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Protein

Estrogen receptor

Gene

esr1

Organism
Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi187 – 252Nuclear receptorPROSITE-ProRule annotationAdd BLAST66
Zinc fingeri187 – 207NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri223 – 247NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • DNA binding transcription factor activity Source: InterPro
  • estrogen receptor activity Source: AgBase
  • hormone binding Source: AgBase
  • sequence-specific DNA binding Source: InterPro
  • steroid binding Source: UniProtKB-KW
  • zinc ion binding Source: InterPro

GO - Biological processi

  • cellular response to estradiol stimulus Source: AgBase
  • intracellular estrogen receptor signaling pathway Source: AgBase
  • regulation of immune response Source: AgBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandLipid-binding, Metal-binding, Steroid-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Estrogen receptor
Short name:
ER
Alternative name(s):
ER-alpha
Estradiol receptor
Nuclear receptor subfamily 3 group A member 1
Gene namesi
Name:esr1
Synonyms:esr, nr3a1
OrganismiIctalurus punctatus (Channel catfish) (Silurus punctatus)
Taxonomic identifieri7998 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiSiluriformesIctaluridaeIctalurus
Proteomesi
  • UP000221080 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000536291 – 617Estrogen receptorAdd BLAST617

Expressioni

Tissue specificityi

Ovary and testis.1 Publication

Interactioni

Subunit structurei

Binds DNA as a homodimer. Can form a heterodimer with ER-beta (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9YHZ7
SMRiQ9YHZ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini316 – 552NR LBDPROSITE-ProRule annotationAdd BLAST237

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 186ModulatingAdd BLAST186
Regioni253 – 315HingeAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi321 – 325Poly-Leu5
Compositional biasi512 – 516Poly-Leu5
Compositional biasi577 – 591Poly-ThrAdd BLAST15

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri187 – 207NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri223 – 247NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOVERGENiHBG108344
KOiK08550

Family and domain databases

Gene3Di3.30.50.101 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR024178 Oest_rcpt/oest-rel_rcp
IPR001292 Oestr_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF02159 Oest_recep, 1 hit
PF00105 zf-C4, 1 hit
PIRSFiPIRSF500101 ER-a, 1 hit
PIRSF002527 ER-like_NR, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9YHZ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEEQARAEA PAGARQRRRS ELEGYSVSLA SLKLSPMYPE EEQRTTGGIS
60 70 80 90 100
STAHYLDGTF NYTTNPDATN SSVDYYSVAP EPQEENLQPL PNGSSSPPVF
110 120 130 140 150
VPSSPQLSPF LGHPPAGQHT AQQVPYYLEP SGTSIYRSSV LASAGSRVEL
160 170 180 190 200
CSAPGRQDVY TAVGASGPSG ASGPSGAIGL VKEIRYCSVC SDYASGYHYG
210 220 230 240 250
VWSCEGCKAF FKRSIQGHND YVCPATNQCT IDRNRRKSCQ ACRLRKCYEV
260 270 280 290 300
GMMKGGFRKE RGGRIIKHNR RPSGLKERER GYSKAQSGSD VREALPQDGQ
310 320 330 340 350
SSSGIGGGVA DVVCMSPEQV LLLLLRAEPP TLCSRQKHSR PYSELTIMSL
360 370 380 390 400
LTNMADRELV HMIAWAKKVP GFQDLSLHDQ VQLLESSWLE ILMIGLIWRS
410 420 430 440 450
IYTPGKLIFA QDLILDKSEG ECVEGMAEIF DMLLATVARF RTLKLKSEEF
460 470 480 490 500
VCLKAIILLN SGAFSFCSSP VEPLRDGFMV QCMMDNITDA LIYYISQSGI
510 520 530 540 550
SVQLQSRRQA QLLLLLSHIR HMSYKGMEHL YSMKCKNKVP LYDLLLEMLD
560 570 580 590 600
AHRLRPLGKV PRIWADRVSS SPTTTATTPT TNTTTTTTTT THHPSNGSTC
610
PADLPSNPPG PGQSPSP
Length:617
Mass (Da):67,671
Last modified:January 11, 2001 - v2
Checksum:i7B208558E5EAD403
GO
Isoform 2 (identifier: Q9YHZ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.

Show »
Length:581
Mass (Da):63,757
Checksum:iD7B534101572AD24
GO
Isoform 3 (identifier: Q9YHZ7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-425: Missing.

Show »
Length:192
Mass (Da):21,273
Checksum:i5A12D744B7727747
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0036821 – 425Missing in isoform 3. CuratedAdd BLAST425
Alternative sequenceiVSP_0036811 – 36Missing in isoform 2. CuratedAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF253505 mRNA Translation: AAG24543.1
AF061275 mRNA Translation: AAC69548.1
AF253506 mRNA Translation: AAG24544.1
RefSeqiNP_001187003.1, NM_001200074.1 [Q9YHZ7-1]
XP_017310819.1, XM_017455330.1 [Q9YHZ7-1]
UniGeneiIpu.11209

Genome annotation databases

GeneIDi100304474
KEGGiipu:100304474

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiESR1_ICTPU
AccessioniPrimary (citable) accession number: Q9YHZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: March 28, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome