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Q9YMG2

- VSSGP_EBOZM

UniProt

Q9YMG2 - VSSGP_EBOZM

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Protein
Super small secreted glycoprotein
Gene
GP
Organism
Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Super small secreted glycoprotein
Short name:
SsGP
Gene namesi
Name:GP
OrganismiZaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus)
Taxonomic identifieri128952 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
Virus hostiEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
Homo sapiens (Human) [TaxID: 9606]
Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]
ProteomesiUP000007209: Genome

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232 Reviewed prediction
Add
BLAST
Chaini33 – 298266Super small secreted glycoprotein
PRO_0000391494Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...); by host Reviewed prediction
Disulfide bondi53 – 53Interchain By similarity
Disulfide bondi108 ↔ 135 By similarity
Disulfide bondi121 ↔ 147 By similarity
Glycosylationi204 – 2041N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi228 – 2281N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi238 – 2381N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi257 – 2571N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi268 – 2681N-linked (GlcNAc...); by host Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR002561. GPC_filovir-type_extra_dom.
[Graphical view]
PfamiPF01611. Filo_glycop. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9YMG2-1 [UniParc]FASTAAdd to Basket

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MGVTGILQLP RDRFKRTSFF LWVIILFQRT FSIPLGVIHN STLQVSDVDK    50
LVCRDKLSST NQLRSVGLNL EGNGVATDVP SATKRWGFRS GVPPKVVNYE 100
AGEWAENCYN LEIKKPDGSE CLPAAPDGIR GFPRCRYVHK VSGTGPCAGD 150
FAFHKEGAFF LYDRLASTVI YRGTTFAEGV VAFLILPQAK KDFFSSHPLR 200
EPVNATEDPS SGYYSTTIRY QATGFGTNET EYLFEVDNLT YVQLESRFTP 250
QFLLQLNETI YTSGKRSNTT GKLIWKVNPE IDTTIGEWAF WETKKKPH 298
Length:298
Mass (Da):33,520
Last modified:February 9, 2010 - v2
Checksum:i584B65414512A61E
GO

RNA editingi

Partially edited. RNA editing at this position consists of an insertion of one or two adenine nucleotides. The sequence displayed here is the super small secreted glycoprotein ssGP, derived from the +2A edited RNA. The unedited RNA gives rise to the small secreted glycoprotein sGP (AC P60170), the +1A edited RNA gives rise to the full-length transmembrane glycoprotein GP (AC Q05320).

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF086833 Genomic RNA. Translation: AAD14586.1. Sequence problems.
EU224440 Viral cRNA. Translation: ABX75369.1. Sequence problems.
RefSeqiNP_066248.1. NC_002549.1.

Genome annotation databases

GeneIDi911829.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF086833 Genomic RNA. Translation: AAD14586.1 . Sequence problems.
EU224440 Viral cRNA. Translation: ABX75369.1 . Sequence problems.
RefSeqi NP_066248.1. NC_002549.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 911829.

Family and domain databases

InterProi IPR002561. GPC_filovir-type_extra_dom.
[Graphical view ]
Pfami PF01611. Filo_glycop. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Processing of the Ebola virus glycoprotein by the proprotein convertase furin."
    Volchkov V.E., Feldmann H., Volchkova V.A., Klenk H.-D.
    Proc. Natl. Acad. Sci. U.S.A. 95:5762-5767(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Mayinga.
  2. "The VP35 and VP40 proteins of filoviruses. Homology between Marburg and Ebola viruses."
    Bukreyev A.A., Volchkov V.E., Blinov V.M., Netesov S.V.
    FEBS Lett. 322:41-46(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Mayinga.
  3. "GP mRNA of Ebola virus is edited by the Ebola virus polymerase and by T7 and vaccinia virus polymerases."
    Volchkov V.E., Becker S., Volchkova V.A., Ternovoj V.A., Kotov A.N., Netesov S.V., Klenk H.-D.
    Virology 214:421-430(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Mayinga.
  4. "Release of viral glycoproteins during Ebola virus infection."
    Volchkov V.E., Volchkova V.A., Slenczka W., Klenk H.-D., Feldmann H.
    Virology 245:110-119(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Mayinga.
  5. "Characterization of the L gene and 5' trailer region of Ebola virus."
    Volchkov V.E., Volchkova V.A., Chepurnov A.A., Blinov V.M., Netesov S.V., Feldmann H.
    J. Gen. Virol. 80:355-362(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Mayinga.
  6. Volchkov V.E.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Mayinga.
  7. "Experimental study of molecular determinants of Ebola virus virulence in guinea pigs."
    Subbotina E.L., Kachko A.V., Dadaeva A.A., Chepurnov A.A.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Mayinga.

Entry informationi

Entry nameiVSSGP_EBOZM
AccessioniPrimary (citable) accession number: Q9YMG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: February 9, 2010
Last modified: December 11, 2013
This is version 39 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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