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Q9YKL3

- Q9YKL3_9FLAV

UniProt

Q9YKL3 - Q9YKL3_9FLAV

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Protein
Submitted name: Polyprotein
Gene
N/A
Organism
Dengue virus 2
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotations

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP-dependent helicase activity Source: InterPro
  3. RNA helicase activity Source: InterPro
  4. RNA-directed RNA polymerase activity Source: UniProtKB-KW
  5. double-stranded RNA binding Source: InterPro
  6. mRNA (guanine-N7-)-methyltransferase activity Source: InterPro
  7. mRNA (nucleoside-2'-O-)-methyltransferase activity Source: InterPro
  8. serine-type endopeptidase activity Source: InterPro
  9. serine-type exopeptidase activity Source: InterPro
  10. structural molecule activity Source: InterPro

GO - Biological processi

  1. clathrin-mediated endocytosis of virus by host cell Source: UniProtKB-KW
  2. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  3. viral RNA genome replication Source: InterPro
  4. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HelicaseSAAS annotations, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymeraseSAAS annotations, Serine proteaseSAAS annotations, Transferase

Keywords - Biological processi

Fusion of virus membrane with host endosomal membraneSAAS annotations, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cellSAAS annotations, Viral penetration into host cytoplasm, Viral RNA replicationSAAS annotations, Virus entry into host cell

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-bindingSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
PolyproteinImported
OrganismiDengue virus 2Imported
Taxonomic identifieri11060 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageFlaviviridaeFlavivirusDengue virus group

Subcellular locationi

GO - Cellular componenti

  1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. viral capsid Source: UniProtKB-KW
  4. viral envelope Source: UniProtKB-KW
  5. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinSAAS annotations, Host membraneSAAS annotations, Membrane, Virion

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2M0SNMR-A1194-1221[»]
ProteinModelPortaliQ9YKL3.
SMRiQ9YKL3. Positions 21-100, 115-195, 281-674, 1394-1440, 1495-2093, 2498-2759, 2765-3374.

Family & Domainsi

Sequence similaritiesi

Contains RdRp catalytic domain.SAAS annotations
Contains helicase ATP-binding domain.SAAS annotations
Contains helicase C-terminal domain.SAAS annotations

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Family and domain databases

Gene3Di2.60.40.350. 1 hit.
2.60.98.10. 2 hits.
3.30.387.10. 1 hit.
3.40.50.150. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR011492. DEAD_Flavivir.
IPR000069. Env_glycoprot_M_flavivir.
IPR013755. Flav_gly_cen_dom_subdom1.
IPR001122. Flavi_capsidC.
IPR026470. Flavi_E_Stem/Anchor_dom.
IPR001157. Flavi_NS1.
IPR000752. Flavi_NS2A.
IPR000487. Flavi_NS2B.
IPR000404. Flavi_NS4A.
IPR001528. Flavi_NS4B.
IPR002535. Flavi_propep.
IPR000336. Flavivir/Alphavir_Ig-like.
IPR001850. Flavivirus_NS3_S7.
IPR027287. Flavovir_Ig-like.
IPR014412. Gen_Poly_FLV.
IPR011998. Glycoprot_cen/dimer.
IPR013754. GlyE_dim.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014756. Ig_E-set.
IPR026490. mRNA_cap_0/1_MeTrfase.
IPR027417. P-loop_NTPase.
IPR000208. RNA-dir_pol_flavivirus.
IPR007094. RNA-dir_pol_PSvirus.
IPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR029063. SAM-dependent_MTases-like.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF01003. Flavi_capsid. 1 hit.
PF07652. Flavi_DEAD. 1 hit.
PF02832. Flavi_glycop_C. 1 hit.
PF00869. Flavi_glycoprot. 1 hit.
PF01004. Flavi_M. 1 hit.
PF00948. Flavi_NS1. 1 hit.
PF01005. Flavi_NS2A. 1 hit.
PF01002. Flavi_NS2B. 1 hit.
PF01350. Flavi_NS4A. 1 hit.
PF01349. Flavi_NS4B. 1 hit.
PF00972. Flavi_NS5. 1 hit.
PF01570. Flavi_propep. 1 hit.
PF01728. FtsJ. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00949. Peptidase_S7. 1 hit.
[Graphical view]
PIRSFiPIRSF003817. Gen_Poly_FLV. 1 hit.
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF53335. SSF53335. 1 hit.
SSF56983. SSF56983. 1 hit.
SSF81296. SSF81296. 1 hit.
TIGRFAMsiTIGR04240. flavi_E_stem. 1 hit.
PROSITEiPS51527. FLAVIVIRUS_NS2B. 1 hit.
PS51528. FLAVIVIRUS_NS3PRO. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
PS51591. RNA_CAP01_NS5_MT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9YKL3-1 [UniParc]FASTAAdd to Basket

