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Q9YTC2

- Q9YTC2_9INFA

UniProt

Q9YTC2 - Q9YTC2_9INFA

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Protein
Submitted name: Haemagglutinin
Gene
N/A
Organism
Influenza A virus (A/swine/Scotland/410440/94(H1N2))
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore By similarity.UniRule annotationSAAS annotations

GO - Biological processi

  1. clathrin-mediated endocytosis of virus by host cell Source: UniProtKB-KW
  2. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  3. fusion of virus membrane with host plasma membrane Source: InterPro
  4. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HemagglutininUniRule annotationSAAS annotations

Keywords - Biological processi

Clathrin- and caveolin-independent endocytosis of virus by hostSAAS annotations, Clathrin-mediated endocytosis of virus by hostSAAS annotations, Fusion of virus membrane with host endosomal membraneSAAS annotations, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cellSAAS annotations, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Submitted name:
HaemagglutininImported
OrganismiInfluenza A virus (A/swine/Scotland/410440/94(H1N2))Imported
Taxonomic identifieri83206 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A

Subcellular locationi

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneSAAS annotations, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotations, Virion

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Interactioni

Subunit structurei

Homotrimer of disulfide-linked HA1-HA2 By similarity.UniRule annotationSAAS annotations

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KXANMR-A345-367[»]
ProteinModelPortaliQ9YTC2.
SMRiQ9YTC2. Positions 18-340, 345-519.

Miscellaneous databases

EvolutionaryTraceiQ9YTC2.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Family and domain databases

Gene3Di2.10.77.10. 1 hit.
3.90.20.10. 1 hit.
3.90.209.20. 1 hit.
InterProiIPR008980. Capsid_hemagglutn.
IPR013828. Hemagglutn_HA1_a/b_dom.
IPR013827. Hemagglutn_HA1_b-rbn_dom.
IPR000149. Hemagglutn_influenz_A.
IPR001364. Hemagglutn_influenz_A/B.
IPR013829. Hemagglutn_stalk.
[Graphical view]
PfamiPF00509. Hemagglutinin. 1 hit.
[Graphical view]
PRINTSiPR00330. HEMAGGLUTN1.
PR00329. HEMAGGLUTN12.
SUPFAMiSSF49818. SSF49818. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9YTC2-1 [UniParc]FASTAAdd to Basket

« Hide

MKEKLLVLLC ALSATDADTI CIGYHANNST DTVDTVLEKN VTVTHSVNLL    50
EDSHNGKLCR LKGIAPLQLG KCSIAGWILG NPECELLFSK KSWSYIAETP 100
NSENGICYPG YFSDYEELRE QLSSVSSFER FEIFPKESSW PKHSVNKGVT 150
KSCSHKGKSS FYRNLLWLTE KNGSYPNLSK SYVNNKEKEV LVLWGVHHPS 200
NIENQKTIYR KETAYVSVVS SHYNRRFTPE ITRRPKVRDQ EGRINYYWTL 250
LEPGDTIIFE ANGNLIAPWY RFALSRGFGS GIIISNASMD ECDAKCQTPQ 300
GAINSSLPFQ NVHPVTIGEC PKYVRSKKLR MVTGLRNIPS IQSRGLFGAI 350
AGFIEGGWTG MIDGWYGYHH QNEQGSGYAA DQKSTQNAIN GITNKVNSVI 400
EKMNTQFTAV GKEFNKLEKR IENLNKKVDD GFLDIWTYNA ELLVLLENER 450
TLDFHDSNVK TLYEKVKNQL KNNAKEIGNG CFEFYHKCNN ECMESVKNGT 500
YDYPKYSEES KLNREKIDGV KLESMGVYQI LAIYSTVASS LVLLVSLGAA 550
SFWMCSNGSL QCRICI 566
Length:566
Mass (Da):63,833
Last modified:May 1, 1999 - v1
Checksum:i2270269582E8969A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF085413 mRNA. Translation: AAD05215.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF085413 mRNA. Translation: AAD05215.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2KXA NMR - A 345-367 [» ]
ProteinModelPortali Q9YTC2.
SMRi Q9YTC2. Positions 18-340, 345-519.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q9YTC2.

Family and domain databases

Gene3Di 2.10.77.10. 1 hit.
3.90.20.10. 1 hit.
3.90.209.20. 1 hit.
InterProi IPR008980. Capsid_hemagglutn.
IPR013828. Hemagglutn_HA1_a/b_dom.
IPR013827. Hemagglutn_HA1_b-rbn_dom.
IPR000149. Hemagglutn_influenz_A.
IPR001364. Hemagglutn_influenz_A/B.
IPR013829. Hemagglutn_stalk.
[Graphical view ]
Pfami PF00509. Hemagglutinin. 1 hit.
[Graphical view ]
PRINTSi PR00330. HEMAGGLUTN1.
PR00329. HEMAGGLUTN12.
SUPFAMi SSF49818. SSF49818. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Brown I.H.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A/swine/Scotland/410440/94Imported.
  2. "The complete influenza hemagglutinin fusion domain adopts a tight helical hairpin arrangement at the lipid:water interface."
    Lorieau J.L., Louis J.M., Bax A.
    Proc. Natl. Acad. Sci. U.S.A. 107:11341-11346(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 345-367.
  3. "Multiple genetic reassortment of avian and human influenza A viruses in European pigs, resulting in the emergence of an H1N2 virus of novel genotype."
    Brown I.H., Harris P.A., McCauley J.W., Alexander D.J.
    J. Gen. Virol. 79:0-0(0) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A/swine/Scotland/410440/94Imported.

Entry informationi

Entry nameiQ9YTC2_9INFA
AccessioniPrimary (citable) accession number: Q9YTC2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: February 19, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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