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Q9YH99

- EYA3_CHICK

UniProt

Q9YH99 - EYA3_CHICK

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Protein

Eyes absent homolog 3

Gene

EYA3

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (By similarity). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Cofactori

Binds 1 Mg2+ ion per subunit.By similarity

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. metal ion binding Source: UniProtKB-KW
  3. protein tyrosine/serine/threonine phosphatase activity Source: Ensembl
  4. protein tyrosine phosphatase activity Source: UniProtKB

GO - Biological processi

  1. double-strand break repair Source: UniProtKB
  2. histone dephosphorylation Source: UniProtKB
  3. multicellular organismal development Source: UniProtKB-KW
  4. peptidyl-tyrosine dephosphorylation Source: GOC
  5. positive regulation of DNA repair Source: UniProtKB
  6. regulation of transcription, DNA-templated Source: UniProtKB-KW
  7. response to ionizing radiation Source: UniProtKB
  8. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Developmental protein, Hydrolase, Protein phosphatase

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Eyes absent homolog 3 (EC:3.1.3.48)
Gene namesi
Name:EYA3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB
  3. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›119›119Eyes absent homolog 3PRO_0000218650Add
BLAST

Expressioni

Gene expression databases

ExpressionAtlasiQ9YH99. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000001125.

Structurei

3D structure databases

ProteinModelPortaliQ9YH99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG297494.
HOGENOMiHOG000293149.
InParanoidiQ9YH99.
PhylomeDBiQ9YH99.

Family and domain databases

InterProiIPR028479. EYA3.
IPR028472. EYA_fam.
[Graphical view]
PANTHERiPTHR10190. PTHR10190. 1 hit.
PTHR10190:SF5. PTHR10190:SF5. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q9YH99-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
RKLAFRYRRV REIYDKYKTN VGGLLSPQKR EALQRLRTDI EVLTDSWLET
60 70 80 90 100
ALKSLLLIQS RKNCVNILIT TTQLVPALAK VLLYGLGEVF PIENIYSATK
110
IGKESCFERI VSRFGKKVT
Length:119
Mass (Da):13,704
Last modified:May 1, 1999 - v1
Checksum:iE062E2FE4A2C62F8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei119 – 1191

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ008003 mRNA. Translation: CAA07823.1.
UniGeneiGga.15800.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ008003 mRNA. Translation: CAA07823.1 .
UniGenei Gga.15800.

3D structure databases

ProteinModelPortali Q9YH99.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000001125.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG297494.
HOGENOMi HOG000293149.
InParanoidi Q9YH99.
PhylomeDBi Q9YH99.

Gene expression databases

ExpressionAtlasi Q9YH99. baseline.

Family and domain databases

InterProi IPR028479. EYA3.
IPR028472. EYA_fam.
[Graphical view ]
PANTHERi PTHR10190. PTHR10190. 1 hit.
PTHR10190:SF5. PTHR10190:SF5. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiEYA3_CHICK
AccessioniPrimary (citable) accession number: Q9YH99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3