Q9YPD5 (RDRP_MBVLF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RNA-directed RNA polymerase
EC=2.7.7.48

Gene names

ORF Names:

ORF3

Organism

Mushroom bacilliform virus (isolate Australia/AUS LF-1) (MBV) [Reference proteome]

Taxonomic identifier

650482 [NCBI]

Taxonomic lineage

Viruses › ssRNA viruses › ssRNA positive-strand viruses, no DNA stage › Barnaviridae › Barnavirus › Mushroom bacilliform virus

Virus host

Agaricus bisporus (White button mushroom) [TaxID: 5341]

Protein attributes

Sequence length	420 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	RNA-dependent RNA polymerase which replicates the viral genome Potential.
Catalytic activity	Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
Post-translational modification	Might be cleaved to release the mature protein(s) Potential.
Sequence similarities	Belongs to the ssRNA positive-strand viruses RNA-directed RNA polymerase family. Contains 1 RdRp catalytic domain.

Ontologies

Keywords
Biological process	Viral RNA replication
Ligand	Nucleotide-binding
Molecular function	Nucleotidyltransferase RNA-directed RNA polymerase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro viral genome replication Inferred from electronic annotation. Source: InterPro
Molecular_function	RNA binding Inferred from electronic annotation. Source: InterPro RNA-directed RNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 420	420	RNA-directed RNA polymerase		PRO_0000402444
Regions
	Domain	199 – 325	127	RdRp catalytic

Sequences

	Sequence		Length	Mass (Da)
	Q9YPD5 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 1E5A910DCDE5A72F	FASTA	420	46,914
	10 20 30 40 50 60 MDSGLYPKTG APTWFYGWSK QREGGFSDFG SEIFRLRALP PLKAEIFRGI REVVEYNITG 70 80 90 100 110 120 DSHPGYPWCK LGSDNKAVLT GFGDLIWDEV AKRFNNMLGY GDAIFSMTPS ELVQNGICDA 130 140 150 160 170 180 VKVFIKQEPH SLEKVNAGRL RIIAAVGLVD QIVTRLLCMK QNNAEIDCWE SCPSAPGMGL 190 200 210 220 230 240 NDEGLRTLYS TAQVMAEHGT ICETDISGWD WSVQQWELDS DARLRTQLAG EEIGGYLNFF 250 260 270 280 290 300 LRVHAYVVGH SVFVMPDGEM LEQTVPGGQL SGDYNTSSSN SRMRVIATMF ARYLAGQVSG 310 320 330 340 350 360 FPLLGIKAMG DDSFEIWFKG LEEYLGKMGH TVKMCVQRPG LVGFEFCSQV FLGLGIAYPV 370 380 390 400 410 420 DFSKTLYRFL SHHPADPKYS EYRAQLMYYF RHLPSSTLQK VIRLAGARVE RAQKLATSSN

References

[1]	"The nucleotide sequence and genome organization of mushroom bacilliform virus: a single-stranded RNA virus of Agaricus bisporus (Lange) Imbach." Revill P.A., Davidson A.D., Wright P.J. Virology 202:904-911(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U07551 Genomic RNA. Translation: AAA53090.1.
RefSeq	NP_042510.2. NC_001633.1.
3D structure databases
ProteinModelPortal	Q9YPD5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1497107.
Family and domain databases
InterPro	IPR001795. RNA-dir_pol_luteovirus. IPR007094. RNA-dir_pol_PSvirus. [Graphical view]
Pfam	PF02123. RdRP_4. 1 hit. [Graphical view]
PRINTS	PR00914. LVIRUSRNAPOL.
PROSITE	PS50507. RDRP_SSRNA_POS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RDRP_MBVLF

Accession

Primary (citable) accession number: Q9YPD5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 30, 2010
Last sequence update:	May 1, 1999
Last modified:	April 3, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program