Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Tight junction protein

Gene

ZO-2

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Tight junction proteinImported
Gene namesi
Name:ZO-2Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ9YHV2.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000024331.

Structurei

3D structure databases

ProteinModelPortaliQ9YHV2.
SMRiQ9YHV2. Positions 1-104, 273-351.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 9788PDZ (DHR)InterPro annotationAdd
BLAST
Domaini274 – 35279PDZ (DHR)InterPro annotationAdd
BLAST
Domaini478 – 55982PDZ (DHR)InterPro annotationAdd
BLAST
Domaini573 – 63866SH3InterPro annotationAdd
BLAST
Domaini743 – 845103Guanylate kinase-likeInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 3 PDZ (DHR) domains.UniRule annotation
Contains SH3 domain.SAAS annotation

Keywords - Domaini

SH3 domainSAAS annotation

Phylogenomic databases

eggNOGiKOG3580. Eukaryota.
ENOG410XQP3. LUCA.
HOGENOMiHOG000230923.
HOVERGENiHBG017627.
KOiK06098.
PhylomeDBiQ9YHV2.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
3.40.50.300. 2 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR005417. ZO.
IPR005419. ZO-2.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 3 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR01597. ZONOCCLUDNS.
PR01599. ZONOCCLUDNS2.
SMARTiSM00072. GuKc. 1 hit.
SM00228. PDZ. 3 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 3 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9YHV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEELIWEQYT VTLQKDSKRG FGIAVSGGRD NPHFENGETS IVISDVLPGG
60 70 80 90 100
PADGLLQEND RVVIVNGTPM ENVPHSFAVQ QLRKSGKVAT IVVKRPRKVQ
110 120 130 140 150
AAALRKNPSL DYEDRALEVM DDHAEFDGKS ARSGYSERSW RSGNGGRSQS
160 170 180 190 200
WGNSLDQSYR DDQDREHNRS RGRSRGCSYS RDQSRGRSID RSLDQDYGRD
210 220 230 240 250
RSRGRSVDRD GGYGQDYRRD YSPASYRHGS QPDPRYVREV RSLSRDRLHS
260 270 280 290 300
RSPSPETRHQ HEYLGPQDQN GPISVLLTKG KHNEEYGLRL GSQIFIKEMT
310 320 330 340 350
STGLATKDGN LHEGDIILKI NGTVTENMSL ADARKLIEKS RGKLQLVVLR
360 370 380 390 400
DRKQTLLNIP SLNDSDSEMD DISEIESNRS FSPQDDRLHH SDLDLHSSNE
410 420 430 440 450
KLKEKTNAKD DPSNRMSRMG AMPTPFKSTG DIATTAVTVV DANKEPKYQD
460 470 480 490 500
DVAVPQPKAV TRTILKPSPE DEAIYGPNTK MVRFKKGDSV GLRLAGGNDV
510 520 530 540 550
GIFIAGIQEG TSADQEGLQE GDQILKVNAQ DFRGIVREDA VLYLLEIPKG
560 570 580 590 600
DTVTILAQSK YEVYRDIMAC GRGDSFFIRS HFECEKESPQ SLAFTRGEIF
610 620 630 640 650
RVVDTLYDGK LGNWLAVRIG NELEKGLIPN RSRAEQMASV QNAQKDGPSD
660 670 680 690 700
RADFWRTRGQ RSGVKKNLRK SREDLTAIVS VGTKFPAYER VQLREAGFKR
710 720 730 740 750
PVVIFGPIAD VAMEKLSTDL PHLYQTAKTE PRDAGSEKAT GVVRLNTVRQ
760 770 780 790 800
IIEQDKHALL DVTPKAVDLL NYTQWFPIVV FFNPDSKQGV KTMRQRLCST
810 820 830 840 850
SNKSSRKLYE QANKLKKTCS HLFTATINLN SANDSWYGSL KDTIQQQQGE
860 870 880 890 900
AVWVSEGKVD GMEDDADDRM SYLTAMGADY LSCDSRLISD LEDTDGEGGA
910 920 930 940 950
YTDNELDEPL DEPRISSVGR SSEPVHHEEN IKKFSLEQRT PLRKAGSREI
960 970 980 990 1000
LREPSPPPAF KPEPPKGKLQ NKEDLYDFPK NYDSKPSSIH VSSETSTVSA
1010 1020 1030 1040 1050
KAAPPPVSVK PTFGRPILRN TQPAVPSAEE EEEGKLEEEG SEQENTPKSV
1060 1070 1080 1090 1100
LRKVKIFEEM DHKARLQRMQ ELQEAQNARI EIAQKHPDIY AVPVKTQKSD
1110 1120 1130 1140 1150
QNWPQPISCR PPEPQKPPTR PYLEDRGSCG SDGEEEEEYR RQLSDHSKKG
1160
YYGQPPRYRD TEL
Length:1,163
Mass (Da):130,669
Last modified:May 1, 1999 - v1
Checksum:i3639431A560B1D4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085184 mRNA. Translation: AAC95469.1.
PIRiJE0366.
RefSeqiNP_990249.1. NM_204918.1.
UniGeneiGga.50260.

Genome annotation databases

GeneIDi395751.
KEGGigga:395751.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085184 mRNA. Translation: AAC95469.1.
PIRiJE0366.
RefSeqiNP_990249.1. NM_204918.1.
UniGeneiGga.50260.

3D structure databases

ProteinModelPortaliQ9YHV2.
SMRiQ9YHV2. Positions 1-104, 273-351.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000024331.

Proteomic databases

PaxDbiQ9YHV2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395751.
KEGGigga:395751.

Organism-specific databases

CTDi9414.

Phylogenomic databases

eggNOGiKOG3580. Eukaryota.
ENOG410XQP3. LUCA.
HOGENOMiHOG000230923.
HOVERGENiHBG017627.
KOiK06098.
PhylomeDBiQ9YHV2.

Miscellaneous databases

NextBioi20815819.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
3.40.50.300. 2 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR005417. ZO.
IPR005419. ZO-2.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 3 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR01597. ZONOCCLUDNS.
PR01599. ZONOCCLUDNS2.
SMARTiSM00072. GuKc. 1 hit.
SM00228. PDZ. 3 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 3 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Protein-binding domains of the tight junction protein, ZO-2, are highly conserved between avian and mammalian species."
    Collins J.R., Rizzolo L.J.
    Biochem. Biophys. Res. Commun. 252:617-622(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: RetinaImported.

Entry informationi

Entry nameiQ9YHV2_CHICK
AccessioniPrimary (citable) accession number: Q9YHV2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: May 11, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.