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Q9YH85

- TECTA_CHICK

UniProt

Q9YH85 - TECTA_CHICK

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Protein

Alpha-tectorin

Gene
TECTA
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

One of the major non-collagenous components of the tectorial membrane. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.1 Publication

GO - Biological processi

  1. cell-matrix adhesion Source: InterPro
  2. sensory perception of sound Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Hearing

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16938.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-tectorin
Gene namesi
Name:TECTA
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor; Extracellular side Inferred. Secretedextracellular spaceextracellular matrix
Note: Found in the non-collagenous matrix of the tectorial membrane By similarity.

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Extracellular matrix, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Chaini25 – 20582034Alpha-tectorinPRO_0000041739Add
BLAST
Propeptidei2059 – 212062Removed in mature form Reviewed predictionPRO_0000041740Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi215 – 2151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi258 – 2581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi277 – 2771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi445 – 4451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi496 – 4961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi666 – 6661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi792 – 7921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi822 – 8221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi834 – 8341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi877 – 8771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi899 – 8991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi907 – 9071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi928 – 9281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1025 – 10251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1041 – 10411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1207 – 12071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1337 – 13371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1511 – 15111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1537 – 15371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1723 – 17231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1739 – 17391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1761 – 17611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1818 – 18181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1831 – 18311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1847 – 18471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1887 – 18871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1906 – 19061N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1947 ↔ 2007 By similarity
Lipidationi2058 – 20581GPI-anchor amidated asparagine Reviewed prediction

Post-translational modificationi

At least 3 products of tectorin seem to exist: HMM, MMM and LMM. They may be generated by active processing or the result of proteolysis occurring between intrachain disulfide bonds.
The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ9YH85.

Expressioni

Tissue specificityi

Expressed in the inner ear.1 Publication

Developmental stagei

Apically located within the epithelium of the developing basilar papilla at days E5.5 to E8. As development proceeds, expression becomes restricted to the basal layer. In the utricle, alpha-tectorin is first expressed at E4.5.1 Publication

Interactioni

Subunit structurei

May form homomeric filament after self-association or heteromeric filament after association with beta-tectorin.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000010663.

Structurei

3D structure databases

ProteinModelPortaliQ9YH85.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini98 – 252155NIDOAdd
BLAST
Domaini260 – 31253VWFCAdd
BLAST
Domaini318 – 520203VWFD 1Add
BLAST
Domaini578 – 62043TIL 1Add
BLAST
Domaini691 – 908218VWFD 2Add
BLAST
Domaini963 – 101351TIL 2Add
BLAST
Domaini1067 – 1289223VWFD 3Add
BLAST
Domaini1345 – 139854TIL 3Add
BLAST
Domaini1459 – 1674216VWFD 4Add
BLAST
Domaini1772 – 2026255ZPAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2091 – 20944Poly-Ser

Domaini

Zona pellucida domain may enable to form filaments.

Sequence similaritiesi

Contains 1 NIDO domain.
Contains 1 VWFC domain.
Contains 4 VWFD domains.
Contains 1 ZP domain.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG317991.
HOVERGENiHBG079244.
KOiK18273.
PhylomeDBiQ9YH85.

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR003886. Nidogen_extracell_dom.
IPR002919. TIL_dom.
IPR025615. TILa_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR006552. VWC_out.
IPR001846. VWF_type-D.
IPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamiPF08742. C8. 3 hits.
PF06119. NIDO. 1 hit.
PF01826. TIL. 3 hits.
PF12714. TILa. 2 hits.
PF00094. VWD. 4 hits.
PF00100. Zona_pellucida. 1 hit.
[Graphical view]
SMARTiSM00832. C8. 3 hits.
SM00181. EGF. 1 hit.
SM00539. NIDO. 1 hit.
SM00215. VWC_out. 1 hit.
SM00216. VWD. 4 hits.
SM00241. ZP. 1 hit.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 3 hits.
PROSITEiPS51220. NIDO. 1 hit.
PS51233. VWFD. 4 hits.
PS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9YH85-1 [UniParc]FASTAAdd to Basket

