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Protein

Cytochrome P450

Gene

CYP1A

Organism
Fundulus heteroclitus (Killifish) (Mummichog)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases.UniRule annotation

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.UniRule annotation

Cofactori

hemeUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450UniRule annotation (EC:1.14.14.1UniRule annotation)
Gene namesi
Name:CYP1AImported
OrganismiFundulus heteroclitus (Killifish) (Mummichog)Imported
Taxonomic identifieri8078 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesFundulidaeFundulus

Subcellular locationi

  • Endoplasmic reticulum membrane UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 29HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, MicrosomeUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ9YI64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOVERGENiHBG106944.
OrthoDBiEOG091G0BT8.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9YI64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALMILPFIG ALSVSEGLIA LVTVCLVYLT LKHFRREIPE GLRRLPGPTP
60 70 80 90 100
LPIIGNFLEL GSKPYLSLTE MSKRFGDVFQ IQLGMRPVVI LSGYETVKQA
110 120 130 140 150
LTKQGDDFAG RPDLYSFRFI NDGKSLAFST DKAGVWRARR KLAYSALRSF
160 170 180 190 200
SSLEGKLPEY SCVLEEHICK ETEHLIKELH NVMTAEGKFD PFRYIVVSVA
210 220 230 240 250
NVICGMCFGR RYDHHNQELL SLVNLAEDFV QVTGSGNPAD FIPALQFLPN
260 270 280 290 300
KSMKKFVNLN NRFNNFVQKI VSEHYSTFDK DNIRDITDSL IDHCEDRKLD
310 320 330 340 350
ENSNIQMSDE KIVGIVNDLF GAGFDTISTA LSWAVMYLVA YPEVEERLYE
360 370 380 390 400
EIKEKVGLDR TPVMSDRSNL PLLESFILEL FRHSSYLPFT IPHCSTKDTS
410 420 430 440 450
LNGYFIPKDT CVFVNQWQIN HDPELWKDPS MFIPDRFLSA DGTEVNKQEG
460 470 480 490 500
EKVLIFGLGR RRCIGEVIAR NEVFLFLAII IQKLHFYKLP GEPVDMTPEY
510 520
GLTMKHKRCY LGVAMRAKDV Q
Length:521
Mass (Da):59,387
Last modified:May 1, 1999 - v1
Checksum:i83B31B243529452A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026800 mRNA. Translation: AAD01809.1.
RefSeqiNP_001296938.1. NM_001310009.1.
UniGeneiFhe.3460.

Genome annotation databases

GeneIDi105930482.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026800 mRNA. Translation: AAD01809.1.
RefSeqiNP_001296938.1. NM_001310009.1.
UniGeneiFhe.3460.

3D structure databases

ProteinModelPortaliQ9YI64.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi105930482.

Phylogenomic databases

HOVERGENiHBG106944.
OrthoDBiEOG091G0BT8.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9YI64_FUNHE
AccessioniPrimary (citable) accession number: Q9YI64
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: October 5, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.