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Q9YKL3

- Q9YKL3_9FLAV

UniProt

Q9YKL3 - Q9YKL3_9FLAV

Protein
Submitted name:

Polyprotein

Gene
N/A
Organism
Dengue virus 2
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ATP-dependent helicase activity Source: InterPro
    3. double-stranded RNA binding Source: InterPro
    4. mRNA (guanine-N7-)-methyltransferase activity Source: InterPro
    5. mRNA (nucleoside-2'-O-)-methyltransferase activity Source: InterPro
    6. RNA-directed RNA polymerase activity Source: UniProtKB-KW
    7. RNA helicase activity Source: InterPro
    8. serine-type endopeptidase activity Source: InterPro
    9. serine-type exopeptidase activity Source: InterPro
    10. structural molecule activity Source: InterPro

    GO - Biological processi

    1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
    2. viral RNA genome replication Source: InterPro
    3. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Molecular functioni

    HelicaseSAAS annotation, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymeraseSAAS annotation, Serine proteaseSAAS annotation, Transferase

    Keywords - Biological processi

    Fusion of virus membrane with host endosomal membraneSAAS annotation, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cellSAAS annotation, Viral penetration into host cytoplasm, Viral RNA replicationSAAS annotation, Virus entry into host cell

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-bindingSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    PolyproteinImported
    OrganismiDengue virus 2Imported
    Taxonomic identifieri11060 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageFlaviviridaeFlavivirusDengue virus group

    Subcellular locationi

    GO - Cellular componenti

    1. host cell membrane Source: UniProtKB-KW
    2. integral component of membrane Source: UniProtKB-KW
    3. viral capsid Source: UniProtKB-KW
    4. viral envelope Source: InterPro

    Keywords - Cellular componenti

    Capsid proteinSAAS annotation, Host membraneSAAS annotation, Membrane, Virion

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2M0SNMR-A1194-1221[»]
    ProteinModelPortaliQ9YKL3.
    SMRiQ9YKL3. Positions 21-100, 115-195, 281-674, 1394-1440, 1495-2093, 2498-2759, 2765-3374.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains RdRp catalytic domain.SAAS annotation
    Contains helicase ATP-binding domain.SAAS annotation
    Contains helicase C-terminal domain.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Family and domain databases

