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Q9YH99

- EYA3_CHICK

UniProt

Q9YH99 - EYA3_CHICK

Protein

Eyes absent homolog 3

Gene

EYA3

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 By similarity. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    Cofactori

    Binds 1 Mg2+ ion per subunit.By similarity

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. metal ion binding Source: UniProtKB-KW
    3. protein tyrosine/serine/threonine phosphatase activity Source: Ensembl
    4. protein tyrosine phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. double-strand break repair Source: UniProtKB
    2. histone dephosphorylation Source: UniProtKB
    3. multicellular organismal development Source: UniProtKB-KW
    4. peptidyl-tyrosine dephosphorylation Source: GOC
    5. positive regulation of DNA repair Source: UniProtKB
    6. regulation of transcription, DNA-templated Source: UniProtKB-KW
    7. response to ionizing radiation Source: UniProtKB
    8. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Chromatin regulator, Developmental protein, Hydrolase, Protein phosphatase

    Keywords - Biological processi

    DNA damage, DNA repair, Transcription, Transcription regulation

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eyes absent homolog 3 (EC:3.1.3.48)
    Gene namesi
    Name:EYA3
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB
    3. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›119›119Eyes absent homolog 3PRO_0000218650Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000001125.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9YH99.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG297494.
    HOGENOMiHOG000293149.
    InParanoidiQ9YH99.
    PhylomeDBiQ9YH99.

    Family and domain databases

    InterProiIPR028479. EYA3.
    IPR028472. EYA_fam.
    [Graphical view]
    PANTHERiPTHR10190. PTHR10190. 1 hit.
    PTHR10190:SF5. PTHR10190:SF5. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Q9YH99-1 [UniParc]FASTAAdd to Basket

    « Hide

    RKLAFRYRRV REIYDKYKTN VGGLLSPQKR EALQRLRTDI EVLTDSWLET    50
    ALKSLLLIQS RKNCVNILIT TTQLVPALAK VLLYGLGEVF PIENIYSATK 100
    IGKESCFERI VSRFGKKVT 119
    Length:119
    Mass (Da):13,704
    Last modified:May 1, 1999 - v1
    Checksum:iE062E2FE4A2C62F8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei119 – 1191

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ008003 mRNA. Translation: CAA07823.1.
    UniGeneiGga.15800.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ008003 mRNA. Translation: CAA07823.1 .
    UniGenei Gga.15800.

    3D structure databases

    ProteinModelPortali Q9YH99.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000001125.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG297494.
    HOGENOMi HOG000293149.
    InParanoidi Q9YH99.
    PhylomeDBi Q9YH99.

    Family and domain databases

    InterProi IPR028479. EYA3.
    IPR028472. EYA_fam.
    [Graphical view ]
    PANTHERi PTHR10190. PTHR10190. 1 hit.
    PTHR10190:SF5. PTHR10190:SF5. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiEYA3_CHICK
    AccessioniPrimary (citable) accession number: Q9YH99
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3