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Q9YIB4

- CO1A1_CYNPY

UniProt

Q9YIB4 - CO1A1_CYNPY

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Protein

Collagen alpha-1(I) chain

Gene

COL1A1

Organism
Cynops pyrrhogaster (Japanese common newt)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Type I collagen is a member of group I collagen (fibrillar forming collagen).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1263 – 12631CalciumBy similarity
Metal bindingi1265 – 12651CalciumBy similarity
Metal bindingi1266 – 12661Calcium; via carbonyl oxygenBy similarity
Metal bindingi1268 – 12681Calcium; via carbonyl oxygenBy similarity
Metal bindingi1271 – 12711CalciumBy similarity

GO - Molecular functioni

  1. extracellular matrix structural constituent Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(I) chain
Alternative name(s):
Alpha-1 type I collagen
Gene namesi
Name:COL1A1
OrganismiCynops pyrrhogaster (Japanese common newt)
Taxonomic identifieri8330 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaCaudataSalamandroideaSalamandridaePleurodelinaeCynops

Subcellular locationi

Secretedextracellular spaceextracellular matrix PROSITE-ProRule annotation

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Propeptidei23 – 148126N-terminal propeptideBy similarityPRO_0000286160Add
BLAST
Chaini149 – 12021054Collagen alpha-1(I) chainPRO_0000286161Add
BLAST
Propeptidei1203 – 1450248C-terminal propeptideBy similarityPRO_0000286162Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei149 – 1491Pyrrolidone carboxylic acidBy similarity
Disulfide bondi1245 ↔ 1277PROSITE-ProRule annotation
Disulfide bondi1251 – 1251Interchain (with C-1268)PROSITE-ProRule annotation
Disulfide bondi1268 – 1268Interchain (with C-1251)PROSITE-ProRule annotation
Disulfide bondi1285 ↔ 1448PROSITE-ProRule annotation
Glycosylationi1351 – 13511N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1356 ↔ 1401PROSITE-ProRule annotation

Post-translational modificationi

Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Pyrrolidone carboxylic acid

Interactioni

Subunit structurei

Trimers of one alpha 2(I) and two alpha 1(I) chains.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9YIB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 9060VWFCPROSITE-ProRule annotationAdd
BLAST
Domaini1215 – 1450236Fibrillar collagen NC1PROSITE-ProRule annotationAdd
BLAST

Domaini

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity).By similarity

Sequence similaritiesi

Belongs to the fibrillar collagen family.PROSITE-ProRule annotation
Contains 1 fibrillar collagen NC1 domain.PROSITE-ProRule annotation
Contains 1 VWFC domain.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

HOVERGENiHBG004933.

