Q9YIB4 (CO1A1_CYNPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Collagen alpha-1(I) chain

Alternative name(s):
Alpha-1 type I collagen

Gene names

Name:

COL1A1

Organism

Cynops pyrrhogaster (Japanese common newt)

Taxonomic identifier

8330 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Caudata › Salamandroidea › Salamandridae › Cynops

Protein attributes

Sequence length	1450 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Type I collagen is a member of group I collagen (fibrillar forming collagen) By similarity.
Subunit structure	Trimers of one alpha 2(I) and two alpha 1(I) chains By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity.
Domain	The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function By similarity.
Post-translational modification	Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains By similarity.
Sequence similarities	Belongs to the fibrillar collagen family. Contains 1 fibrillar collagen NC1 domain. Contains 1 VWFC domain.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Domain	Collagen Repeat Signal
Ligand	Calcium Metal-binding
PTM	Disulfide bond Glycoprotein Hydroxylation Pyrrolidone carboxylic acid
Gene Ontology (GO)
Cellular_component	collagen Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	extracellular matrix structural constituent Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Propeptide	23 – 148	126	N-terminal propeptide By similarity		PRO_0000286160
	Chain	149 – 1202	1054	Collagen alpha-1(I) chain		PRO_0000286161
	Propeptide	1203 – 1450	248	C-terminal propeptide By similarity		PRO_0000286162
Regions
	Domain	31 – 90	60	VWFC
	Domain	1215 – 1450	236	Fibrillar collagen NC1
Sites
	Metal binding	1263	1	Calcium By similarity
	Metal binding	1265	1	Calcium By similarity
	Metal binding	1266	1	Calcium; via carbonyl oxygen By similarity
	Metal binding	1268	1	Calcium; via carbonyl oxygen By similarity
	Metal binding	1271	1	Calcium By similarity
Amino acid modifications
	Modified residue	149	1	Pyrrolidone carboxylic acid By similarity
	Glycosylation	1351	1	N-linked (GlcNAc...) Potential
	Disulfide bond	1245 ↔ 1277		By similarity
	Disulfide bond	1251		Interchain (with C-1268) By similarity
	Disulfide bond	1268		Interchain (with C-1251) By similarity
	Disulfide bond	1285 ↔ 1448		By similarity
	Disulfide bond	1356 ↔ 1401		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9YIB4 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: ABF8A74841B87B7C	FASTA	1,450	137,563
	10 20 30 40 50 60 MFSFVDNRLL VLLAACVLLV RALDQEDIES GLCHQEGTTY SDKDVWKPEP CVICVCDNGN 70 80 90 100 110 120 IMCDDVTCGD YPVDCPNAEI PFGECCPVCP DGDGTSYSEQ TGVEGPKGEV GPKGDRGLPG 130 140 150 160 170 180 PPGRDGNPGL PGPPGPPGPP GLGGNFAPQM SYGYDEKSAG ISVPGPMGPM GPRGPPGPSG 190 200 210 220 230 240 SPGPQGFQGP SGEPGEPGAA GALGPRGLPG PPGKNGDDGE SGKPGRPGER GPSGPQGARG 250 260 270 280 290 300 LPGTAGLPGM KGHRGFNGLD GAKGDNGPAG PKGEPGNPGE NGAPGQAGPR GLPGERGRPG 310 320 330 340 350 360 APGPAGARGN DGSPGAAGPP GPTGPTGPPG FPGAVGAKGD AGPQGSRGSE GPQGARGEPG 370 380 390 400 410 420 APGPAGAAGP SGNPGTDGQP GGKGATGSPG IAGAPGFPGA RGAPGPQGPA GAPGPKGNNG 430 440 450 460 470 480 EPGAQGNKGE PGAKGEPGPA GVQGPPGPSG EEGKRGSRGE PGPAGPPGPA GERGGPGSRG 490 500 510 520 530 540 FPGSDGASGP KGAPGERGSV GPAGPKGSTG ESGRPGEPGL PGAKGLTGSP GSPGPDGKTG 550 560 570 580 590 600 PAGAAGQDGH PGPPGPSGAR GQSGVMGFPG PKGAAGEPGK SGERGVAGPP GATGAPGKDG 610 620 630 640 650 660 EAGAQGPPGP SGPSGERGEQ GPAGSPGFQG LPGSPGPAGE AGKPGEQGAP GDAGGPGPSG 670 680 690 700 710 720 PRGERGFPGE RGGQGPAGAQ GPRGSPGSPG NDGAKGEAGA AGAPGGRGPP GLQGMPGERG 730 740 750 760 770 780 SAGMPGAKGD RGDAGTKGAD GAPGKDGARG LTGPIGPPGP SGAPGDKGEG GPSGPAGPTG 790 800 810 820 830 840 ARGSPGERGE PGAPGPAGIC GPPGADGQPG AKGESGDAGP KGDAGAPGPA GPTGAPGPAG 850 860 870 880 890 900 NVGAPGPKGT RGAAGPPGAT GFPGAAGRLG PPGPSGNAGP PGPPGPGGKE GAKGSRGETG 910 920 930 940 950 960 PAGRSGEPGP AGPPGPSGEK GSPGSDGPAG APGIPGPQGI AGQRGVVGLP GQRGERGFSG 970 980 990 1000 1010 1020 LPGPAGEPGK QGPSGPNGER GPPGPSGPPG LGGPPGEPGR EGSPGSEGAP GRDGSPGPKG 1030 1040 1050 1060 1070 1080 DRGENGPSGP PGAPGAPGAP GPVGPAGKNG DRGETGPAGP AGPAGPSGVR GAPGPAGARG 1090 1100 1110 1120 1130 1140 DKGEAGEQGE RGMKGHRGFN GMQGPPGPPG SSGEQGAPGP SGPAGPRGPP GSSGSTGKDG 1150 1160 1170 1180 1190 1200 VNGLPGPIGP PGPRGRNGDV GPAGPPGPPG PPGPPGPPSG GFDFSFMPQP PEPKSHGDGR 1210 1220 1230 1240 1250 1260 YFRADDANVV RDRDLEVDTT LKSLSAQIEN IRSPEGTRKN PARTCRDLKM CHSDWKSGDY 1270 1280 1290 1300 1310 1320 WIDPNQGCNL DAIKVHCNME TGETCVYPSQ ASISQKNWYT SKNPREKKHV WFGETMSDGF 1330 1340 1350 1360 1370 1380 QFEYGGEGSD PADVNIQLTF LRLMATEASQ NITYHCKNSV AYMDQETGNL KKAVLLQGSN 1390 1400 1410 1420 1430 1440 EIEIRAEGNS RFTYGVTEDG CTQHTGEWGK TVIEYKTTKT SRLPIIDIAP MDVGTPDQEF 1450 GIDIGPVCFL

References

[1]

"Expression of genes of type I and type II collagen in the formation and development of the blastema of regenerating newt limb." Asahina K., Obara M., Yoshizato K. Dev. Dyn. 216:59-71(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Regenerating forelimb blastema.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB015438 mRNA. Translation: BAA36973.1.
3D structure databases
HSSP	HSSP built from PDB template 1Q7D based on UniProtKB Q15201.
ProteinModelPortal	Q9YIB4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG004933.
Family and domain databases
InterPro	IPR008160. Collagen. IPR000885. Fib_collagen_C. IPR001007. VWF_C. [Graphical view]
Pfam	PF01410. COLFI. 1 hit. PF01391. Collagen. 12 hits. PF00093. VWC. 1 hit. [Graphical view]
ProDom	PD002078. Fib_collagen_C. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00038. COLFI. 1 hit. SM00214. VWC. 1 hit. [Graphical view]
PROSITE	PS51461. NC1_FIB. 1 hit. PS01208. VWFC_1. 1 hit. PS50184. VWFC_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CO1A1_CYNPY

Accession

Primary (citable) accession number: Q9YIB4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	May 1, 1999
Last modified:	April 3, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program