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MNNQRKKARS TPFNMLKRER NRVSTVQQLT KRFSLGMLQG RGPLKLFMAL     50
VAFLRFLTIP PTAGILKRWG TIKKSKAINV LRGFRKEIGR MLNILNRRRR 100
TVGVIIMLIP TAMAFHLTTR NGEPHMIVGR QEKGKSLLFK TEDGVNMCTL 150
MAIDLGELCE DTITYKCPLL RQNEPEDIDC WCNSTSTWVT YGTCTTTGEH 200
RREKRSVALV PHVGMGLETR TETWMSSEGA WKHAQRIETW ILRHPGFIIM 250
AAILAYTIGT THFQRALIFI LLTAVAPSMT MRCIGVSNRD FVEGVSGGSW 300
VDIVLEHGSC VTTMAKNKPT LDFELIKTEA KQPVTLRKYC IKAKLTNTTT 350
ESRCPTQGEP SLNEEQDKRF VCKHSMVDRG WGNGCGLFGK GGIVTCATFT 400
CKKNMEGKIV QPENLEYTIV ITPHSGEEHA VGNDTGKHGK EIKITPQSSI 450
TEAELTGYGT VTMECSPRTG LDFNEMVLLQ MEDKAWLVHR QWFLDLPLPW 500
LPGADTQGSN WIQKETLVTF KNPHAKKQDV VVLGSQEGAM HTALTGATEI 550
QMSSGNLLFT GHLKCRLRMD KLQLKGMSYS MCTGKFKIVK EIAETQHGTI 600
VIRVQYEGDG SPCKIPFEIM DLEKRHVLGR LITVNPIVTE KDSPVNIEAE 650
PPFGDSYIII GVEPGQLKLN WVKKGSSIGQ MFETTMRGAK RMAILGDTAW 700
DFGSLGGVFT SIGKALHQVF GAIYGAAFSG VSWTMKILIG VIITWIGMNS 750
RSTSLSVSLV LVGVITLYLG AMVQADSGCV VSWKNKELKC GSGIFITDNV 800
HTWTEQYKFQ PESPSKLASA IQKAHEEGIC GIRSVTRLEN LMWKQITPEL 850
NHILSENEVK LTIMTGDIKG IMQAGKRSLR PQPTELKYSW KTWGKAKMLS 900
TESHNQTFLI DGPETAECPN TNRAWNSLEV EDYGFGVFTT NIWLKLREKQ 950
DVFCDSKLMS AAIKDNRAVH ADMGYWIESA LNDTWKMEKA SFIEVKSCHW 1000
PKSHTLWSNG VLESEMIIPK SFAGPVSQHN YRPGYYTQTA GPWHLGKLEM 1050
DFDFCEGTTV VVTEDCGNRG PSLRTTTASG KLITEWCCRS CTLPPLRYRG 1100
EDGCWYGMEI RPLKEKEESL VDSLVTAGHG QIDNFSLGVL GMALFLEEML 1150
RTRVGTKHAI LLVAVSFVTL ITGNMSLRDL GRVMVMVGAT MTDDIGMGVT 1200
YLALLAAFKV RPTFAAGLLL RKLTSKELMM ATIGIALLSQ STIPETILEL 1250
TDALALGMMV LKIVRNMEKY QLAVTIMAIS CVPNAVILQN AWKVSCTILA 1300
AVSVSPLLLT SSQQKADWIP LALTIKGLNP TAIFLTTLAR TSKKRSWPLN 1350
EAIMAVGMVS ILASSLLKND IPMTGPLVAG GLLTVCYVLT GRSADLELER 1400
ATDVKWEDQA EISGSSPILS ITISEDGSMS IKNEEEEQTL TILIRTGLLV 1450
ISGLFPVSIP ITAAAWYLWE VKKQRAGVLW DVPSPPPVEK AELEDGAYRI 1500
KQKGILGYSQ IGTGVYKEGT FHTMWHVTRG AVLMHRGKRI EPSWADVKKD 1550
LISYGGGWKL EGEWKEGEEV QVLALEPGKN PRAVQTKPGL FKTNTGTIGA 1600
VSLDFSPGTS GSPIVDRKGK VVGLYGNGVV TRSGAYVSAI AQTEKSIEDN 1650
PEIEDDIFRK KRLTIMDLHP GAGKTKRYLP AIVREAIKRG LRTLILAPTR 1700
VVAAEMEEAL RGLPIRYQTP AIRAEHTGRE IVDLMCHATF TMRLLSPVRV 1750
PNYNLIIMDE AHFTDPANIA ARGYISTRVE MGEAAGIFMT ATPPGSRDPF 1800
PQSNAPIMDE EREIPERSWN SGHEWVTDFK GKTVWFVPSI KAGNDIAACL 1850
RKNGKKVIQL SRKTFDSEYV KTRTNDWDFV VTTDISEMGA NFKAERVIDP 1900
RRCMKPVILT DGEERVILAG PMPVTHSSAA QRRGRIGRNP KNENDQYIYM 1950
