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Protein

Estrogen receptor

Gene

esr1

Organism
Oreochromis niloticus (Nile tilapia) (Tilapia nilotica)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi139 – 20466Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri139 – 15921NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri175 – 19925NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Lipid-binding, Metal-binding, Steroid-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Estrogen receptor
Short name:
ER
Alternative name(s):
ER-alpha
Estradiol receptor
Nuclear receptor subfamily 3 group A member 1
Gene namesi
Name:esr1
Synonyms:esr, nr3a1
OrganismiOreochromis niloticus (Nile tilapia) (Tilapia nilotica)
Taxonomic identifieri8128 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaCichlomorphaeCichliformesCichlidaeAfrican cichlidsPseudocrenilabrinaeOreochrominiOreochromis
Proteomesi
  • UP000005207 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 585585Estrogen receptorPRO_0000053633Add
BLAST

Interactioni

Subunit structurei

Binds DNA as a homodimer. Can form a heterodimer with ER-beta (By similarity).By similarity

Protein-protein interaction databases

STRINGi8128.ENSONIP00000016788.

Structurei

3D structure databases

ProteinModelPortaliQ9YH33.
SMRiQ9YH33. Positions 134-207, 265-506.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 138138ModulatingBy similarityAdd
BLAST
Regioni205 – 26662HingeAdd
BLAST
Regioni267 – 585319Steroid-bindingBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi250 – 2556Poly-Ser
Compositional biasi463 – 4675Poly-Leu

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri139 – 15921NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri175 – 19925NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOVERGENiHBG108344.
InParanoidiQ9YH33.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001292. Oestr_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF02159. Oest_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF500101. ER-a. 1 hit.
PIRSF002527. ER-like_NR. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9YH33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYPEESRGSG GVATVDFLEG TYDYAAPTPA PTPLYSHSTT GCYSAPLDAH
60 70 80 90 100
GPLSDGSLQS LGSGPTSPLV FVPSSPRLSP FMHPPSHHYL ETTSTPVYRS
110 120 130 140 150
SHQPVPREDQ CGTRDEAYSV GELGAGAGGF EMTKDTRFCA VCSDYASGYH
160 170 180 190 200
YGVWSCEGCK AFFKRSIQGH NDYMCPATNQ CTIDKNRRKS CQACRLRKCY
210 220 230 240 250
EVGMMKGGMR KDRGRVLRRE KRRACDRDKP AKDLPHTRAS PQDGRKRAMS
260 270 280 290 300
SSSTSGGGGR SSLNNMPPDQ VLLLLQGAEP PILSSRQKMS RPYTEVTIMT
310 320 330 340 350
LLTSMADKEL VHMITWAKKL PGFLQLSLHD QVLLLESSWL EVLMIGLIWR
360 370 380 390 400
SIQCPGKLIF AQDLILDRNE GTCVEGMAEI FDMLLATASR FRVLKLKPEE
410 420 430 440 450
FVCLKAIILL NSGAFSFCTG TMEPLHDSAA VQHMLDTITD ALIFHISHLG
460 470 480 490 500
CSAQQQSRRQ AQLLLLLSHI RHMSNKGMEH LYSMKCKNKV PLYDLLLEML
510 520 530 540 550
DAHRIHRPVK PFQSWSQGDR DSPTASSTSS SGGGGGDDEG ASSAGSSSGP
560 570 580
QGSHESPRRE NLSRAPTGPG VLQYRGSHSD CTRIP
Length:585
Mass (Da):64,166
Last modified:May 1, 1999 - v1
Checksum:i36A96BCB668707B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75604 mRNA. Translation: AAD00245.1.
RefSeqiNP_001266699.1. NM_001279770.1.
UniGeneiOni.44460.

Genome annotation databases

GeneIDi100534514.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75604 mRNA. Translation: AAD00245.1.
RefSeqiNP_001266699.1. NM_001279770.1.
UniGeneiOni.44460.

3D structure databases

ProteinModelPortaliQ9YH33.
SMRiQ9YH33. Positions 134-207, 265-506.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8128.ENSONIP00000016788.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100534514.

Organism-specific databases

CTDi246870.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOVERGENiHBG108344.
InParanoidiQ9YH33.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001292. Oestr_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF02159. Oest_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF500101. ER-a. 1 hit.
PIRSF002527. ER-like_NR. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "cDNA sequence of Tilapia type alpha estrogen receptor."
    Chang X.T., Kobayashi T., Todo T., Yoshiura Y., Ikeuchi T., Kajiura H., Nakamura M., Nagahama Y.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiESR1_ORENI
AccessioniPrimary (citable) accession number: Q9YH33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: February 17, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.