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Protein

Endogenous retrovirus group K member 19 Gag polyprotein

Gene

ERVK-19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri544 – 561CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri580 – 597CCHC-type 2PROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Endogenous retrovirus group K member 19 Gag polyprotein
Alternative name(s):
HERV-K(C19) Gag protein
HERV-K_19q11 provirus ancestral Gag polyprotein
Short name:
Gag polyprotein
Gene namesi
Name:ERVK-19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:39026 ERVK-19
neXtProtiNX_Q9YNA8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi100862685

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00001867462 – 666Endogenous retrovirus group K member 19 Gag polyproteinAdd BLAST665

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Post-translational modificationi

Myristoylation is essential for retroviral assembly. Alteration of the glycine residue leads to a block in the budding of particles and an accumulation of Gag inside the cell (By similarity).By similarity
Specific enzymatic cleavages may yield mature proteins.Curated

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PRIDEiQ9YNA8

PTM databases

iPTMnetiQ9YNA8
PhosphoSitePlusiQ9YNA8

Structurei

3D structure databases

ProteinModelPortaliQ9YNA8
SMRiQ9YNA8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi206 – 257Pro-richAdd BLAST52
Compositional biasi611 – 666Gln-richAdd BLAST56

Domaini

HERV-K Gag polyprotein contains regions homologous to the matrix (MA), capsid (CA) and nucleocapsid (NC) proteins from infectious retroviruses. Evidence suggests that HERV-K(HML-2) Gag polyprotein can be cleaved into mature MA, CA and NC under certain circumstances. However, the exact boundaries as well as the size of processed Gag proteins have not been precisely determined yet.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri544 – 561CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri580 – 597CCHC-type 2PROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG081547
PhylomeDBiQ9YNA8

Family and domain databases

Gene3Di1.10.1200.30, 1 hit
1.10.150.490, 1 hit
1.10.375.10, 1 hit
InterProiView protein in InterPro
IPR003322 B_retro_matrix
IPR038124 B_retro_matrix_sf
IPR000721 Gag_p24
IPR008916 Retrov_capsid_C
IPR008919 Retrov_capsid_N
IPR010999 Retrovr_matrix
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF02337 Gag_p10, 1 hit
PF00607 Gag_p24, 1 hit
PF00098 zf-CCHC, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004265 B_retro_matrix_N, 1 hit
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 2 hits
SUPFAMiSSF47836 SSF47836, 1 hit
SSF47943 SSF47943, 1 hit
SSF57756 SSF57756, 2 hits
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by ribosomal frameshifting. AlignAdd to basket

Note: This protein is synthesized as a Gag polypeptide and as a Gag-Pro-Pol polyprotein. The later is the precursor of the Pro and Pol proteins. It is thought, by similarity with type-B retroviruses, to be generated by -1 frameshifts occurring at the Gag-Pro and Pro-Pol genes boundaries.
Isoform 1 (identifier: Q9YNA8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQTKSKIKS KYASYLSFIK ILLKRGGVKV STKNLIKLFQ IIEQFCPWFP
60 70 80 90 100
EQGTLDLKDW KRIGKELKQA GRKGNIIPLT VWNDWAIIKA ALEPFQTEED
110 120 130 140 150
SVSVSDAPGS CIIDCNENTR KKSQKETESL HCEYVAEPVM AQSTQNVDYN
160 170 180 190 200
QLQEVIYPET LKLEGKVPEL VGPSESKPRG TSRLPAGQVP VTLQPQTQVK
210 220 230 240 250
ENKTQPPVAY QYWPPAELQY RPPLESQYGY PGMPPAPQGR APYPQPPTRR
260 270 280 290 300
LNPTAPPSRR GSELHEIIDK SRKEGDTEAW QFPVTLEPMP PGEGAQEGEP
310 320 330 340 350
PTVEARYKSF SIKMLKDMKE GVKQYGPNSP YMRTLLDSIA HGHRLIPYDW
360 370 380 390 400
EILAKSSLSP SQFLQFKTWW IDGVQEQVRR NRAANPPVNI DADQLLGIGQ
410 420 430 440 450
NWSTISQQAL MQNEAIEQVR AICLRAWEKI QDPGSTCPSF NTVRQGSKEP
460 470 480 490 500
YPDFVARLQD VAQKSIAIEK ARKVIVELMA YENPNPECQS AIKPLKGKVP
510 520 530 540 550
AGSDVISEYV KACDGMGGAM HKAMLMAQAI TGVVLGGQVR TFGGKCYNCG
560 570 580 590 600
QIGHLKKNCP VLNKQNITIQ ATTTGREPPD LCPRCKKGKH WASQCRSKFD
610 620 630 640 650
KNGQPLSGNE QRGQPQAPQQ TGAFPIQPFV PHGFQGQQPP LSQVFQGISQ
660
LPQYNNCPPP QAAVQQ
Length:666
Mass (Da):74,183
Last modified:January 23, 2007 - v3
Checksum:i1B05B2577A693F55
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti167V → G in CAA76881 (PubMed:10516026).Curated1
Sequence conflicti224L → V in CAA76881 (PubMed:10516026).Curated1
Sequence conflicti285T → M in CAA76881 (PubMed:10516026).Curated1
Sequence conflicti468I → N in CAA76881 (PubMed:10516026).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17833 Genomic DNA Translation: CAA76881.1
AC112702 Genomic DNA No translation available.

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Similar proteinsi

Entry informationi

Entry nameiGAK19_HUMAN
AccessioniPrimary (citable) accession number: Q9YNA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 106 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, ERV, Reference proteome, Transposable element

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