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Q9YIB4

- CO1A1_CYNPY

UniProt

Q9YIB4 - CO1A1_CYNPY

Protein

Collagen alpha-1(I) chain

Gene

COL1A1

Organism
Cynops pyrrhogaster (Japanese common newt)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Type I collagen is a member of group I collagen (fibrillar forming collagen).By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi1263 – 12631CalciumBy similarity
    Metal bindingi1265 – 12651CalciumBy similarity
    Metal bindingi1266 – 12661Calcium; via carbonyl oxygenBy similarity
    Metal bindingi1268 – 12681Calcium; via carbonyl oxygenBy similarity
    Metal bindingi1271 – 12711CalciumBy similarity

    GO - Molecular functioni

    1. extracellular matrix structural constituent Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Collagen alpha-1(I) chain
    Alternative name(s):
    Alpha-1 type I collagen
    Gene namesi
    Name:COL1A1
    OrganismiCynops pyrrhogaster (Japanese common newt)
    Taxonomic identifieri8330 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaCaudataSalamandroideaSalamandridaePleurodelinaeCynops

    Subcellular locationi

    Secretedextracellular spaceextracellular matrix PROSITE-ProRule annotation

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Propeptidei23 – 148126N-terminal propeptideBy similarityPRO_0000286160Add
    BLAST
    Chaini149 – 12021054Collagen alpha-1(I) chainPRO_0000286161Add
    BLAST
    Propeptidei1203 – 1450248C-terminal propeptideBy similarityPRO_0000286162Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei149 – 1491Pyrrolidone carboxylic acidBy similarity
    Disulfide bondi1245 ↔ 1277PROSITE-ProRule annotation
    Disulfide bondi1251 – 1251Interchain (with C-1268)PROSITE-ProRule annotation
    Disulfide bondi1268 – 1268Interchain (with C-1251)PROSITE-ProRule annotation
    Disulfide bondi1285 ↔ 1448PROSITE-ProRule annotation
    Glycosylationi1351 – 13511N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1356 ↔ 1401PROSITE-ProRule annotation

    Post-translational modificationi

    Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Hydroxylation, Pyrrolidone carboxylic acid

    Interactioni

    Subunit structurei

    Trimers of one alpha 2(I) and two alpha 1(I) chains.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9YIB4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 9060VWFCPROSITE-ProRule annotationAdd
    BLAST
    Domaini1215 – 1450236Fibrillar collagen NC1PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function By similarity.By similarity

    Sequence similaritiesi

    Belongs to the fibrillar collagen family.PROSITE-ProRule annotation
    Contains 1 fibrillar collagen NC1 domain.PROSITE-ProRule annotation
    Contains 1 VWFC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Collagen, Repeat, Signal

    Phylogenomic databases

    HOVERGENiHBG004933.

    Family and domain databases

    InterProiIPR008160. Collagen.
    IPR000885. Fib_collagen_C.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF01410. COLFI. 1 hit.
    PF01391. Collagen. 12 hits.
    PF00093. VWC. 1 hit.
    [Graphical view]
    ProDomiPD002078. Fib_collagen_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00038. COLFI. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view]
    PROSITEiPS51461. NC1_FIB. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9YIB4-1 [UniParc]FASTAAdd to Basket

