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Protein

Eyes absent homolog 4

Gene

eya4

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator, Developmental protein, Hydrolase, Protein phosphatase
Biological processDNA damage, DNA repair, Transcription, Transcription regulation
LigandMagnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Eyes absent homolog 4 (EC:3.1.3.48)
Gene namesi
Name:eya4
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
Proteomesi
  • UP000005226 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000218654‹1 – ›119Eyes absent homolog 4Add BLAST›119

Interactioni

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000009464

Structurei

3D structure databases

ProteinModelPortaliQ9YHA1
SMRiQ9YHA1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3107 Eukaryota
ENOG410XT12 LUCA
InParanoidiQ9YHA1

Family and domain databases

Gene3Di3.40.50.12350, 1 hit
InterProiView protein in InterPro
IPR028478 EYA4
IPR038102 EYA_dom_sf
IPR028472 EYA_fam
PANTHERiPTHR10190 PTHR10190, 1 hit
PTHR10190:SF17 PTHR10190:SF17, 1 hit

Sequencei

Sequence statusi: Fragment.

Q9YHA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RKLAFRYRRV KELYTTYKNN VGGLLGPAKR DAWLQLRAEV EALTDSWLTH
60 70 80 90 100
ALKSLSIISS RSNCVNVLVT TTQLIPALAK VLLYSLGAVF PIENIYSATK
110
IGKESCFERI VSRFGTNIT
Length:119
Mass (Da):13,350
Last modified:May 1, 1999 - v1
Checksum:i9BB3E01C3372C904
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1191

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007998
, AJ007999, AJ008000, AJ008001 Genomic DNA Translation: CAA07821.1

Similar proteinsi

Entry informationi

Entry nameiEYA4_TAKRU
AccessioniPrimary (citable) accession number: Q9YHA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health