GEPLENDEDC AHWKEAKMLL DNINTPEGII PSMFEPEREK VDAIDGEYRL 2000
RGEARKTFVD LMRRGDLPVW LAYRVAAEGI NYADRRWCFD GVKNNQILEE 2050
NVEVEIWTKE GERKKLKPRW LDARIYSDPL ALKEFKEFAA GRKSLTLNLI 2100
TEMGRLPTFM TQKARDALDN LAVLHTAEAG GRAYNHALSE LPETLETLLL 2150
LTLLATVTGG IFLFLMSGKG VGKMTLGMCC IITASILLWY AQIQPHWIAA 2200
SIILEFFLMV LLIPEPEKQR TPQDNQLTYV VIAILTVVAA TMANEMGFLE 2250
KTKKDLGLGS IATQEPESNI LDIDLRPASA WTLYAVATTF VTPMLRHSIE 2300
NSSVNVSLTA IANQATVLMG LGKGWPLSKM DIGVPLLAIG CYSQVNPITL 2350
TAALLLLVAH YAIIGPGLQA KATREAQKRA AAGIMKNPTV DGITVIDLDP 2400
IPYDPKFEKQ LGQVMLLILC VTQVLMMRTT WALCEALTLA TGPISTLWEG 2450
NPGRFWNTTI AVSMANIFRG SYLAGAGLLF FIMKNTTNTR RGTGNIGETL 2500
GEKWKSRLNA LGKSEFQIYK KSGIQEVDRT LAKEGIKRGE TDHHAVSRGS 2550
AKLRWFVERN MVTPEGKVVD LGCGRGGWSY YCGGLKNVRE VKGLTKGGPG 2600
HEEPIPMSTY GWNLVRLQSG VDVFFTPPEK CDTLLCDIGE SSPNPTIEAG 2650
RTLRVLSLVE NWLNNDTQFC IKVLNPYMPS VIEKMETLQR KYGGALVRNP 2700
LSRNSTHEMY WVSNATGNIV SSVNMISRML INRFTMKHKK ATYEPDVDLG 2750
SGTRNIGIES EIPNLDIIGK RIEKIKQEHE TSWHYDQDHP YKTWAYHGSY 2800
ETKQTGSASS MVNGVVRLLT KPWDVVPMVT QMAMTDTTPF GQQRVFKEKV 2850
DTRTQEPKEG TKKLMKITAE WLWKELGKKK TPRMCTREEF TRKVRSNAAL 2900
GAIFTDENKW KSAREAVEDN RFWELVDKER NLHLEGKCET CVYNMMGKRE 2950
KKLGEFGKAK GSRAIWYMWL GARFLEFEAL GFLNEDHWFS RENSLSGVEG 3000
EGLHKLGYIL RDVSKKEGGA MYADDTAGWD TRITLEDLKN EEMVTNHMEG 3050
EHKKLAEAIF KLTYQNKAVR VQRPTPRGTV MDIISRRDQR GSGQVGTYGL 3100
NTFTNMEAQL IRQMEGEGIF KSIQHLTVTE EIAVQNWLAR VGRERLSRMA 3150
ISGDDCVVKP LDDRFASALT ALNDMGKVRK DIQQWEPSRG WNDWTQVPFC 3200
SHHFHELIMK DGRVLVVPCR NQDELIGRAR ISQGAGWSLK ETACLGKSYA 3250
QMWSLMYFHR RDLRLAANAI CSAVPSHWVP TSRTTWSIHA KHEWMTTEDM 3300
LTVWNRVWIQ ENPWMEDKTP VESWEEVPYL GKREDQWCGS LIGLTSRATW 3350
AKNIQTAINQ VRSLIGNEEY TDYMPSMKRF RREEEEAGVL W 3391
Length:3,391
Mass (Da):379,439
Last modified:May 1, 1999 - v1
Checksum:i9116552CBE254A70
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF119661 Genomic RNA. Translation: AAD18036.1.
PIRiB25817.
JS0219.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF119661 Genomic RNA. Translation: AAD18036.1 .
PIRi B25817.
JS0219.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2M0S NMR - A 1194-1221 [» ]
ProteinModelPortali Q9YKL3.
SMRi Q9YKL3. Positions 21-100, 115-195, 281-674, 1394-1440, 1495-2093, 2498-2759, 2765-3374.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.40.350. 1 hit.
2.60.98.10. 2 hits.
3.30.387.10. 1 hit.
