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Protein

Non-structural protein 1

Gene
N/A
Organism
Rotavirus A (isolate RVA/Dog/United States/K9/1981/G3P5A[3]) (RV-A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a role in the inhibition of host innate immunity by inducing the degradation of key host factors required to activate interferon production such as IRF3, IRF5 or IRF7. Associates with components of cullin RING ligases (CRLs) including CUL1 or CUL3, which are essential multisubunit ubiquitination complexes, to modulate their activities.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virus, Inhibition of host IRF7 by virus, Inhibition of host RLR pathway by virus, Interferon antiviral system evasion, Viral immunoevasion
LigandMetal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein 1UniRule annotation
Short name:
NSP1UniRule annotation
Alternative name(s):
NCVP2UniRule annotation
Non-structural RNA-binding protein 53UniRule annotation
Short name:
NS53UniRule annotation
OrganismiRotavirus A (isolate RVA/Dog/United States/K9/1981/G3P5A[3]) (RV-A)
Taxonomic identifieri557232 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
Virus hostiCanis lupus familiaris (Dog) (Canis familiaris) [TaxID: 9615]

Subcellular locationi

  • host cytoskeleton UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003690701 – 493Non-structural protein 1Add BLAST493

Interactioni

Subunit structurei

Interacts (via C-terminus) with host IRF3; this interaction leads to IRF3 degradation. Interacts with host IRF7; this interaction leads to IRF7 degradation. Interacts with host CUL1 and CUL3.UniRule annotation

Structurei

3D structure databases

SMRiQ9YKL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 81RNA-bindingUniRule annotationAdd BLAST81
Regioni42 – 79Zinc-binding domainUniRule annotationAdd BLAST38
Regioni82 – 176Important for cytoskeleton localizationUniRule annotationAdd BLAST95
Regioni318 – 493Interaction with host IRF3UniRule annotationAdd BLAST176

Domaini

The integrity of the zinc-binding domain in NSP1 is important for degradation of host IRF3.UniRule annotation

Sequence similaritiesi

Belongs to the rotavirus NSP1 family.UniRule annotation

Family and domain databases

HAMAPiMF_04088 ROTA_NSP1, 1 hit
InterProiView protein in InterPro
IPR002148 Rotavirus_NSP1
PfamiView protein in Pfam
PF00981 Rota_NS53, 1 hit

Sequencei

Sequence statusi: Complete.

Q9YKL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATFKDACFH YRKITKLNRE LLRIGANSVW IPVSSNKIKG WCIECCQLTE
60 70 80 90 100
LTFCHGCSLA HVCQWCIQNK RCFLDNEPHL LKLRTFESPI TKEKLQCIID
110 120 130 140 150
LYNLLFPINP GIINRFKKIV NQRKCRNEFE QSWYNQLLFP ITLNAAVFKF
160 170 180 190 200
HSREVYVFGL YEGSSSCINL PYRIVNCIDL YDRLLLDQIN FERMSSLPAS
210 220 230 240 250
LQSVYANKYF KLSRLPSMKL KQIYYSDFSK QNLINKCKIK SRIVLRNLTE
260 270 280 290 300
FTWDSQISLH YDVINNREKI LTALSTSSLK RFETHDLNLG RIKADIFELG
310 320 330 340 350
HHCKPNFISS NHWQPASNVS QCRWCNVKYV FRNMDWKMES MYNELLSFIQ
360 370 380 390 400
ACYKSNVNVG NCSSIENAYP LVKDMIWHSI TKYIDQTIEK LFNVMNPVEV
410 420 430 440 450
DGQQVISFHW QIDVALYIHI KMILKTETLP FALTLYQFGS IIKGIVNQWY
460 470 480 490
DVTELDYLPL CTEQTDKLVK LEEEGKISEE YELLISDSED DDQ
Length:493
Mass (Da):57,940
Last modified:May 1, 1999 - v1
Checksum:i9CAF6149EAFF8AA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111946 Genomic RNA Translation: AAD20225.1

Similar proteinsi

Entry informationi

Entry nameiNSP1_ROTD9
AccessioniPrimary (citable) accession number: Q9YKL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 1, 1999
Last modified: April 25, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

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