HYGIAFSFPQ PEQTITYVTK LTLYVQFRQF APNNPST 247
    Length:247
    Mass (Da):28,942
    Last modified:May 1, 1999 - v1
    Checksum:i25E086A559ABAB7E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF080560 Genomic DNA. Translation: AAC69862.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF080560 Genomic DNA. Translation: AAC69862.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR003383. Circovirus_capsid.
    [Graphical view ]
    Pfami PF02443. Circo_capsid. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Psittacine beak and feather disease virus nucleotide sequence analysis and its relationship to porcine circovirus, plant circoviruses, and chicken anaemia virus."
      Bassami M.R., Berryman D., Wilcox G.E., Raidal S.R.
      Virology 249:453-459(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The capsid protein of beak and feather disease virus binds to the viral DNA and is responsible for transporting the replication-associated protein into the nucleus."
      Heath L., Williamson A.L., Rybicki E.P.
      J. Virol. 80:7219-7225(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH REP, DNA-BINDING.

    Entry informationi

    Entry nameiCAPSD_BFDV
    AccessioniPrimary (citable) accession number: Q9YUC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3