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MNTRSLLSAW AALLVVTVRH RAHAMASLYP FWPNDTKTPK VDDGSSSEIK     50
LSVPFIFFRS PYRTVYVNNN GVISFNSLVS QFTPEAFPLA DGRAFVAPFC 100
GDVANGIRGE IYYRESTNPE LLGESSKDIR KYFKDMASFS ASWVFIVTWE 150
EVQFYGGSST TPVNTFQAVL ITDGVSSFAI FNYQEISWTT GTASGGDPLT 200
GLGGVMAQAG FNGGNISNFF SIPGSRTPDI VNIEQTTNVN IPGRWAFKID 250
GREIDPANLS LRGQFLHQGE IFWENSNCST KCRCLDFNNE IFCQEMLAPF 300
ETVEPKIKFF QCVPVETACV VFGDPHYHTF DGFLFHFQGS CSYLLARQCW 350
PGSQLPYFNV EAKNERGGSS VSWAEDIFVE VYRHKIVLPK GGFGKAKVDD 400
LVVSLGAIKV YQSGLSTALE TDFGLLVTYD GQHYASVSVP GTYINGTCGL 450
CGNYNKDPED DALRSDGRLA SSVPELGESW RVPHPERKCS PGCVENCSVC 500
DASRILYSPI CGFSQECGAW SVLVATAFVH SCVYDLCSAR RTHRLCQAIQ 550
VTLRCCQGLG IRWENGVPDG MRGGLAVPGH SHYSGCASGC PATCSDLTAP 600
LRCTAPCPEG CECDDGHVLS ARPLHSLCRS GCVVDGRSRC REVFWATADC 650
TAECQCEDGG EAKCFNTSCP EGEVCTIEDG YRGCYPKREG LCSVGQNQVL 700
RTFDGVTFPY PLEHSYTLLK TCMEKPDFIE VDISQKKPDT LPMAGRVVRI 750
QVVGQEVKVG GASLSEVKVN GYDVDLPYFH PSGHLEIYRT DNGTVTESEG 800
LLSIGYYDSG LLEIRLSTAY FNCTGGLCGF FNGNDSDEFC TPKAKCTDNL 850
ELFLESWTTF DEICNGECGD LLKACNNDSE LLKTYRSRSN CAIINDPTNS 900
SFLECHNVSI VSAYYRTCLF RLCQSGGNQS ELCSAVARYA SACKNSEVDV 950
GQWRSHSFCP LACPENSHFE ECMSCVETCE TLATGCCMDT CTEGCQCDEG 1000
FALRSPCVPR GECGCNFEGH ELATNQTFWM DISCHLLCYC NGSDNSVYCE 1050
NVLQDDEYYC HVRTDASCIV SGYGHYLTFD GFSFDFQSSC ALVLCTTIHG 1100
ACERSDTFPT FTVTVTAKNE DRDTSLACVV KQVEVEVFNY YIVIHRAYKY 1150
TVMINNERLY LPLKLGQGKV NIFAFGFHIV VETDFGLKVV YDWKTFLSVT 1200
IPRSFQNLTY GLCGRYNGNP DDDLVAAGGT PRFGVTDFVQ SWAKRDTFCR 1250
VGSGDRCPAC GKVEGFWKPQ QLCSLIPSQS GVFAKCHSKI NPSYFYKNCL 1300
FDTVVDGGAM ARRVADWLQN YASTCQTQGI AIIGWRNFTS CSVSCPPNSH 1350
YESCVSLCQP RCAAIRLKSD CGHYCVEGCQ CDPGYVLNGK SCILPQNCGC 1400
YSDGKYYEPK QLFWNGDCTR RCARFRRNLI QCDPRHCKSD EECASRNGVR 1450
GCFSTRSSFC LAAGGGVFRT FDGAFLRFPA NCAFVLSTIC QRLADFSFQL 1500
IINFDKWSSP NLTIISVYIY INEEQILISD RSTVKVNGSL VSIPFVTGLS 1550
TKIYSQEGFL VIDSGPDIHI RYNGFNVIKI TIGDRLQNKV CGLCGNFNGD 1600
PADDYATLRG KPVVSSVVLA QSWKTNGMQK SCNELQYSQY AASCDNVQIQ 1650
KLQSDSYCLK LTDMKGFFQP CYGLLDPLPF YESCFLDGCY NRKQVQLCGS 1700
LAAYGEACRT FGILGTEWIE KENCSGVVED PCAGADCPNR TCELDDGGEL 1750
CGCIEPPPYG NTTHDIIDAE VTCKAAQMEV SISKCKLFQL GFEREGVRVN 1800
DRHCPGIEGE DFISFQINNT KGNCGNLVQS NSTHIVYKNT VWIESANNTG 1850
NIITRDRTIN VEVFCAYELD IKISLDSVVR PMLSVINLTV PTQEGSFTTK 1900
MALYKNSSYK HPYRQGEVVL TTRDVLYVGV FVVGADSNHL ILMLNKCYAT 1950
PSRDSNDKLR YFIIEGGCQN LKDNTIGIEE NGVSLTCRFH VTVFKFIGDY 2000
DEVHLHCAVS LCDSEKYSCK INCPQHRRSA SAFAQEAHEQ ILSVGPIRRK 2050
RSDWCEDNGG CEQICTSQAD GPLCSCVTGT LQGDGKSCMA SSSSADIRAQ 2100
ASLLVAAQLW LWAALHDPTS 2120
Length:2,120
Mass (Da):233,965
Last modified:May 1, 1999 - v1
Checksum:iE93F69EA18B51A4C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1114 – 11152Missing AA sequence 1 Publication
Sequence conflicti1123 – 11231Missing AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ012287 mRNA. Translation: CAA09979.1.
PIRiT30243.
RefSeqiNP_990204.1. NM_204873.1.
UniGeneiGga.399.