Family and domain databases

InterProiIPR008160. Collagen.
IPR000885. Fib_collagen_C.
IPR001007. VWF_C.
[Graphical view]
PfamiPF01410. COLFI. 1 hit.
PF01391. Collagen. 12 hits.
PF00093. VWC. 1 hit.
[Graphical view]
ProDomiPD002078. Fib_collagen_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00038. COLFI. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
PROSITEiPS51461. NC1_FIB. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9YIB4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFSFVDNRLL VLLAACVLLV RALDQEDIES GLCHQEGTTY SDKDVWKPEP
60 70 80 90 100
CVICVCDNGN IMCDDVTCGD YPVDCPNAEI PFGECCPVCP DGDGTSYSEQ
110 120 130 140 150
TGVEGPKGEV GPKGDRGLPG PPGRDGNPGL PGPPGPPGPP GLGGNFAPQM
160 170 180 190 200
SYGYDEKSAG ISVPGPMGPM GPRGPPGPSG SPGPQGFQGP SGEPGEPGAA
210 220 230 240 250
GALGPRGLPG PPGKNGDDGE SGKPGRPGER GPSGPQGARG LPGTAGLPGM
260 270 280 290 300
KGHRGFNGLD GAKGDNGPAG PKGEPGNPGE NGAPGQAGPR GLPGERGRPG
310 320 330 340 350
APGPAGARGN DGSPGAAGPP GPTGPTGPPG FPGAVGAKGD AGPQGSRGSE
360 370 380 390 400
GPQGARGEPG APGPAGAAGP SGNPGTDGQP GGKGATGSPG IAGAPGFPGA
410 420 430 440 450
RGAPGPQGPA GAPGPKGNNG EPGAQGNKGE PGAKGEPGPA GVQGPPGPSG
460 470 480 490 500
EEGKRGSRGE PGPAGPPGPA GERGGPGSRG FPGSDGASGP KGAPGERGSV
510 520 530 540 550
GPAGPKGSTG ESGRPGEPGL PGAKGLTGSP GSPGPDGKTG PAGAAGQDGH
560 570 580 590 600
PGPPGPSGAR GQSGVMGFPG PKGAAGEPGK SGERGVAGPP GATGAPGKDG
610 620 630 640 650
EAGAQGPPGP SGPSGERGEQ GPAGSPGFQG LPGSPGPAGE AGKPGEQGAP
660 670 680 690 700
GDAGGPGPSG PRGERGFPGE RGGQGPAGAQ GPRGSPGSPG NDGAKGEAGA
710 720 730 740 750
AGAPGGRGPP GLQGMPGERG SAGMPGAKGD RGDAGTKGAD GAPGKDGARG
760 770 780 790 800
LTGPIGPPGP SGAPGDKGEG GPSGPAGPTG ARGSPGERGE PGAPGPAGIC
810 820 830 840 850
GPPGADGQPG AKGESGDAGP KGDAGAPGPA GPTGAPGPAG NVGAPGPKGT
860 870 880 890 900
RGAAGPPGAT GFPGAAGRLG PPGPSGNAGP PGPPGPGGKE GAKGSRGETG
910 920 930 940 950
PAGRSGEPGP AGPPGPSGEK GSPGSDGPAG APGIPGPQGI AGQRGVVGLP
960 970 980 990 1000
GQRGERGFSG LPGPAGEPGK QGPSGPNGER GPPGPSGPPG LGGPPGEPGR
1010 1020 1030 1040 1050
EGSPGSEGAP GRDGSPGPKG DRGENGPSGP PGAPGAPGAP GPVGPAGKNG
1060 1070 1080 1090 1100
DRGETGPAGP AGPAGPSGVR GAPGPAGARG DKGEAGEQGE RGMKGHRGFN
1110 1120 1130 1140 1150
GMQGPPGPPG SSGEQGAPGP SGPAGPRGPP GSSGSTGKDG VNGLPGPIGP
1160 1170 1180 1190 1200
PGPRGRNGDV GPAGPPGPPG PPGPPGPPSG GFDFSFMPQP PEPKSHGDGR
1210 1220 1230 1240 1250
YFRADDANVV RDRDLEVDTT LKSLSAQIEN IRSPEGTRKN PARTCRDLKM
1260 1270 1280 1290 1300
CHSDWKSGDY WIDPNQGCNL DAIKVHCNME TGETCVYPSQ ASISQKNWYT
1310 1320 1330 1340 1350
SKNPREKKHV WFGETMSDGF QFEYGGEGSD PADVNIQLTF LRLMATEASQ
1360 1370 1380 1390 1400
NITYHCKNSV AYMDQETGNL KKAVLLQGSN EIEIRAEGNS RFTYGVTEDG
1410 1420 1430 1440 1450
CTQHTGEWGK TVIEYKTTKT SRLPIIDIAP MDVGTPDQEF GIDIGPVCFL
Length:1,450
Mass (Da):137,563
Last modified:May 1, 1999 - v1
Checksum:iABF8A74841B87B7C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015438 mRNA. Translation: BAA36973.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015438 mRNA. Translation: BAA36973.1 .

3D structure databases

ProteinModelPortali Q9YIB4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG004933.

Family and domain databases

InterProi IPR008160. Collagen.
IPR000885. Fib_collagen_C.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF01410. COLFI. 1 hit.
PF01391. Collagen. 12 hits.
PF00093. VWC. 1 hit.
[Graphical view ]
ProDomi PD002078. Fib_collagen_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00038. COLFI. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
PROSITEi PS51461. NC1_FIB. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression of genes of type I and type II collagen in the formation and development of the blastema of regenerating newt limb."
    Asahina K., Obara M., Yoshizato K.
    Dev. Dyn. 216:59-71(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Regenerating forelimb blastema.

Entry informationi

Entry nameiCO1A1_CYNPY
AccessioniPrimary (citable) accession number: Q9YIB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3