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Q9YS52

- Q9YS52_9INFA

UniProt

Q9YS52 - Q9YS52_9INFA

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Protein
Submitted name:

Hemagglutinin

Gene
HA
Organism
Influenza A virus (A/Swine/Netherlands/L2/93(H3N2))
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore By similarity.UniRule annotationSAAS annotations

GO - Biological processi

  1. clathrin-mediated endocytosis of virus by host cell Source: UniProtKB-KW
  2. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  3. fusion of virus membrane with host plasma membrane Source: InterPro
  4. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HemagglutininUniRule annotationSAAS annotations

Keywords - Biological processi

Clathrin- and caveolin-independent endocytosis of virus by hostSAAS annotations, Clathrin-mediated endocytosis of virus by hostSAAS annotations, Fusion of virus membrane with host endosomal membraneSAAS annotations, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cellSAAS annotations, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Submitted name:
HemagglutininImported
Gene namesi
Name:HAImported
OrganismiInfluenza A virus (A/Swine/Netherlands/L2/93(H3N2))Imported
Taxonomic identifieri83928 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A

Subcellular locationi

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. viral envelope Source: UniProtKB-KW
  3. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneSAAS annotations, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotations, Virion

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Interactioni

Subunit structurei

Homotrimer of disulfide-linked HA1-HA2 By similarity.UniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliQ9YS52.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Family and domain databases

Gene3Di2.10.77.10. 1 hit.
3.90.209.20. 1 hit.
InterProiIPR008980. Capsid_hemagglutn.
IPR013828. Hemagglutn_HA1_a/b_dom.
IPR013827. Hemagglutn_HA1_b-rbn_dom.
IPR000149. Hemagglutn_influenz_A.
IPR001364. Hemagglutn_influenz_A/B.
[Graphical view]
PfamiPF00509. Hemagglutinin. 1 hit.
[Graphical view]
PRINTSiPR00330. HEMAGGLUTN1.
PR00329. HEMAGGLUTN12.
SUPFAMiSSF49818. SSF49818. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q9YS52-1 [UniParc]FASTAAdd to Basket

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QDLPGNGNNT ATLCLGHHAV PNGTLVRTIT DDQIEVTNAT ELVQNFSMGK    50
ICNNPHRILD GANCTLIDAL LGDPHCDGFQ NEKWDLFIER SKAFSNCYPY 100
DVPEYTSLRS LIASSGTLEF INEGFNWTGV TQNGGSNACK RGPNSSFFSR 150
LNWLYKSGNT YPMLNVTMPN SDSFDKLYIW GVHHPSTDRE QINLYVQASG 200
KITVSTKRSQ QTIIPNVGSR PWVRGLSSRI SIYWTIVKPG DILIINSNGN 250
LIAPRGYFKV HTGKSSIMRS DAPIDTCSSE CITPNGSIPN DKPFQNVNKI 300
TYGACPKYVK QNTLKLATGM RNIPEKQTR 329
Length:329
Mass (Da):36,457
Last modified:May 1, 1999 - v1
Checksum:i935A469B7C517952
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei329 – 3291Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF092056 Genomic RNA. Translation: AAC78090.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF092056 Genomic RNA. Translation: AAC78090.1 .

3D structure databases

ProteinModelPortali Q9YS52.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.10.77.10. 1 hit.
3.90.209.20. 1 hit.
InterProi IPR008980. Capsid_hemagglutn.
IPR013828. Hemagglutn_HA1_a/b_dom.
IPR013827. Hemagglutn_HA1_b-rbn_dom.
IPR000149. Hemagglutn_influenz_A.
IPR001364. Hemagglutn_influenz_A/B.
[Graphical view ]
Pfami PF00509. Hemagglutinin. 1 hit.
[Graphical view ]
PRINTSi PR00330. HEMAGGLUTN1.
PR00329. HEMAGGLUTN12.
SUPFAMi SSF49818. SSF49818. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A/Swine/Netherlands/L2/93Imported.
  2. "Antigenic drift in swine influenza H3 haemagglutinins with implications for vaccination policy."
    de Jong J.C., van Nieuwstadt A.P., Kimman T.G., Loeffen W.L.A., Bestebroer T.M., Bijlsma K., Verweij C., Osterhaus A.M.E., Class E.C.J.
    Vaccine 17:1321-1328(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A/Swine/Netherlands/L2/93Imported.

Entry informationi

Entry nameiQ9YS52_9INFA
AccessioniPrimary (citable) accession number: Q9YS52
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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