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Q9YH98 (EYA4_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Eyes absent homolog 4

EC=3.1.3.48
Gene names
Name:EYA4
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length119 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Cofactor

Binds 1 Mg2+ ion per subunit By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the HAD-like hydrolase superfamily. EYA family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›119›119Eyes absent homolog 4
PRO_0000218653

Experimental info

Non-terminal residue11
Non-terminal residue1191

Sequences

Sequence LengthMass (Da)Tools
Q9YH98 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 9E6BC4F6F8D0679D

FASTA11913,340
        10         20         30         40         50         60 
RKLAFRYRRV KELYNTYKNN IGGLLGPAKR DAWLQLRAEI EALTDSWLTN ALKSLSIIST 

        70         80         90        100        110 
RSNCVNVLVT TTQLIPALAK VLLYSLGGAF PIENIYSATK IGKESCFERI VSRFGTNIT 

« Hide

References

[1]"EYA4, a novel vertebrate gene related to Drosophila eyes absent."
Borsani G., DeGrandi A., Ballabio A., Bulfone A., Bernard L., Banfi S., Gattuso C., Mariani M., Dixon M., Donnai D., Metcalfe K., Winter R., Robertson M., Axton R., Brown A., van Heyningen V., Hanson I.
Hum. Mol. Genet. 8:11-23(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ008004 mRNA. Translation: CAA07824.1.
UniGeneGga.25747.

3D structure databases

ProteinModelPortalQ9YH98.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000022622.

Proteomic databases

PaxDbQ9YH98.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG297494.
HOGENOMHOG000045156.
OMANTSGCAS.
PhylomeDBQ9YH98.

Family and domain databases

InterProIPR028478. EYA4.
IPR028472. EYA_fam.
[Graphical view]
PANTHERPTHR10190. PTHR10190. 1 hit.
PTHR10190:SF17. PTHR10190:SF17. 1 hit.
ProtoNetSearch...

Entry information

Entry nameEYA4_CHICK
AccessionPrimary (citable) accession number: Q9YH98
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families