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Q9YH64 (CP1A1_PLAFE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length521 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 521521Cytochrome P450 1A1
PRO_0000051636

Sites

Metal binding4631Iron (heme axial ligand) By similarity
Binding site2291Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9YH64 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 58BA7DC3913C9091

FASTA52159,009
        10         20         30         40         50         60 
MMLMMLPFIG SVSVSESLVA MTTMCLVYLI LKFFQTEIPE GLLRLPGPKP LPIIGNVLGL 

        70         80         90        100        110        120 
GSKPYLSLTD MSKRYGHVFQ IQIGMRPVVV LSGSETVRQA LIKQGDDFAG RPDLYSFRFI 

       130        140        150        160        170        180 
NAGKSLAFST DQAGVWRARR KLAYSALRSF SNLEGTTPEY SCVLEEHICK EGEYLIKQLN 

       190        200        210        220        230        240 
TVMKADGSFD PFRHIVVSVA NVICGMCFGR RYDHDDQELV GLVTLSDEFG RVVGSGNPAD 

       250        260        270        280        290        300 
FIPILQYLPS AAMKNFLRIN SRFTEFVQKI VTEHYTTFDK DNIRDITDSL IDHCEDRKLD 

       310        320        330        340        350        360 
ENSNVQMSDE KIVGIVNDLF GAGFDTVSTA LSWSVMYLVA HPEIQERLYQ EIEDKVGLDR 

       370        380        390        400        410        420 
MPLLSDKPNL PFLEAFILEI LRHSSFLPFT IPHCTTKDTS LNGYFIPKDT CVFINQWQIN 

       430        440        450        460        470        480 
HDPELWKDPS SFNPDRFLSA DGSEVNKLDG EKVMAFGMGK RRCIGEVIAR NEVYLFLAII 

       490        500        510        520 
IQKLHFLPIP GEKLDMTPEY GLTMKHKRCH LKATMRARNE H 

« Hide

References

[1]"The cytochrome P450 1A gene (CYP1A) from European flounder (Platichthys flesus), analysis of regulatory regions and development of a dual luciferase reporter gene system."
Williams T.D., Lee J.S., Sheader D.L., Chipman J.K.
Mar. Environ. Res. 50:1-6(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: North Sea population.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ132353 Genomic DNA. Translation: CAA10645.1.

3D structure databases

ProteinModelPortalQ9YH64.
SMRQ9YH64. Positions 38-513.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG106944.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP1A1_PLAFE
AccessionPrimary (citable) accession number: Q9YH64
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families