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Protein

Cytochrome P450

Gene

cyp1a1

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases.UniRule annotation

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.UniRule annotation

Cofactori

hemeUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450UniRule annotation (EC:1.14.14.1UniRule annotation)
Gene namesi
Name:cyp1a1Imported
Synonyms:LOC100036775Imported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-990178. cyp1a1.

Subcellular locationi

  • Endoplasmic reticulum membrane UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3423HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, MicrosomeUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOVERGENiHBG106944.
KOiK07408.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9YI88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNWIGTVAG MMANTTITEF LVASVVFAIV FLVIRSQRVK IPPGTKKLPG
60 70 80 90 100
PMPYPVIGNL LSLSKNPHLS LTRMSETYGD VFQIQIGTKP VLVLSGLETL
110 120 130 140 150
KQALIRQGDE FAGRPDLFTF RMVGDGQSMT FSSDSGEVWR ARRRLAQNAL
160 170 180 190 200
KTFATSPSPT SSSSCLVEEN IITEAEYLVK KFMQLIDEKG EFDPYRYVVV
210 220 230 240 250
SVANIICGMC FGKRYNHDDE ELLNVVNLTD EFGAAAASGN PADFIPILQY
260 270 280 290 300
LPSSSMKAFK EINRKFIDFM QKFATEHYKT FDKNHIRDIT DSLIQHSQEK
310 320 330 340 350
RVDENSNVQL SNQKIVNIVN DLFGAGFDTI TTALSWSLMY LVAHPNIQEK
360 370 380 390 400
IQDELDRVIG KERRPRLSDR AQLPYTEAFI FEMFRHSSFM PFTIPHCTTK
410 420 430 440 450
DTVLNGYFIP KGICVLVNQW QVNHDPNLWK DPSKFYPERF LNTDGTMVNK
460 470 480 490 500
TEMEKVMVFG LGKRRCVGEA IGRMEVFLFL TTMLQQMQFF KQDGEKLDMS
510 520
PQYGLTMKHK RCHVTAKLRF PLLTTD
Length:526
Mass (Da):59,873
Last modified:May 1, 1999 - v1
Checksum:i508FA3BAC78789DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC170421 mRNA. Translation: AAI70421.1.
BC170423 mRNA. Translation: AAI70423.1.
AB022088 mRNA. Translation: BAA37080.1.
RefSeqiNP_001090541.1. NM_001097072.1.
UniGeneiXl.1220.

Genome annotation databases

GeneIDi100036775.
KEGGixla:100036775.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC170421 mRNA. Translation: AAI70421.1.
BC170423 mRNA. Translation: AAI70423.1.
AB022088 mRNA. Translation: BAA37080.1.
RefSeqiNP_001090541.1. NM_001097072.1.
UniGeneiXl.1220.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100036775.
KEGGixla:100036775.

Organism-specific databases

CTDi1543.
XenbaseiXB-GENE-990178. cyp1a1.

Phylogenomic databases

HOVERGENiHBG106944.
KOiK07408.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and sequence analysis of cDNAs coding for 3-methylcholanthrene-inducible cytochromes P450 in Xenopus laevis liver."
    Fujita Y., Ohi H., Murayama N., Saguchi K., Higuchi S.
    Arch. Biochem. Biophys. 371:24-28(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: LiverImported.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: OocytesImported.

Entry informationi

Entry nameiQ9YI88_XENLA
AccessioniPrimary (citable) accession number: Q9YI88
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: July 6, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.