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Q9YMG2 (VSSGP_EBOZM) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length298 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the filoviruses glycoprotein family.

RNA editing

Edited at position 295.
Partially edited. RNA editing at this position consists of an insertion of one or two adenine nucleotides. The sequence displayed here is the super small secreted glycoprotein ssGP, derived from the +2A edited RNA. The unedited RNA gives rise to the small secreted glycoprotein sGP (AC P60170), the +1A edited RNA gives rise to the full-length transmembrane glycoprotein GP (AC Q05320).

Sequence caution

The sequence AAD14586.1 differs from that shown. Reason: Erroneous translation. A lysine is missing at the editing site.

The sequence ABX75369.1 differs from that shown. Reason: Erroneous translation. A lysine is missing at the editing site.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityRNA editing
   DomainSignal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3232 Potential
Chain33 – 298266Super small secreted glycoprotein
PRO_0000391494

Amino acid modifications

Glycosylation401N-linked (GlcNAc...); by host Potential
Glycosylation2041N-linked (GlcNAc...); by host Potential
Glycosylation2281N-linked (GlcNAc...); by host Potential
Glycosylation2381N-linked (GlcNAc...); by host Potential
Glycosylation2571N-linked (GlcNAc...); by host Potential
Glycosylation2681N-linked (GlcNAc...); by host Potential
Disulfide bond53Interchain By similarity
Disulfide bond108 ↔ 135 By similarity
Disulfide bond121 ↔ 147 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9YMG2 [UniParc].

Last modified February 9, 2010. Version 2.
Checksum: 584B65414512A61E

FASTA29833,520
        10         20         30         40         50         60 
MGVTGILQLP RDRFKRTSFF LWVIILFQRT FSIPLGVIHN STLQVSDVDK LVCRDKLSST 

        70         80         90        100        110        120 
NQLRSVGLNL EGNGVATDVP SATKRWGFRS GVPPKVVNYE AGEWAENCYN LEIKKPDGSE 

       130        140        150        160        170        180 
CLPAAPDGIR GFPRCRYVHK VSGTGPCAGD FAFHKEGAFF LYDRLASTVI YRGTTFAEGV 

       190        200        210        220        230        240 
VAFLILPQAK KDFFSSHPLR EPVNATEDPS SGYYSTTIRY QATGFGTNET EYLFEVDNLT 

       250        260        270        280        290 
YVQLESRFTP QFLLQLNETI YTSGKRSNTT GKLIWKVNPE IDTTIGEWAF WETKKKPH 

« Hide

References

[1]"Processing of the Ebola virus glycoprotein by the proprotein convertase furin."
Volchkov V.E., Feldmann H., Volchkova V.A., Klenk H.-D.
Proc. Natl. Acad. Sci. U.S.A. 95:5762-5767(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Mayinga.
[2]"The VP35 and VP40 proteins of filoviruses. Homology between Marburg and Ebola viruses."
Bukreyev A.A., Volchkov V.E., Blinov V.M., Netesov S.V.
FEBS Lett. 322:41-46(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Mayinga.
[3]"GP mRNA of Ebola virus is edited by the Ebola virus polymerase and by T7 and vaccinia virus polymerases."
Volchkov V.E., Becker S., Volchkova V.A., Ternovoj V.A., Kotov A.N., Netesov S.V., Klenk H.-D.
Virology 214:421-430(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Mayinga.
[4]"Release of viral glycoproteins during Ebola virus infection."
Volchkov V.E., Volchkova V.A., Slenczka W., Klenk H.-D., Feldmann H.
Virology 245:110-119(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Mayinga.
[5]"Characterization of the L gene and 5' trailer region of Ebola virus."
Volchkov V.E., Volchkova V.A., Chepurnov A.A., Blinov V.M., Netesov S.V., Feldmann H.
J. Gen. Virol. 80:355-362(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Mayinga.
[6]Volchkov V.E.
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Mayinga.
[7]"Experimental study of molecular determinants of Ebola virus virulence in guinea pigs."
Subbotina E.L., Kachko A.V., Dadaeva A.A., Chepurnov A.A.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Mayinga.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF086833 Genomic RNA. Translation: AAD14586.1. Sequence problems.
EU224440 Viral cRNA. Translation: ABX75369.1. Sequence problems.
RefSeqNP_066248.1. NC_002549.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID911829.

Family and domain databases

InterProIPR002561. GPC_filovir-type_extra_dom.
[Graphical view]
PfamPF01611. Filo_glycop. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameVSSGP_EBOZM
AccessionPrimary (citable) accession number: Q9YMG2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: February 9, 2010
Last modified: December 11, 2013
This is version 39 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families