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Q9YS17 - NSP4_ROTPC
Non-structural glycoprotein 4
- Names & Taxonomy
- Subcellular locationSubcell. location
- Pathology & BiotechPathol./Biotech
- PTM / Processing
- Family & Domains
- Entry information
- BLAST>sp|Q9YS17|NSP4_ROTPC Non-structural glycoprotein 4 OS=Rotavirus C (strain Pig/United States/Cowden/1980) PE=2 SV=1 MEFINQTFFSDYSEGKIDTIPYALGIVLALTNGSRILKFINLLISLLRKFIITSKTVIGK FKIENNTSHQNDDIHKEYEEVMKQMREMRVHVTALFDSIHKDNMEWRMSESIRREKKREM KASTAENEVKIHTNDVNICDTSGLETEVCL
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Select a section on the left to see content.Involved in virus morphogenesis. Functions as a receptor for the immature double-layered inner capsid particle (ICP) which transiently buds into the lumen of the rough endoplasmic reticulum during viral maturation By similarity.By similarityEnterotoxin that causes a phospholipase C-dependent elevation of the intracellular calcium concentration in host intestinal mucosa cells. Increased concentration of intracellular calcium disrupts the cytoskeleton and the tight junctions, raising the paracellular permeability. Potentiates chloride ion secretion through a calcium ion-dependent signaling pathway, inducing age-dependent diarrhea. To perform this enterotoxigenic role in vivo, NSP4 is probably released from infected enterocytes in a soluble form capable of diffusing within the intestinal lumen and interacting with the plasma membrane receptors on neighboring epithelial cells By similarity.By similarity
Recommended name:Non-structural glycoprotein 4Short name:NSP4
- pathogenesis Source: UniProtKB-KW
Rotavirus C (strain Pig/United States/Cowden/1980) (RV-C) 10916 [NCBI] Viruses › dsRNA viruses › Reoviridae › Sedoreovirinae › Rotavirus › Rotavirus C › Porcine rotavirus C <p>Only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.</p><p><a href='../manual/virus_host' target='_top'>More...</a></p>Virus hosti Sus scrofa (Pig) [TaxID: 9823] UP000008175: GenomeChain Non-structural glycoprotein 4 : Host rough endoplasmic reticulum membrane By similarity; Single-pass type III membrane protein By similarity. Host membrane › host caveola; Single-pass type III membrane protein. Secreted By similarity
Note: Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles. NSP4 also localizes in vesicular structures, which contain an autophagosomal marker and associate with viroplasms in virus-infected cells By similarity.By similarity
- host caveola Source: UniProtKB-SubCell
- host cell rough endoplasmic reticulum membrane Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Feature key Position(s) Length Description Graphical view Feature identifier Actions 1 – 150 150 Non-structural glycoprotein 4 PRO_0000369891 Add
Amino acid modifications
Feature key Position(s) Length Description Graphical view Feature identifier Actions <p>Specifies the position and type of each covalently attached glycan group (mono-, di- , or polysaccharide).</p><p><a href='../manual/carbohyd' target='_top'>More...</a></p>Glycosylationi 5 – 5 1 N-linked (GlcNAc...); by hostSequence AnalysisHomotetramer.By similarity
Feature key Position(s) Length Description Graphical view Feature identifier Actions <p>Describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.</p><p><a href='../manual/topo_dom' target='_top'>More...</a></p>Topological domaini 1 – 21 21 LumenalBy similarity Add
<p>Describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.</p><p><a href='../manual/topo_dom' target='_top'>More...</a></p>Topological domaini 47 – 150 104 CytoplasmicBy similarity Add
Feature key Position(s) Length Description Graphical view Feature identifier Actions <p>Describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.</p><p><a href='../manual/transmem' target='_top'>More...</a></p>Transmembranei 22 – 46 25 HelicalSequence Analysis Add
Feature key Position(s) Length Description Graphical view Feature identifier Actions <p>Denotes the positions of regions of coiled coil within the protein.</p><p><a href='../manual/coiled' target='_top'>More...</a></p>Coiled coili 68 – 90 23 Sequence Analysis Add
<p>Provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.</p><p><a href='../manual/domain_cc' target='_top'>More...</a></p>DomainiThe coiled coil region mediates oligomerization.By similarityBelongs to the rotavirus NSP4 family.CuratedQ9YS17-1 [UniParc]FASTAAdd to Basket
MEFINQTFFS DYSEGKIDTI PYALGIVLAL TNGSRILKFI NLLISLLRKF 50
IITSKTVIGK FKIENNTSHQ NDDIHKEYEE VMKQMREMRV HVTALFDSIH 100
KDNMEWRMSE SIRREKKREM KASTAENEVK IHTNDVNICD TSGLETEVCL 150Length:150Mass (Da):17,489Last modified:May 1, 1999 - v1<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5093C34FEFBE8FC2
Feature key Position(s) Length Description Graphical view Feature identifier Actions 50 – 50 1 F → L in strain: Cowden-virulent. 97 – 97 1 D → N in strain: Cowden-virulent.
Sequence databasesSelect the link destinations:
AF093202 mRNA. Translation: AAC83711.1.
AF093203 mRNA. Translation: AAC83712.1.
Sequence databasesSelect the link destinations:
AF093202 mRNA. Translation: AAC83711.1 .
AF093203 mRNA. Translation: AAC83712.1 .
3D structure databases
Database of comparative protein structure models<br/><a href='/database/63'>More..</a> ModBasei Search... Search...
Protocols and materials databases
Structural Biology Knowledgebase Search...
Family and domain databases
- "Comparisons of nucleotide and deduced amino acid sequences of NSP4 genes of virulent and attenuated pairs of group A and C rotaviruses."
Chang K.O., Kim Y.J., Saif L.J.
Virus Genes 18:229-233(1999) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA].Strain: Cowden-attenuated and Cowden-virulent.
NSP4_ROTPC Q9YS17Primary (citable) accession number: Q9YS17
Secondary accession number(s): Q9YS18
Integrated into UniProtKB/Swiss-Prot: April 14, 2009 Last sequence update: May 1, 1999 Last modified: October 1, 2014 This is version 26 of the entry and version 1 of the sequence. [Complete history] Reviewed (UniProtKB/Swiss-Prot) Annotation program Viral Protein Annotation Program
- SIMILARITY commentsIndex of protein domains and families
External DataDasty 3