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Protein

Estrogen receptor

Gene

esr1

Organism
Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi187 – 25266Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri187 – 20721NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri223 – 24725NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Lipid-binding, Metal-binding, Steroid-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Estrogen receptor
Short name:
ER
Alternative name(s):
ER-alpha
Estradiol receptor
Nuclear receptor subfamily 3 group A member 1
Gene namesi
Name:esr1
Synonyms:esr, nr3a1
OrganismiIctalurus punctatus (Channel catfish) (Silurus punctatus)
Taxonomic identifieri7998 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiSiluriformesIctaluridaeIctalurus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 617617Estrogen receptorPRO_0000053629Add
BLAST

Expressioni

Tissue specificityi

Ovary and testis.1 Publication

Interactioni

Subunit structurei

Binds DNA as a homodimer. Can form a heterodimer with ER-beta (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9YHZ7.
SMRiQ9YHZ7. Positions 181-255, 315-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 186186ModulatingAdd
BLAST
Regioni253 – 31563HingeAdd
BLAST
Regioni316 – 617302Steroid-bindingSequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi321 – 3255Poly-Leu
Compositional biasi512 – 5165Poly-Leu
Compositional biasi577 – 59115Poly-ThrAdd
BLAST

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri187 – 20721NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri223 – 24725NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOVERGENiHBG108344.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001292. Oestr_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF02159. Oest_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF500101. ER-a. 1 hit.
PIRSF002527. ER-like_NR. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9YHZ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEEQARAEA PAGARQRRRS ELEGYSVSLA SLKLSPMYPE EEQRTTGGIS
60 70 80 90 100
STAHYLDGTF NYTTNPDATN SSVDYYSVAP EPQEENLQPL PNGSSSPPVF
110 120 130 140 150
VPSSPQLSPF LGHPPAGQHT AQQVPYYLEP SGTSIYRSSV LASAGSRVEL
160 170 180 190 200
CSAPGRQDVY TAVGASGPSG ASGPSGAIGL VKEIRYCSVC SDYASGYHYG
210 220 230 240 250
VWSCEGCKAF FKRSIQGHND YVCPATNQCT IDRNRRKSCQ ACRLRKCYEV
260 270 280 290 300
GMMKGGFRKE RGGRIIKHNR RPSGLKERER GYSKAQSGSD VREALPQDGQ
310 320 330 340 350
SSSGIGGGVA DVVCMSPEQV LLLLLRAEPP TLCSRQKHSR PYSELTIMSL
360 370 380 390 400
LTNMADRELV HMIAWAKKVP GFQDLSLHDQ VQLLESSWLE ILMIGLIWRS
410 420 430 440 450
IYTPGKLIFA QDLILDKSEG ECVEGMAEIF DMLLATVARF RTLKLKSEEF
460 470 480 490 500
VCLKAIILLN SGAFSFCSSP VEPLRDGFMV QCMMDNITDA LIYYISQSGI
510 520 530 540 550
SVQLQSRRQA QLLLLLSHIR HMSYKGMEHL YSMKCKNKVP LYDLLLEMLD
560 570 580 590 600
AHRLRPLGKV PRIWADRVSS SPTTTATTPT TNTTTTTTTT THHPSNGSTC
610
PADLPSNPPG PGQSPSP
Length:617
Mass (Da):67,671
Last modified:January 11, 2001 - v2
Checksum:i7B208558E5EAD403
GO
Isoform 2 (identifier: Q9YHZ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.

Show »
Length:581
Mass (Da):63,757
Checksum:iD7B534101572AD24
GO
Isoform 3 (identifier: Q9YHZ7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-425: Missing.

Show »
Length:192
Mass (Da):21,273
Checksum:i5A12D744B7727747
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 425425Missing in isoform 3. CuratedVSP_003682Add
BLAST
Alternative sequencei1 – 3636Missing in isoform 2. CuratedVSP_003681Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF253505 mRNA. Translation: AAG24543.1.
AF061275 mRNA. Translation: AAC69548.1.
AF253506 mRNA. Translation: AAG24544.1.
RefSeqiNP_001187003.1. NM_001200074.1. [Q9YHZ7-1]
UniGeneiIpu.11209.

Genome annotation databases

GeneIDi100304474.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF253505 mRNA. Translation: AAG24543.1.
AF061275 mRNA. Translation: AAC69548.1.
AF253506 mRNA. Translation: AAG24544.1.
RefSeqiNP_001187003.1. NM_001200074.1. [Q9YHZ7-1]
UniGeneiIpu.11209.

3D structure databases

ProteinModelPortaliQ9YHZ7.
SMRiQ9YHZ7. Positions 181-255, 315-554.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100304474.

Organism-specific databases

CTDi246870.

Phylogenomic databases

HOVERGENiHBG108344.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001292. Oestr_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF02159. Oest_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF500101. ER-a. 1 hit.
PIRSF002527. ER-like_NR. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiESR1_ICTPU
AccessioniPrimary (citable) accession number: Q9YHZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: October 14, 2015
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.