##gff-version 3 Q9YN02 UniProtKB Chain 1 3961 . . . ID=PRO_0000036657;Note=Replicase polyprotein 1ab Q9YN02 UniProtKB Chain 1 382 . . . ID=PRO_0000410826;Note=Nsp1;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9YN02 UniProtKB Chain 1 180 . . . ID=PRO_0000036659;Note=Nsp1-alpha papain-like cysteine proteinase;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9YN02 UniProtKB Chain 181 383 . . . ID=PRO_0000036660;Note=Nsp1-beta papain-like cysteine proteinase;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9YN02 UniProtKB Chain 384 1579 . . . ID=PRO_0000036661;Note=Nsp2 cysteine proteinase;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9YN02 UniProtKB Chain 1580 1809 . . . ID=PRO_0000036662;Note=Non-structural protein 3;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9YN02 UniProtKB Chain 1810 2013 . . . ID=PRO_0000036663;Note=Serine protease nsp4;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9YN02 UniProtKB Chain 2014 2458 . . . ID=PRO_0000036664;Note=Non-structural protein 5-6-7;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9YN02 UniProtKB Chain 2014 2183 . . . ID=PRO_0000423118;Note=Non-structural protein 5;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9YN02 UniProtKB Chain 2184 2199 . . . ID=PRO_0000423119;Note=Non-structural protein 6;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9YN02 UniProtKB Chain 2200 2348 . . . ID=PRO_0000423120;Note=Non-structural protein 7-alpha;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9YN02 UniProtKB Chain 2349 2458 . . . ID=PRO_0000423121;Note=Non-structural protein 7-beta;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9YN02 UniProtKB Chain 2459 3144 . . . ID=PRO_0000036665;Note=RNA-directed RNA polymerase;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9YN02 UniProtKB Chain 2459 2503 . . . ID=PRO_0000036666;Note=Non-structural protein 8;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9YN02 UniProtKB Chain 3145 3585 . . . ID=PRO_0000036667;Note=Helicase nsp10;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9YN02 UniProtKB Chain 3586 3808 . . . ID=PRO_0000036668;Note=Uridylate-specific endoribonuclease nsp11;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9YN02 UniProtKB Chain 3809 3961 . . . ID=PRO_0000036669;Note=Non-structural protein 12;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9YN02 UniProtKB Transmembrane 1266 1286 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9YN02 UniProtKB Transmembrane 1296 1316 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9YN02 UniProtKB Transmembrane 1345 1365 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9YN02 UniProtKB Transmembrane 1368 1388 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9YN02 UniProtKB Transmembrane 1583 1603 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9YN02 UniProtKB Transmembrane 1650 1670 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9YN02 UniProtKB Transmembrane 1685 1705 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9YN02 UniProtKB Transmembrane 1719 1739 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9YN02 UniProtKB Transmembrane 2012 2032 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9YN02 UniProtKB Transmembrane 2060 2080 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9YN02 UniProtKB Transmembrane 2092 2112 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9YN02 UniProtKB Transmembrane 2137 2157 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9YN02 UniProtKB Transmembrane 2164 2184 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9YN02 UniProtKB Domain 69 180 . . . Note=Peptidase C31;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00872 Q9YN02 UniProtKB Domain 263 383 . . . Note=Peptidase C32;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00873 Q9YN02 UniProtKB Domain 428 535 . . . Note=Peptidase C33;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00871 Q9YN02 UniProtKB Domain 1810 2013 . . . Note=Peptidase S32;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00826 Q9YN02 UniProtKB Domain 2488 2651 . . . Note=NiRAN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01292 Q9YN02 UniProtKB Domain 2890 3024 . . . Note=RdRp catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00539 Q9YN02 UniProtKB Domain 3145 3208 . . . Note=AV ZBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00985 Q9YN02 UniProtKB Domain 3265 3417 . . . Note=(+)RNA virus helicase ATP-binding Q9YN02 UniProtKB Domain 3418 3546 . . . Note=(+)RNA virus helicase C-terminal Q9YN02 UniProtKB Domain 3585 3681 . . . Note=AV-Nsp11N/CoV-Nsp15M;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01306 Q9YN02 UniProtKB Domain 3683 3805 . . . Note=NendoU;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01303 Q9YN02 UniProtKB Zinc finger 8 28 . . . Note=C4-type%3B atypical Q9YN02 UniProtKB Region 69 182 . . . Note=PCP1-alpha Q9YN02 UniProtKB Region 199 200 . . . Note=Important for host EIF2AK2 inhibition;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A6YQT5 Q9YN02 UniProtKB Region 263 382 . . . Note=PCP1-beta Q9YN02 UniProtKB Region 426 513 . . . Note=OTU-like Q9YN02 UniProtKB Region 809 862 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9YN02 UniProtKB Region 898 979 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9YN02 UniProtKB Region 1153 1213 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9YN02 UniProtKB Region 1266 1388 . . . Note=HD1 Q9YN02 UniProtKB Region 1583 1745 . . . Note=HD2 Q9YN02 UniProtKB Region 2036 2157 . . . Note=HD3 Q9YN02 UniProtKB Region 2329 2358 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9YN02 UniProtKB Compositional bias 825 840 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9YN02 UniProtKB Compositional bias 953 969 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9YN02 UniProtKB Compositional bias 1160 1179 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9YN02 UniProtKB Compositional bias 1181 1198 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9YN02 UniProtKB Compositional bias 2329 2346 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9YN02 UniProtKB Active site 76 76 . . . Note=For Nsp1-alpha papain-like cysteine proteinase activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00872 Q9YN02 UniProtKB Active site 146 146 . . . Note=For Nsp1-alpha papain-like cysteine proteinase activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00872 Q9YN02 UniProtKB Active site 270 270 . . . Note=For Nsp1-beta papain-like cysteine proteinase activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00873 Q9YN02 UniProtKB Active site 339 339 . . . Note=For Nsp1-beta papain-like cysteine proteinase activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00873 Q9YN02 UniProtKB Active site 437 437 . . . Note=For Nsp2 cysteine proteinase activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00871 Q9YN02 UniProtKB Active site 506 506 . . . Note=For Nsp2 cysteine proteinase activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00871 Q9YN02 UniProtKB Active site 1848 1848 . . . Note=Charge relay system%3B for 3C-like serine proteinase activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00826 Q9YN02 UniProtKB Active site 1873 1873 . . . Note=Charge relay system%3B for 3C-like serine proteinase activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00826 Q9YN02 UniProtKB Active site 1927 1927 . . . Note=Charge relay system%3B for 3C-like serine proteinase activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00826 Q9YN02 UniProtKB Active site 3714 3714 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01303 Q9YN02 UniProtKB Active site 3729 3729 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01303 Q9YN02 UniProtKB Active site 3758 3758 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01303 Q9YN02 UniProtKB Binding site 3151 3151 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00985 Q9YN02 UniProtKB Binding site 3154 3154 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00985 Q9YN02 UniProtKB Binding site 3164 3164 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00985 Q9YN02 UniProtKB Binding site 3169 3169 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00985 Q9YN02 UniProtKB Binding site 3172 3172 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00985 Q9YN02 UniProtKB Binding site 3174 3174 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00985 Q9YN02 UniProtKB Binding site 3176 3176 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00985 Q9YN02 UniProtKB Binding site 3178 3178 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00985 Q9YN02 UniProtKB Binding site 3185 3185 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00985 Q9YN02 UniProtKB Binding site 3187 3187 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00985 Q9YN02 UniProtKB Binding site 3194 3194 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00985 Q9YN02 UniProtKB Binding site 3197 3197 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00985 Q9YN02 UniProtKB Binding site 3298 3305 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9YN02 UniProtKB Site 180 181 . . . Note=Cleavage%3B by autolysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WJB2 Q9YN02 UniProtKB Site 383 384 . . . Note=Cleavage%3B by autolysis;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9YN02 UniProtKB Site 1579 1580 . . . Note=Cleavage%3B by CP2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A0MD28 Q9YN02 UniProtKB Site 1809 1810 . . . Note=Cleavage%3B by 3CLSP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A0MD28 Q9YN02 UniProtKB Site 2013 2014 . . . Note=Cleavage%3B by 3CLSP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A0MD28 Q9YN02 UniProtKB Site 2183 2184 . . . Note=Cleavage%3B by 3CLSP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A0MD28 Q9YN02 UniProtKB Site 2199 2200 . . . Note=Cleavage%3B by 3CLSP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A0MD28 Q9YN02 UniProtKB Site 2348 2349 . . . Note=Cleavage%3B by 3CLSP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A0MD28 Q9YN02 UniProtKB Site 2458 2459 . . . Note=Cleavage%3B by 3CLSP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A0MD28 Q9YN02 UniProtKB Site 2503 2504 . . . Note=Cleavage%3B by 3CLSP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A0MD28 Q9YN02 UniProtKB Site 3144 3145 . . . Note=Cleavage%3B by 3CLSP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A0MD28 Q9YN02 UniProtKB Site 3195 3195 . . . Note=Involved in mRNA transcription process;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9YN02 UniProtKB Site 3585 3586 . . . Note=Cleavage%3B by 3CLSP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9YN02 UniProtKB Site 3808 3809 . . . Note=Cleavage%3B by 3CLSP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9YN02 UniProtKB Alternative sequence 2504 3961 . . . ID=VSP_032890;Note=In isoform Replicase polyprotein 1a. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9YN02 UniProtKB Helix 3592 3597 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EYI Q9YN02 UniProtKB Beta strand 3602 3605 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EYI Q9YN02 UniProtKB Beta strand 3609 3611 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EYI Q9YN02 UniProtKB Helix 3614 3619 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EYI Q9YN02 UniProtKB Beta strand 3622 3626 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EYI Q9YN02 UniProtKB Beta strand 3632 3640 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EYI Q9YN02 UniProtKB Beta strand 3647 3651 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EYI Q9YN02 UniProtKB Beta strand 3654 3656 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EYI Q9YN02 UniProtKB Beta strand 3659 3661 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EYI Q9YN02 UniProtKB Beta strand 3667 3676 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EYI Q9YN02 UniProtKB Beta strand 3679 3681 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EYI Q9YN02 UniProtKB Helix 3692 3695 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EYI Q9YN02 UniProtKB Helix 3703 3711 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EYI Q9YN02 UniProtKB Helix 3713 3716 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EYI Q9YN02 UniProtKB Beta strand 3719 3721 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EYI Q9YN02 UniProtKB Beta strand 3724 3726 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EYI Q9YN02 UniProtKB Beta strand 3742 3752 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EYI Q9YN02 UniProtKB Turn 3753 3755 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EYI Q9YN02 UniProtKB Beta strand 3756 3764 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EYI Q9YN02 UniProtKB Helix 3768 3774 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EYI Q9YN02 UniProtKB Beta strand 3778 3788 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EYI Q9YN02 UniProtKB Beta strand 3791 3798 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EYI Q9YN02 UniProtKB Turn 3799 3801 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EYI Q9YN02 UniProtKB Beta strand 3802 3806 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EYI