Genome annotation databases

GeneIDi395686.
KEGGigga:395686.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ012287 mRNA. Translation: CAA09979.1 .
PIRi T30243.
RefSeqi NP_990204.1. NM_204873.1.
UniGenei Gga.399.

3D structure databases

ProteinModelPortali Q9YH85.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000010663.

Proteomic databases

PaxDbi Q9YH85.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395686.
KEGGi gga:395686.

Organism-specific databases

CTDi 7007.

Phylogenomic databases

eggNOGi NOG317991.
HOVERGENi HBG079244.
KOi K18273.
PhylomeDBi Q9YH85.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-16938.

Miscellaneous databases

NextBioi 20815758.
PROi Q9YH85.

Family and domain databases

InterProi IPR000742. EG-like_dom.
IPR003886. Nidogen_extracell_dom.
IPR002919. TIL_dom.
IPR025615. TILa_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR006552. VWC_out.
IPR001846. VWF_type-D.
IPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view ]
Pfami PF08742. C8. 3 hits.
PF06119. NIDO. 1 hit.
PF01826. TIL. 3 hits.
PF12714. TILa. 2 hits.
PF00094. VWD. 4 hits.
PF00100. Zona_pellucida. 1 hit.
[Graphical view ]
SMARTi SM00832. C8. 3 hits.
SM00181. EGF. 1 hit.
SM00539. NIDO. 1 hit.
SM00215. VWC_out. 1 hit.
SM00216. VWD. 4 hits.
SM00241. ZP. 1 hit.
[Graphical view ]
SUPFAMi SSF57567. SSF57567. 3 hits.
PROSITEi PS51220. NIDO. 1 hit.
PS51233. VWFD. 4 hits.
PS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Chick alpha-tectorin: molecular cloning and expression during embryogenesis."
    Coutinho P., Goodyear R., Legan P.K., Richardson G.P.
    Hear. Res. 130:62-74(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Cochlear duct.
  2. "The mouse tectorins. Modular matrix proteins of the inner ear homologous to components of the sperm-egg adhesion system."
    Legan P.K., Rau A., Keene J.N., Richardson G.P.
    J. Biol. Chem. 272:8791-8801(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-33; 325-334 AND 1105-1124.
  3. "The protein composition of the avian tectorial membrane."
    Killick R., Malenczak C., Richardson G.P.
    Hear. Res. 64:21-38(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiTECTA_CHICK
AccessioniPrimary (citable) accession number: Q9YH85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi