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Q9YH26

- AT1A1_OREMO

UniProt

Q9YH26 - AT1A1_OREMO

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Protein
Sodium/potassium-transporting ATPase subunit alpha-1
Gene
atp1a1
Organism
Oreochromis mossambicus (Mozambique tilapia) (Tilapia mossambica)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei376 – 37614-aspartylphosphate intermediate By similarity
Binding sitei487 – 4871ATP By similarity
Metal bindingi717 – 7171Magnesium By similarity
Metal bindingi721 – 7211Magnesium By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sodium:potassium-exchanging ATPase activity Source: UniProtKB-EC

GO - Biological processi

  1. ATP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-1 (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-1 subunit
Alternative name(s):
Sodium pump subunit alpha-1
Gene namesi
Name:atp1a1
OrganismiOreochromis mossambicus (Mozambique tilapia) (Tilapia mossambica)
Taxonomic identifieri8127 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaCichlomorphaeCichliformesCichlidaeAfrican cichlidsPseudocrenilabrinaeOreochrominiOreochromis

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini6 – 8782Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei88 – 10821Helical; Reviewed prediction
Add
BLAST
Topological domaini109 – 13123Extracellular Reviewed prediction
Add
BLAST
Transmembranei132 – 15221Helical; Reviewed prediction
Add
BLAST
Topological domaini153 – 288136Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei289 – 30820Helical; Reviewed prediction
Add
BLAST
Topological domaini309 – 32012Extracellular Reviewed prediction
Add
BLAST
Transmembranei321 – 33818Helical; Reviewed prediction
Add
BLAST
Topological domaini339 – 772434Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei773 – 79220Helical; Reviewed prediction
Add
BLAST
Topological domaini793 – 80210Extracellular Reviewed prediction
Transmembranei803 – 82321Helical; Reviewed prediction
Add
BLAST
Topological domaini824 – 84320Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei844 – 86623Helical; Reviewed prediction
Add
BLAST
Topological domaini867 – 91852Extracellular Reviewed prediction
Add
BLAST
Transmembranei919 – 93820Helical; Reviewed prediction
Add
BLAST
Topological domaini939 – 95113Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei952 – 97019Helical; Reviewed prediction
Add
BLAST
Topological domaini971 – 98515Extracellular Reviewed prediction
Add
BLAST
Transmembranei986 – 100621Helical; Reviewed prediction
Add
BLAST
Topological domaini1007 – 102317Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 55 By similarity
PRO_0000002499
Chaini6 – 10231018Sodium/potassium-transporting ATPase subunit alpha-1
PRO_0000002500Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161Phosphoserine; by PKC By similarity
Modified residuei943 – 9431Phosphoserine; by PKA By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9YH26.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9YH26.
SMRiQ9YH26. Positions 26-1023.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni82 – 843Interaction with phosphoinositide-3 kinase By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004298.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9YH26-1 [UniParc]FASTAAdd to Basket

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MGLGKGKDEY KLAATSEDGG KKDKKAKAKK DMDDLKKEVD LDDHKLTLDE     50
LHRKYGTDLT RGLSSSRAKE ILARDGPNAL TPPPTTPEWV KFCKQLFGGF 100
SMLLWIGAIL CFLAYGIQAA SEDEPANDNL YLGIVLSAVV IITGCFSYYQ 150
EAKSSKIMES FKNLVPRQAL GIRDGEKKNI NAEEVVLGDL VEVKGGDRIP 200
ADLRIISAHG CKVDNSSLTG ESEPQTRSPD FSNENPLETR NISFFSTNCI 250
EGTARGIVIN TEDRTVMGRI ATLASSLEGG KTPIAIEIEH FIHIITGVAV 300
FLGVSFFILS LILGYNWLEA VIFLIGIIVA NVPEGLLATV TVCLTLTAKR 350
MAKKNCLVKN LEAVETLGST STICSDKTGT LTQNRMTVAH MWFDNQIHEA 400
DTTENQSGTS FDRSSATWAN LSRIAGLCNR AVFLADQSNI PILKRDVAGD 450
ASEAALLKCI ELCCGSVNEM REKYPKIAEI PFNSTNKYQL SIHKNTTPGE 500
TKHLLVMKGA PERILDRCNS IVLQGKVQAL DDEMKDAFQN AYVELGGLGE 550
RVLGFCHYHL PDDEFPEGFA FDTDEVNFPT ENLCFVGLMA MIDPPRAAVP 600
DAVGKCRSAG IKVIMVTGDH PITAKAIAKG VGIISEGNET VEDIAARLNV 650
PVSEVNPRDA KACVVHGSEL KDMTSEELDD LLKHHTEIVF ARTSPQQKLI 700
IVEGCQRQGA IVAVTGDGVN DSPALKKADI GVAMGIAGSD VSKQAADMIL 750
LDDNFASIVT GVEEGRLIFD NLKKSIAYTL TSNIPEISPF LLFIIANIPL 800
PLGTVTILCI DLGTDMVPAI SLAYEKAESD IMKRQPRNPK TDKLVNERLI 850
SIAYGQIGMM QATAGFFTYF VILAENGFLP MDLIGVRVLW DDKYVNDLED 900
SYGQQWTYER RKIVEYSCHT AFFASIVIVQ WADLIICKTR RNSIVQQGMT 950
NRILIFGLFE ETALAAFLSY CPGMDVALRM YPMKPLWWFC AFPYSLLIFL 1000
YDEARRYILR RNPGGWVEKE TYY 1023
Length:1,023
Mass (Da):112,669
Last modified:May 1, 2000 - v2
Checksum:i19B5221173BC4454
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U82549 mRNA. Translation: AAD11455.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U82549 mRNA. Translation: AAD11455.2 .

3D structure databases

ProteinModelPortali Q9YH26.
SMRi Q9YH26. Positions 26-1023.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9YH26.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG004298.

Family and domain databases

Gene3Di 1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Gene expression of Na+-K+-ATPase alpha 1 and alpha 3 subunits in gills of the teleost Oreochromis mossambicus, adapted to different environmental salinities."
    Feng S.H., Leu J.H., Yang C.H., Fang M.J., Huang C.J., Hwang P.P.
    Mar. Biotechnol. 4:379-391(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiAT1A1_OREMO
AccessioniPrimary (citable) accession number: Q9YH26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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