Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9YHA0

- EYA1_CHICK

UniProt

Q9YHA0 - EYA1_CHICK

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Eyes absent homolog 1

Gene

EYA1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for other transcription factors of this family. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro). Required for normal embryonic development of the skeleton, kidneys and ears (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg(2+) ion per subunit.By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
  2. RNA binding Source: Ensembl

GO - Biological processi

  1. aorta morphogenesis Source: Ensembl
  2. branching involved in ureteric bud morphogenesis Source: Ensembl
  3. cellular protein localization Source: Ensembl
  4. cochlea morphogenesis Source: Ensembl
  5. double-strand break repair Source: UniProtKB
  6. embryonic skeletal system morphogenesis Source: Ensembl
  7. establishment of mitotic spindle orientation Source: Ensembl
  8. establishment or maintenance of apical/basal cell polarity Source: Ensembl
  9. histone dephosphorylation Source: UniProtKB
  10. lung epithelial cell differentiation Source: Ensembl
  11. metanephros development Source: Ensembl
  12. middle ear morphogenesis Source: Ensembl
  13. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  14. neuron fate specification Source: Ensembl
  15. otic vesicle morphogenesis Source: Ensembl
  16. outer ear morphogenesis Source: Ensembl
  17. outflow tract morphogenesis Source: Ensembl
  18. pattern specification process Source: Ensembl
  19. pharyngeal system development Source: Ensembl
  20. positive regulation of DNA repair Source: UniProtKB
  21. positive regulation of epithelial cell proliferation Source: Ensembl
  22. positive regulation of Notch signaling pathway Source: Ensembl
  23. positive regulation of secondary heart field cardioblast proliferation Source: Ensembl
  24. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  25. protein sumoylation Source: UniProtKB
  26. regulation of neuron differentiation Source: Ensembl
  27. response to ionizing radiation Source: UniProtKB
  28. semicircular canal morphogenesis Source: Ensembl
  29. striated muscle tissue development Source: Ensembl
  30. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Developmental protein, Hydrolase, Protein phosphatase

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Eyes absent homolog 1 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:EYA1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›119›119Eyes absent homolog 1PRO_0000218645Add
BLAST

Proteomic databases

PaxDbiQ9YHA0.

Expressioni

Gene expression databases

ExpressionAtlasiQ9YHA0. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025135.

Structurei

3D structure databases

ProteinModelPortaliQ9YHA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG297494.
HOGENOMiHOG000293149.
InParanoidiQ9YHA0.
PhylomeDBiQ9YHA0.

Family and domain databases

InterProiIPR028472. EYA_fam.
[Graphical view]
PANTHERiPTHR10190. PTHR10190. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q9YHA0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
RKLAFRYRRV KEIYNTYKNN VGGLLGPAKR EAWLQLRAEI EALTDSWLTL
60 70 80 90 100
ALKALTLIHS RTNCVNILVT TTQLIPALAK VLLYGLGVVF PIENIYSATK
110
IGKESCFERI IQRFGRKVV
Length:119
Mass (Da):13,549
Last modified:May 1, 1999 - v1
Checksum:iDD24DF364AD166E6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei119 – 1191

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ008002 mRNA. Translation: CAA07822.1.
UniGeneiGga.2329.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ008002 mRNA. Translation: CAA07822.1 .
UniGenei Gga.2329.

3D structure databases

ProteinModelPortali Q9YHA0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000025135.

Proteomic databases

PaxDbi Q9YHA0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG297494.
HOGENOMi HOG000293149.
InParanoidi Q9YHA0.
PhylomeDBi Q9YHA0.

Gene expression databases

ExpressionAtlasi Q9YHA0. baseline.

Family and domain databases

InterProi IPR028472. EYA_fam.
[Graphical view ]
PANTHERi PTHR10190. PTHR10190. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiEYA1_CHICK
AccessioniPrimary (citable) accession number: Q9YHA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 26, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3