ID   Q9YHU5_TAKRU            Unreviewed;       440 AA.
AC   Q9YHU5;
DT   01-MAY-1999, integrated into UniProtKB/TrEMBL.
DT   01-MAY-1999, sequence version 1.
DT   03-MAY-2023, entry version 110.
DE   SubName: Full=Transcription factor E4TF1 {ECO:0000313|EMBL:AAD13395.1};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|EMBL:AAD13395.1};
RN   [1] {ECO:0000313|EMBL:AAD13395.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=9599080; DOI=10.1016/S0378-1119(98)00032-8;
RA   Villard L., Tassone F., Crnogorac-Jurcevic T., Clancy K., Gardiner K.;
RT   "Analysis of pufferfish homologues of the AT-rich human APP gene.";
RL   Gene 210:17-24(1998).
RN   [2] {ECO:0000313|EMBL:AAD13395.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=9931491; DOI=10.1016/S0378-1119(98)00559-9;
RA   Tassone F., Villard L., Clancy K., Gardiner K.;
RT   "Structures, sequence characteristics, and synteny relationships of the
RT   transcription factor E4TF1, the splicing factor U2AF35 and the
RT   cystathionine beta synthetase genes from Fugu rubripes.";
RL   Gene 226:211-223(1999).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU004019}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC       ECO:0000256|RuleBase:RU004019}.
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DR   EMBL; AF090120; AAD13395.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9YHU5; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd08534; SAM_PNT-GABP-alpha; 1.
DR   CDD; cd17039; Ubl_ubiquitin_like; 1.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR046328; ETS_fam.
DR   InterPro; IPR024668; GABP_asu_N.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR016312; TF_GA-bd_asu.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849; ETS; 1.
DR   PANTHER; PTHR11849:SF195; GA-BINDING PROTEIN ALPHA CHAIN; 1.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF11620; GABP-alpha; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PIRSF; PIRSF001703; GABP_alpha; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW   Nucleus {ECO:0000256|RuleBase:RU004019};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          161..244
FT                   /note="PNT"
FT                   /evidence="ECO:0000259|PROSITE:PS51433"
FT   DOMAIN          308..388
FT                   /note="ETS"
FT                   /evidence="ECO:0000259|PROSITE:PS50061"
FT   REGION          281..305
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   440 AA;  49595 MW;  C25C0A21F78B0BCD CRC64;
     MSKTDTEEMI EIEIDEREKQ ACLEEGVEEQ NITASDLIQQ DIDINEPVGN LKKLLEPRIQ
     IALDAYDICL QDIQIHPDHS LFDQGVKTDG TVQLSLQIIT KPGEEKLNIL EIVKPVETVE
     VVIDPDAAGE EGALVEDGQL IAVERSGLSD EASEQVTRWA AALEGYRKEQ VRLGIPYDPV
     LWSADQVIHW AVWVMKEFNI DEMEIGSIHI PGRDLCSFSQ EEFLQKVPNG EILWSHLELL
     RKYVLASQDQ SGGDATVTID QPVQIIPTQV NTPTAIKVLK QSRGPRAPRI SGEERSSPGN
     RTGNNGQIQM WQFLLELLTD KDARDCIYRV GEEGEFKLNQ PELVAQKWGQ RKNKPTMNYE
     KLSRALRYYY DGDMISKVQG KRFVNKFVCD LRTLIGYSAA EFNALVSECE QKKVTRMQIH
     GMGQPITTVT LATTTLDKDS
//