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Q9YI58

- Q9YI58_CHICK

UniProt

Q9YI58 - Q9YI58_CHICK

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Protein
Submitted name:

Glutamate decarboxylase 67

Gene

GAD67

Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: Ensembl
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. carboxylic acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_197535. GABA synthesis.
REACT_244277. GABA synthesis, release, reuptake and degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
Glutamate decarboxylase 67Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:GAD67Imported
Synonyms:GAD1Imported
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 7

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: Ensembl
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015612.

Structurei

3D structure databases

SMRiQ9YI58. Positions 89-589.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
GeneTreeiENSGT00760000119205.
HOGENOMiHOG000005382.
HOVERGENiHBG004980.
KOiK01580.
OMAiEYLYTKI.
OrthoDBiEOG7H1JM3.
PhylomeDBiQ9YI58.
TreeFamiTF314688.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9YI58-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASSAPSSSN DAPDPAPTNL RPTTYDSWCG VAHGCTRKIG LKICGFLQRT
60 70 80 90 100
NSLEDKGRIV GSLKERQSSK NLLACENSER EARFRRTETD FSNLYARDLL
110 120 130 140 150
PAKNGEEQTM QFLLEVVDIL LNYVRKTFDR STKVLDFHHP HQLLEGMEGF
160 170 180 190 200
NLELSDNPES LEQILVDCRD TLKYGVRTGH PRFFNQLSTG LDMIGLAGEW
210 220 230 240 250
LTSTANTNMF TYEIAPVFVL MEQITLRKMR EIIGWSNKDG DGIFSPGGAI
260 270 280 290 300
SNMYSIMAAR YKYFPEVKTK GMAAVPKLVL FTSEHSHYSI KKAGAALGFG
310 320 330 340 350
TDNVILIKCN ERGKIIPADL EAKILEAKQK GYVPLFVNAT AGTTVYGAFD
360 370 380 390 400
PIQEIADICE KYNLWLHVDA AWGGGLLMSR KHRHKLNGIE RANSVTWNPH
410 420 430 440 450
KMMGVLLQCS AILVREKGIL QGCNQMCAGY LFQQDKQYDV SYDTGDKAIQ
460 470 480 490 500
CGRHVDIFKF WLMWKAKGTV GFENQINKCL ELAEYLYTKI KNREEFEMVF
510 520 530 540 550
EGEPEHTNVC FWYIPPSLRG MPDCDERREK LHRVAPKIKA LMMESGTTMV
560 570 580 590
GYQPQGDKVN FFRMVISNPA ATKSDIDFLI EEIERLGQEL
Length:590
Mass (Da):66,711
Last modified:May 1, 1999 - v1
Checksum:i9DE9A26C834A5474
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03005349 Genomic DNA. No translation available.
AF030355 mRNA. Translation: AAD01902.1.
RefSeqiNP_990244.1. NM_204913.1.
UniGeneiGga.441.

Genome annotation databases

EnsembliENSGALT00000015628; ENSGALP00000015612; ENSGALG00000009589.
ENSGALT00000043162; ENSGALP00000040750; ENSGALG00000009589.
GeneIDi395743.
KEGGigga:395743.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03005349 Genomic DNA. No translation available.
AF030355 mRNA. Translation: AAD01902.1 .
RefSeqi NP_990244.1. NM_204913.1.
UniGenei Gga.441.

3D structure databases

SMRi Q9YI58. Positions 89-589.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000015612.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000015628 ; ENSGALP00000015612 ; ENSGALG00000009589 .
ENSGALT00000043162 ; ENSGALP00000040750 ; ENSGALG00000009589 .
GeneIDi 395743.
KEGGi gga:395743.

Organism-specific databases

CTDi 2571.

Phylogenomic databases

eggNOGi COG0076.
GeneTreei ENSGT00760000119205.
HOGENOMi HOG000005382.
HOVERGENi HBG004980.
KOi K01580.
OMAi EYLYTKI.
OrthoDBi EOG7H1JM3.
PhylomeDBi Q9YI58.
TreeFami TF314688.

Enzyme and pathway databases

Reactomei REACT_197535. GABA synthesis.
REACT_244277. GABA synthesis, release, reuptake and degradation.

Miscellaneous databases

NextBioi 20815811.
PROi Q9YI58.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view ]
Pfami PF00282. Pyridoxal_deC. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of glutamate decarboxylase in chicken."
    Wagberg F.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: White leghornImported.
  2. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
    International Chicken Genome Sequencing Consortium
    Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
    , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
    Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Red jungle fowlImported.
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Red jungle fowlImported.
  4. Ensembl
    Submitted (MAY-2013) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Red jungle fowlImported.

Entry informationi

Entry nameiQ9YI58_CHICK
AccessioniPrimary (citable) accession number: Q9YI58
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: January 7, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.