Reviewed, UniProtKB/Swiss-Prot Q9YHU0 (CTBP1_XENLA)

Names and origin

Protein names

Recommended name:
    C-terminal-binding protein 1
      Short name=CtBP1
    EC=1.1.1.-
Alternative name(s):
    C-terminal-binding protein A

Gene names

Name:	ctbp1
Synonyms:	ctbp-A

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	440 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Corepressor targeting diverse transcription regulators. Has dehydrogenase activity.
Cofactor	NAD By similarity.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 440	440	C-terminal-binding protein 1		PRO_0000076046

Sequences

	Sequence		Length	Mass (Da)
	Q9YHU0-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: E1AB044901A00116	FASTA	440	47,777
	10 20 30 40 50 60 MGSSHLLNKG LPLGIRPPIM NGPMHPRPLV ALLDGRDCTV EMPILKDVAT VAFCDAQSTQ 70 80 90 100 110 120 EIHEKVLNEA VGALMYHTIT LTREDLEKFK ALRIIVRIGS GFDNIDIKSA GDLGIAVCNV 130 140 150 160 170 180 PAASVEETAD STMCHILNLY RRTTWLHQAL REGTRVQSVE QIREVASGAA RIRGETLGII 190 200 210 220 230 240 GLGRVGQAVA LRAKTFGFNV FFYDPYLSDG IERALGLQRV STLQDLLFHS DCVTLHCGLN 250 260 270 280 290 300 EHNHHLINDF TIKQMRQGAF LVNTARGGLV DEKALAQALK EGRIRGAALD VHESEPFSFT 310 320 330 340 350 360 QGPLKDAPNL ICTPHAAWYS EQASIEMREE AAREIRRAIT GRIPDSLKNC VNKDHLTAAT 370 380 390 400 410 420 HWASMDPGVV HPELNGGAYR YPQGVVSVAP AGLPAAVEGI VPSAMSLSHA HPAVAHPPHA 430 440 PSPGQTIKPE ADRDHPSDQL

References

[1]

"C-terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate polycomb proteins." Sewalt R.G.A.B., Gunster M.J., van der Vlag J., Satijn D.P.E., Otte A.P. Mol. Cell. Biol. 19:777-787(1999) [PubMed: 9858600] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF091554 mRNA. Translation: AAD14596.1.
RefSeq	NP_001079151.1.
UniGene	Xl.447
3D structure databases
HSSP	HSSP built from PDB template 1HKU based on UniProtKB Q9Z2F5.
SMR	Q9YHU0. Positions 28-352.
ModBase	Search...
Genome annotation databases
GeneID	373701.
KEGG	xla:373701.
Organism-specific databases
Xenbase	XB-FEAT-483378. ctbp1.
Phylogenomic databases
HOVERGEN	Q9YHU0.
Family and domain databases
InterPro	IPR006139. D-isomer_2_OHA_DH. IPR006140. D-isomer_2_OHA_DH_NAD-bd. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF00389. 2-Hacid_dh. 1 hit. PF02826. 2-Hacid_dh_C. 1 hit. [Graphical view]
PROSITE	PS00065. D_2_HYDROXYACID_DH_1. 1 hit. PS00670. D_2_HYDROXYACID_DH_2. False negative. PS00671. D_2_HYDROXYACID_DH_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CTBP1_XENLA

Accession

Primary (citable) accession number: Q9YHU0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 1999
Last modified:	June 16, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project