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Q9YH26

- AT1A1_OREMO

UniProt

Q9YH26 - AT1A1_OREMO

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Protein

Sodium/potassium-transporting ATPase subunit alpha-1

Gene

atp1a1

Organism
Oreochromis mossambicus (Mozambique tilapia) (Tilapia mossambica)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei376 – 37614-aspartylphosphate intermediateBy similarity
Binding sitei487 – 4871ATPBy similarity
Metal bindingi717 – 7171MagnesiumBy similarity
Metal bindingi721 – 7211MagnesiumBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sodium:potassium-exchanging ATPase activity Source: UniProtKB-EC

GO - Biological processi

  1. ATP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-1 (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-1 subunit
Alternative name(s):
Sodium pump subunit alpha-1
Gene namesi
Name:atp1a1
OrganismiOreochromis mossambicus (Mozambique tilapia) (Tilapia mossambica)
Taxonomic identifieri8127 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaCichlomorphaeCichliformesCichlidaeAfrican cichlidsPseudocrenilabrinaeOreochrominiOreochromis

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 55By similarityPRO_0000002499
Chaini6 – 10231018Sodium/potassium-transporting ATPase subunit alpha-1PRO_0000002500Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161Phosphoserine; by PKCBy similarity
Modified residuei943 – 9431Phosphoserine; by PKABy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9YH26.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9YH26.
SMRiQ9YH26. Positions 26-1023.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini6 – 8782CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini109 – 13123ExtracellularSequence AnalysisAdd
BLAST
Topological domaini153 – 288136CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini309 – 32012ExtracellularSequence AnalysisAdd
BLAST
Topological domaini339 – 772434CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini793 – 80210ExtracellularSequence Analysis
Topological domaini824 – 84320CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini867 – 91852ExtracellularSequence AnalysisAdd
BLAST
Topological domaini939 – 95113CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini971 – 98515ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1007 – 102317CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei88 – 10821HelicalSequence AnalysisAdd
BLAST
Transmembranei132 – 15221HelicalSequence AnalysisAdd
BLAST
Transmembranei289 – 30820HelicalSequence AnalysisAdd
BLAST
Transmembranei321 – 33818HelicalSequence AnalysisAdd
BLAST
Transmembranei773 – 79220HelicalSequence AnalysisAdd
BLAST
Transmembranei803 – 82321HelicalSequence AnalysisAdd
BLAST
Transmembranei844 – 86623HelicalSequence AnalysisAdd
BLAST
Transmembranei919 – 93820HelicalSequence AnalysisAdd
BLAST
Transmembranei952 – 97019HelicalSequence AnalysisAdd
BLAST
Transmembranei986 – 100621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni82 – 843Interaction with phosphoinositide-3 kinaseBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004298.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9YH26-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLGKGKDEY KLAATSEDGG KKDKKAKAKK DMDDLKKEVD LDDHKLTLDE
60 70 80 90 100
LHRKYGTDLT RGLSSSRAKE ILARDGPNAL TPPPTTPEWV KFCKQLFGGF
110 120 130 140 150
SMLLWIGAIL CFLAYGIQAA SEDEPANDNL YLGIVLSAVV IITGCFSYYQ
160 170 180 190 200
EAKSSKIMES FKNLVPRQAL GIRDGEKKNI NAEEVVLGDL VEVKGGDRIP
210 220 230 240 250
ADLRIISAHG CKVDNSSLTG ESEPQTRSPD FSNENPLETR NISFFSTNCI
260 270 280 290 300
EGTARGIVIN TEDRTVMGRI ATLASSLEGG KTPIAIEIEH FIHIITGVAV
310 320 330 340 350
FLGVSFFILS LILGYNWLEA VIFLIGIIVA NVPEGLLATV TVCLTLTAKR
360 370 380 390 400
MAKKNCLVKN LEAVETLGST STICSDKTGT LTQNRMTVAH MWFDNQIHEA
410 420 430 440 450
DTTENQSGTS FDRSSATWAN LSRIAGLCNR AVFLADQSNI PILKRDVAGD
460 470 480 490 500
ASEAALLKCI ELCCGSVNEM REKYPKIAEI PFNSTNKYQL SIHKNTTPGE
510 520 530 540 550
TKHLLVMKGA PERILDRCNS IVLQGKVQAL DDEMKDAFQN AYVELGGLGE
560 570 580 590 600
RVLGFCHYHL PDDEFPEGFA FDTDEVNFPT ENLCFVGLMA MIDPPRAAVP
610 620 630 640 650
DAVGKCRSAG IKVIMVTGDH PITAKAIAKG VGIISEGNET VEDIAARLNV
660 670 680 690 700
PVSEVNPRDA KACVVHGSEL KDMTSEELDD LLKHHTEIVF ARTSPQQKLI
710 720 730 740 750
IVEGCQRQGA IVAVTGDGVN DSPALKKADI GVAMGIAGSD VSKQAADMIL
760 770 780 790 800
LDDNFASIVT GVEEGRLIFD NLKKSIAYTL TSNIPEISPF LLFIIANIPL
810 820 830 840 850
PLGTVTILCI DLGTDMVPAI SLAYEKAESD IMKRQPRNPK TDKLVNERLI
860 870 880 890 900
SIAYGQIGMM QATAGFFTYF VILAENGFLP MDLIGVRVLW DDKYVNDLED
910 920 930 940 950
SYGQQWTYER RKIVEYSCHT AFFASIVIVQ WADLIICKTR RNSIVQQGMT
960 970 980 990 1000
NRILIFGLFE ETALAAFLSY CPGMDVALRM YPMKPLWWFC AFPYSLLIFL
1010 1020
YDEARRYILR RNPGGWVEKE TYY
Length:1,023
Mass (Da):112,669
Last modified:May 1, 2000 - v2
Checksum:i19B5221173BC4454
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U82549 mRNA. Translation: AAD11455.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U82549 mRNA. Translation: AAD11455.2 .

3D structure databases

ProteinModelPortali Q9YH26.
SMRi Q9YH26. Positions 26-1023.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9YH26.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG004298.

Family and domain databases

Gene3Di 1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Gene expression of Na+-K+-ATPase alpha 1 and alpha 3 subunits in gills of the teleost Oreochromis mossambicus, adapted to different environmental salinities."
    Feng S.H., Leu J.H., Yang C.H., Fang M.J., Huang C.J., Hwang P.P.
    Mar. Biotechnol. 4:379-391(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiAT1A1_OREMO
AccessioniPrimary (citable) accession number: Q9YH26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 2000
Last modified: October 1, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3