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Protein

Super small secreted glycoprotein

Gene

GP

Organism
Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Super small secreted glycoprotein
Short name:
SsGP
Gene namesi
Name:GP
OrganismiZaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus)
Taxonomic identifieri128952 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
Virus hostiEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
Homo sapiens (Human) [TaxID: 9606]
Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]
ProteomesiUP000007209 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence AnalysisAdd
BLAST
Chaini33 – 298266Super small secreted glycoproteinPRO_0000391494Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...); by hostSequence Analysis
Disulfide bondi53 – 53InterchainBy similarity
Disulfide bondi108 ↔ 135By similarity
Disulfide bondi121 ↔ 147By similarity
Glycosylationi204 – 2041N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi228 – 2281N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi238 – 2381N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi257 – 2571N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi268 – 2681N-linked (GlcNAc...); by hostSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the filoviruses glycoprotein family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR002561. GPC_filovir-type_extra_dom.
[Graphical view]
PfamiPF01611. Filo_glycop. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9YMG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVTGILQLP RDRFKRTSFF LWVIILFQRT FSIPLGVIHN STLQVSDVDK
60 70 80 90 100
LVCRDKLSST NQLRSVGLNL EGNGVATDVP SATKRWGFRS GVPPKVVNYE
110 120 130 140 150
AGEWAENCYN LEIKKPDGSE CLPAAPDGIR GFPRCRYVHK VSGTGPCAGD
160 170 180 190 200
FAFHKEGAFF LYDRLASTVI YRGTTFAEGV VAFLILPQAK KDFFSSHPLR
210 220 230 240 250
EPVNATEDPS SGYYSTTIRY QATGFGTNET EYLFEVDNLT YVQLESRFTP
260 270 280 290
QFLLQLNETI YTSGKRSNTT GKLIWKVNPE IDTTIGEWAF WETKKKPH
Length:298
Mass (Da):33,520
Last modified:February 9, 2010 - v2
Checksum:i584B65414512A61E
GO

Sequence cautioni

The sequence AAD14586.1 differs from that shown. Reason: Erroneous translation. A lysine is missing at the editing site.Curated
The sequence ABX75369.1 differs from that shown. Reason: Erroneous translation. A lysine is missing at the editing site.Curated

RNA editingi

Edited at position 295.
Partially edited. RNA editing at this position consists of an insertion of one or two adenine nucleotides. The sequence displayed here is the super small secreted glycoprotein ssGP, derived from the +2A edited RNA. The unedited RNA gives rise to the small secreted glycoprotein sGP (AC P60170), the +1A edited RNA gives rise to the full-length transmembrane glycoprotein GP (AC Q05320).

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF086833 Genomic RNA. Translation: AAD14586.1. Sequence problems.
EU224440 Viral cRNA. Translation: ABX75369.1. Sequence problems.
RefSeqiNP_066248.1. NC_002549.1.

Genome annotation databases

GeneIDi911829.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF086833 Genomic RNA. Translation: AAD14586.1. Sequence problems.
EU224440 Viral cRNA. Translation: ABX75369.1. Sequence problems.
RefSeqiNP_066248.1. NC_002549.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi911829.

Family and domain databases

InterProiIPR002561. GPC_filovir-type_extra_dom.
[Graphical view]
PfamiPF01611. Filo_glycop. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Processing of the Ebola virus glycoprotein by the proprotein convertase furin."
    Volchkov V.E., Feldmann H., Volchkova V.A., Klenk H.-D.
    Proc. Natl. Acad. Sci. U.S.A. 95:5762-5767(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Mayinga.
  2. "The VP35 and VP40 proteins of filoviruses. Homology between Marburg and Ebola viruses."
    Bukreyev A.A., Volchkov V.E., Blinov V.M., Netesov S.V.
    FEBS Lett. 322:41-46(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Mayinga.
  3. "GP mRNA of Ebola virus is edited by the Ebola virus polymerase and by T7 and vaccinia virus polymerases."
    Volchkov V.E., Becker S., Volchkova V.A., Ternovoj V.A., Kotov A.N., Netesov S.V., Klenk H.-D.
    Virology 214:421-430(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Mayinga.
  4. "Release of viral glycoproteins during Ebola virus infection."
    Volchkov V.E., Volchkova V.A., Slenczka W., Klenk H.-D., Feldmann H.
    Virology 245:110-119(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Mayinga.
  5. "Characterization of the L gene and 5' trailer region of Ebola virus."
    Volchkov V.E., Volchkova V.A., Chepurnov A.A., Blinov V.M., Netesov S.V., Feldmann H.
    J. Gen. Virol. 80:355-362(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Mayinga.
  6. Volchkov V.E.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Mayinga.
  7. "Experimental study of molecular determinants of Ebola virus virulence in guinea pigs."
    Subbotina E.L., Kachko A.V., Dadaeva A.A., Chepurnov A.A.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Mayinga.

Entry informationi

Entry nameiVSSGP_EBOZM
AccessioniPrimary (citable) accession number: Q9YMG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: February 9, 2010
Last modified: July 22, 2015
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.