    Gene3Di2.60.40.350. 1 hit.
    2.60.98.10. 2 hits.
    3.30.387.10. 1 hit.
    3.40.50.150. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR011492. DEAD_Flavivir.
    IPR000069. Env_glycoprot_M_flavivir.
    IPR013755. Flav_gly_cen_dom_subdom1.
    IPR001122. Flavi_capsidC.
    IPR026470. Flavi_E_Stem/Anchor_dom.
    IPR001157. Flavi_NS1.
    IPR000752. Flavi_NS2A.
    IPR000487. Flavi_NS2B.
    IPR000404. Flavi_NS4A.
    IPR001528. Flavi_NS4B.
    IPR002535. Flavi_propep.
    IPR000336. Flavivir/Alphavir_Ig-like.
    IPR001850. Flavivirus_NS3_S7.
    IPR027287. Flavovir_Ig-like.
    IPR014412. Gen_Poly_FLV.
    IPR011998. Glycoprot_cen/dimer.
    IPR013754. GlyE_dim.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR014756. Ig_E-set.
    IPR026490. mRNA_cap_0/1_MeTrfase.
    IPR027417. P-loop_NTPase.
    IPR000208. RNA-dir_pol_flavivirus.
    IPR007094. RNA-dir_pol_PSvirus.
    IPR002877. rRNA_MeTrfase_FtsJ_dom.
    IPR029063. SAM-dependent_MTases-like.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF01003. Flavi_capsid. 1 hit.
    PF07652. Flavi_DEAD. 1 hit.
    PF02832. Flavi_glycop_C. 1 hit.
    PF00869. Flavi_glycoprot. 1 hit.
    PF01004. Flavi_M. 1 hit.
    PF00948. Flavi_NS1. 1 hit.
    PF01005. Flavi_NS2A. 1 hit.
    PF01002. Flavi_NS2B. 1 hit.
    PF01350. Flavi_NS4A. 1 hit.
    PF01349. Flavi_NS4B. 1 hit.
    PF00972. Flavi_NS5. 1 hit.
    PF01570. Flavi_propep. 1 hit.
    PF01728. FtsJ. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF00949. Peptidase_S7. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003817. Gen_Poly_FLV. 1 hit.
    SMARTiSM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    SSF52540. SSF52540. 2 hits.
    SSF53335. SSF53335. 1 hit.
    SSF56983. SSF56983. 1 hit.
    SSF81296. SSF81296. 1 hit.
    TIGRFAMsiTIGR04240. flavi_E_stem. 1 hit.
    PROSITEiPS51527. FLAVIVIRUS_NS2B. 1 hit.
    PS51528. FLAVIVIRUS_NS3PRO. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS50507. RDRP_SSRNA_POS. 1 hit.
    PS51591. RNA_CAP01_NS5_MT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9YKL3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNQRKKARS TPFNMLKRER NRVSTVQQLT KRFSLGMLQG RGPLKLFMAL     50
    VAFLRFLTIP PTAGILKRWG TIKKSKAINV LRGFRKEIGR MLNILNRRRR 100
    TVGVIIMLIP TAMAFHLTTR NGEPHMIVGR QEKGKSLLFK TEDGVNMCTL 150
    MAIDLGELCE DTITYKCPLL RQNEPEDIDC WCNSTSTWVT YGTCTTTGEH 200
    RREKRSVALV PHVGMGLETR TETWMSSEGA WKHAQRIETW ILRHPGFIIM 250
    AAILAYTIGT THFQRALIFI LLTAVAPSMT MRCIGVSNRD FVEGVSGGSW 300
    VDIVLEHGSC VTTMAKNKPT LDFELIKTEA KQPVTLRKYC IKAKLTNTTT 350
    ESRCPTQGEP SLNEEQDKRF VCKHSMVDRG WGNGCGLFGK GGIVTCATFT 400
    CKKNMEGKIV QPENLEYTIV ITPHSGEEHA VGNDTGKHGK EIKITPQSSI 450
    TEAELTGYGT VTMECSPRTG LDFNEMVLLQ MEDKAWLVHR QWFLDLPLPW 500
    LPGADTQGSN WIQKETLVTF KNPHAKKQDV VVLGSQEGAM HTALTGATEI 550
    QMSSGNLLFT GHLKCRLRMD KLQLKGMSYS MCTGKFKIVK EIAETQHGTI 600
    VIRVQYEGDG SPCKIPFEIM DLEKRHVLGR LITVNPIVTE KDSPVNIEAE 650
    PPFGDSYIII GVEPGQLKLN WVKKGSSIGQ MFETTMRGAK RMAILGDTAW 700
    DFGSLGGVFT SIGKALHQVF GAIYGAAFSG VSWTMKILIG VIITWIGMNS 750
    RSTSLSVSLV LVGVITLYLG AMVQADSGCV VSWKNKELKC GSGIFITDNV 800
    HTWTEQYKFQ PESPSKLASA IQKAHEEGIC GIRSVTRLEN LMWKQITPEL 850
    NHILSENEVK LTIMTGDIKG IMQAGKRSLR PQPTELKYSW KTWGKAKMLS 900