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    MFSFVDNRLL VLLAACVLLV RALDQEDIES GLCHQEGTTY SDKDVWKPEP     50
    CVICVCDNGN IMCDDVTCGD YPVDCPNAEI PFGECCPVCP DGDGTSYSEQ 100
    TGVEGPKGEV GPKGDRGLPG PPGRDGNPGL PGPPGPPGPP GLGGNFAPQM 150
    SYGYDEKSAG ISVPGPMGPM GPRGPPGPSG SPGPQGFQGP SGEPGEPGAA 200
    GALGPRGLPG PPGKNGDDGE SGKPGRPGER GPSGPQGARG LPGTAGLPGM 250
    KGHRGFNGLD GAKGDNGPAG PKGEPGNPGE NGAPGQAGPR GLPGERGRPG 300
    APGPAGARGN DGSPGAAGPP GPTGPTGPPG FPGAVGAKGD AGPQGSRGSE 350
    GPQGARGEPG APGPAGAAGP SGNPGTDGQP GGKGATGSPG IAGAPGFPGA 400
    RGAPGPQGPA GAPGPKGNNG EPGAQGNKGE PGAKGEPGPA GVQGPPGPSG 450
    EEGKRGSRGE PGPAGPPGPA GERGGPGSRG FPGSDGASGP KGAPGERGSV 500
    GPAGPKGSTG ESGRPGEPGL PGAKGLTGSP GSPGPDGKTG PAGAAGQDGH 550
    PGPPGPSGAR GQSGVMGFPG PKGAAGEPGK SGERGVAGPP GATGAPGKDG 600
    EAGAQGPPGP SGPSGERGEQ GPAGSPGFQG LPGSPGPAGE AGKPGEQGAP 650
    GDAGGPGPSG PRGERGFPGE RGGQGPAGAQ GPRGSPGSPG NDGAKGEAGA 700
    AGAPGGRGPP GLQGMPGERG SAGMPGAKGD RGDAGTKGAD GAPGKDGARG 750
    LTGPIGPPGP SGAPGDKGEG GPSGPAGPTG ARGSPGERGE PGAPGPAGIC 800
    GPPGADGQPG AKGESGDAGP KGDAGAPGPA GPTGAPGPAG NVGAPGPKGT 850
    RGAAGPPGAT GFPGAAGRLG PPGPSGNAGP PGPPGPGGKE GAKGSRGETG 900
    PAGRSGEPGP AGPPGPSGEK GSPGSDGPAG APGIPGPQGI AGQRGVVGLP 950
    GQRGERGFSG LPGPAGEPGK QGPSGPNGER GPPGPSGPPG LGGPPGEPGR 1000
    EGSPGSEGAP GRDGSPGPKG DRGENGPSGP PGAPGAPGAP GPVGPAGKNG 1050
    DRGETGPAGP AGPAGPSGVR GAPGPAGARG DKGEAGEQGE RGMKGHRGFN 1100
    GMQGPPGPPG SSGEQGAPGP SGPAGPRGPP GSSGSTGKDG VNGLPGPIGP 1150
    PGPRGRNGDV GPAGPPGPPG PPGPPGPPSG GFDFSFMPQP PEPKSHGDGR 1200
    YFRADDANVV RDRDLEVDTT LKSLSAQIEN IRSPEGTRKN PARTCRDLKM 1250
    CHSDWKSGDY WIDPNQGCNL DAIKVHCNME TGETCVYPSQ ASISQKNWYT 1300
    SKNPREKKHV WFGETMSDGF QFEYGGEGSD PADVNIQLTF LRLMATEASQ 1350
    NITYHCKNSV AYMDQETGNL KKAVLLQGSN EIEIRAEGNS RFTYGVTEDG 1400
    CTQHTGEWGK TVIEYKTTKT SRLPIIDIAP MDVGTPDQEF GIDIGPVCFL 1450
    Length:1,450
    Mass (Da):137,563
    Last modified:May 1, 1999 - v1
    Checksum:iABF8A74841B87B7C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015438 mRNA. Translation: BAA36973.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015438 mRNA. Translation: BAA36973.1 .

    3D structure databases

    ProteinModelPortali Q9YIB4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG004933.

    Family and domain databases

    InterProi IPR008160. Collagen.
    IPR000885. Fib_collagen_C.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF01410. COLFI. 1 hit.
    PF01391. Collagen. 12 hits.
    PF00093. VWC. 1 hit.
    [Graphical view ]
    ProDomi PD002078. Fib_collagen_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00038. COLFI. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view ]
    PROSITEi PS51461. NC1_FIB. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of genes of type I and type II collagen in the formation and development of the blastema of regenerating newt limb."
      Asahina K., Obara M., Yoshizato K.
      Dev. Dyn. 216:59-71(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Regenerating forelimb blastema.

    Entry informationi

    Entry nameiCO1A1_CYNPY
    AccessioniPrimary (citable) accession number: Q9YIB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3