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Q9YH64

- CP1A1_PLAFE

UniProt

Q9YH64 - CP1A1_PLAFE

Protein

Cytochrome P450 1A1

Gene

cyp1a1

Organism
Platichthys flesus (European flounder) (Pleuronectes flesus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei229 – 2291SubstrateBy similarity
    Metal bindingi463 – 4631Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA1
    Gene namesi
    Name:cyp1a1
    Synonyms:cyp1a
    OrganismiPlatichthys flesus (European flounder) (Pleuronectes flesus)
    Taxonomic identifieri8260 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataCarangimorphariaePleuronectiformesPleuronectoideiPleuronectidaePleuronectinaePlatichthys

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 521521Cytochrome P450 1A1PRO_0000051636Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ9YH64.
    SMRiQ9YH64. Positions 38-513.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG106944.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9YH64-1 [UniParc]FASTAAdd to Basket

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    MMLMMLPFIG SVSVSESLVA MTTMCLVYLI LKFFQTEIPE GLLRLPGPKP    50
    LPIIGNVLGL GSKPYLSLTD MSKRYGHVFQ IQIGMRPVVV LSGSETVRQA 100
    LIKQGDDFAG RPDLYSFRFI NAGKSLAFST DQAGVWRARR KLAYSALRSF 150
    SNLEGTTPEY SCVLEEHICK EGEYLIKQLN TVMKADGSFD PFRHIVVSVA 200
    NVICGMCFGR RYDHDDQELV GLVTLSDEFG RVVGSGNPAD FIPILQYLPS 250
    AAMKNFLRIN SRFTEFVQKI VTEHYTTFDK DNIRDITDSL IDHCEDRKLD 300
    ENSNVQMSDE KIVGIVNDLF GAGFDTVSTA LSWSVMYLVA HPEIQERLYQ 350
    EIEDKVGLDR MPLLSDKPNL PFLEAFILEI LRHSSFLPFT IPHCTTKDTS 400
    LNGYFIPKDT CVFINQWQIN HDPELWKDPS SFNPDRFLSA DGSEVNKLDG 450
    EKVMAFGMGK RRCIGEVIAR NEVYLFLAII IQKLHFLPIP GEKLDMTPEY 500
    GLTMKHKRCH LKATMRARNE H 521
    Length:521
    Mass (Da):59,009
    Last modified:May 1, 1999 - v1
    Checksum:i58BA7DC3913C9091
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ132353 Genomic DNA. Translation: CAA10645.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ132353 Genomic DNA. Translation: CAA10645.1 .

    3D structure databases

    ProteinModelPortali Q9YH64.
    SMRi Q9YH64. Positions 38-513.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG106944.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The cytochrome P450 1A gene (CYP1A) from European flounder (Platichthys flesus), analysis of regulatory regions and development of a dual luciferase reporter gene system."
      Williams T.D., Lee J.S., Sheader D.L., Chipman J.K.
      Mar. Environ. Res. 50:1-6(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: North Sea population.
      Tissue: Liver.

    Entry informationi

    Entry nameiCP1A1_PLAFE
    AccessioniPrimary (citable) accession number: Q9YH64
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3