    TESHNQTFLI DGPETAECPN TNRAWNSLEV EDYGFGVFTT NIWLKLREKQ 950
    DVFCDSKLMS AAIKDNRAVH ADMGYWIESA LNDTWKMEKA SFIEVKSCHW 1000
    PKSHTLWSNG VLESEMIIPK SFAGPVSQHN YRPGYYTQTA GPWHLGKLEM 1050
    DFDFCEGTTV VVTEDCGNRG PSLRTTTASG KLITEWCCRS CTLPPLRYRG 1100
    EDGCWYGMEI RPLKEKEESL VDSLVTAGHG QIDNFSLGVL GMALFLEEML 1150
    RTRVGTKHAI LLVAVSFVTL ITGNMSLRDL GRVMVMVGAT MTDDIGMGVT 1200
    YLALLAAFKV RPTFAAGLLL RKLTSKELMM ATIGIALLSQ STIPETILEL 1250
    TDALALGMMV LKIVRNMEKY QLAVTIMAIS CVPNAVILQN AWKVSCTILA 1300
    AVSVSPLLLT SSQQKADWIP LALTIKGLNP TAIFLTTLAR TSKKRSWPLN 1350
    EAIMAVGMVS ILASSLLKND IPMTGPLVAG GLLTVCYVLT GRSADLELER 1400
    ATDVKWEDQA EISGSSPILS ITISEDGSMS IKNEEEEQTL TILIRTGLLV 1450
    ISGLFPVSIP ITAAAWYLWE VKKQRAGVLW DVPSPPPVEK AELEDGAYRI 1500
    KQKGILGYSQ IGTGVYKEGT FHTMWHVTRG AVLMHRGKRI EPSWADVKKD 1550
    LISYGGGWKL EGEWKEGEEV QVLALEPGKN PRAVQTKPGL FKTNTGTIGA 1600
    VSLDFSPGTS GSPIVDRKGK VVGLYGNGVV TRSGAYVSAI AQTEKSIEDN 1650
    PEIEDDIFRK KRLTIMDLHP GAGKTKRYLP AIVREAIKRG LRTLILAPTR 1700
    VVAAEMEEAL RGLPIRYQTP AIRAEHTGRE IVDLMCHATF TMRLLSPVRV 1750
    PNYNLIIMDE AHFTDPANIA ARGYISTRVE MGEAAGIFMT ATPPGSRDPF 1800
    PQSNAPIMDE EREIPERSWN SGHEWVTDFK GKTVWFVPSI KAGNDIAACL 1850
    RKNGKKVIQL SRKTFDSEYV KTRTNDWDFV VTTDISEMGA NFKAERVIDP 1900
    RRCMKPVILT DGEERVILAG PMPVTHSSAA QRRGRIGRNP KNENDQYIYM 1950
    GEPLENDEDC AHWKEAKMLL DNINTPEGII PSMFEPEREK VDAIDGEYRL 2000
    RGEARKTFVD LMRRGDLPVW LAYRVAAEGI NYADRRWCFD GVKNNQILEE 2050
    NVEVEIWTKE GERKKLKPRW LDARIYSDPL ALKEFKEFAA GRKSLTLNLI 2100
    TEMGRLPTFM TQKARDALDN LAVLHTAEAG GRAYNHALSE LPETLETLLL 2150
    LTLLATVTGG IFLFLMSGKG VGKMTLGMCC IITASILLWY AQIQPHWIAA 2200
    SIILEFFLMV LLIPEPEKQR TPQDNQLTYV VIAILTVVAA TMANEMGFLE 2250
    KTKKDLGLGS IATQEPESNI LDIDLRPASA WTLYAVATTF VTPMLRHSIE 2300
    NSSVNVSLTA IANQATVLMG LGKGWPLSKM DIGVPLLAIG CYSQVNPITL 2350
    TAALLLLVAH YAIIGPGLQA KATREAQKRA AAGIMKNPTV DGITVIDLDP 2400
    IPYDPKFEKQ LGQVMLLILC VTQVLMMRTT WALCEALTLA TGPISTLWEG 2450
    NPGRFWNTTI AVSMANIFRG SYLAGAGLLF FIMKNTTNTR RGTGNIGETL 2500
    GEKWKSRLNA LGKSEFQIYK KSGIQEVDRT LAKEGIKRGE TDHHAVSRGS 2550
    AKLRWFVERN MVTPEGKVVD LGCGRGGWSY YCGGLKNVRE VKGLTKGGPG 2600
    HEEPIPMSTY GWNLVRLQSG VDVFFTPPEK CDTLLCDIGE SSPNPTIEAG 2650
    RTLRVLSLVE NWLNNDTQFC IKVLNPYMPS VIEKMETLQR KYGGALVRNP 2700
    LSRNSTHEMY WVSNATGNIV SSVNMISRML INRFTMKHKK ATYEPDVDLG 2750
    SGTRNIGIES EIPNLDIIGK RIEKIKQEHE TSWHYDQDHP YKTWAYHGSY 2800
    ETKQTGSASS MVNGVVRLLT KPWDVVPMVT QMAMTDTTPF GQQRVFKEKV 2850
    DTRTQEPKEG TKKLMKITAE WLWKELGKKK TPRMCTREEF TRKVRSNAAL 2900
    GAIFTDENKW KSAREAVEDN RFWELVDKER NLHLEGKCET CVYNMMGKRE 2950
    KKLGEFGKAK GSRAIWYMWL GARFLEFEAL GFLNEDHWFS RENSLSGVEG 3000
    EGLHKLGYIL RDVSKKEGGA MYADDTAGWD TRITLEDLKN EEMVTNHMEG 3050
    EHKKLAEAIF KLTYQNKAVR VQRPTPRGTV MDIISRRDQR GSGQVGTYGL 3100
    NTFTNMEAQL IRQMEGEGIF KSIQHLTVTE EIAVQNWLAR VGRERLSRMA 3150
    ISGDDCVVKP LDDRFASALT ALNDMGKVRK DIQQWEPSRG WNDWTQVPFC 3200
    SHHFHELIMK DGRVLVVPCR NQDELIGRAR ISQGAGWSLK ETACLGKSYA 3250
    QMWSLMYFHR RDLRLAANAI CSAVPSHWVP TSRTTWSIHA KHEWMTTEDM 3300
    LTVWNRVWIQ ENPWMEDKTP VESWEEVPYL GKREDQWCGS LIGLTSRATW 3350
    AKNIQTAINQ VRSLIGNEEY TDYMPSMKRF RREEEEAGVL W 3391
    Length:3,391
    Mass (Da):379,439
    Last modified:May 1, 1999 - v1
    Checksum:i9116552CBE254A70