3.40.50.150. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR011492. DEAD_Flavivir.
IPR000069. Env_glycoprot_M_flavivir.
IPR013755. Flav_gly_cen_dom_subdom1.
IPR001122. Flavi_capsidC.
IPR026470. Flavi_E_Stem/Anchor_dom.
IPR001157. Flavi_NS1.
IPR000752. Flavi_NS2A.
IPR000487. Flavi_NS2B.
IPR000404. Flavi_NS4A.
IPR001528. Flavi_NS4B.
IPR002535. Flavi_propep.
IPR000336. Flavivir/Alphavir_Ig-like.
IPR001850. Flavivirus_NS3_S7.
IPR027287. Flavovir_Ig-like.
IPR014412. Gen_Poly_FLV.
IPR011998. Glycoprot_cen/dimer.
IPR013754. GlyE_dim.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014756. Ig_E-set.
IPR026490. mRNA_cap_0/1_MeTrfase.
IPR027417. P-loop_NTPase.
IPR000208. RNA-dir_pol_flavivirus.
IPR007094. RNA-dir_pol_PSvirus.
IPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR029063. SAM-dependent_MTases-like.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF01003. Flavi_capsid. 1 hit.
PF07652. Flavi_DEAD. 1 hit.
PF02832. Flavi_glycop_C. 1 hit.
PF00869. Flavi_glycoprot. 1 hit.
PF01004. Flavi_M. 1 hit.
PF00948. Flavi_NS1. 1 hit.
PF01005. Flavi_NS2A. 1 hit.
PF01002. Flavi_NS2B. 1 hit.
PF01350. Flavi_NS4A. 1 hit.
PF01349. Flavi_NS4B. 1 hit.
PF00972. Flavi_NS5. 1 hit.
PF01570. Flavi_propep. 1 hit.
PF01728. FtsJ. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00949. Peptidase_S7. 1 hit.
[Graphical view ]
PIRSFi PIRSF003817. Gen_Poly_FLV. 1 hit.
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF53335. SSF53335. 1 hit.
SSF56983. SSF56983. 1 hit.
SSF81296. SSF81296. 1 hit.
TIGRFAMsi TIGR04240. flavi_E_stem. 1 hit.
PROSITEi PS51527. FLAVIVIRUS_NS2B. 1 hit.
PS51528. FLAVIVIRUS_NS3PRO. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
PS51591. RNA_CAP01_NS5_MT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequencing of the complete genome of dengue type 2 virus (04) isolated from a Chinese patient with dengue hemorrhagic fever."
    Yang J., Yang P.Y., Hu Z.J., Qin E.D., Yu M., Ou W., Zhou Y.S.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: China 04Imported.
  2. "Membrane topology and function of dengue virus NS2A protein."
    Xie X., Gayen S., Kang C., Yuan Z., Shi P.Y.
    J. Virol. 87:4609-4622(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 1194-1221.

Entry informationi

Entry nameiQ9YKL3_9FLAV
AccessioniPrimary (citable) accession number: Q9YKL3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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