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Q9YS52 (Q9YS52_9INFA) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length329 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore By similarity. RuleBase RU003324

Subunit structure

Homotrimer of disulfide-linked HA1-HA2 By similarity. RuleBase RU003324 SAAS SAAS000149

Subcellular location

Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein By similarity SAAS SAAS000149.

Sequence similarities

Belongs to the influenza viruses hemagglutinin family. RuleBase RU003324

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL AAC78090.1
Non-terminal residue3291 EMBL AAC78090.1

Sequences

Sequence LengthMass (Da)Tools
Q9YS52 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 935A469B7C517952

FASTA32936,457
        10         20         30         40         50         60 
QDLPGNGNNT ATLCLGHHAV PNGTLVRTIT DDQIEVTNAT ELVQNFSMGK ICNNPHRILD 

        70         80         90        100        110        120 
GANCTLIDAL LGDPHCDGFQ NEKWDLFIER SKAFSNCYPY DVPEYTSLRS LIASSGTLEF 

       130        140        150        160        170        180 
INEGFNWTGV TQNGGSNACK RGPNSSFFSR LNWLYKSGNT YPMLNVTMPN SDSFDKLYIW 

       190        200        210        220        230        240 
GVHHPSTDRE QINLYVQASG KITVSTKRSQ QTIIPNVGSR PWVRGLSSRI SIYWTIVKPG 

       250        260        270        280        290        300 
DILIINSNGN LIAPRGYFKV HTGKSSIMRS DAPIDTCSSE CITPNGSIPN DKPFQNVNKI 

       310        320 
TYGACPKYVK QNTLKLATGM RNIPEKQTR 

« Hide

References

[1]De Jong J.C., Van Nieuwstadt A.P., Kimman T.G., Loeffen W.L.A., Bestebroer T.M., Bijlsma K., Verweij C., Osterhaus A.D.M.E., Claas E.C.J.
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: A/Swine/Netherlands/L2/93 EMBL AAC78090.1.
[2]"Antigenic drift in swine influenza H3 haemagglutinins with implications for vaccination policy."
de Jong J.C., van Nieuwstadt A.P., Kimman T.G., Loeffen W.L.A., Bestebroer T.M., Bijlsma K., Verweij C., Osterhaus A.M.E., Class E.C.J.
Vaccine 17:1321-1328(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: A/Swine/Netherlands/L2/93 EMBL AAC78090.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF092056 Genomic RNA. Translation: AAC78090.1.

3D structure databases

ProteinModelPortalQ9YS52.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.10.77.10. 1 hit.
3.90.209.20. 1 hit.
InterProIPR008980. Capsid_hemagglutn.
IPR013828. Hemagglutn_HA1_a/b_dom.
IPR013827. Hemagglutn_HA1_b-rbn_dom.
IPR000149. Hemagglutn_influenz_A.
IPR001364. Hemagglutn_influenz_A/B.
[Graphical view]
PfamPF00509. Hemagglutinin. 1 hit.
[Graphical view]
PRINTSPR00330. HEMAGGLUTN1.
PR00329. HEMAGGLUTN12.
SUPFAMSSF49818. SSF49818. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ9YS52_9INFA
AccessionPrimary (citable) accession number: Q9YS52
Entry history
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: February 19, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)