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF119661 Genomic RNA. Translation: AAD18036.1.
    PIRiB25817.
    JS0219.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF119661 Genomic RNA. Translation: AAD18036.1 .
    PIRi B25817.
    JS0219.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2M0S NMR - A 1194-1221 [» ]
    ProteinModelPortali Q9YKL3.
    SMRi Q9YKL3. Positions 21-100, 115-195, 281-674, 1394-1440, 1495-2093, 2498-2759, 2765-3374.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.40.350. 1 hit.
    2.60.98.10. 2 hits.
    3.30.387.10. 1 hit.
    3.40.50.150. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR011492. DEAD_Flavivir.
    IPR000069. Env_glycoprot_M_flavivir.
    IPR013755. Flav_gly_cen_dom_subdom1.
    IPR001122. Flavi_capsidC.
    IPR026470. Flavi_E_Stem/Anchor_dom.
    IPR001157. Flavi_NS1.
    IPR000752. Flavi_NS2A.
    IPR000487. Flavi_NS2B.
    IPR000404. Flavi_NS4A.
    IPR001528. Flavi_NS4B.
    IPR002535. Flavi_propep.
    IPR000336. Flavivir/Alphavir_Ig-like.
    IPR001850. Flavivirus_NS3_S7.
    IPR027287. Flavovir_Ig-like.
    IPR014412. Gen_Poly_FLV.
    IPR011998. Glycoprot_cen/dimer.
    IPR013754. GlyE_dim.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR014756. Ig_E-set.
    IPR026490. mRNA_cap_0/1_MeTrfase.
    IPR027417. P-loop_NTPase.
    IPR000208. RNA-dir_pol_flavivirus.
    IPR007094. RNA-dir_pol_PSvirus.
    IPR002877. rRNA_MeTrfase_FtsJ_dom.
    IPR029063. SAM-dependent_MTases-like.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF01003. Flavi_capsid. 1 hit.
    PF07652. Flavi_DEAD. 1 hit.
    PF02832. Flavi_glycop_C. 1 hit.
    PF00869. Flavi_glycoprot. 1 hit.
    PF01004. Flavi_M. 1 hit.
    PF00948. Flavi_NS1. 1 hit.
    PF01005. Flavi_NS2A. 1 hit.
    PF01002. Flavi_NS2B. 1 hit.
    PF01350. Flavi_NS4A. 1 hit.
    PF01349. Flavi_NS4B. 1 hit.
    PF00972. Flavi_NS5. 1 hit.
    PF01570. Flavi_propep. 1 hit.
    PF01728. FtsJ. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF00949. Peptidase_S7. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003817. Gen_Poly_FLV. 1 hit.
    SMARTi SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    SSF52540. SSF52540. 2 hits.
    SSF53335. SSF53335. 1 hit.
    SSF56983. SSF56983. 1 hit.
    SSF81296. SSF81296. 1 hit.
    TIGRFAMsi TIGR04240. flavi_E_stem. 1 hit.
    PROSITEi PS51527. FLAVIVIRUS_NS2B. 1 hit.
    PS51528. FLAVIVIRUS_NS3PRO. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS50507. RDRP_SSRNA_POS. 1 hit.
    PS51591. RNA_CAP01_NS5_MT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of the complete genome of dengue type 2 virus (04) isolated from a Chinese patient with dengue hemorrhagic fever."
      Yang J., Yang P.Y., Hu Z.J., Qin E.D., Yu M., Ou W., Zhou Y.S.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: China 04Imported.
    2. "Membrane topology and function of dengue virus NS2A protein."
      Xie X., Gayen S., Kang C., Yuan Z., Shi P.Y.
      J. Virol. 87:4609-4622(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 1194-1221.

    Entry informationi

    Entry nameiQ9YKL3_9FLAV
    AccessioniPrimary (citable) accession number: Q9YKL3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 1999
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3