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Q9YIB4

- CO1A1_CYNPY

UniProt

Q9YIB4 - CO1A1_CYNPY

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Protein

Collagen alpha-1(I) chain

Gene
COL1A1
Organism
Cynops pyrrhogaster (Japanese common newt)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Type I collagen is a member of group I collagen (fibrillar forming collagen) By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1263 – 12631Calcium By similarity
Metal bindingi1265 – 12651Calcium By similarity
Metal bindingi1266 – 12661Calcium; via carbonyl oxygen By similarity
Metal bindingi1268 – 12681Calcium; via carbonyl oxygen By similarity
Metal bindingi1271 – 12711Calcium By similarity

GO - Molecular functioni

  1. extracellular matrix structural constituent Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(I) chain
Alternative name(s):
Alpha-1 type I collagen
Gene namesi
Name:COL1A1
OrganismiCynops pyrrhogaster (Japanese common newt)
Taxonomic identifieri8330 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaCaudataSalamandroideaSalamandridaePleurodelinaeCynops

Subcellular locationi

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed predictionAdd
BLAST
Propeptidei23 – 148126N-terminal propeptide By similarityPRO_0000286160Add
BLAST
Chaini149 – 12021054Collagen alpha-1(I) chainPRO_0000286161Add
BLAST
Propeptidei1203 – 1450248C-terminal propeptide By similarityPRO_0000286162Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei149 – 1491Pyrrolidone carboxylic acid By similarity
Disulfide bondi1245 ↔ 1277 By similarity
Disulfide bondi1251 – 1251Interchain (with C-1268) By similarity
Disulfide bondi1268 – 1268Interchain (with C-1251) By similarity
Disulfide bondi1285 ↔ 1448 By similarity
Glycosylationi1351 – 13511N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1356 ↔ 1401 By similarity

Post-translational modificationi

Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Pyrrolidone carboxylic acid

Interactioni

Subunit structurei

Trimers of one alpha 2(I) and two alpha 1(I) chains By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9YIB4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 9060VWFCAdd
BLAST
Domaini1215 – 1450236Fibrillar collagen NC1Add
BLAST

Domaini

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function By similarity.

Sequence similaritiesi

Contains 1 VWFC domain.

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

HOVERGENiHBG004933.

Family and domain databases

InterProiIPR008160. Collagen.
IPR000885. Fib_collagen_C.
IPR001007. VWF_C.
[Graphical view]
PfamiPF01410. COLFI. 1 hit.
PF01391. Collagen. 12 hits.
PF00093. VWC. 1 hit.
[Graphical view]
ProDomiPD002078. Fib_collagen_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00038. COLFI. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
PROSITEiPS51461. NC1_FIB. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9YIB4-1 [UniParc]FASTAAdd to Basket

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MFSFVDNRLL VLLAACVLLV RALDQEDIES GLCHQEGTTY SDKDVWKPEP     50
CVICVCDNGN IMCDDVTCGD YPVDCPNAEI PFGECCPVCP DGDGTSYSEQ 100
TGVEGPKGEV GPKGDRGLPG PPGRDGNPGL PGPPGPPGPP GLGGNFAPQM 150
SYGYDEKSAG ISVPGPMGPM GPRGPPGPSG SPGPQGFQGP SGEPGEPGAA 200
GALGPRGLPG PPGKNGDDGE SGKPGRPGER GPSGPQGARG LPGTAGLPGM 250
KGHRGFNGLD GAKGDNGPAG PKGEPGNPGE NGAPGQAGPR GLPGERGRPG 300
APGPAGARGN DGSPGAAGPP GPTGPTGPPG FPGAVGAKGD AGPQGSRGSE 350
GPQGARGEPG APGPAGAAGP SGNPGTDGQP GGKGATGSPG IAGAPGFPGA 400
RGAPGPQGPA GAPGPKGNNG EPGAQGNKGE PGAKGEPGPA GVQGPPGPSG 450
EEGKRGSRGE PGPAGPPGPA GERGGPGSRG FPGSDGASGP KGAPGERGSV 500
GPAGPKGSTG ESGRPGEPGL PGAKGLTGSP GSPGPDGKTG PAGAAGQDGH 550
PGPPGPSGAR GQSGVMGFPG PKGAAGEPGK SGERGVAGPP GATGAPGKDG 600
EAGAQGPPGP SGPSGERGEQ GPAGSPGFQG LPGSPGPAGE AGKPGEQGAP 650
GDAGGPGPSG PRGERGFPGE RGGQGPAGAQ GPRGSPGSPG NDGAKGEAGA 700
AGAPGGRGPP GLQGMPGERG SAGMPGAKGD RGDAGTKGAD GAPGKDGARG 750
LTGPIGPPGP SGAPGDKGEG GPSGPAGPTG ARGSPGERGE PGAPGPAGIC 800
GPPGADGQPG AKGESGDAGP KGDAGAPGPA GPTGAPGPAG NVGAPGPKGT 850
RGAAGPPGAT GFPGAAGRLG PPGPSGNAGP PGPPGPGGKE GAKGSRGETG 900
PAGRSGEPGP AGPPGPSGEK GSPGSDGPAG APGIPGPQGI AGQRGVVGLP 950
GQRGERGFSG LPGPAGEPGK QGPSGPNGER GPPGPSGPPG LGGPPGEPGR 1000
EGSPGSEGAP GRDGSPGPKG DRGENGPSGP PGAPGAPGAP GPVGPAGKNG 1050
DRGETGPAGP AGPAGPSGVR GAPGPAGARG DKGEAGEQGE RGMKGHRGFN 1100
GMQGPPGPPG SSGEQGAPGP SGPAGPRGPP GSSGSTGKDG VNGLPGPIGP 1150
PGPRGRNGDV GPAGPPGPPG PPGPPGPPSG GFDFSFMPQP PEPKSHGDGR 1200
YFRADDANVV RDRDLEVDTT LKSLSAQIEN IRSPEGTRKN PARTCRDLKM 1250
CHSDWKSGDY WIDPNQGCNL DAIKVHCNME TGETCVYPSQ ASISQKNWYT 1300
SKNPREKKHV WFGETMSDGF QFEYGGEGSD PADVNIQLTF LRLMATEASQ 1350
NITYHCKNSV AYMDQETGNL KKAVLLQGSN EIEIRAEGNS RFTYGVTEDG 1400
CTQHTGEWGK TVIEYKTTKT SRLPIIDIAP MDVGTPDQEF GIDIGPVCFL 1450
Length:1,450
Mass (Da):137,563
Last modified:May 1, 1999 - v1
Checksum:iABF8A74841B87B7C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015438 mRNA. Translation: BAA36973.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015438 mRNA. Translation: BAA36973.1 .

3D structure databases

ProteinModelPortali Q9YIB4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG004933.

Family and domain databases

InterProi IPR008160. Collagen.
IPR000885. Fib_collagen_C.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF01410. COLFI. 1 hit.
PF01391. Collagen. 12 hits.
PF00093. VWC. 1 hit.
[Graphical view ]
ProDomi PD002078. Fib_collagen_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00038. COLFI. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
PROSITEi PS51461. NC1_FIB. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression of genes of type I and type II collagen in the formation and development of the blastema of regenerating newt limb."
    Asahina K., Obara M., Yoshizato K.
    Dev. Dyn. 216:59-71(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Regenerating forelimb blastema.

Entry informationi

Entry nameiCO1A1_CYNPY
AccessioniPrimary (citable) accession number: Q9YIB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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