ID   EYA4_CHICK              Reviewed;         119 AA.
AC   Q9YH98;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   24-JAN-2024, entry version 99.
DE   RecName: Full=Eyes absent homolog 4;
DE            EC=3.1.3.48 {ECO:0000250|UniProtKB:Q99502};
DE   Flags: Fragment;
GN   Name=EYA4;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryo;
RX   PubMed=9887327; DOI=10.1093/hmg/8.1.11;
RA   Borsani G., DeGrandi A., Ballabio A., Bulfone A., Bernard L., Banfi S.,
RA   Gattuso C., Mariani M., Dixon M., Donnai D., Metcalfe K., Winter R.,
RA   Robertson M., Axton R., Brown A., van Heyningen V., Hanson I.;
RT   "EYA4, a novel vertebrate gene related to Drosophila eyes absent.";
RL   Hum. Mol. Genet. 8:11-23(1999).
CC   -!- FUNCTION: Tyrosine phosphatase that specifically dephosphorylates 'Tyr-
CC       142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone
CC       H2AX plays a central role in DNA repair and acts as a mark that
CC       distinguishes between apoptotic and repair responses to genotoxic
CC       stress. Promotes efficient DNA repair by dephosphorylating H2AX,
CC       promoting the recruitment of DNA repair complexes containing MDC1. Its
CC       function as histone phosphatase probably explains its role in
CC       transcription regulation during organogenesis. May be involved in
CC       development of the eye (By similarity). {ECO:0000250|UniProtKB:Q99502}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620; EC=3.1.3.48;
CC         Evidence={ECO:0000250|UniProtKB:Q99502};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000250|UniProtKB:O00167};
CC       Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000250|UniProtKB:O00167};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99502}. Nucleus
CC       {ECO:0000250|UniProtKB:Q99502}.
CC   -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily. EYA family.
CC       {ECO:0000305}.
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DR   EMBL; AJ008004; CAA07824.1; -; mRNA.
DR   RefSeq; NP_001292106.1; NM_001305177.1.
DR   AlphaFoldDB; Q9YH98; -.
DR   SMR; Q9YH98; -.
DR   STRING; 9031.ENSGALP00000045083; -.
DR   PaxDb; 9031-ENSGALP00000022622; -.
DR   GeneID; 395716; -.
DR   KEGG; gga:395716; -.
DR   CTD; 2070; -.
DR   VEuPathDB; HostDB:geneid_395716; -.
DR   eggNOG; KOG3107; Eukaryota.
DR   InParanoid; Q9YH98; -.
DR   PhylomeDB; Q9YH98; -.
DR   Proteomes; UP000000539; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.12350; -; 1.
DR   InterPro; IPR038102; EYA_dom_sf.
DR   InterPro; IPR028472; EYA_fam.
DR   PANTHER; PTHR10190; EYES ABSENT; 1.
DR   PANTHER; PTHR10190:SF17; EYES ABSENT HOMOLOG 4; 1.
PE   2: Evidence at transcript level;
KW   Activator; Chromatin regulator; Cytoplasm; Developmental protein;
KW   DNA damage; DNA repair; Hydrolase; Magnesium; Nucleus; Protein phosphatase;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           <1..>119
FT                   /note="Eyes absent homolog 4"
FT                   /id="PRO_0000218653"
FT   NON_TER         1
FT   NON_TER         119
SQ   SEQUENCE   119 AA;  13340 MW;  9E6BC4F6F8D0679D CRC64;
     RKLAFRYRRV KELYNTYKNN IGGLLGPAKR DAWLQLRAEI EALTDSWLTN ALKSLSIIST
     RSNCVNVLVT TTQLIPALAK VLLYSLGGAF PIENIYSATK IGKESCFERI VSRFGTNIT
//