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Q9YHA0

- EYA1_CHICK

UniProt

Q9YHA0 - EYA1_CHICK

Protein

Eyes absent homolog 1

Gene

EYA1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for other transcription factors of this family. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro). Required for normal embryonic development of the skeleton, kidneys and ears By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 1 Mg2+ ion per subunit.By similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC
    2. RNA binding Source: Ensembl

    GO - Biological processi

    1. aorta morphogenesis Source: Ensembl
    2. branching involved in ureteric bud morphogenesis Source: Ensembl
    3. cellular protein localization Source: Ensembl
    4. cochlea morphogenesis Source: Ensembl
    5. double-strand break repair Source: UniProtKB
    6. embryonic skeletal system morphogenesis Source: Ensembl
    7. establishment of mitotic spindle orientation Source: Ensembl
    8. establishment or maintenance of apical/basal cell polarity Source: Ensembl
    9. histone dephosphorylation Source: UniProtKB
    10. lung epithelial cell differentiation Source: Ensembl
    11. metanephros development Source: Ensembl
    12. middle ear morphogenesis Source: Ensembl
    13. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    14. neuron fate specification Source: Ensembl
    15. otic vesicle morphogenesis Source: Ensembl
    16. outer ear morphogenesis Source: Ensembl
    17. outflow tract morphogenesis Source: Ensembl
    18. pattern specification process Source: Ensembl
    19. pharyngeal system development Source: Ensembl
    20. positive regulation of DNA repair Source: UniProtKB
    21. positive regulation of epithelial cell proliferation Source: Ensembl
    22. positive regulation of Notch signaling pathway Source: Ensembl
    23. positive regulation of secondary heart field cardioblast proliferation Source: Ensembl
    24. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    25. protein sumoylation Source: UniProtKB
    26. regulation of neuron differentiation Source: Ensembl
    27. response to ionizing radiation Source: UniProtKB
    28. semicircular canal morphogenesis Source: Ensembl
    29. striated muscle tissue development Source: Ensembl
    30. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Chromatin regulator, Developmental protein, Hydrolase, Protein phosphatase

    Keywords - Biological processi

    DNA damage, DNA repair, Transcription, Transcription regulation

    Keywords - Ligandi

    Magnesium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eyes absent homolog 1 (EC:3.1.3.16, EC:3.1.3.48)
    Gene namesi
    Name:EYA1
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›119›119Eyes absent homolog 1PRO_0000218645Add
    BLAST

    Proteomic databases

    PaxDbiQ9YHA0.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000025135.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9YHA0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG297494.
    HOGENOMiHOG000293149.
    InParanoidiQ9YHA0.
    PhylomeDBiQ9YHA0.

    Family and domain databases

    InterProiIPR028472. EYA_fam.
    [Graphical view]
    PANTHERiPTHR10190. PTHR10190. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Q9YHA0-1 [UniParc]FASTAAdd to Basket

    « Hide

    RKLAFRYRRV KEIYNTYKNN VGGLLGPAKR EAWLQLRAEI EALTDSWLTL    50
    ALKALTLIHS RTNCVNILVT TTQLIPALAK VLLYGLGVVF PIENIYSATK 100
    IGKESCFERI IQRFGRKVV 119
    Length:119
    Mass (Da):13,549
    Last modified:May 1, 1999 - v1
    Checksum:iDD24DF364AD166E6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei119 – 1191

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ008002 mRNA. Translation: CAA07822.1.
    UniGeneiGga.2329.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ008002 mRNA. Translation: CAA07822.1 .
    UniGenei Gga.2329.

    3D structure databases

    ProteinModelPortali Q9YHA0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000025135.

    Proteomic databases

    PaxDbi Q9YHA0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG297494.
    HOGENOMi HOG000293149.
    InParanoidi Q9YHA0.
    PhylomeDBi Q9YHA0.

    Family and domain databases

    InterProi IPR028472. EYA_fam.
    [Graphical view ]
    PANTHERi PTHR10190. PTHR10190. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiEYA1_CHICK
    AccessioniPrimary (citable) accession number: Q9YHA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3