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Protein

Eyes absent homolog 1

Gene

EYA1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for other transcription factors of this family. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro). Required for normal embryonic development of the skeleton, kidneys and ears (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.By similarity
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.By similarity

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator, Developmental protein, Hydrolase, Protein phosphatase
Biological processDNA damage, DNA repair, Transcription, Transcription regulation
LigandMagnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Eyes absent homolog 1 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:EYA1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000218645‹1 – ›119Eyes absent homolog 1Add BLAST›119

Proteomic databases

PaxDbiQ9YHA0

Expressioni

Gene expression databases

BgeeiENSGALG00000015622

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025135

Structurei

3D structure databases

ProteinModelPortaliQ9YHA0
SMRiQ9YHA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3107 Eukaryota
ENOG410XT12 LUCA
HOGENOMiHOG000293149
InParanoidiQ9YHA0
OrthoDBiEOG091G04YD
PhylomeDBiQ9YHA0

Family and domain databases

Gene3Di3.40.50.12350, 1 hit
InterProiView protein in InterPro
IPR028478 EYA4
IPR038102 EYA_dom_sf
IPR028472 EYA_fam
PANTHERiPTHR10190 PTHR10190, 1 hit
PTHR10190:SF17 PTHR10190:SF17, 1 hit

Sequencei

Sequence statusi: Fragment.

Q9YHA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RKLAFRYRRV KEIYNTYKNN VGGLLGPAKR EAWLQLRAEI EALTDSWLTL
60 70 80 90 100
ALKALTLIHS RTNCVNILVT TTQLIPALAK VLLYGLGVVF PIENIYSATK
110
IGKESCFERI IQRFGRKVV
Length:119
Mass (Da):13,549
Last modified:May 1, 1999 - v1
Checksum:iDD24DF364AD166E6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1191

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ008002 mRNA Translation: CAA07822.1
UniGeneiGga.2329

Similar proteinsi

Entry informationi

Entry nameiEYA1_CHICK
AccessioniPrimary (citable) accession number: Q9YHA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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