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Q9YH26 (AT1A1_OREMO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium/potassium-transporting ATPase subunit alpha-1

Short name=Na(+)/K(+) ATPase alpha-1 subunit
EC=3.6.3.9
Alternative name(s):
Sodium pump subunit alpha-1
Gene names
Name:atp1a1
OrganismOreochromis mossambicus (Mozambique tilapia) (Tilapia mossambica)
Taxonomic identifier8127 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiEuteleosteiNeoteleosteiAcanthomorphaAcanthopterygiiPercomorphaPerciformesLabroideiCichlidaeAfrican cichlidsPseudocrenilabrinaeOreochrominiOreochromis

Protein attributes

Sequence length1023 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activity

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Subunit structure

Composed of three subunits: alpha (catalytic), beta and gamma By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 55 By similarity
PRO_0000002499
Chain6 – 10231018Sodium/potassium-transporting ATPase subunit alpha-1
PRO_0000002500

Regions

Topological domain6 – 8782Cytoplasmic Potential
Transmembrane88 – 10821Helical; Potential
Topological domain109 – 13123Extracellular Potential
Transmembrane132 – 15221Helical; Potential
Topological domain153 – 288136Cytoplasmic Potential
Transmembrane289 – 30820Helical; Potential
Topological domain309 – 32012Extracellular Potential
Transmembrane321 – 33818Helical; Potential
Topological domain339 – 772434Cytoplasmic Potential
Transmembrane773 – 79220Helical; Potential
Topological domain793 – 80210Extracellular Potential
Transmembrane803 – 82321Helical; Potential
Topological domain824 – 84320Cytoplasmic Potential
Transmembrane844 – 86623Helical; Potential
Topological domain867 – 91852Extracellular Potential
Transmembrane919 – 93820Helical; Potential
Topological domain939 – 95113Cytoplasmic Potential
Transmembrane952 – 97019Helical; Potential
Topological domain971 – 98515Extracellular Potential
Transmembrane986 – 100621Helical; Potential
Topological domain1007 – 102317Cytoplasmic Potential
Region82 – 843Interaction with phosphoinositide-3 kinase By similarity

Sites

Active site37614-aspartylphosphate intermediate By similarity
Metal binding7171Magnesium By similarity
Metal binding7211Magnesium By similarity
Binding site4871ATP By similarity

Amino acid modifications

Modified residue161Phosphoserine; by PKC By similarity
Modified residue9431Phosphoserine; by PKA By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9YH26 [UniParc].

Last modified May 1, 2000. Version 2.
Checksum: 19B5221173BC4454

FASTA1,023112,669
        10         20         30         40         50         60 
MGLGKGKDEY KLAATSEDGG KKDKKAKAKK DMDDLKKEVD LDDHKLTLDE LHRKYGTDLT 

        70         80         90        100        110        120 
RGLSSSRAKE ILARDGPNAL TPPPTTPEWV KFCKQLFGGF SMLLWIGAIL CFLAYGIQAA 

       130        140        150        160        170        180 
SEDEPANDNL YLGIVLSAVV IITGCFSYYQ EAKSSKIMES FKNLVPRQAL GIRDGEKKNI 

       190        200        210        220        230        240 
NAEEVVLGDL VEVKGGDRIP ADLRIISAHG CKVDNSSLTG ESEPQTRSPD FSNENPLETR 

       250        260        270        280        290        300 
NISFFSTNCI EGTARGIVIN TEDRTVMGRI ATLASSLEGG KTPIAIEIEH FIHIITGVAV 

       310        320        330        340        350        360 
FLGVSFFILS LILGYNWLEA VIFLIGIIVA NVPEGLLATV TVCLTLTAKR MAKKNCLVKN 

       370        380        390        400        410        420 
LEAVETLGST STICSDKTGT LTQNRMTVAH MWFDNQIHEA DTTENQSGTS FDRSSATWAN 

       430        440        450        460        470        480 
LSRIAGLCNR AVFLADQSNI PILKRDVAGD ASEAALLKCI ELCCGSVNEM REKYPKIAEI 

       490        500        510        520        530        540 
PFNSTNKYQL SIHKNTTPGE TKHLLVMKGA PERILDRCNS IVLQGKVQAL DDEMKDAFQN 

       550        560        570        580        590        600 
AYVELGGLGE RVLGFCHYHL PDDEFPEGFA FDTDEVNFPT ENLCFVGLMA MIDPPRAAVP 

       610        620        630        640        650        660 
DAVGKCRSAG IKVIMVTGDH PITAKAIAKG VGIISEGNET VEDIAARLNV PVSEVNPRDA 

       670        680        690        700        710        720 
KACVVHGSEL KDMTSEELDD LLKHHTEIVF ARTSPQQKLI IVEGCQRQGA IVAVTGDGVN 

       730        740        750        760        770        780 
DSPALKKADI GVAMGIAGSD VSKQAADMIL LDDNFASIVT GVEEGRLIFD NLKKSIAYTL 

       790        800        810        820        830        840 
TSNIPEISPF LLFIIANIPL PLGTVTILCI DLGTDMVPAI SLAYEKAESD IMKRQPRNPK 

       850        860        870        880        890        900 
TDKLVNERLI SIAYGQIGMM QATAGFFTYF VILAENGFLP MDLIGVRVLW DDKYVNDLED 

       910        920        930        940        950        960 
SYGQQWTYER RKIVEYSCHT AFFASIVIVQ WADLIICKTR RNSIVQQGMT NRILIFGLFE 

       970        980        990       1000       1010       1020 
ETALAAFLSY CPGMDVALRM YPMKPLWWFC AFPYSLLIFL YDEARRYILR RNPGGWVEKE 


TYY 

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References

[1]"Gene expression of Na+-K+-ATPase alpha 1 and alpha 3 subunits in gills of the teleost Oreochromis mossambicus, adapted to different environmental salinities."
Feng S.H., Leu J.H., Yang C.H., Fang M.J., Huang C.J., Hwang P.P.
Mar. Biotechnol. 4:379-391(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U82549 mRNA. Translation: AAD11455.2.

3D structure databases

ProteinModelPortalQ9YH26.
SMRQ9YH26. Positions 26-1023.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ9YH26.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG004298.

Family and domain databases

Gene3D1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
SMARTSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAT1A1_OREMO
AccessionPrimary (citable) accession number: Q9YH26
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families